Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidine kinase 1, soluble | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0054 | 0.0353 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.0353 | 0.0353 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0301 | 0.3459 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0036 | 0.055 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0079 | 0.0659 | 0.0317 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0046 | 0.0243 | 0.0243 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.0353 | 0.0353 |
Echinococcus granulosus | lamin | 0.0054 | 0.0353 | 0.0353 |
Onchocerca volvulus | 0.0054 | 0.0353 | 0.5 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0822 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0054 | 0.0353 | 0.0353 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0301 | 0.3459 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0301 | 0.3459 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.0353 | 0.5358 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0079 | 0.0659 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0079 | 0.0659 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0079 | 0.0659 | 0.0659 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0822 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0301 | 0.3459 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0301 | 0.3459 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0301 | 0.3459 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.0353 | 0.5358 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0353 | 0.5358 |
Giardia lamblia | Thymidine kinase | 0.0301 | 0.3459 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.0353 | 0.5088 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.0353 | 0.5088 |
Leishmania major | thymidine kinase, putative | 0.0301 | 0.3459 | 1 |
Echinococcus multilocularis | lamin | 0.0054 | 0.0353 | 0.0353 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0046 | 0.0243 | 0.0243 |
Entamoeba histolytica | thymidine kinase, putative | 0.0301 | 0.3459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0341 | 0.5168 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0079 | 0.0659 | 0.0659 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 uM | Inhibition of recombinant TK1-mediated phosphorylation of [CH3-3H]deoxythymidine | ChEMBL. | 18556209 |
IC50 (binding) | = 405 uM | Inhibition of recombinant TK1-mediated phosphorylation of [CH3-3H]deoxythymidine in presence of dithiothreitol | ChEMBL. | 18556209 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.