Detailed information for compound 971883

Basic information

Technical information
  • TDR Targets ID: 971883
  • Name: (1R)-1-(naphthalen-2-ylmethyl)-1,2,3,4-tetrah ydroisoquinoline-6,7-diol
  • MW: 305.37 | Formula: C20H19NO2
  • H donors: 3 H acceptors: 2 LogP: 3.86 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc2CCN[C@@H](c2cc1O)Cc1ccc2c(c1)cccc2
  • InChi: 1S/C20H19NO2/c22-19-11-16-7-8-21-18(17(16)12-20(19)23)10-13-5-6-14-3-1-2-4-15(14)9-13/h1-6,9,11-12,18,21-23H,7-8,10H2/t18-/m1/s1
  • InChiKey: WTHURCRQFHKJKU-GOSISDBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1R)-1-(2-naphthylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0341 0.0604
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0226 0.04
Loa Loa (eye worm) doublecortin family protein 0.002 0.0199 0.0353
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0985 0.0954
Loa Loa (eye worm) hypothetical protein 0.0029 0.041 0.0726
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0341 0.0307
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0226 0.04
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0261 0.0228
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.1412 0.5705
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0985 0.0954
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0479 0.0446
Echinococcus granulosus chromobox protein 1 0.0075 0.1412 0.1383
Brugia malayi nuclear hormone receptor 0.0055 0.0985 0.1817
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0035 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0985 0.1817
Brugia malayi hypothetical protein 0.0029 0.041 0.0717
Schistosoma mansoni ferritin light chain 0.0019 0.0191 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0688 0.1364
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0985 0.0954
Onchocerca volvulus 0.0055 0.0985 0.1984
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0226 0.0192
Schistosoma mansoni loxhd1 0.002 0.0199 0.0258
Schistosoma mansoni ferritin 0.0019 0.0191 0.0247
Brugia malayi Pre-SET motif family protein 0.0029 0.0403 0.0704
Loa Loa (eye worm) DR-78 0.0026 0.0341 0.0604
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0226 0.0541
Loa Loa (eye worm) hypothetical protein 0.0029 0.041 0.0726
Echinococcus granulosus bloom syndrome protein 0.0021 0.0226 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0985 0.1817
Brugia malayi MH2 domain containing protein 0.0135 0.2745 0.518
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0759 0.1511
Brugia malayi hypothetical protein 0.0029 0.041 0.0717
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0199 0.0165
Brugia malayi hypothetical protein 0.002 0.0199 0.0314
Schistosoma mansoni tar DNA-binding protein 0.014 0.2862 0.3711
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0985 0.0954
Echinococcus multilocularis zinc finger protein 0.0023 0.0274 0.024
Schistosoma mansoni hypothetical protein 0.0021 0.0219 0.0284
Schistosoma mansoni chromobox protein 0.0012 0.0035 0.0045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0985 0.0954
Schistosoma mansoni zinc finger protein 0.0015 0.0102 0.0132
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.2399 1
Brugia malayi nuclear receptor RXR 0.0029 0.041 0.0717
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0985 0.0954
Schistosoma mansoni polycystin 1-related 0.002 0.0199 0.0258
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.1158 0.1127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0035 0.0245
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0479 0.0446
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2022 0.3799
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0199 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0985 0.1746
Schistosoma mansoni hypothetical protein 0.0024 0.0299 0.0388
Loa Loa (eye worm) hypothetical protein 0.0029 0.041 0.0726
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0985 0.1277
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0226 0.2077
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0199 0.2082
Schistosoma mansoni tar DNA-binding protein 0.014 0.2862 0.3711
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0672 0.0872
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0035 0.00000000039679
Schistosoma mansoni tar DNA-binding protein 0.014 0.2862 0.3711
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0688 0.1364
Schistosoma mansoni hypothetical protein 0.002 0.0199 0.0258
Brugia malayi chromobox protein homolog 3 0.0042 0.0688 0.125
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0956 0.3986
Onchocerca volvulus 0.0026 0.0341 0.0639
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0341 0.0307
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0341 0.0442
Brugia malayi hypothetical protein 0.002 0.0199 0.0314
Loa Loa (eye worm) hypothetical protein 0.0011 0.00000000019013 0.00000000033688
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0985 0.1984
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0985 0.1817
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0341 0.0442
Brugia malayi Bromodomain containing protein 0.0078 0.1495 0.279
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0299 0.0266
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0199 0.0165
Trypanosoma cruzi ISWI complex protein 0.0015 0.0102 0.0721
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0035 0.00000000039679
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0479 0.085
Schistosoma mansoni hypothetical protein 0.036 0.7714 1
