TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 309.294 | Formula: C17H12FN3O2
H donors: 1 H acceptors: 2 LogP: 3.7 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1noc(n1)c1cc2c([nH]1)ccc(c2)F
InChi: 1S/C17H12FN3O2/c1-22-13-5-2-10(3-6-13)16-20-17(23-21-16)15-9-11-8-12(18)4-7-14(11)19-15/h2-9,19H,1H3
InChiKey: RUSAJDVJVRYZJC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0021	0.0167	0.0167
Schistosoma mansoni	inositol transporter	0.0078	0.0991	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0043
Echinococcus granulosus	GPCR family 2	0.0015	0.0093	0.0093
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0021	0.0167	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0093	0.005
Echinococcus multilocularis		0.0389	0.5414	0.5414
Schistosoma mansoni	hypothetical protein	0.004	0.0441	0.0399
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.1265	0.1227
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.074	0.07
Schistosoma mansoni	hypothetical protein	0.004	0.0441	0.0399
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0043	0.0043
Echinococcus granulosus	furin	0.0482	0.6743	0.6743
Schistosoma mansoni	sodium/solute symporter	0.0078	0.0991	0.0951
Onchocerca volvulus		0.0078	0.0991	0.4899
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0114	0.1496	0.3423
Echinococcus multilocularis	Furin 1	0.0114	0.1496	0.1496
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0078	0.0991	0.0991
Loa Loa (eye worm)	hypothetical protein	0.071	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0348	0.0306
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0293	0.4049	0.4049
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Onchocerca volvulus		0.0148	0.1977	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.051	0.0469
Echinococcus multilocularis	expressed conserved protein	0.009	0.1161	0.1161
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0043	0.0043
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0462	0.0462
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0043	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0078	0.0991	0.0991
Echinococcus granulosus	expressed conserved protein	0.009	0.1161	0.1161
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1244	1
Schistosoma mansoni	hypothetical protein	0.0408	0.5691	0.5672
Loa Loa (eye worm)	hypothetical protein	0.0189	0.2568	0.2568
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0374	0.0374
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.051	0.051
Brugia malayi	Subtilase family protein	0.0021	0.0167	0.0125
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0043	0.0043
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0043	0.0043
Plasmodium vivax	subtilisin-like protease 1	0.0021	0.0167	0.5
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0078	0.0991	0.0991
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0021	0.0167	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0462	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0348	0.0348
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.051	0.0469
Echinococcus granulosus	cpg binding protein	0.003	0.0305	0.0305
Schistosoma mansoni	hypothetical protein	0.004	0.0441	0.0399
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.051	0.0469
Echinococcus granulosus	Furin 1	0.0114	0.1496	0.1496
Echinococcus multilocularis	geminin	0.0346	0.481	0.481
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0021	0.0167	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0043	0.0043
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1244	0.1244
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1244	0.1244
Schistosoma mansoni	hypothetical protein	0.0015	0.0093	0.005
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0021	0.0167	0.5
Schistosoma mansoni	patched 1	0.0041	0.0462	0.042
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0462	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0093	0.0093
Schistosoma mansoni	hypothetical protein	0.0346	0.481	0.4788
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0021	0.0167	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Brugia malayi	celfurPC protein	0.0389	0.5414	0.5395
Trypanosoma brucei	RNA helicase, putative	0.0244	0.3346	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0043	0.0043
Schistosoma mansoni	high-affinity choline transporter	0.071	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0043	0.0043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0114	0.1496	0.3423
Giardia lamblia	High cysteine membrane protein Group 2	0.0179	0.2426	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0043	0.0043
Schistosoma mansoni	inositol transporter	0.0078	0.0991	0.0951
Brugia malayi	Sodium:solute symporter family protein	0.0078	0.0991	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0482	0.6743	0.6743
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0043	0.0043
Schistosoma mansoni	hypothetical protein	0.004	0.0441	0.0399
Schistosoma mansoni	hypothetical protein	0.0015	0.0093	0.005
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3953	0.3953
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0568	0.0527
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0021	0.0167	0.0125
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0021	0.0167	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Leishmania major	subtilisin-like serine peptidase	0.0021	0.0167	0.5
Echinococcus granulosus	membrane bound transcription factor site 1	0.0021	0.0167	0.0167
Loa Loa (eye worm)	subtilase	0.0021	0.0167	0.0167
Brugia malayi	Nuclear hormone receptor-like 1	0.0287	0.3963	0.3937
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0568	0.0568
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0043	0.0043
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0568	0.0568
Brugia malayi	hypothetical protein	0.0035	0.0374	0.0333
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0021	0.0167	0.5
Schistosoma mansoni	hypothetical protein	0.0244	0.3346	0.3317
Echinococcus multilocularis	dnaJ subfamily B	0.0408	0.5691	0.5691
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1244	0.1244
Plasmodium vivax	subtilisin-like protease 2, putative	0.0021	0.0167	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0114	0.1496	0.3423
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0043	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0545	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0021	0.0167	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0374	0.0374
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0021	0.0167	0.0167
Echinococcus granulosus	sodium:glucose cotransporter	0.0078	0.0991	0.0991
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0078	0.0991	0.0991
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0462	0.0759
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0021	0.0167	0.0125
Schistosoma mansoni	hypothetical protein	0.0093	0.1202	0.1164
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0282	0.024
Brugia malayi	CHE-14 protein	0.0041	0.0462	0.042
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0021	0.0167	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0043	0.0043
