Detailed information for compound 964243

Basic information

Technical information
  • TDR Targets ID: 964243
  • Name: MLS000563507
  • MW: 482.565 | Formula: C28H34O7
  • H donors: 0 H acceptors: 3 LogP: 4.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@@H]1C[C@H]2C(C)(C)C(=O)C=C[C@@]2([C@@H]2[C@]1(C)[C@@]13O[C@@H]1C(=O)O[C@H]([C@@]3(CC2)C)c1ccoc1)C
  • InChi: 1S/C28H34O7/c1-15(29)33-20-13-18-24(2,3)19(30)8-10-25(18,4)17-7-11-26(5)21(16-9-12-32-14-16)34-23(31)22-28(26,35-22)27(17,20)6/h8-10,12,14,17-18,20-22H,7,11,13H2,1-6H3/t17-,18+,20-,21+,22-,25-,26+,27+,28-/m1/s1
  • InChiKey: YJXDGWUNRYLINJ-BHAPSIHVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • SMR000232316

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Chlamydia trachomatis recombinase RecA Get druggable targets OG5_130095 All targets in OG5_130095
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Chlamydia trachomatis replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Mycobacterium ulcerans recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Wolbachia endosymbiont of Brugia malayi recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Get druggable targets OG5_130095 All targets in OG5_130095
Treponema pallidum replicative DNA helicase (dnaB) Get druggable targets OG5_131890 All targets in OG5_131890
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Treponema pallidum recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. Get druggable targets OG5_130095 All targets in OG5_130095
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Leishmania major DNA topoisomerase III, putative 0.00325126 0.00074621 0.000996294
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Brugia malayi AKH receptor 0.00277599 0.000436394 0.000420991
Echinococcus granulosus neuropeptide Y receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni biogenic amine (5HT) receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00277599 0.000436394 0.000432402
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0189254 0.0109638 0.0109599
Giardia lamblia DNA topoisomerase III 0.00325126 0.00074621 1
Echinococcus multilocularis allatostatin A receptor 0.00277599 0.000436394 0.000432402
Entamoeba histolytica DNA topoisomerase III, putative 0.00325126 0.00074621 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus phospholipase A 2 activating protein 0.00486424 0.00179767 0.00179369
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus biogenic amine 5HT receptor 0.00277599 0.000436394 0.000432402
Brugia malayi sulfakinin receptor protein 0.00277599 0.000436394 0.000420991
Trypanosoma brucei membrane transporter protein, putative 0.0189254 0.0109638 0.0147116
Loa Loa (eye worm) hypothetical protein 0.00672295 0.00300933 0.00299397
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus dro:myosuppressin receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Leishmania major DNA topoisomerase III, putative 0.00213019 0.0000154093 0.0000153239
Echinococcus granulosus rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.00327052 0.000758765 0.295223
Echinococcus granulosus sex peptide receptor 0.00277599 0.000436394 0.000432402
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0274647 0.0165304 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.00277599 0.000436394 0.000420991
Trypanosoma cruzi DNA topoisomerase III, putative 0.00325126 0.00074621 0.000996294
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus somatostatin receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0320623 0.0195275 0.0195235
Plasmodium falciparum DNA topoisomerase 3, putative 0.00325126 0.00074621 0.00074222
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00277599 0.000436394 0.000420991
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis alkaline phosphatase 0.0320623 0.0195275 0.0195235
Schistosoma mansoni growth hormone secretagogue receptor 0.00277599 0.000436394 0.000432402
Brugia malayi Melatonin receptor type 1A 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus peptide allatostatin:somatostatin 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) neuropeptide F receptor 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.0336015 0.0205308 0.0205158
Echinococcus granulosus rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis somatostatin receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis neuropeptide Y receptor 0.00277599 0.000436394 0.000432402
Leishmania major hypothetical protein, conserved 0.00486424 0.00179767 0.0024077
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Brugia malayi Dopamine receptor protein 2 0.00277599 0.000436394 0.000420991
Echinococcus granulosus G protein coupled receptor 139 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis sex peptide receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus epidermal growth factor receptor 0.0429912 0.0266518 0.0266479
Loa Loa (eye worm) acetylcholinesterase 1 0.00672295 0.00300933 0.00299397
