Detailed information for compound 973972

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.981 | Formula: C23H34ClFN2
  • H donors: 0 H acceptors: 0 LogP: 6.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN([C@@H]1C[C@@H]2C([C@@]1(C)CC2)(C)C)C1CCN(CC1)Cc1ccc(cc1F)Cl
  • InChi: 1S/C23H34ClFN2/c1-22(2)17-7-10-23(22,3)21(13-17)26(4)19-8-11-27(12-9-19)15-16-5-6-18(24)14-20(16)25/h5-6,14,17,19,21H,7-13,15H2,1-4H3/t17-,21-,23+/m1/s1
  • InChiKey: SOJREUGGTXHBCU-OAOOKAIFSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-X-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.2056 0.1432 1
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.1098 0.0759 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.001 0.0096
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Plasmodium vivax endoplasmin, putative 0.0134 0.0083 0.0548
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0108 0.0065 0.0622
Loa Loa (eye worm) DNA topoisomerase III 0.0167 0.0106 0.1074
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0007 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0016 0.0102
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0108 0.0065 0.0344
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0002 0.0018
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.2056 0.1432 1
Plasmodium vivax DNA gyrase subunit B, putative 0.2135 0.1487 1
Trypanosoma brucei heat shock protein, putative 0.0134 0.0083 0.0472
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0007 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.0054 0.0532
Mycobacterium leprae Probable two-component sensor kinase 0.0108 0.0065 0.0058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0002 0.0002
Mycobacterium ulcerans beta-lactamase 0.0039 0.0016 0.0013
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0108 0.0065 0.0642
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0171
Chlamydia trachomatis DNA gyrase subunit A 0.0259 0.0171 0.1128
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0108 0.0065 0.0443
Onchocerca volvulus 0.0029 0.001 0.0103
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0027 0.0177
Leishmania major hypothetical protein, conserved 0.0039 0.0016 0.0102
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0016 0.0148
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0017 0.0105
Entamoeba histolytica DNA topoisomerase III, putative 0.0167 0.0106 0.1058
Trypanosoma cruzi DNA topoisomerase II, putative 0.1258 0.0872 0.6082
Mycobacterium ulcerans lipase LipD 0.0039 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0016 0.0166
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0022 0.0144
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Leishmania major DNA topoisomerase ii 0.1258 0.0872 0.6082
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0108 0.0065 0.0062
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.0002
Loa Loa (eye worm) ctsf protein 0.0018 0.0002 0.0018
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0022 0.0138
Trypanosoma brucei DNA topoisomerase III, putative 0.0167 0.0106 0.0634
Trypanosoma brucei heat shock protein 90, putative 0.0134 0.0083 0.0472
Plasmodium falciparum endoplasmin, putative 0.0122 0.0074 0.0489
Brugia malayi Cation transporter family protein 0.0018 0.0002 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0002 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0108 0.0065 0.0062
Echinococcus multilocularis GPCR, family 2 0.0018 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0016 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0065 0.0427
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) glutaminase 2 0.0592 0.0404 0.4088
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0002 0.0018
Schistosoma mansoni hypothetical protein 0.0197 0.0127 0.1274
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0017 0.0066
Brugia malayi Cathepsin L-like precursor 0.0018 0.0002 0.0018
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0016 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.003 0.0301
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0108 0.0065 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0002 0.0018
Echinococcus granulosus DNA topoisomerase 2 alpha 0.1425 0.0989 1
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0167 0.0106 0.1058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.003 0.0301
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0008 0.0047
Schistosoma mansoni glutaminase 0.0592 0.0404 0.4078
Echinococcus granulosus lamin 0.0029 0.001 0.0079
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0166
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0022 0.0103
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.0096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0092
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0108 0.0065 0.0642
Loa Loa (eye worm) hypothetical protein 0.0724 0.0497 0.503
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0016 0.0148
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0166
Brugia malayi hypothetical protein 0.0449 0.0304 0.3078
Mycobacterium tuberculosis Conserved protein 0.0039 0.0016 0.0014
Trypanosoma brucei DNA topoisomerase ii 0.2056 0.1432 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0085
