Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0117502 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0117502 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.00662042 | 0.22516 | 0.22516 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0117502 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0117502 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0117502 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0117502 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0117502 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0117502 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.00512976 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0107801 | 0.853467 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0117502 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0117502 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0117502 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0117502 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0107801 | 0.853467 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0117502 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0117502 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0117502 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.00512976 | 0 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0117502 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.00759053 | 0.371693 | 0.371693 |
Brugia malayi | FAD binding domain containing protein | 0.0117502 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0117502 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0117502 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0117502 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0117502 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.00759053 | 0.371693 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0117502 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0117502 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 166 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs | ChEMBL. | 19041248 |
IC50 (functional) | = 197 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs | ChEMBL. | 19041248 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19041248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.