Brugia malayi hypothetical protein 0.0173 0.3581 0.6778
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.2399 1
Onchocerca volvulus 0.0041 0.0672 0.1331
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.5267 0.525
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0956 1
Brugia malayi hypothetical protein 0.0035 0.0534 0.0955
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0985 0.1817
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.041 0.0726
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0341 0.0442
Echinococcus granulosus chromobox protein 1 0.0075 0.1412 0.1383
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0985 0.0954
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0199 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2022 0.3799
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0341 0.0307
Brugia malayi Pre-SET motif family protein 0.0201 0.4212 0.7984
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0341 0.0585
Schistosoma mansoni survival motor neuron protein 0.0051 0.0887 0.115
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0035 0.0000000003634
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.2399 0.311
Loa Loa (eye worm) hypothetical protein 0.0249 0.5267 0.9332
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.2399 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0035 0.00000000019079
Brugia malayi nuclear hormone receptor 0.0026 0.0341 0.0585
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0341 0.0307
Brugia malayi PHD-finger family protein 0.0028 0.0392 0.0682
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0403 0.0369
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.014 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0985 0.1746
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1412 0.2875
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.2399 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.041 0.0531
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1412 1
Echinococcus multilocularis ferritin 0.0019 0.0191 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0353
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0985 0.1984
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0719 0.0686
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Echinococcus granulosus zinc finger protein 0.0023 0.0274 0.024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0756 0.1505
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0035 0.0362
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0035 0.00000000039679
Schistosoma mansoni nuclear receptor 0.0026 0.0341 0.0442
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0556 0.0523
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0226 0.1601
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0985 0.1746
Echinococcus multilocularis RUN 0.002 0.0199 0.0165
Loa Loa (eye worm) hypothetical protein 0.0266 0.5644 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0985 0.1817
Brugia malayi ecdysteroid receptor 0.0055 0.0985 0.1817
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0226 0.0192
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0341 0.0639
Echinococcus multilocularis Chromo domain 0.0012 0.0035 0.00000000019079
Loa Loa (eye worm) hypothetical protein 0.0055 0.0985 0.1746
Echinococcus granulosus RUN 0.002 0.0199 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0985 0.1277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0035 0.00000000039679
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0985 0.1817
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0226 0.0192
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0479 0.0849
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0985 0.1277
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0985 0.0954
Schistosoma mansoni hypothetical protein 0.0032 0.0479 0.0621
Schistosoma mansoni ferritin 0.0019 0.0191 0.0247
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0985 0.1277
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.2362 0.2335
Loa Loa (eye worm) hypothetical protein 0.0102 0.2022 0.3583
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0778 0.0746
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0035 0.0144
Brugia malayi steroid hormone receptor 0.0055 0.0985 0.1817
Echinococcus multilocularis chromobox protein 1 0.0075 0.1412 0.1383
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0341 0.0307
Schistosoma mansoni hypothetical protein 0.0012 0.0035 0.0045
Onchocerca volvulus 0.0033 0.0489 0.0948
Loa Loa (eye worm) hypothetical protein 0.0055 0.0985 0.1746
Schistosoma mansoni lipoxygenase 0.0082 0.158 0.2049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0479 0.0446
Echinococcus multilocularis neuropeptide s receptor 0.0464 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0061
Entamoeba histolytica hypothetical protein 0.0012 0.0035 0.0245
Schistosoma mansoni ferritin 0.0019 0.0191 0.0247
Schistosoma mansoni apoferritin-2 0.0019 0.0191 0.0247
Echinococcus granulosus Chromobox protein 3 0.0012 0.0035 0.00000002681
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0299 0.0266
Onchocerca volvulus 0.002 0.0199 0.0343
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.1412 0.2634
Loa Loa (eye worm) hypothetical protein 0.0029 0.041 0.0726
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0019 0.0191 0.5
Loa Loa (eye worm) hypothetical protein 0.0173 0.3581 0.6344
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0035 0.00000000019079