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0002 0.0018
Echinococcus granulosus intermediate filament protein 0.0029 0.001 0.0079
Mycobacterium leprae Probable lipase LipE 0.0039 0.0016 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0002 0.0000089926
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0002 0.0002
Echinococcus multilocularis geminin 0.0197 0.0127 0.1274
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0108 0.0065 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0002 0.0018
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 1.4267 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Giardia lamblia Fructose-bisphosphate aldolase 0.0592 0.0405 0.439
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0007 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0167 0.0106 0.073
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Chlamydia trachomatis DNA gyrase subunit A 0.0626 0.0428 0.2861
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0108 0.0065 0.0392
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0108 0.0065 0.0642
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0167 0.0106 0.1074
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0167 0.0106 0.067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.0164 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0085
Leishmania major DNA topoisomerase III, putative 0.0167 0.0106 0.073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0035
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0108 0.0065 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Loa Loa (eye worm) endoplasmin 0.0134 0.0083 0.0841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0007 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0016 0.0148
Loa Loa (eye worm) glutaminase 0.0592 0.0404 0.4088
Onchocerca volvulus 0.0039 0.0016 0.0193
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.2135 0.1487 1
Echinococcus multilocularis lamin dm0 0.0029 0.001 0.0079
Echinococcus multilocularis musashi 0.0029 0.001 0.0079
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0037 0.025
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0002 0.0018
Echinococcus multilocularis cysteine protease 0.0018 0.0002 0.0000089926
Schistosoma mansoni hypothetical protein 0.004 0.0017 0.0153
Trypanosoma brucei heat shock protein 90, putative 0.0134 0.0083 0.0472
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 1.4267 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.0002
Echinococcus multilocularis heat shock protein 90 0.0134 0.0083 0.0825
Onchocerca volvulus 0.0168 0.0107 0.1392
Brugia malayi intermediate filament protein 0.0029 0.001 0.0096
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0108 0.0065 0.0062
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0008 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0053 0.0518
Loa Loa (eye worm) hypothetical protein 0.0449 0.0304 0.3078
Onchocerca volvulus 0.0449 0.0304 0.3993
Giardia lamblia DNA topoisomerase III 0.0167 0.0106 0.1094
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0085
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0168 0.0107 0.1069
Schistosoma mansoni endoplasmin 0.0134 0.0083 0.0825
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0007 0.0037
Mycobacterium ulcerans DNA gyrase subunit B 0.2135 0.1487 0.1484
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0035
Schistosoma mansoni heat shock protein 0.0134 0.0083 0.0825
Treponema pallidum fructose-bisphosphate aldolase 0.0592 0.0405 0.2686
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0002 0.0018
Toxoplasma gondii DNA topoisomerase 2, putative 0.1425 0.0989 0.9685
Echinococcus granulosus heat shock protein 90 0.0134 0.0083 0.0825
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0648 0.0444 0.4488
Trichomonas vaginalis glutaminase, putative 0.0592 0.0404 0.4078
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 1.4267 1 1
Brugia malayi Endoplasmin precursor 0.0134 0.0083 0.0841
Loa Loa (eye worm) heat shock protein 90 0.0134 0.0083 0.0841
Plasmodium falciparum DNA gyrase subunit B 0.2135 0.1487 1
Leishmania major cathepsin L-like protease 0.0069 0.0037 0.025
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0108 0.0065 0.0062
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0872
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Entamoeba histolytica hypothetical protein 0.0047 0.0022 0.0208
Trypanosoma brucei heat shock protein, putative 0.0134 0.0083 0.0472
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0022 0.0201
Mycobacterium ulcerans two component sensor kinase MprB 0.0108 0.0065 0.0062
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.001 0.0096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0017 0.0066
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0108 0.0065 0.0062
Trypanosoma brucei DNA topoisomerase III, putative 0.0167 0.0106 0.0634
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 1.4267 1 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0108 0.0065 0.0642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Plasmodium falciparum DNA topoisomerase 2 0.1425 0.0989 0.6645
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0008 0.0067
