Detailed information for compound 971928

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 522.5 | Formula: C22H21F3N6O4S
  • H donors: 4 H acceptors: 4 LogP: 4.36 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OC(C)(C)C)Nc1cccc(c1)c1noc(n1)C(=O)NNC(=S)Nc1ccc(cc1)C(F)(F)F
  • InChi: 1S/C22H21F3N6O4S/c1-21(2,3)34-20(33)27-15-6-4-5-12(11-15)16-28-18(35-31-16)17(32)29-30-19(36)26-14-9-7-13(8-10-14)22(23,24)25/h4-11H,1-3H3,(H,27,33)(H,29,32)(H2,26,30,36)
  • InChiKey: DYGFEHHDEYKYEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0159 0.0429
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0066 0.0919 1
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0108 0.0257
Brugia malayi hypothetical protein 0.0094 0.1403 0.184
Schistosoma mansoni ankyrin 23/unc44 0.003 0.0311 0.0311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0885 0.264
Echinococcus multilocularis thioredoxin glutathione reductase 0.0191 0.3022 0.4193
Echinococcus granulosus Vacuolar ATP synthase 16 kDa proteolipid 0.002 0.0154 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0433 0.7086 0.8958
Trichomonas vaginalis DNA polymerase eta, putative 0.0064 0.0885 0.0905
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0108 0.0257
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0404 0.1344
Mycobacterium tuberculosis Probable reductase 0.0433 0.7086 0.8958
Mycobacterium tuberculosis Probable dehydrogenase 0.0433 0.7086 0.8958
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0193 0.0254
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0019
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0199 0.0261
Loa Loa (eye worm) hypothetical protein 0.0029 0.0305 0.04
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0286 0.0851
Onchocerca volvulus 0.0023 0.0193 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0193 0.0254
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0147 0.0438
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0305 0.0919
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0944 0.3145
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0193 0.0249
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.0311 0.0413
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0193 0.0249
Brugia malayi serine/threonine-protein kinase plk-2 0.0211 0.3353 0.4399
Brugia malayi nuclear hormone receptor 0.0023 0.0193 0.0254
Brugia malayi steroid hormone receptor 0.0023 0.0193 0.0254
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0108 0.013
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0066 0.0919 0.2501
Loa Loa (eye worm) hypothetical protein 0.002 0.0159 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0193 0.0254
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0193 0.0099
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0108 0.036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0108 0.0141
Leishmania major DNA polymerase eta, putative 0.0047 0.0606 0.1535
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0211 0.3353 0.4655
Schistosoma mansoni cpg binding protein 0.0031 0.0332 0.0332
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0108 0.0322
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.017 0.017
Brugia malayi Protein kinase domain containing protein 0.003 0.0322 0.0423
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.1671 0.2309
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0381 0.1178
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0015 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0885 0.0998
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0066 0.0919 0.2501
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0553 0.165
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0193 0.0254
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0108 0.0322
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0253
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0944 0.1296
Leishmania major DNA polymerase eta, putative 0.0091 0.1344 0.381
Brugia malayi nuclear receptor RXR 0.0012 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0253
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0027 0.0017
Trypanosoma brucei DNA polymerase eta, putative 0.0091 0.1344 0.401
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0147 0.0438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0193 0.0253
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0002
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0066 0.0919 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0211 0.3353 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.053 0.053
Schistosoma mansoni vacuolar ATP synthase proteolipid subunit 1 2 3 0.002 0.0154 0.0154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0015 0.0015
Brugia malayi CXXC zinc finger family protein 0.0031 0.0332 0.0436
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0147 0.049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0193 0.0249
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0019
Leishmania major vacuolar type h ATPase subunit, putative 0.002 0.0154 0.0142
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0193 0.0249
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0179 0.0228
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0433 0.7086 0.8958
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0985 0.1292
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0193 0.0254
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0179 0.0218
Loa Loa (eye worm) hypothetical protein 0.0094 0.1403 0.184
Brugia malayi glutathione reductase 0.019 0.3003 0.394
Onchocerca volvulus 0.0529 0.8698 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0108 0.013