Echinococcus granulosus alpha 1A adrenergic receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis neuropeptide receptor A26 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.00260293 0.000323579 0.000428987
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00277599 0.000436394 0.000432402
Schistosoma mansoni tyrosine kinase 0.0255684 0.0152942 0.0152903
Echinococcus granulosus neuropeptide FF receptor 2 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) neuropeptide F receptor 0.00277599 0.000436394 0.000420991
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00277599 0.000436394 0.000420991
Schistosoma mansoni biogenic amine (5HT) receptor 0.00277599 0.000436394 0.000432402
Leishmania major DNA topoisomerase type IB small subunit 0.493467 0.320307 0.42995
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Onchocerca volvulus Neuropeptide F receptor homolog 0.00277599 0.000436394 0.122253
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.00265417 0.00035698 0.000473822
Echinococcus granulosus intestinal type alkaline phosphatase 0.0320623 0.0195275 0.0195235
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Brugia malayi G protein-coupled receptor F59B2.13 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi membrane transporter protein, putative 0.0189254 0.0109638 0.0147116
Brugia malayi WD domain containing protein 0.00486424 0.00179767 0.00178229
Echinococcus granulosus hypothetical protein 0.00277599 0.000436394 0.000432402
Echinococcus granulosus insulin receptor 0.0255684 0.0152942 0.0152903
Trypanosoma cruzi DNA topoisomerase III, putative 0.00213019 0.0000154093 0.0000153239
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus tachykinin peptides receptor 99D 0.00277599 0.000436394 0.000432402
Echinococcus granulosus 7tm_1 domain containing protein 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis serotonin receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus epidermal growth factor receptor 0.0800147 0.0507866 0.0507828
Echinococcus multilocularis DNA topoisomerase 1 1.53614 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00277599 0.000436394 0.000432402
Leishmania major DNA topoisomerase IB, large subunit 1.14493 0.744982 1
Echinococcus granulosus alkaline phosphatase 0.0320623 0.0195275 0.0195235
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis neuropeptides capa receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis rho GTPase activating protein 20 0.00325126 0.00074621 0.00074222
Schistosoma mansoni serine/threonine protein kinase 0.0246007 0.0146635 0.0146595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis neuropeptide receptor 0.00277599 0.000436394 0.000432402
Brugia malayi putative neuropeptide receptor NPR1 0.00277599 0.000436394 0.000420991
Brugia malayi Carboxylesterase family protein 0.00672295 0.00300933 0.00299397
Echinococcus granulosus serotonin receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni DNA topoisomerase type I 1.53614 1 1
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) G-protein coupled receptor 0.00277599 0.000436394 0.000420991
Schistosoma mansoni biogenic amine receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis g-protein coupled receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Brugia malayi ORL1-like opioid receptor 0.00277599 0.000436394 0.000420991
Schistosoma mansoni prokaryotic DNA topoisomerase 0.00213019 0.0000154093 0.000011416
Schistosoma mansoni biogenic amine receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni neuropeptide receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis carboxylesterase 5A 0.00672295 0.00300933 0.00300535
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0170774 0.00975919 0.00975524
Brugia malayi hypoxia-induced factor 1 0.0309986 0.0188341 0.0188189
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Trypanosoma cruzi hypothetical protein, conserved 0.0189254 0.0109638 0.0147116
Echinococcus granulosus g protein coupled receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus tm gpcr rhodopsin 0.00277599 0.000436394 0.000432402
Schistosoma mansoni DNA topoisomerase type I 1.14493 0.744982 0.744981
Loa Loa (eye worm) hypoxia-induced factor 1 0.0309986 0.0188341 0.0188189
Echinococcus granulosus aryl hydrocarbon receptor 0.00260293 0.000323579 0.000319587
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Brugia malayi G-protein coupled receptor 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) DNA topoisomerase III 0.00325126 0.00074621 0.000730812
Schistosoma mansoni hypothetical protein 0.00277599 0.000436394 0.000432402
Schistosoma mansoni aryl hydrocarbon receptor 0.0100156 0.00515575 0.00515178
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0255684 0.0152942 0.0152903
Echinococcus multilocularis 0.0247663 0.0147714 0.0147675
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Entamoeba histolytica hypothetical protein 0.00318743 0.000704603 0.943942
Brugia malayi Dopamine receptor 0.00277599 0.000436394 0.000420991