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0002 0.0000089926
Treponema pallidum DNA topoisomerase I (topA) 0.0167 0.0106 0.067
Trypanosoma cruzi DNA topoisomerase III, putative 0.0167 0.0106 0.073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0017 0.0105
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0108 0.0065 0.0415
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0007 0.0054
Plasmodium vivax DNA topoisomerase 3, putative 0.0167 0.0106 0.0703
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0016 0.0148
Brugia malayi glutaminase DH11.1 0.0592 0.0404 0.4088
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0016 0.0014
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0167 0.0106 0.1058
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0002 0.0018
Brugia malayi Cathepsin L-like precursor 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0166
Echinococcus granulosus histone lysine methyltransferase setb 0.0093 0.0054 0.0532
Brugia malayi DNA topoisomerase II, alpha isozyme 0.1425 0.0989 1
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0108 0.0065 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0054 0.0532
Giardia lamblia DNA topoisomerase II 0.1316 0.0913 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0002 0.0018
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0002 0.0018
Entamoeba histolytica DNA topoisomerase III, putative 0.0167 0.0106 0.1058
Entamoeba histolytica heat shock protein 90, putative 0.0134 0.0083 0.0825
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0017 0.0171
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0289 0.0192 0.0189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0002 0.0019
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0108 0.0065 0.0062
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0016 0.0148
Trichomonas vaginalis DNA topoisomerase II, putative 0.1425 0.0989 1
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0017 0.017
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0108 0.0065 0.0062
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0002 0.0018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0093 0.0054 0.0532
Echinococcus multilocularis rho GTPase activating protein 20 0.0167 0.0106 0.1058
Onchocerca volvulus 0.0738 0.0507 0.6662
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0108 0.0065 0.0062
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0872
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0167 0.0106 0.1058
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.2135 0.1487 1
Echinococcus multilocularis cysteine protease 0.0018 0.0002 0.0000089926
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0002 0.0000089926
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0016 0.0166
Schistosoma mansoni lamin 0.0029 0.001 0.0079
Echinococcus granulosus geminin 0.0197 0.0127 0.1274
Echinococcus multilocularis endoplasmin 0.0026 0.0007 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0053 0.0518
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0108 0.0065 0.0642
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 1.4267 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0008 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0053 0.0518
Trypanosoma brucei heat shock protein, putative 0.0134 0.0083 0.0472
Leishmania major cathepsin L-like protease 0.0069 0.0037 0.025
Loa Loa (eye worm) hypothetical protein 0.0672 0.046 0.4657
Trypanosoma cruzi heat shock protein 85, putative 0.0134 0.0083 0.0569
Mycobacterium tuberculosis Conserved protein 0.0108 0.0065 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0002 0.0018
Onchocerca volvulus 0.0028 0.0008 0.0088
Leishmania major developmentally regulated phosphoprotein-like protein 0.0108 0.0065 0.0443
Loa Loa (eye worm) hypothetical protein 0.0168 0.0107 0.1085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0019
Mycobacterium tuberculosis Possible two component sensor kinase 0.0108 0.0065 0.0062
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0289 0.0192 0.0189
Trypanosoma brucei heat shock protein, putative 0.0134 0.0083 0.0472
Mycobacterium ulcerans glutaminase 0.0592 0.0404 0.0401
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0002 0.0000089926
Onchocerca volvulus 0.0039 0.0016 0.0193
Brugia malayi Cathepsin L-like precursor 0.0018 0.0002 0.0018
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0017 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0037 0.025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0017 0.0105
Onchocerca volvulus 0.0029 0.001 0.0103
Giardia lamblia DNA topoisomerase III 0.0167 0.0106 0.1094
Brugia malayi beta-lactamase 0.0039 0.0016 0.0166
Schistosoma mansoni ap endonuclease 0.004 0.0017 0.0152
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0093 0.0054 0.0549
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0016 0.0014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0878 0.0605 0.6113
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Echinococcus granulosus L aminoadipate semialdehyde 0.0168 0.0107 0.1069
Brugia malayi Pre-SET motif family protein 0.0093 0.0054 0.0549
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0054 0.0532
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0289 0.0192 0.0185