Brugia malayi Pre-SET motif family protein 0.0067 0.0944 0.1239
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0381 0.0511
Leishmania major DNA polymerase kappa, putative 0.002 0.0147 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0019
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0108 0.0322
Loa Loa (eye worm) hypothetical protein 0.0022 0.0179 0.0234
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit, putative 0.002 0.0154 0.0054
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0159 0.0629
Trichomonas vaginalis DNA helicase recq1, putative 0.0052 0.0696 0.0685
Trypanosoma brucei trypanothione reductase 0.019 0.3003 0.8956
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0041
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0276 0.2065
Schistosoma mansoni jumonji domain containing protein 0.0088 0.1289 0.1289
Schistosoma mansoni hypothetical protein 0.0013 0.0035 0.0035
Brugia malayi hypothetical protein 0.0012 0.0015 0.0019
Trichomonas vaginalis glutathione reductase, putative 0.0066 0.0919 0.0945
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0066 0.0919 0.2501
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0944 0.0944
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0276 0.2065
Giardia lamblia DNA damage repair protein 0.002 0.0147 0.012
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0066 0.0919 0.2989
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0381 0.0381
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0919 0.2742
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0381 0.127
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0193 0.0254
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0041
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0045 0.0572 0.0777
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0276 0.0215
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0108 0.0322
Schistosoma mansoni blooms syndrome DNA helicase 0.0041 0.0511 0.0511
Trypanosoma cruzi vacuolar ATP synthase, putative 0.002 0.0154 0.0459
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.7185 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0179 0.0595
Schistosoma mansoni eyes absent homolog 0.0094 0.1403 0.1403
Loa Loa (eye worm) hypothetical protein 0.002 0.0159 0.0208
Giardia lamblia NADH oxidase lateral transfer candidate 0.0066 0.0919 0.2501
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0147 0.0439
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0481 0.7898 1
Trichomonas vaginalis DNA helicase recq, putative 0.0052 0.0696 0.0685
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0193 0.0249
Treponema pallidum oxidoreductase 0.0017 0.0108 0.1173
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0017 0.0108 0.0322
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0108 0.0322
Leishmania major DNA damage repair protein, putative 0.002 0.0147 0.012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0276 0.0362
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0048 0.0626 0.0822
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0944 0.0944
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0067 0.0944 0.0944
Brugia malayi jmjC domain containing protein 0.011 0.1671 0.2192
Loa Loa (eye worm) hypothetical protein 0.0027 0.0276 0.0361
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0066 0.0919 1
Echinococcus granulosus Vacuolar ATP synthase 16 kDa proteolipid 0.002 0.0154 0.0194
Schistosoma mansoni hypothetical protein 0.0034 0.0381 0.0381
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0885 0.2641
Brugia malayi glutamate synthase 0.0017 0.0108 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0919 0.2742
Trypanosoma brucei vacuolar ATP synthase, putative 0.002 0.0154 0.046
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0045 0.0572 0.0777
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0433 0.7086 0.8958
Plasmodium vivax thioredoxin reductase, putative 0.019 0.3003 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0553 0.165
Mycobacterium tuberculosis Probable oxidoreductase 0.0481 0.7898 1
Echinococcus granulosus dna polymerase eta 0.0091 0.1344 0.1854
Echinococcus granulosus glutamate synthase 0.0017 0.0108 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.3353 0.3777
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0017 0.0108 0.0322
Schistosoma mansoni hypothetical protein 0.0439 0.7185 0.7185
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0108 0.0257
Echinococcus multilocularis dna polymerase eta 0.0091 0.1344 0.1854
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0885 0.264
Brugia malayi polk-prov protein 0.002 0.0147 0.0193
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0919 0.2742
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0501 0.0678
Trichomonas vaginalis set domain proteins, putative 0.0529 0.8698 1
Echinococcus granulosus death domain containing protein 0.003 0.0311 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0193 0.0254
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0193 0.0254
Echinococcus multilocularis netrin receptor unc 5 0.003 0.0311 0.0413
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0276 0.0362
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0046 0.0589 0.1876
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0193 0.0249
Schistosoma mansoni netrin receptor unc5 0.003 0.0311 0.0311
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0193 0.0253
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0885 0.958
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0311 0.0407
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0193 0.0193
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0108 0.013