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.00486424 0.00179767 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi DNA topoisomerase IA, putative 0.00325126 0.00074621 0.000996294
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis phospholipase A 2 activating protein 0.00486424 0.00179767 0.00179369
Schistosoma mansoni adenoreceptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis acetylcholinesterase 0.00672295 0.00300933 0.00300535
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00277599 0.000436394 0.000432402
Brugia malayi DNA topoisomerase III 0.00325126 0.00074621 0.000730812
Echinococcus multilocularis neuropeptide receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.00260293 0.000323579 0.000308174
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0295453 0.0178867 1
Leishmania major hypothetical protein, conserved 0.0189254 0.0109638 0.0147116
Schistosoma mansoni opsin-like receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis neuropeptide s receptor 0.00277599 0.000436394 0.000432402
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Echinococcus multilocularis neuropeptides capa receptor 0.00277599 0.000436394 0.000432402
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus neuropeptide receptor 0.00277599 0.000436394 0.000432402
Brugia malayi PAS domain containing protein 0.0100156 0.00515575 0.00514042
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) TK/EGFR protein kinase 0.0800147 0.0507866 0.050772
Echinococcus granulosus neuropeptides capa receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni opsin-like receptor 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.00265417 0.00035698 0.000473822
Echinococcus multilocularis rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Echinococcus granulosus carboxylesterase 5A 0.00672295 0.00300933 0.00300535
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0246007 0.0146635 0.0146483
Brugia malayi DNA topoisomerase I 1.53614 1 1
Echinococcus multilocularis fmrfamide receptor 0.00277599 0.000436394 0.000432402
Trypanosoma brucei DNA topoisomerase IB, large subunit 1.14493 0.744982 1
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.00213019 0.0000154093 0.000011416
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.00325126 0.00074621 0.286706
Echinococcus multilocularis 0.0560858 0.0351879 0.0351841
Toxoplasma gondii DNA topoisomerase family protein 0.00325126 0.00074621 0.00074222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.00486424 0.00179767 0.0024077
Brugia malayi follicle stimulating hormone receptor 0.00277599 0.000436394 0.000420991
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.00260293 0.000323579 0.000319587
Brugia malayi RE15519p 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0320623 0.0195275 0.0195235
Trypanosoma cruzi hypothetical protein, conserved 0.0189254 0.0109638 0.0147116
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni tyrosine kinase 0.0429912 0.0266518 0.0266479
Echinococcus granulosus g protein coupled receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni hypothetical protein 0.00277599 0.000436394 0.000432402
Schistosoma mansoni amine GPCR 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00260293 0.000323579 0.000308174
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00277599 0.000436394 0.000420991
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.00265417 0.00035698 0.000473822
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Brugia malayi neuropeptide F receptor 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00327052 0.000758765 0.000743367
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Brugia malayi Serotonin receptor 0.00277599 0.000436394 0.000420991
Echinococcus granulosus g-protein coupled receptor 0.00277599 0.000436394 0.000432402
Trypanosoma brucei MATE efflux family protein, putative 0.0189254 0.0109638 0.0147116
Echinococcus granulosus rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Trypanosoma brucei membrane transporter protein, putative 0.0189254 0.0109638 0.0147116
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.00325126 0.00074621 0.286706
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni amine GPCR 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0429912 0.0266518 0.0266479
Brugia malayi G-protein coupled receptor 0.00277599 0.000436394 0.000420991
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Schistosoma mansoni neuropeptide receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni alkaline phosphatase 0.0320623 0.0195275 0.0195235
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.00325126 0.00074621 0.5
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni amine GPCR 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Toxoplasma gondii PUL domain-containing protein 0.00486424 0.00179767 0.00179369
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00277599 0.000436394 0.000420991
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00277599 0.000436394 0.122253