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0108 0.0065 0.0443
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0022 0.0201
Schistosoma mansoni hypothetical protein 0.0197 0.0127 0.1274
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0108 0.0065 0.0062
Mycobacterium ulcerans hypothetical protein 0.0028 0.0008 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0008 0.0047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0052 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0002 0.0018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0033 0.0221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0016 0.0013
Plasmodium vivax DNA gyrase subunit A, putative 0.0626 0.0428 0.287
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0016 0.0148
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0108 0.0065 0.0062
Loa Loa (eye worm) runx1 0.0056 0.0029 0.0289
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0002 0.0018
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 1.4267 1 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.1098 0.0759 1
Trypanosoma cruzi heat shock protein 90, putative 0.0121 0.0074 0.0504
Schistosoma mansoni heat shock protein 0.0134 0.0083 0.0825
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0167 0.0106 0.073
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0002 0.0000089926
Plasmodium vivax SET domain protein, putative 0.0093 0.0054 0.0353
Mycobacterium ulcerans DNA gyrase subunit A 0.0626 0.0428 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0054 0.0532
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0002 0.0019
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0017 0.0101
Plasmodium vivax DNA topoisomerase II, putative 0.1425 0.0989 0.6645
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Brugia malayi heat shock protein 90 0.0134 0.0083 0.0841
Mycobacterium ulcerans hypothetical protein 0.0039 0.0016 0.0013
Brugia malayi DNA topoisomerase III beta-1 0.0167 0.0106 0.1074
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.1425 0.0989 1
Trichomonas vaginalis endoplasmin, putative 0.0122 0.0074 0.0736
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0008 0.0001
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0108 0.0065 0.0062
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0002 0.0018
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0626 0.0428 0.2844
Loa Loa (eye worm) beta-lactamase 0.0039 0.0016 0.0166
Schistosoma mansoni endoplasmin 0.0134 0.0083 0.0825
Leishmania major DNA topoisomerase 1A 0.0167 0.0106 0.073
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0724 0.0497 0.503
Trichomonas vaginalis sensor histidine kinase, putative 0.0108 0.0065 0.0642
Loa Loa (eye worm) hypothetical protein 0.0108 0.0065 0.0659
Leishmania major DNA topoisomerase III, putative 0.0167 0.0106 0.073
Toxoplasma gondii heat shock protein 90, putative 0.0134 0.0083 0.0799
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0022 0.0138
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0002 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0053 0.0535
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0166
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0108 0.0065 0.0392
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0016 0.0014
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.0022 0.0103
Trypanosoma brucei DNA topoisomerase IA, putative 0.0167 0.0106 0.0634
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0007 0.0037
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0167 0.0106 0.1058
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0037 0.025
Chlamydia trachomatis DNA topoisomerase I 0.0167 0.0106 0.0692
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0108 0.0065 0.0392
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0022 0.0019
Toxoplasma gondii exonuclease III APE 0.004 0.0017 0.0147
Chlamydia trachomatis DNA gyrase subunit B 0.2135 0.1487 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0167 0.0106 0.1025
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0008 0.0005
Brugia malayi DNA topoisomerase III 0.0167 0.0106 0.1074
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0035
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0002 0.0000089926
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Loa Loa (eye worm) hypothetical protein 0.0058 0.003 0.0301
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0017 0.0152
Trypanosoma cruzi DNA topoisomerase II, putative 0.1258 0.0872 0.6082
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) TOPoisomerase family member 0.1425 0.0989 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0002 0.0018
Trichomonas vaginalis receptor histidine kinase, putative 0.0108 0.0065 0.0642
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0017 0.017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0016 0.0148
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0108 0.0065 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0053 0.0518
Entamoeba histolytica heat shock protein 90, putative 0.0134 0.0083 0.0825
Onchocerca volvulus 0.0093 0.0054 0.0693
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0017 0.0152