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0147 0.0439
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0211 0.3353 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0066 0.0919 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0066 0.0919 0.2989
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0193 0.0253
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0885 0.2641
Trypanosoma cruzi DNA polymerase eta, putative 0.0091 0.1344 0.4009
Brugia malayi Vacuolar ATP synthase 16 kDa proteolipid subunit, putative 0.002 0.0154 0.0202
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0179 0.0228
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0066 0.0919 0.2742
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0108 0.013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0066 0.0919 1
Brugia malayi Bloom's syndrome protein homolog 0.0052 0.0696 0.0913
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0108 0.0142
Giardia lamblia Kinase, PLK 0.0211 0.3353 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0276 0.0361
Schistosoma mansoni cpg binding protein 0.0033 0.0362 0.0362
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.3353 0.3777
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0305 0.0919
Loa Loa (eye worm) hypothetical protein 0.002 0.0159 0.0208
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0108 0.0108
Entamoeba histolytica thioredoxin reductase, putative 0.0017 0.0108 0.0322
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0048 0.0626 0.0822
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0381 0.0511
Loa Loa (eye worm) hypothetical protein 0.002 0.0159 0.0208
Loa Loa (eye worm) hypothetical protein 0.0091 0.1344 0.1764
Brugia malayi hypothetical protein 0.0012 0.0015 0.0019
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0603 0.0821
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0067 0.0944 0.1239
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Plasmodium falciparum phd finger protein, putative 0.0034 0.0381 0.1178
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0108 0.0322
Echinococcus granulosus peregrin 0.0034 0.0381 0.0511
Leishmania major trypanothione reductase 0.019 0.3003 0.8921
Toxoplasma gondii NADPH-glutathione reductase 0.0066 0.0919 0.3062
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0286 0.0207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0253
Trypanosoma cruzi polo-like protein kinase, putative 0.0211 0.3353 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0381 0.127
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0108 0.0322
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0276 0.0215
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0147 0.0389
Plasmodium vivax SET domain protein, putative 0.0067 0.0944 0.3072
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0179 0.0228
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0108 0.0322
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0885 0.958
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0066 0.0919 0.1042
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0108 0.0257
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0433 0.7086 0.8958
Echinococcus multilocularis peregrin 0.0034 0.0381 0.0511
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0276 0.0215
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0885 0.1214
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0885 0.264
Trypanosoma cruzi trypanothione reductase, putative 0.019 0.3003 0.8956
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0276 0.0821
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0464 0.7621 1
Trypanosoma brucei vacuolar ATP synthase 16 kDa proteolipid subunit, putative 0.002 0.0154 0.046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0944 0.0944
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.0885 0.2396
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.053 0.0719
Trypanosoma cruzi vacuolar ATP synthase, putative 0.002 0.0154 0.0459
Echinococcus granulosus cpg binding protein 0.0033 0.0362 0.0484
Schistosoma mansoni hypothetical protein 0.0017 0.0108 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0919 0.2742
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0253
Toxoplasma gondii selenide, water dikinase 0.0017 0.0108 0.036
Loa Loa (eye worm) hypothetical protein 0.0027 0.0276 0.0361
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0108 0.036
Schistosoma mansoni kinase 0.0107 0.1613 0.1613
Schistosoma mansoni coup transcription factor 0.0023 0.0193 0.0193
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.1344 0.1764
Echinococcus multilocularis Vacuolar ATP synthase 16 kDa proteolipid 0.002 0.0154 0.0194
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0305 0.0908
Brugia malayi hypothetical protein 0.0019 0.0131 0.0172
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0015 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0066 0.0919 0.2742
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0253
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0179 0.0495
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0193 0.0193
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0147 0.049
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0147 0.0147
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0147 0.0389
Onchocerca volvulus 0.0067 0.0944 0.0973
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0253
Schistosoma mansoni hypothetical protein 0.003 0.0311 0.0311
Giardia lamblia PHD finger protein 15 0.0034 0.0381 0.0843
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0944 0.1296
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0286 0.0547