Plasmodium vivax DNA topoisomerase 3, putative 0.00325126 0.00074621 0.00074222
Schistosoma mansoni neuropeptide F-like receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis epidermal growth factor receptor 0.0800147 0.0507866 0.0507828
Brugia malayi G protein-coupled receptor 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis neuropeptide Y receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis orexin receptor type 2 0.00277599 0.000436394 0.000432402
Brugia malayi larval opioid receptor 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis serotonin receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) DNA topoisomerase I 1.53614 1 1
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Leishmania major DNA topoisomerase 1A 0.00325126 0.00074621 0.000996294
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.00260293 0.000323579 0.000428987
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus fmrfamide receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis aryl hydrocarbon receptor 0.00260293 0.000323579 0.000319587
Brugia malayi Serotonin receptor 0.00277599 0.000436394 0.000420991
Brugia malayi Furin-like cysteine rich region family protein 0.0800147 0.0507866 0.050772
Echinococcus multilocularis rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi DNA topoisomerase III, putative 0.00325126 0.00074621 0.000996294
Schistosoma mansoni phospholipase A-2-activating protein 0.00327052 0.000758765 0.000754775
Chlamydia trachomatis DNA topoisomerase I 0.00325126 0.00074621 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0424233 0.0262816 0.0262777
Schistosoma mansoni neuropeptide receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus orexin receptor type 2 0.00277599 0.000436394 0.000432402
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Echinococcus multilocularis g protein coupled receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00277599 0.000436394 0.000432402
Brugia malayi Carboxylesterase family protein 0.00672295 0.00300933 0.00299397
Trypanosoma brucei WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.00327052 0.000758765 0.00101315
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00672295 0.00300933 0.00300535
Brugia malayi GnHR receptor homolog 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00277599 0.000436394 0.000432402
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0189254 0.0109638 0.0109599
Schistosoma mansoni tyrosine kinase 0.0425376 0.0263561 0.0263522
Schistosoma mansoni DNA topoisomerase type I 1.14493 0.744982 0.744981
Echinococcus multilocularis epidermal growth factor receptor 0.0429912 0.0266518 0.0266479
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00277599 0.000436394 0.000420991
Leishmania major protein kinase, putative 0.00265417 0.00035698 0.000473822
Plasmodium vivax topoisomerase I, putative 1.53614 1 1
Schistosoma mansoni multidrug resistance protein 0.0189254 0.0109638 0.0109599
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0255684 0.0152942 0.0152903
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00277599 0.000436394 0.000432402
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.493467 0.320307 0.42995
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00277599 0.000436394 0.000432402
Echinococcus granulosus neuropeptide s receptor 0.00277599 0.000436394 0.000432402
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni biogenic amine receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00277599 0.000436394 0.000432402
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Echinococcus multilocularis dro:myosuppressin receptor 0.00277599 0.000436394 0.000432402
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Trypanosoma brucei membrane transporter protein, putative 0.0189254 0.0109638 0.0147116
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) melatonin receptor type 1A 0.00277599 0.000436394 0.000420991
Brugia malayi hypothetical protein 0.00277599 0.000436394 0.000420991
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Treponema pallidum DNA topoisomerase I (topA) 0.00325126 0.00074621 0.5
Plasmodium falciparum topoisomerase I 1.53614 1 1
Leishmania major protein kinase, putative 0.00265417 0.00035698 0.000473822
Loa Loa (eye worm) hypothetical protein 0.00672295 0.00300933 0.00299397
Schistosoma mansoni single-minded 0.0100156 0.00515575 0.00515178
Echinococcus granulosus biogenic amine 5HT receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni neuropeptide f receptor 76f 0.00277599 0.000436394 0.000432402
Echinococcus granulosus tm gpcr rhodopsin 0.00277599 0.000436394 0.000432402
Schistosoma mansoni alkaline phosphatase 0.0320623 0.0195275 0.0195235
Schistosoma mansoni prokaryotic DNA topoisomerase 0.00325126 0.00074621 0.00074222
Brugia malayi hypothetical protein 0.0336015 0.0205308 0.0205158
Echinococcus multilocularis g protein coupled receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) WD domain-containing protein 0.00327052 0.000758765 0.000743367