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.2399 0.2373
Echinococcus granulosus expressed protein 0.0019 0.0191 0.0157
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1412 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0756 0.3149
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0556 0.0523
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0985 0.1984
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0479 0.085
Schistosoma mansoni zinc finger protein 0.0023 0.0274 0.0355
Schistosoma mansoni nuclear receptor 0.0026 0.0341 0.0442
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0341 0.0604
Loa Loa (eye worm) hypothetical protein 0.0055 0.0985 0.1746
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0035 0.0045
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0226 0.0366
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.041 0.0376
Onchocerca volvulus 0.0012 0.0035 0.000000055756
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0403 0.0522
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.2867 0.2842
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0035 0.0000000020625
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0226 0.04
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.014 0.0182
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0341 0.0307
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0035 0.00000000039679
Brugia malayi nuclear receptor NHR-67 0.0026 0.0341 0.0585
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.2745 0.4863
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.1412 0.1383
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0226 0.0366
Onchocerca volvulus 0.0229 0.4826 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0625 1
Brugia malayi nuclear receptor NHR-88 0.0055 0.0985 0.1817
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0061
Loa Loa (eye worm) acetyltransferase 0.0147 0.3008 0.5331
Brugia malayi hypothetical protein 0.0026 0.0341 0.0585
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0985 0.1817
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0985 0.1277
Brugia malayi TAR-binding protein 0.014 0.2862 0.5405
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0778 0.0746
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0985 0.1277
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0756 0.3149
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0341 0.0585
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0756 0.79
Trypanosoma cruzi ISWI complex protein 0.0015 0.0102 0.0721
Brugia malayi RNA binding protein 0.014 0.2862 0.5405
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0261 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0419 0.0802
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Onchocerca volvulus 0.0026 0.0341 0.0639
Schistosoma mansoni apoferritin-2 0.0019 0.0191 0.0247
Echinococcus multilocularis chromobox protein 1 0.0075 0.1412 0.1383
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0077 0.0099
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.1412 0.2503
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0985 0.1817
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0035 0.00000000039679
Onchocerca volvulus 0.0051 0.0887 0.1779
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0985 0.1277
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0035 0.0144
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0341 0.0442
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0226 0.1601
Plasmodium vivax SET domain protein, putative 0.0029 0.0403 0.4212
Echinococcus multilocularis GPCR, family 2 0.0032 0.0479 0.0446
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0077 0.0136
Entamoeba histolytica hypothetical protein 0.0012 0.0035 0.0245
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0341 0.0442
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.3008 0.5684
Loa Loa (eye worm) hypothetical protein 0.0042 0.0688 0.122
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0985 0.0954
Schistosoma mansoni coup transcription factor 0.0055 0.0985 0.1277
Loa Loa (eye worm) TAR-binding protein 0.014 0.2862 0.5072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0985 0.0954
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0035 0.00000000039679
Onchocerca volvulus 0.0173 0.3581 0.74
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0379 0.0346
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0219 0.0389
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.041 0.0717
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0226 0.2077
Brugia malayi conserved hypotetical protein 0.0026 0.0341 0.0585
Loa Loa (eye worm) hypothetical protein 0.0038 0.061 0.1081
Echinococcus granulosus neuropeptide receptor A26 0.0464 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0985 0.1277
Schistosoma mansoni ferritin light chain 0.0019 0.0191 0.0247
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0035 0.0144
Loa Loa (eye worm) hypothetical protein 0.0055 0.0985 0.1746
Brugia malayi ecdysone receptor 0.0026 0.0341 0.0585
Brugia malayi nuclear receptor RXR 0.0026 0.0341 0.0585
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0985 0.1277
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0226 0.0401
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0759 0.1511
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0985 0.1817
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Echinococcus multilocularis geminin 0.036 0.7714 0.7706