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1566 0.1697
Toxoplasma gondii thioredoxin reductase 0.019 0.3003 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0179 0.0228
Entamoeba histolytica recQ family helicase, putative 0.0028 0.0286 0.0851
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0919 0.2742
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0193 0.0254
Loa Loa (eye worm) hypothetical protein 0.0159 0.2494 0.3272
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0253
Mycobacterium ulcerans hypothetical protein 0.0027 0.0276 0.2065
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0276 0.2065
Brugia malayi MH2 domain containing protein 0.0138 0.2135 0.2802
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0276 0.0821
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0066 0.0919 0.2742
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0108 0.036
Brugia malayi PHD-finger family protein 0.0013 0.003 0.0039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.053 0.053
Echinococcus granulosus thioredoxin glutathione reductase 0.0191 0.3022 0.4193
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0481 0.7898 1
Brugia malayi Bromodomain containing protein 0.0034 0.0381 0.05
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0159 0.0629
Brugia malayi ecdysteroid receptor 0.0023 0.0193 0.0254
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0045 0.0572 0.0777
Trypanosoma brucei unspecified product 0.0044 0.0553 0.165
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.3353 0.3777
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0193 0.0193
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0276 0.0516
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0885 0.2641
Echinococcus multilocularis glutamate synthase 0.0017 0.0108 0.013
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0064 0.0885 0.0905
Plasmodium falciparum thioredoxin reductase 0.019 0.3003 1
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0381 0.05
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0193 0.0254
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0147 0.0439
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.053 0.0695
Trypanosoma brucei polo-like protein kinase 0.0211 0.3353 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0193 0.0254
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0066 0.0919 0.2742
Plasmodium falciparum glutathione reductase 0.0066 0.0919 0.2989
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0311 0.0311
Echinococcus granulosus Ankyrin 0.003 0.0311 0.0413
Loa Loa (eye worm) thioredoxin reductase 0.019 0.3003 0.394
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0066 0.0919 0.2989
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0147 0.0438
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0276 0.0362
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0885 0.1161
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0253
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.014 0.0041
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0885 0.0885
Trypanosoma brucei unspecified product 0.0064 0.0885 0.2641
Loa Loa (eye worm) hypothetical protein 0.002 0.0159 0.0208
Echinococcus granulosus netrin receptor unc 5 0.003 0.0311 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0193 0.0254
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0193 0.0249
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0193 0.0193
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0193 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0193 0.0253
Brugia malayi Death domain containing protein 0.003 0.0311 0.0408
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0066 0.0919 0.1206
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0193 0.0249
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0108 0.013
Entamoeba histolytica serine/threonine protein kinase, putative 0.0211 0.3353 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0193 0.0249
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0066 0.0919 0.1262
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0193 0.0099
Schistosoma mansoni glutamate synthase 0.0017 0.0108 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0108 0.0322
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit, putative 0.002 0.0154 0.0054
Echinococcus granulosus dna polymerase kappa 0.0064 0.0885 0.1214
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0433 0.7086 0.8958
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0193 0.0254
Leishmania major hypothetical protein, conserved 0.0029 0.0305 0.0606
Giardia lamblia DINP protein human, muc B family 0.0064 0.0885 0.2396
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0276 0.2065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0381 0.05
Mycobacterium ulcerans hypothetical protein 0.002 0.0147 0.0481
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0193 0.0193
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0108 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.3353 0.3777
Brugia malayi Uncoordinated protein 44 0.003 0.0311 0.0408
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0193 0.0253
Treponema pallidum thioredoxin reductase (trxB) 0.0017 0.0108 0.1173
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0885 0.1162
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0035 0.0411 0.1276
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0045 0.0572 0.0777
Plasmodium vivax V-type proton ATPase 16 kDa proteolipid subunit, putative 0.002 0.0154 0.0412
Onchocerca volvulus Alhambra homolog 0.0034 0.0381 0.0318
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.2135 0.2801
