Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0132 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0092 | 0.3867 | 0.2044 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0132 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0132 | 1 | 0.5 |
Onchocerca volvulus | 0.0092 | 0.3867 | 0.5 | |
Leishmania major | cytochrome P450 reductase, putative | 0.0117 | 0.7709 | 0.6264 |
Giardia lamblia | Hypothetical protein | 0.0117 | 0.7709 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0132 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0092 | 0.3867 | 0.2044 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3867 | 0.2044 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0132 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0132 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0132 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0132 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0132 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0092 | 0.3867 | 0.2044 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0132 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0132 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.3867 | 0.2044 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0132 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0132 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0132 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0132 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0082 | 0.2291 | 0.2291 |
Trypanosoma cruzi | p450 reductase, putative | 0.0132 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0092 | 0.3867 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0132 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0082 | 0.2291 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.3867 | 0.3867 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0117 | 0.7709 | 0.6264 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0132 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0117 | 0.7709 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0092 | 0.3867 | 0.2044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.