Loa Loa (eye worm) TYRA-2 protein 0.00277599 0.000436394 0.000420991
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.00213019 0.0000154093 0.000011416
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni tyrosine kinase 0.0425376 0.0263561 0.0263522
Brugia malayi putative neuropeptide receptor 0.00277599 0.000436394 0.000420991
Echinococcus granulosus DNA topoisomerase 3 alpha 0.00325126 0.00074621 0.00074222
Mycobacterium ulcerans DNA topoisomerase I 0.00325126 0.00074621 0.0415047
Trypanosoma brucei DNA topoisomerase III, putative 0.00325126 0.00074621 0.000996294
Schistosoma mansoni myosin xvIII 0.00277599 0.000436394 0.000432402
Schistosoma mansoni opsin-like receptor 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi hypothetical protein, conserved 0.0189254 0.0109638 0.0147116
Onchocerca volvulus 0.0074127 0.00345896 1
Echinococcus granulosus single minded 2 0.0074127 0.00345896 0.00345498
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.00260293 0.000323579 0.000428987
Schistosoma mansoni neuropeptide receptor 0.00277599 0.000436394 0.000432402
Brugia malayi Dopamine receptor protein 1 0.00277599 0.000436394 0.000420991
Brugia malayi Protein kinase domain containing protein 0.0255684 0.0152942 0.0152791
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00277599 0.000436394 0.000432402
Brugia malayi neuropeptide F receptor 0.00277599 0.000436394 0.000420991
Echinococcus granulosus g protein coupled receptor 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi DNA topoisomerase IA, putative 0.00325126 0.00074621 0.000996294
Schistosoma mansoni tyrosine kinase 0.0425376 0.0263561 0.0263522
Schistosoma mansoni amine GPCR 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) carboxylesterase 0.00672295 0.00300933 0.00299397
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00277599 0.000436394 0.000432402
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0320623 0.0195275 0.0195235
Leishmania major hypothetical protein, conserved 0.0189254 0.0109638 0.0147116
Schistosoma mansoni hypothetical protein 0.00277599 0.000436394 0.000432402
Brugia malayi bHLH-PAS transcription factor 0.0074127 0.00345896 0.0034436
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00277599 0.000436394 0.000432402
Toxoplasma gondii DNA topoisomerase I, putative 1.53614 1 1
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Echinococcus granulosus acetylcholinesterase 0.00672295 0.00300933 0.00300535
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00277599 0.000436394 0.000420991
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Entamoeba histolytica DNA topoisomerase III, putative 0.00213019 0.0000154093 0.0153809
Trypanosoma brucei DNA topoisomerase III, putative 0.00213019 0.0000154093 0.0000153239
Echinococcus multilocularis acetylcholinesterase 0.00672295 0.00300933 0.00300535
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0320623 0.0195275 0.0195235
Onchocerca volvulus 0.00260293 0.000323579 0.0894919
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis fmrfamide receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0320623 0.0195275 0.0195235
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus neuropeptides capa receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00277599 0.000436394 0.000432402
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.00213019 0.0000154093 0.000011416
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Mycobacterium ulcerans putative regulatory protein 0.0074127 0.00345896 0.193201
Plasmodium falciparum polyubiquitin binding protein, putative 0.00486424 0.00179767 0.00179369
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni hypothetical protein 0.0166598 0.00948694 0.00948299
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Brugia malayi Tachykinin-like peptides receptor 99D 0.00277599 0.000436394 0.000420991
Trypanosoma cruzi hypothetical protein, conserved 0.0189254 0.0109638 0.0147116
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.493467 0.320307 0.42995
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.00486424 0.00179767 0.0024077
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.00325126 0.00074621 1
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni hypothetical protein 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00277599 0.000436394 0.000420991
Schistosoma mansoni histamine h1 receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus acetylcholinesterase 0.00672295 0.00300933 0.00300535
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.00260293 0.000323579 0.000319587
Schistosoma mansoni alpha-1 adrenergic receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus 7TM GPCR rhodopsin 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis g protein coupled receptor 0.00277599 0.000436394 0.000432402
Schistosoma mansoni tyrosine kinase 0.0800147 0.0507866 0.0507828