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0179 0.0234
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0108 0.0322
Schistosoma mansoni glutamate synthase 0.0017 0.0108 0.0108
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0027 0.0017
Giardia lamblia Vacuolar ATP synthase 16 kDa proteolipid subunit 0.002 0.0154 0.0142
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.2135 0.2801
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit 1, 2, 3, putative 0.002 0.0154 0.0054
Plasmodium falciparum V-type proton ATPase 16 kDa proteolipid subunit 0.002 0.0154 0.0412
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0305 0.0908
Brugia malayi nuclear receptor NHR-88 0.0023 0.0193 0.0254
Echinococcus multilocularis Vacuolar ATP synthase 16 kDa proteolipid 0.002 0.0154 0.0194
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0066 0.0919 0.1262
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0193 0.0193
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0892 0.1223
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0147 0.0439
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0193 0.0249
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0606 0.2018
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0885 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0193 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0885 0.264
Brugia malayi Pre-SET motif family protein 0.0464 0.7621 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0193 0.0249
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0066 0.0919 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0108 0.0141
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0193 0.0249
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0035 0.0028
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0276 0.2065
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0276 0.0821
Plasmodium vivax glutathione reductase, putative 0.019 0.3003 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0193 0.0254
Echinococcus multilocularis cpg binding protein 0.0033 0.0362 0.0484
Brugia malayi Thioredoxin reductase 0.019 0.3003 0.394
Schistosoma mansoni DNA polymerase eta 0.0091 0.1344 0.1344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0919 0.2742
Onchocerca volvulus 0.0031 0.0332 0.0261
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0407
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0108 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0108 0.0322
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0066 0.0919 0.2501
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0179 0.0595
Loa Loa (eye worm) hypothetical protein 0.0094 0.1403 0.184
Echinococcus granulosus bloom syndrome protein 0.0052 0.0696 0.095
Schistosoma mansoni tumor necrosis factor receptor related 0.0045 0.0572 0.0572
Loa Loa (eye worm) RecQ helicase 0.0052 0.0696 0.0913
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0276 0.2065
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0066 0.0919 0.2742
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0066 0.0919 0.2989
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0193 0.0254
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.3353 0.3777
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0193 0.0193
Echinococcus multilocularis Ankyrin 0.003 0.0311 0.0413
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0066 0.0919 0.2742
Plasmodium falciparum thioredoxin reductase 0.0066 0.0919 0.2989
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0211 0.3353 0.4655
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0211 0.3353 0.4399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0193 0.0253
Onchocerca volvulus 0.0027 0.0276 0.0195
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0193 0.0193
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0954 0.0954
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0286 0.0852
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0193 0.0193
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0944 0.1296
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0066 0.0919 0.0919
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0276 0.0215
Entamoeba histolytica V-type ATPase, C subunit, putative 0.002 0.0154 0.0459
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0108 0.0322
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0147 0.0438
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0193 0.0249
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0193 0.0249
Brugia malayi jmjC domain containing protein 0.0043 0.053 0.0696
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.0885 0.0998
Schistosoma mansoni cpg binding protein 0.0033 0.0362 0.0362
Leishmania major vacuolar ATP synthase, putative 0.002 0.0154 0.0142
Giardia lamblia Vacuolar ATP synthase 16 kDa proteolipid subunit 0.002 0.0154 0.0142
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0332 0.0436
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.3353 0.3777
Trypanosoma brucei unspecified product 0.0044 0.0553 0.165
Schistosoma mansoni DNA helicase recq1 0.0022 0.0179 0.0179
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0305 0.0909
Loa Loa (eye worm) hypothetical protein 0.0337 0.5474 0.7183
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0108 0.0322
Trichomonas vaginalis mercuric reductase, putative 0.0066 0.0919 0.0945
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0919 0.2742
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0108 0.0322
Entamoeba histolytica disulphide oxidoreductase, putative 0.0017 0.0108 0.0322
Brugia malayi PHD-finger family protein 0.0034 0.0381 0.05