Schistosoma mansoni	furin-1 (S08 family)	0.021	0.2862	0.2831
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0462	0.0462
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.051	0.051
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0293	0.4049	1
Echinococcus multilocularis	cpg binding protein	0.003	0.0305	0.0305
Loa Loa (eye worm)	proprotein convertase 2	0.0114	0.1496	0.1496
Loa Loa (eye worm)	endoprotease bli-4	0.0482	0.6743	0.6743
Echinococcus multilocularis	high affinity choline transporter 1	0.071	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0043	0.0043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0114	0.1496	0.3423
Plasmodium falciparum	subtilisin-like protease 1	0.0021	0.0167	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0043	0.0043
Echinococcus granulosus	high affinity choline transporter 1	0.071	1	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0348	0.0306
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0078	0.0991	0.0991
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0093	0.0093
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0043	0.0043
Echinococcus granulosus	dnaJ subfamily B	0.0408	0.5691	0.5691
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0374	0.0333
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0282	0.0282
Schistosoma mansoni	cpg binding protein	0.003	0.0305	0.0263
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0287	0.3963	0.3963
Onchocerca volvulus		0.0029	0.0282	0.1235
Brugia malayi	hypothetical protein	0.0148	0.1977	0.1942
Brugia malayi	endoprotease bli-4 precursor	0.0482	0.6743	0.6729
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0114	0.1496	0.3423
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0021	0.0167	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0043
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0078	0.0991	1
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.051	0.051
Brugia malayi	neuroendocrine convertase 1 precursor	0.0303	0.4191	0.4165
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0043	0.0043
Echinococcus multilocularis	protein patched	0.0041	0.0462	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0043	0.0043
Plasmodium falciparum	subtilisin-like protease 3	0.0021	0.0167	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0043	0.0043
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0093	0.0093
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0293	0.4049	0.4049
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.051	0.051
Schistosoma mansoni	cpg binding protein	0.003	0.0305	0.0263
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0093	0.1202	0.2667
Brugia malayi	proprotein convertase 2	0.0303	0.4191	0.4165
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.051	0.0469
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0043	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0594	0.0594
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0021	0.0167	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Onchocerca volvulus		0.0021	0.0167	0.0642
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0021	0.0167	0.0125
Echinococcus granulosus	neuroendocrine convertase 2	0.0303	0.4191	0.4191
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0021	0.0167	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0043
Trichomonas vaginalis	hypothetical protein	0.0093	0.1202	0.2667
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.1832	0.1832
Brugia malayi	Nuclear hormone receptor-like 1	0.0292	0.4043	0.4017
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.1202	0.2667
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0021	0.0167	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0293	0.4049	1
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0093	0.1202	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0043
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0462	0.0462
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0093	0.0093
Trypanosoma cruzi	subtilisin peptidase	0.0021	0.0167	0.5
Echinococcus granulosus	geminin	0.0346	0.481	0.481
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0167	0.0167
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0078	0.0991	0.0991
Schistosoma mansoni	hypothetical protein	0.0015	0.0093	0.005
Echinococcus multilocularis	neuroendocrine convertase 2	0.0303	0.4191	0.4191
Plasmodium falciparum	subtilisin-like protease 2	0.0021	0.0167	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1977	0.1977
Schistosoma mansoni	cpg binding protein	0.0029	0.0282	0.024
Echinococcus multilocularis	solute carrier family 5	0.0078	0.0991	0.0991
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0043	0.0043
Mycobacterium leprae	Possible secreted protease	0.0021	0.0167	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0043	0.0043
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0093	0.0093
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0043	0.0043
Schistosoma mansoni	hypothetical protein	0.0035	0.0374	0.0333
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0093	0.1202	0.2667
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0093	0.0093
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.1832	0.1832
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0043	0.0043
Plasmodium vivax	subtilisin-like serine protease, putative	0.0021	0.0167	0.5
Schistosoma mansoni	hypothetical protein	0.0015	0.0093	0.005
Echinococcus granulosus	solute carrier family 5	0.0078	0.0991	0.0991
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0021	0.0167	0.0125
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0043	0.0043
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0114	0.1496	0.1459
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0093	0.005
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0568	0.0527
Brugia malayi	Nuclear hormone receptor-like 1	0.0287	0.3963	0.3937
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0021	0.0167	0.0167
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0021	0.0167	0.0125
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0647	0.5833
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0114	0.1496	0.3423
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0482	0.6743	0.6729
Schistosoma mansoni	hypothetical protein	0.0346	0.481	0.4788
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1244	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0991	0.0991

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 10.3 uM	Anticancer activity against human MIAPaCa2 cells after 72 hrs by WST-1 assay	ChEMBL.	20705365
IC50 (functional)	> 50 uM	Anticancer activity against human MCF7 cells after 72 hrs by WST-1 assay	ChEMBL.	20705365
IC50 (functional)	> 50 uM	Anticancer activity against human Jurkat cells after 72 hrs by WST-1 assay	ChEMBL.	20705365

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	20705365

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1254409

Bibliographic References

No literature references available for this target.

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Detailed information for compound 972613