Loa Loa (eye worm) hypothetical protein 0.0029 0.041 0.0726
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1412 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0985 0.1746
Brugia malayi Bromodomain containing protein 0.0042 0.0686 0.1246
Schistosoma mansoni lipoxygenase 0.0118 0.2362 0.3062
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0625 0.4427
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0226 0.0192
Trichomonas vaginalis set domain proteins, putative 0.0229 0.4826 1
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0719 0.0686
Loa Loa (eye worm) hypothetical protein 0.0021 0.0226 0.0401
Brugia malayi SET domain containing protein 0.0013 0.0058 0.0045
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0956 0.6521
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0688 0.1364
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.1412 0.1383
Brugia malayi RNA recognition motif domain containing protein 0.014 0.2862 0.5405
Brugia malayi hypothetical protein 0.0249 0.5267 1
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.041 0.0717
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.3008 0.39
Brugia malayi hypothetical protein 0.0054 0.0956 0.1762
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0061
Entamoeba histolytica hypothetical protein 0.0012 0.0035 0.0245
Leishmania major hypothetical protein, conserved 0.0054 0.0956 0.372
Loa Loa (eye worm) hypothetical protein 0.0055 0.0985 0.1746
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0341 0.0307
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0035 0.0362
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0035 0.00000000039679
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0985 0.0954
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0985 0.0954
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0985 0.1277
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0226 0.0948
Brugia malayi Doublecortin family protein 0.002 0.0199 0.0314
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Schistosoma mansoni tar DNA-binding protein 0.014 0.2862 0.3711
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0985 0.0954
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0985 0.1817
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0341 0.0604
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0985 0.0954
Schistosoma mansoni chromobox protein 0.0075 0.1412 0.1831
Schistosoma mansoni hypothetical protein 0.007 0.1308 0.1696
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Loa Loa (eye worm) hypothetical protein 0.007 0.1308 0.2318
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0232 0.0411
Loa Loa (eye worm) hypothetical protein 0.0071 0.1322 0.2343
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0341 0.0307
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0199 0.1785
Echinococcus granulosus tar DNA binding protein 0.014 0.2862 0.2838
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.014 0.2862 0.5072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0985 0.1817
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0479 0.0446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0985 0.1746
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.041 0.0376
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0035 0.0000000003634
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.1412 0.1831
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0778 0.1009
Echinococcus granulosus ferritin 0.0019 0.0191 0.0157
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0887 0.1629
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0226 0.0942
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0985 0.1817
Loa Loa (eye worm) hypothetical protein 0.0046 0.0778 0.1379
Echinococcus multilocularis neuropeptide receptor A26 0.0464 1 1
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0035 0.00000002681
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0985 0.1746
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0035 0.00000000039679
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0341 0.0585
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0956 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0756 0.1505
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0035 0.0245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0778 0.1009
Loa Loa (eye worm) hypothetical protein 0.0044 0.074 0.1311
Loa Loa (eye worm) hypothetical protein 0.0032 0.0479 0.0849
Echinococcus granulosus geminin 0.036 0.7714 0.7706
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.041 0.0531
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0985 0.1277
Echinococcus multilocularis expressed protein 0.0019 0.0191 0.0157
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0261 0.0339
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0035 0.0362
Loa Loa (eye worm) helicase 0.0012 0.0035 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0985 0.1746
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0341 0.0307
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.2399 0.2373
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0019 0.0191 0.5
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1412 0.2875
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0341 0.0585
Schistosoma mansoni bromodomain containing protein 0.0067 0.1237 0.1603
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0035 0.00000000039679