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0276 0.2065
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0066 0.0919 0.3062
Schistosoma mansoni glutamate synthase 0.0017 0.0108 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0553 0.165
Brugia malayi hypothetical protein 0.0337 0.5474 0.7183
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0108 0.013
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0147 0.0439
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0159 0.0429
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0108 0.013
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0108 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1566 0.1697
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0193 0.0249
Brugia malayi hypothetical protein 0.0029 0.0305 0.04
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0108 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0193 0.0253
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0836 0.2785
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0002
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0108 0.0322
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0108 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0193 0.0253
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0606 0.1807
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0108 0.013
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0159 0.0066
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.1671 0.2309
Echinococcus granulosus dnaJ subfamily B 0.0439 0.7185 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0311 0.0408
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0108 0.0108
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0147 0.0439
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0193 0.0249
Plasmodium falciparum glutathione reductase 0.019 0.3003 1
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0193 0.0193
Leishmania major DNA polymerase kappa, putative 0.0064 0.0885 0.2396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0193 0.0249
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0276 0.0516
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0885 0.264
Leishmania major vacuolar ATP synthase, putative 0.002 0.0154 0.0142
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0016 0.0021
Schistosoma mansoni DNA helicase recq5 0.0022 0.0179 0.0179
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.0311 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0603 0.0821
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0193 0.0193
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0108 0.0141
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0038
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0108 0.013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.019 0.3003 0.3716
Loa Loa (eye worm) vacuolar ATP synthase proteolipid subunit 0.002 0.0154 0.0202
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0108 0.013
Onchocerca volvulus 0.0337 0.5474 0.6247
Treponema pallidum NADH oxidase 0.0066 0.0919 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0108 0.036
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0193 0.0249
Trichomonas vaginalis vacuolar ATP synthase proteolipid subunit, putative 0.002 0.0154 0.0054
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0017 0.0108 0.0322
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0305 0.1015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0147 0.0439
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0179 0.0234
Onchocerca volvulus Netrin receptor homolog 0.003 0.0311 0.0236
Onchocerca volvulus Serine\/threonine kinase homolog 0.0211 0.3353 0.3777
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0885 0.1214
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.3353 0.3353
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0305 0.0919
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0108 0.0108
Echinococcus multilocularis dna polymerase kappa 0.0064 0.0885 0.1214
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.0193
Loa Loa (eye worm) hypothetical protein 0.0058 0.0786 0.1031
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0108 0.013
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0108 0.0322
Echinococcus multilocularis bloom syndrome protein 0.0052 0.0696 0.095
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0108 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0885 0.2641
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0015 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0211 0.3353 0.3777
Schistosoma mansoni vacuolar ATP synthase proteolipid subunit 1 2 3 0.002 0.0154 0.0154
Loa Loa (eye worm) glutathione reductase 0.019 0.3003 0.394
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0108 0.0322
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0276 0.0516
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0179 0.0234
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0015 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0481 0.7898 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0035 0.0028

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 129 umol/L Inhibition of human SIRT2 assessed as nicotinamide releasing by microplate filtration assay ChEMBL. 18642893
IC50 (binding) = 168 umol/L Inhibition of human SIRT1 assessed as nicotinamide releasing by microplate filtration assay ChEMBL. 18642893
Inhibition (binding) = 69 % Inhibition of human SIRT1 at 200 uM ChEMBL. 18642893
Inhibition (binding) = 71 % Inhibition of human SIRT2 at 200 uM ChEMBL. 18642893

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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