Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein jagged 2 | 0.0522 | 0.2247 | 0.033 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0522 | 0.2247 | 0.2247 |
Echinococcus multilocularis | protein jagged 1 | 0.0522 | 0.2247 | 0.033 |
Echinococcus granulosus | peroxidasin | 0.1616 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus multilocularis | protein jagged 2 | 0.0522 | 0.2247 | 0.033 |
Echinococcus multilocularis | protein jagged 1 | 0.0522 | 0.2247 | 0.033 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0522 | 0.2247 | 0.033 |
Schistosoma mansoni | cell polarity protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus multilocularis | neural cadherin | 0.0522 | 0.2247 | 0.033 |
Schistosoma mansoni | slit | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | 0.1616 | 1 | 1 | |
Echinococcus granulosus | neurogenic locus notch protein | 0.0522 | 0.2247 | 0.033 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | Peroxidase homolog | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0522 | 0.2247 | 0.033 |
Echinococcus multilocularis | peroxidasin | 0.1616 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | notch protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus granulosus | fibropellin Ia | 0.0522 | 0.2247 | 0.033 |
Echinococcus granulosus | protein jagged 1 | 0.0522 | 0.2247 | 0.033 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0522 | 0.2247 | 0.033 |
Onchocerca volvulus | 0.1616 | 1 | 1 | |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1616 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus granulosus | neural cadherin | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Echinococcus granulosus | notch | 0.0522 | 0.2247 | 0.033 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0522 | 0.2247 | 0.033 |
Giardia lamblia | High cysteine protein | 0.0522 | 0.2247 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1616 | 1 | 1 |
Schistosoma mansoni | notch | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.1616 | 1 | 1 |
Schistosoma mansoni | notch | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | 0.0522 | 0.2247 | 0.2247 | |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0522 | 0.2247 | 0.033 |
Brugia malayi | Cadherin domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0522 | 0.2247 | 0.033 |
Brugia malayi | hypothetical protein | 0.0525 | 0.2269 | 0.2269 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1616 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | Animal haem peroxidase family protein | 0.1616 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.1616 | 1 | 1 |
Onchocerca volvulus | 0.0522 | 0.2247 | 0.2247 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.1616 | 1 | 1 |
Schistosoma mansoni | notch | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | EGF-like domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0522 | 0.2247 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1616 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0522 | 0.2247 | 0.033 |
Brugia malayi | notch-like transmembrane receptor | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | EGF-like domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus multilocularis | slit 2 protein | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Onchocerca volvulus | 0.1616 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Echinococcus granulosus | delta-like protein 1 | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | Peroxidase homolog | 0.1616 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | 0.0522 | 0.2247 | 0.2247 | |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus multilocularis | fibropellin Ia | 0.0522 | 0.2247 | 0.033 |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | sulfakinin receptor protein | 0.0525 | 0.2269 | 0.2269 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | Muscle positioning protein 4 | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | Animal haem peroxidase family protein | 0.1616 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | 0.0522 | 0.2247 | 0.2247 | |
Onchocerca volvulus | Putative cubilin | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | Animal haem peroxidase family protein | 0.1616 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | 0.0522 | 0.2247 | 0.2247 | |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0485 | 0.1983 | 0.1983 |
Schistosoma mansoni | peroxidasin | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0485 | 0.1983 | 0.1983 |
Schistosoma mansoni | notch | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | notch | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0485 | 0.1983 | 0.1983 |
Brugia malayi | Cadherin domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | Peroxidasin homolog | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | notch | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Echinococcus multilocularis | notch | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | Animal haem peroxidase family protein | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1616 | 1 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0522 | 0.2247 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | Animal haem peroxidase family protein | 0.1616 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.1616 | 1 | 1 |
Loa Loa (eye worm) | Notch2 | 0.0522 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | hypothetical protein | 0.0525 | 0.2269 | 0.2269 |
Onchocerca volvulus | Dual oxidase homolog | 0.1616 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.2247 | 0.2247 |
Schistosoma mansoni | septate junction protein | 0.0522 | 0.2247 | 0.2247 |
Onchocerca volvulus | Peroxidasin homolog | 0.1616 | 1 | 1 |
Onchocerca volvulus | Slit protein homolog | 0.0522 | 0.2247 | 0.2247 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0522 | 0.2247 | 0.2247 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Induction of receptor internalization in YFP-tagged human CCK1 receptor expressed in CHO cells at 100 nM after 90 mins | ChEMBL. | 19271701 | |
Activity (functional) | Agonist activity at human CCK2 receptor expressed in CHO cells assessed as stimulation of intracellular calcium response | ChEMBL. | 19271701 | |
Activity (functional) | Agonist activity at human CCK1 receptor expressed in CHO cells assessed as stimulation of intracellular calcium response | ChEMBL. | 19271701 | |
Activity (functional) | Antagonist activity at human CCK1 receptor expressed in CHO cells assessed as inhibition of CCK8-stimulated intracellular calcium response preincubated for 100 seconds before CCK8 challenge | ChEMBL. | 19271701 | |
Activity (functional) | Antagonist activity at human CCK2 receptor expressed in CHO cells assessed as inhibition of CCK8-stimulated intracellular calcium response preincubated for 100 seconds before CCK8 challenge | ChEMBL. | 19271701 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.