Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 386 aa | 23.1 % |
Echinococcus multilocularis | neuropeptides capa receptor | Histamine H3 receptor | 445 aa | 441 aa | 20.4 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 412 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.0549 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.4834 | 0.4565 | 0.453 |
Brugia malayi | Dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Echinococcus granulosus | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1011 | 0.0929 | 0.0965 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0101 | 0.0064 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Mycobacterium tuberculosis | Hypothetical protein | 0.4834 | 0.4565 | 0.474 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1011 | 0.0929 | 0.0965 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0101 | 0.0064 | 0.0067 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4834 | 0.4565 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.0549 | 1 | 1 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0101 | 0.0064 | 0.0067 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1011 | 0.0929 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.1011 | 0.0929 | 0.0904 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1011 | 0.0929 | 0.0965 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.0549 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.0162 | 0.9632 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.0549 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0101 | 0.0064 | 0.0067 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0101 | 0.0064 | 0.0067 |
Echinococcus granulosus | dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Onchocerca volvulus | 1.0162 | 0.9632 | 1 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.0162 | 0.9632 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0154 | 0.0114 | 0.0118 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0154 | 0.0114 | 0.0118 |
Mycobacterium ulcerans | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Brugia malayi | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Brugia malayi | hypothetical protein | 0.4834 | 0.4565 | 0.4704 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0154 | 0.0114 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.0549 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.0162 | 0.9632 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 7.2 | Antagonist activity at histamine H3 receptor in guinea pig jejunum assessed as electrically evoked contractions | ChEMBL. | 18990469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.