Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | p450 reductase, putative | 0.00586908 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.00586908 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.00379138 | 0.371693 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.00538452 | 0.853467 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.00256226 | 0 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.00586908 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.00586908 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.00586908 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.00586908 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.00330682 | 0.22516 | 0.22516 |
Schistosoma mansoni | cytochrome P450 reductase | 0.00586908 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.00586908 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.00538452 | 0.853467 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.00586908 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.00586908 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.00586908 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.00586908 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.00586908 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.00256226 | 0 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.00586908 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.00379138 | 0.371693 | 0.371693 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.00586908 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.00586908 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.00586908 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.00586908 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00586908 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.00586908 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.00586908 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.00586908 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.00586908 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.41 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by alamar blue assay | ChEMBL. | 19395265 |
IC50 (functional) | = 0.65 uM | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs as [3H]hypoxanthine uptake | ChEMBL. | 19395265 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 19395265 | ||
Trypanosoma brucei gambiense | 19395265 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.