Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0252528 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.00875083 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0252528 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0252528 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0252528 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0252528 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.00875083 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.00875083 | 0 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.00875083 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0252528 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.00875083 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0252528 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0252528 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0252528 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0252528 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0252528 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0252528 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.00875083 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.00875083 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00875083 | 0 | 0.5 |
Treponema pallidum | NADH oxidase | 0.00875083 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0252528 | 1 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.00875083 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00875083 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0252528 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0252528 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antileishmanial activity against Leishmania major MRHO/IR/75/ER amastigotes by MTT assay | ChEMBL. | 18321711 | |
Activity (functional) | Antileishmanial activity against Leishmania major amastigotes in mouse macrophages assessed as decrease in infectivity index after 24 hrs | ChEMBL. | 18321711 | |
Activity (functional) | Antileishmanial activity against Leishmania major amastigotes assessed as decrease in infectivity in mouse macrophages after 24 hrs | ChEMBL. | 18321711 | |
IC50 (functional) | = 10.73 uM | Antileishmanial activity against Leishmania major MRHO/IR/75/ER promastigotes by MTT assay | ChEMBL. | 18321711 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania major | ChEMBL23 | 18321711 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.