Schistosoma mansoni zinc finger protein 0.0026 0.0341 0.0442
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0341 0.0639
Schistosoma mansoni chromobox protein 0.0012 0.0035 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.2399 0.311
Schistosoma mansoni DNA helicase recq1 0.0021 0.0226 0.0293
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0199 0.0165
Schistosoma mansoni DNA helicase recq5 0.0021 0.0226 0.0293
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0077 0.0042
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0985 0.0954
Loa Loa (eye worm) RNA binding protein 0.014 0.2862 0.5072
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0226 0.0942
Brugia malayi Heterochromatin protein 1 0.0075 0.1412 0.2633
Schistosoma mansoni hypothetical protein 0.0051 0.0887 0.115
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.014 0.0106
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0956 0.6772
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0341 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.014 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0985 0.1746
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.1412 0.2502
Loa Loa (eye worm) hypothetical protein 0.0046 0.0782 0.1386
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0035 0.0245
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0625 0.6408
Brugia malayi hypothetical protein 0.0026 0.0341 0.0585
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0985 0.1817
Loa Loa (eye worm) RecQ helicase 0.0021 0.0226 0.0401
Loa Loa (eye worm) hypothetical protein 0.0055 0.0985 0.1746
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.1158 0.1127
Brugia malayi nuclear receptor NHR-88 0.0026 0.0341 0.0585
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0985 0.0954
Schistosoma mansoni tar DNA-binding protein 0.014 0.2862 0.3711
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0035 0.00000000039679
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0419 0.0802
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.2745 0.4863
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0985 0.0954
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0341 0.0307
Schistosoma mansoni ferritin 0.0019 0.0191 0.0247
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.2399 1
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0985 0.1817
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0956 0.6772
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0341 0.0585
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0226 0.0192
Loa Loa (eye worm) hypothetical protein 0.0033 0.0489 0.0866
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.3008 0.2984
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0035 0.00000000039679
Schistosoma mansoni hypothetical protein 0.036 0.7714 1
Schistosoma mansoni hypothetical protein 0.0015 0.0102 0.0132
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2022 0.3583
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0985 0.1277
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0035 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0035 0.00000000039679
Brugia malayi tailless protein 0.0026 0.0341 0.0585
Brugia malayi CHD4 protein 0.0014 0.0077 0.008
Echinococcus granulosus GPCR family 2 0.0032 0.0479 0.0446
Loa Loa (eye worm) hypothetical protein 0.0054 0.0956 0.1695
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.4212 0.7463
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0759 0.1511
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0985 0.0954
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0985 0.1817
Treponema pallidum bacterioferrin (TpF1) 0.0019 0.0191 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0985 0.1746
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0403 0.1679
Trichomonas vaginalis ferritin, putative 0.0019 0.0191 0.0326
Loa Loa (eye worm) hypothetical protein 0.0026 0.0341 0.0604
Onchocerca volvulus 0.002 0.0199 0.0343
Loa Loa (eye worm) hypothetical protein 0.0055 0.0985 0.1746
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.2399 1
Schistosoma mansoni hypothetical protein 0.0032 0.0479 0.0621
Schistosoma mansoni hypothetical protein 0.0032 0.0479 0.0621
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.2362 0.2335
Schistosoma mansoni rab6-interacting 0.002 0.0199 0.0258
Echinococcus multilocularis tar DNA binding protein 0.014 0.2862 0.2838
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0341 0.0307
Schistosoma mansoni rab6-interacting 0.002 0.0199 0.0258
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0199 0.0165
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0956 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0756 0.0724
Schistosoma mansoni chromobox protein 0.0075 0.1412 0.1831
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.5267 0.525
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.1412 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0077 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0061
Schistosoma mansoni hypothetical protein 0.0032 0.0479 0.0621
Echinococcus granulosus Chromo domain 0.0012 0.0035 0.00000000019079
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0985 0.1817
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1308 0.2434
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0226 0.0366
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0341 0.0585

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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