Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | caspase-3 (C14 family) | 0.0245 | 1 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0224 | 0.9072 | 0.904 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0224 | 0.9072 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0224 | 0.9072 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0104 | 0.3826 | 0.3826 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0023 | 0.0336 | 0.0879 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0023 | 0.0336 | 0.0371 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0336 | 0.0879 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0075 | 0.2568 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0224 | 0.9072 | 0.9072 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0075 | 0.2568 | 0.2831 |
Echinococcus granulosus | cathepsin l1 | 0.0023 | 0.0336 | 0.0336 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0075 | 0.2568 | 0.6713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Loa Loa (eye worm) | ctsf protein | 0.0023 | 0.0336 | 0.0371 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Echinococcus granulosus | caspase 8 | 0.0104 | 0.3826 | 0.3826 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0075 | 0.2568 | 0.6713 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0336 | 0.0371 |
Echinococcus multilocularis | caspase 8 | 0.0104 | 0.3826 | 0.3611 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0336 | 0.0879 |
Loa Loa (eye worm) | cysteine protease | 0.0023 | 0.0336 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.3826 | 0.4217 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0075 | 0.2568 | 0.6396 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.3826 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0104 | 0.3826 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0104 | 0.3826 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0245 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.0336 | 0.0371 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.3826 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0075 | 0.2568 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0224 | 0.9072 | 0.9072 |
Echinococcus granulosus | caspase | 0.0245 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.0336 | 0.0371 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Echinococcus granulosus | caspase 3 | 0.0142 | 0.5493 | 0.5493 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0121 | 0.4566 | 0.4377 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0075 | 0.2568 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0121 | 0.4566 | 0.4566 |
Plasmodium vivax | metacaspase 1, putative | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.3826 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0075 | 0.2568 | 0.6396 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0075 | 0.2568 | 0.2568 |
Trypanosoma brucei | metacaspase MCA3 | 0.0104 | 0.3826 | 1 |
Onchocerca volvulus | 0.0023 | 0.0336 | 0.0371 | |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0075 | 0.2568 | 0.231 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Plasmodium falciparum | metacaspase-like protein | 0.0104 | 0.3826 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.4566 | 0.5033 |
Onchocerca volvulus | 0.0023 | 0.0336 | 0.0371 | |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0336 | 0.0371 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0104 | 0.3826 | 0.4217 |
Echinococcus multilocularis | caspase 3 | 0.0142 | 0.5493 | 0.5336 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0075 | 0.2568 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trypanosoma cruzi | metacaspase, putative | 0.0104 | 0.3826 | 1 |
Onchocerca volvulus | 0.0023 | 0.0336 | 0.0371 | |
Plasmodium falciparum | metacaspase 1 | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.9072 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0023 | 0.0336 | 0.1309 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Leishmania major | metacaspase, putative | 0.0104 | 0.3826 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0104 | 0.3826 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0023 | 0.0336 | 0.0371 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0336 | 0.0371 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0336 | 0.0371 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0336 | 0.0371 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trypanosoma brucei | metacaspase 5, putative | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0075 | 0.2568 | 0.6396 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0245 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0075 | 0.2568 | 0.2568 |
Brugia malayi | hypothetical protein | 0.0121 | 0.4566 | 0.5033 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0075 | 0.2568 | 0.6396 |
Onchocerca volvulus | 0.0121 | 0.4566 | 0.5033 | |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0336 | 0.0371 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.0336 | 0.0371 |
Onchocerca volvulus | Cathepsin F homolog | 0.0023 | 0.0336 | 0.0371 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0336 | 0.0879 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0336 | 0.0371 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.0336 | 0.0336 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0023 | 0.0336 | 0.0336 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0023 | 0.0336 | 0.1309 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0336 | 0.0879 |
Echinococcus multilocularis | caspase | 0.0245 | 1 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0104 | 0.3826 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0075 | 0.2568 | 0.6396 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Entamoeba histolytica | cysteine protease, putative | 0.0023 | 0.0336 | 0.1309 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0023 | 0.0336 | 0.0371 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0075 | 0.2568 | 0.2831 |
Onchocerca volvulus | 0.0023 | 0.0336 | 0.0371 | |
Trypanosoma cruzi | metacaspase, putative | 0.0104 | 0.3826 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0023 | 0.0336 | 0.0336 |
Trypanosoma cruzi | metacaspase, putative | 0.0104 | 0.3826 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.0336 | 0.0336 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0075 | 0.2568 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Onchocerca volvulus | 0.0023 | 0.0336 | 0.0371 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Onchocerca volvulus | 0.0023 | 0.0336 | 0.0371 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0075 | 0.2568 | 0.6713 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0121 | 0.4566 | 0.4566 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0023 | 0.0336 | 0.0371 |
Trypanosoma brucei | Metacaspase-4 | 0.0104 | 0.3826 | 1 |
Trypanosoma brucei | metacaspase | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0336 | 0.0879 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0104 | 0.3826 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0104 | 0.3826 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0104 | 0.3826 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.