Detailed information for compound 972454

Basic information

Technical information
  • TDR Targets ID: 972454
  • Name: [5-(2,4-dichlorophenyl)-2H-pyrazol-3-yl]-(4-e thylpiperazin-1-yl)methanone
  • MW: 353.246 | Formula: C16H18Cl2N4O
  • H donors: 1 H acceptors: 2 LogP: 3.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)C(=O)c1[nH]nc(c1)c1ccc(cc1Cl)Cl
  • InChi: 1S/C16H18Cl2N4O/c1-2-21-5-7-22(8-6-21)16(23)15-10-14(19-20-15)12-4-3-11(17)9-13(12)18/h3-4,9-10H,2,5-8H2,1H3,(H,19,20)
  • InChiKey: RTVLLHCNTYJZTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-(2,4-dichlorophenyl)-2H-pyrazol-3-yl]-(4-ethyl-1-piperazinyl)methanone
  • MLS-0146158.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens alkaline phosphatase, liver/bone/kidney Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni acetylcholinesterase 0.007 0.0435 0.0435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0235 0.0235
Loa Loa (eye worm) prolyl oligopeptidase 0.0138 0.0972 0.0972
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.1122 0.8707 0.8707
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0138 0.0972 0.155
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0053 0.0053
Trypanosoma brucei prolyl endopeptidase 0.0138 0.0972 0.155
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0196 0.1429 0.1429
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0808 0.6238 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0427 0.439
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0235 0.0235
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0138 0.0972 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0235 0.0235
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0518 0.0518
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0808 0.6238 1
Echinococcus multilocularis acetylcholinesterase 0.0414 0.3137 0.3137
Brugia malayi Serine protease Z688.6 precursor 0.006 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0448 0.3409 0.3409
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0053 0.0053
Brugia malayi Carboxylesterase family protein 0.0414 0.3137 0.3137
Loa Loa (eye worm) hypothetical protein 0.0414 0.3137 0.3137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0235 0.0235
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0427 0.439
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0235 0.0235
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.006 0.0359 0.0359
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0138 0.0972 0.0972
Onchocerca volvulus 0.007 0.0435 0.0186
Toxoplasma gondii hypothetical protein 0.0138 0.0972 0.2152
Brugia malayi Carboxylesterase family protein 0.0414 0.3137 0.3137
Brugia malayi Carboxylesterase family protein 0.007 0.0435 0.0435
Onchocerca volvulus 0.007 0.0435 0.0186
Echinococcus granulosus family S9 non peptidase ue S09 family 0.007 0.0435 0.0435
Echinococcus granulosus para nitrobenzyl esterase 0.007 0.0435 0.0435
Echinococcus multilocularis para nitrobenzyl esterase 0.007 0.0435 0.0435
Trypanosoma brucei prolyl oligopeptidase, putative 0.0138 0.0972 0.155
Giardia lamblia Alanyl dipeptidyl peptidase 0.0138 0.0972 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0138 0.0972 1
Echinococcus granulosus acylamino acid releasing enzyme 0.0138 0.0972 0.0972
Trypanosoma brucei oligopeptidase b 0.0138 0.0972 0.155
Echinococcus granulosus carboxylesterase 5A 0.0414 0.3137 0.3137
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.006 0.0359 0.0567
Loa Loa (eye worm) hypothetical protein 0.007 0.0435 0.0435
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0053 0.0053
Brugia malayi hypothetical protein 0.023 0.1692 0.1692
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0808 0.6238 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0414 0.3137 0.3137
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0587 0.4496 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.1287 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0006 0.0006
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.0465 0.0465
Brugia malayi Serine carboxypeptidase S28 family protein 0.006 0.0359 0.0359
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Loa Loa (eye worm) hypothetical protein 0.006 0.0359 0.0359
Entamoeba histolytica prolyl oligopeptidase family protein 0.0138 0.0972 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.007 0.0435 0.4472
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.1287 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0972 0.155
Echinococcus granulosus prolyl endopeptidase 0.0138 0.0972 0.0972
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0138 0.0972 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0518 0.0518
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Brugia malayi Serine protease Z688.6 precursor 0.006 0.0359 0.0359