Echinococcus granulosus DNA topoisomerase 1 1.53614 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Schistosoma mansoni neuropeptide F-like receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis insulin receptor 0.0255684 0.0152942 0.0152903
Schistosoma mansoni tyrosine kinase 0.0255684 0.0152942 0.0152903
Onchocerca volvulus 0.00277599 0.000436394 0.122253
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00277599 0.000436394 0.000432402
Echinococcus granulosus allatostatin A receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis G protein coupled receptor 139 0.00277599 0.000436394 0.000432402
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.00265417 0.00035698 0.000473822
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus multilocularis transfer RNA-Lys 0.0074127 0.00345896 0.00345498
Echinococcus granulosus neuropeptide Y receptor 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis neuropeptide FF receptor 2 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Trypanosoma cruzi hypothetical protein, conserved 0.0189254 0.0109638 0.0147116
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 1.14493 0.744982 1
Echinococcus granulosus neuropeptide receptor 0.00277599 0.000436394 0.000432402
Brugia malayi Protein kinase domain containing protein 0.0246007 0.0146635 0.0146483
Giardia lamblia DNA topoisomerase III 0.00213019 0.0000154093 0.0206501
Echinococcus multilocularis G-protein coupled receptor, putative 0.00277599 0.000436394 0.000432402
Schistosoma mansoni tyrosine kinase 0.0429912 0.0266518 0.0266479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Echinococcus granulosus tm gpcr rhodopsin 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) hypothetical protein 0.00277599 0.000436394 0.000420991
Schistosoma mansoni amine GPCR 0.00277599 0.000436394 0.000432402
Echinococcus granulosus rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0295453 0.0178867 1
Trypanosoma brucei DNA topoisomerase IA, putative 0.00325126 0.00074621 0.000996294
Echinococcus multilocularis rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Echinococcus multilocularis rhodopsin orphan GPCR 0.00277599 0.000436394 0.000432402
Loa Loa (eye worm) TK/INSR protein kinase 0.0255684 0.0152942 0.0152791
Echinococcus granulosus neuropeptide receptor A26 0.00277599 0.000436394 0.000432402

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 4.566 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (functional) = 44.53 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
Activity (binding) Inhibition of Hsp90-mediated Raf degradation in human SKBR3 cells after 24 hrs by Western blot ChEMBL. 18816111
Activity (binding) Inhibition of HSP90 binding to Cdc37 in human SKBR-3 cells by Western blotting ChEMBL. 21129982
Activity (binding) Inhibition of Hsp90-mediated HER2 degradation in human SKBR3 cells after 24 hrs by Western blot ChEMBL. 18816111
Activity (binding) Inhibition of HSP90 in human MCF7 cells assessed as degradation of Hsp70 protein up to 50 uM after 48 hrs by Western blotting ChEMBL. 21129982
Activity (binding) Inhibition of HSP90 in human MCF7 cells assessed as degradation of Her2 protein after 48 hrs by Western blotting ChEMBL. 21129982
Activity (binding) Inhibition of HSP90 in human MCF7 cells assessed as degradation of AKT protein after 48 hrs by Western blotting ChEMBL. 21129982
Activity (binding) Modulation proteolytic fingerprint of HSP90 in rabbit reticulocyte lysates at 20 uM after 5 mins by SDS-PAGE analysis in presence of 125 ug/ml of trypsin ChEMBL. 21129982
Activity (functional) = 32 % Cytotoxicity against human KB cells assessed as viability at 20000 ng/ml ChEMBL. 9134742
AFI (functional) = 81 % Antifeedant activity against larvae of Drosophila melanogaster at 10 ug/ml after 12 to 24 hr ChEMBL. No reference
AFI (functional) = 98 % Antifeedant activity against larvae of Drosophila melanogaster at 25 ug/ml after 12 to 24 hr ChEMBL. No reference
AFI (functional) = 100 % Antifeedant activity against larvae of Drosophila melanogaster at 100 ug/ml after 12 to 24 hr ChEMBL. No reference
AFI (functional) = 100 % Antifeedant activity against larvae of Drosophila melanogaster at 50 ug/ml after 12 to 24 hr ChEMBL. No reference
EC50 (functional) = 38.95 nM Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release ChEMBL. 19138859
EC50 (functional) = 16.1 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] ChEMBL. No reference
IC50 (functional) = 20 ng/ml Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake ChEMBL. 9134742
IC50 (functional) = 39 ng/ml Antimalarial activity against Plasmodium falciparum D6 by [3H]hypoxanthine uptake ChEMBL. 9134742
IC50 (functional) = 720 ng/ml Antimalarial activity against Plasmodium falciparum ChEMBL. 9134742
IC50 (functional) = 800 ng/ml Antimalarial activity against Plasmodium falciparum FCR3TC by radioisotope micro dilution assay ChEMBL. 9134742
IC50 (functional) = 2300 ng/ml Cytotoxicity against human KB cells ChEMBL. 9134742
IC50 (functional) = 3.3 ug ml-1 Cytotoxicity against mouse P388 cells ChEMBL. 16989525