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0808 0.6238 0.6238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0235 0.0235
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1692 0.1692
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0359 0.3696
Loa Loa (eye worm) carboxylesterase 0.0414 0.3137 0.3137
Loa Loa (eye worm) hypothetical protein 0.007 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.006 0.0359 0.0359
Plasmodium vivax hypothetical protein, conserved 0.0138 0.0972 1
Echinococcus multilocularis carboxylesterase 5A 0.0414 0.3137 0.3137
Schistosoma mansoni hypothetical protein 0.0047 0.0254 0.0254
Onchocerca volvulus Prolyl endopeptidase homolog 0.0138 0.0972 0.0737
Loa Loa (eye worm) hypothetical protein 0.0138 0.0972 0.0972
Brugia malayi prolyl oligopeptidase family protein 0.0138 0.0972 0.0972
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0006 0.0006
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0138 0.0972 0.155
Echinococcus multilocularis prolyl endopeptidase 0.0138 0.0972 0.0972
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0435 0.0435
Echinococcus multilocularis neuroligin 0.007 0.0435 0.0435
Echinococcus granulosus BC026374 protein S09 family 0.007 0.0435 0.0435
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0235 0.0235
Schistosoma mansoni BC026374 protein (S09 family) 0.007 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.007 0.0435 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0359 0.3696
Loa Loa (eye worm) carboxylesterase 0.007 0.0435 0.0435
Brugia malayi isocitrate dehydrogenase 0.0015 0.0006 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0235 0.0235
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.3419 0.3419
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.0465 0.0465
Brugia malayi hypothetical protein 0.007 0.0435 0.0435
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1692 0.1692
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.006 0.0359 0.0567
Echinococcus granulosus acetylcholinesterase 0.0414 0.3137 0.3137
Loa Loa (eye worm) hypothetical protein 0.006 0.0359 0.0359
Echinococcus multilocularis BC026374 protein (S09 family) 0.007 0.0435 0.0435
Echinococcus granulosus neuropeptide s receptor 0.0449 0.3419 0.3419
Loa Loa (eye worm) hypothetical protein 0.0414 0.3137 0.3137
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0053 0.0053
Loa Loa (eye worm) prolyl oligopeptidase 0.1287 1 1
Loa Loa (eye worm) carboxylesterase 0.007 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.007 0.0435 0.0435
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.007 0.0435 0.4437
Onchocerca volvulus 0.007 0.0435 0.0186
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0254 0.0254
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.0465 0.0465
Schistosoma mansoni alkaline phosphatase 0.0196 0.1429 0.1429
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0435 0.0435
Brugia malayi Carboxylesterase family protein 0.007 0.0435 0.0435
Brugia malayi Carboxylesterase family protein 0.007 0.0435 0.0435
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0138 0.0972 1
Echinococcus granulosus intestinal type alkaline phosphatase 0.0196 0.1429 0.1429
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0006 0.0006
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0972 0.155
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.1287 1 1
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0006 0.0006
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.1122 0.8707 0.8707
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.3419 0.3419
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0138 0.0972 0.155
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0138 0.0972 0.0972
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0138 0.0972 0.155
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0808 0.6238 0.6238
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0006 0.0006
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0138 0.0972 0.2152
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Echinococcus granulosus Dipeptidyl peptidase 9 0.0808 0.6238 0.6238
Brugia malayi Carboxylesterase family protein 0.007 0.0435 0.0435
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.007 0.0435 0.0435
Entamoeba histolytica hypothetical protein, conserved 0.0138 0.0972 1
Echinococcus multilocularis alkaline phosphatase 0.0196 0.1429 0.1429
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0053 0.0053
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0435 0.0435
Schistosoma mansoni survival motor neuron protein 0.0047 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.007 0.0435 0.0435
Echinococcus granulosus alkaline phosphatase 0.0196 0.1429 0.1429
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0006 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0006 0.0006
Schistosoma mansoni alkaline phosphatase 0.0196 0.1429 0.1429
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.006 0.0359 0.0359
Echinococcus multilocularis acetylcholinesterase 0.0414 0.3137 0.3137
Brugia malayi hypothetical protein 0.0448 0.3409 0.3409
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.006 0.0359 0.3696
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.006 0.0359 0.3696
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0808 0.6238 1
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0972 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0138 0.0972 1
Loa Loa (eye worm) hypothetical protein 0.036 0.2714 0.2714
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0006 0.0006
Trypanosoma cruzi prolyl endopeptidase 0.0138 0.0972 0.155
Echinococcus granulosus neuroligin 0.007 0.0435 0.0435
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0053 0.0053
Brugia malayi prolyl oligopeptidase family protein 0.0808 0.6238 0.6238
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.006 0.0359 0.0359
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0138 0.0972 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0435 0.0435
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.3419 0.3419
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.0465 0.0465
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0196 0.1429 0.1429
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.1287 1 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0808 0.6238 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0138 0.0972 0.0972
Plasmodium falciparum peptidase, putative 0.0138 0.0972 1
Brugia malayi prolyl oligopeptidase family protein 0.0138 0.0972 0.0972
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0196 0.1429 0.1429
Entamoeba histolytica prolyl oligopeptidase family protein 0.0138 0.0972 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0138 0.0972 0.155
Loa Loa (eye worm) hypothetical protein 0.0138 0.0972 0.0972
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0196 0.1429 0.1429
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0138 0.0972 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0235 0.0235
Schistosoma mansoni neuroligin 3 (S09 family) 0.007 0.0435 0.0435
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.006 0.0359 0.0567
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0053
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0196 0.1429 0.1429
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.1122 0.8707 0.8707
Echinococcus multilocularis acylamino acid releasing enzyme 0.0138 0.0972 0.0972
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0414 0.3137 0.3137
Trichomonas vaginalis spcc417.12 protein, putative 0.007 0.0435 0.4472
Loa Loa (eye worm) hypothetical protein 0.006 0.0359 0.0359
Onchocerca volvulus 0.006 0.0359 0.0108
Leishmania major oligopeptidase b 0.0138 0.0972 0.155
Toxoplasma gondii serine carboxypeptidase s28 protein 0.006 0.0359 0.0787
Mycobacterium tuberculosis Probable peptidase 0.0138 0.0972 1
Onchocerca volvulus 0.007 0.0435 0.0186
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.006 0.0359 0.3696
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.007 0.0435 0.4437
Schistosoma mansoni gliotactin 0.007 0.0435 0.0435
Toxoplasma gondii prolyl endopeptidase 0.0138 0.0972 0.2152
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0138 0.0972 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Onchocerca volvulus 0.007 0.0435 0.0186
Schistosoma mansoni hypothetical protein 0.0102 0.0687 0.0687
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0006 0.0006
Trypanosoma cruzi oligopeptidase b 0.0138 0.0972 0.155
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0053 0.0053
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.006 0.0359 0.3696
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0138 0.0972 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0388 0.0388
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0138 0.0972 0.0972
Trypanosoma cruzi oligopeptidase b 0.0138 0.0972 0.155
Brugia malayi prolyl oligopeptidase family protein 0.0138 0.0972 0.0972
Echinococcus granulosus acetylcholinesterase 0.0414 0.3137 0.3137
Loa Loa (eye worm) hypothetical protein 0.023 0.1692 0.1692
Loa Loa (eye worm) hypothetical protein 0.007 0.0435 0.0435
Mycobacterium tuberculosis Carboxylesterase LipT 0.007 0.0435 0.4437
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0138 0.0972 0.155

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.488 uM Inhibition of TNSALP ChEMBL. 19038545
IC50 (binding) = 0.488 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference
IC50 (binding) > 100 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1577, AID518, AID690] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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