IC50 (functional) = 0.3 uM Antimalarial activity against Plasmodium falciparum after 96 hrs by [3H]hypoxanthine uptake ChEMBL. 2607354
IC50 (functional) = 0.76 uM HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells ChEMBL. 22586124
IC50 (functional) = 1 uM Antimalarial activity against Plasmodium falciparum after 48 hrs by [3H]hypoxanthine uptake ChEMBL. 2607354
IC50 (functional) = 1.31 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by LDH assay ChEMBL. 20669933
IC50 (functional) = 1.66 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 72 hrs by LDH assay ChEMBL. 20669933
IC50 (functional) = 3.22 uM Antiproliferative activity against human SKBr3 cells after 72 hrs ChEMBL. 18816111
IC50 (functional) = 5.9 uM Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 21381696
IC50 (functional) = 8.3 uM Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 21381696
IC50 (functional) = 8.84 uM Antiproliferative activity against human MCF7 cells after 72 hrs ChEMBL. 18816111
IC50 (functional) = 10.9 uM Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay ChEMBL. 25756299
IC50 (functional) > 20 uM Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 21381696
IC50 > 100 uM HARVARD: Cytotoxicity in HepG2 cell line ChEMBL. 22586124
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as disruption of interaction with Cdc37 at 5 times IC50 after 24 hrs by co-immunoprecipitation assay ChEMBL. 25756299
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as induction of heat shock response-mediated HSP27 production at 5 times to 10 times IC50 after 24 hrs by Western blot analysis relative to vehicle-treated control ChEMBL. 25756299
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as induction of heat shock response-mediated HSP27 production at 5 times IC50 after 24 hrs by Western blot analysis relative to vehicle-treated control ChEMBL. 25756299
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as Cdk6 degradation at 5 times IC50 after 24 hrs by Western blot analysis ChEMBL. 25756299
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as Raf degradation at 5 times IC50 after 24 hrs by Western blot analysis ChEMBL. 25756299
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as Her2 degradation at 5 times IC50 after 24 hrs by Western blot analysis ChEMBL. 25756299
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as pAkt degradation at 5 times IC50 after 24 hrs by Western blot analysis ChEMBL. 25756299
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as induction of heat shock response-mediated HSP70 production at 5 times IC50 after 24 hrs by Western blot analysis relative to vehicle-treated control ChEMBL. 25756299
Inhibition (binding) Inhibition of HSP90 in human MCF7 cells assessed as induction of heat shock response-mediated HSP90 production at 5 times IC50 after 24 hrs by Western blot analysis relative to vehicle-treated control ChEMBL. 25756299
Inhibition (ADMET) = 65.45339758 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 105.3940726 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
LC50 (functional) = 11.93 ug ml-1 Insecticidal activity against larvae of Drosophila melanogaster assessed as mortality after 72 hr by not choice test ChEMBL. No reference
LC50 (functional) = 11.93 ug ml-1 Insecticidal activity against Drosophila melanogaster larvae fed with compound incorporated diet assessed as mortality after 72 hr by not choice test ChEMBL. No reference
mortality (functional) = 11 % Insecticidal activity against Drosophila melanogaster larvae fed with compound incorporated diet assessed as mortality at 100 ug/ml after 72 hr by not choice test (Rvb = 0%) ChEMBL. No reference
mortality (functional) = 87.1 % Insecticidal activity against larvae of Drosophila melanogaster assessed as mortality at 20 ug/ml after 72 hr by not choice test ChEMBL. No reference
mortality (functional) = 87.1 % Insecticidal activity against Drosophila melanogaster larvae fed with compound incorporated diet assessed as mortality at 20 ug/ml after 72 hr by not choice test (Rvb = 0%) ChEMBL. No reference
mortality (functional) = 100 % Insecticidal activity against larvae of Drosophila melanogaster assessed as mortality at 50 ug/ml after 72 hr by not choice test ChEMBL. No reference
mortality (functional) = 100 % Insecticidal activity against Drosophila melanogaster larvae fed with compound incorporated diet assessed as mortality at 50 ug/ml after 72 hr by not choice test (Rvb = 0%) ChEMBL. No reference
mortality (functional) = 100 % Insecticidal activity against larvae of Drosophila melanogaster assessed as mortality at 100 ug/ml after 72 hr by not choice test ChEMBL. No reference
Potency (functional) 0.2512 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 16989525
Homo sapiens ChEMBL23 18816111
Plasmodium berghei ChEMBL23 22586124
Plasmodium falciparum ChEMBL23 20669933

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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