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Echinococcus granulosus cathepsin l1 0.0018 0.0002 0.0000089926
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0108 0.0065 0.0427
Trypanosoma brucei heat shock protein, putative 0.0134 0.0083 0.0472
Echinococcus multilocularis lamin 0.0029 0.001 0.0079
Schistosoma mansoni lozenge 0.0056 0.0029 0.0272
Mycobacterium leprae Probable two component sensor kinase MprB 0.0108 0.0065 0.0058
Toxoplasma gondii ABC1 family protein 0.0039 0.0016 0.0144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0002 0.0018
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0626 0.0428 0.2844
Mycobacterium tuberculosis Probable two component sensor kinase 0.0108 0.0065 0.0062
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0008 0.0005
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0626 0.0428 0.4183
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0008 0.0001
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Schistosoma mansoni ap endonuclease 0.004 0.0017 0.0152
Mycobacterium ulcerans DNA topoisomerase I 0.0167 0.0106 0.0103
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0872
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0166
Giardia lamblia Pms1-like protein 0.0108 0.0065 0.0641
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0085
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0022 0.0019
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Trypanosoma brucei heat shock protein, putative 0.0134 0.0083 0.0472
Trichomonas vaginalis heat shock protein, putative 0.0134 0.0083 0.0825
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0017 0.0152
Echinococcus multilocularis L aminoadipate semialdehyde 0.0168 0.0107 0.1069
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0016 0.0009
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 1.4267 1 1
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0002 0.0018
Toxoplasma gondii heat shock protein HSP90 0.0134 0.0083 0.0799
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0022 0.0015
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0008 0.0005
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0108 0.0065 0.0062
Leishmania major hypothetical protein, conserved 0.0108 0.0065 0.0443
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0108 0.0065 0.0642
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.077 0.0529 0.0523
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0166
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0168 0.0107 0.1085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Trichomonas vaginalis set domain proteins, putative 0.0738 0.0507 0.5114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0053 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0054 0.0532
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Plasmodium falciparum heat shock protein 90 0.0134 0.0083 0.0548
Toxoplasma gondii DNA topoisomerase family protein 0.0167 0.0106 0.1025
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0016 0.0014
Echinococcus granulosus heat shock protein 90 0.0026 0.0007 0.0054
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0004 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0053 0.0518
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0016 0.0102
Loa Loa (eye worm) hypothetical protein 0.0449 0.0304 0.3078
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0017 0.0107
Trypanosoma cruzi DNA topoisomerase III, putative 0.0167 0.0106 0.073
Brugia malayi kinase, mitochondrial precursor 0.0108 0.0065 0.0659
Trypanosoma brucei DNA topoisomerase II beta, putative 0.1258 0.0872 0.6042
Brugia malayi Probable DNA topoisomerase II 0.1425 0.0989 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0167 0.0106 0.073
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0167 0.0106 0.0099
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0167 0.0106 0.1058
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0017 0.0152
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.1425 0.0989 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.003 0.0301
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0053 0.0535
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0008 0.0067
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0004 0.0012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0017 0.0003
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0167 0.0106 0.1058
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0195 0.0126 0.0119
Trypanosoma brucei heat shock protein, putative 0.0134 0.0083 0.0472
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0054 0.0515
Schistosoma mansoni DNA topoisomerase II 0.1425 0.0989 1
Trichomonas vaginalis heat shock protein, putative 0.0122 0.0074 0.0736
Echinococcus granulosus lamin dm0 0.0029 0.001 0.0079
Trichomonas vaginalis receptor histidine kinase, putative 0.0108 0.0065 0.0642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0006
Trypanosoma brucei developmentally regulated phosphoprotein 0.0108 0.0065 0.0344
Mycobacterium ulcerans putative regultory protein 0.0108 0.0065 0.0062
Echinococcus granulosus heat shock protein 0.0134 0.0083 0.0825
Schistosoma mansoni intermediate filament proteins 0.0029 0.001 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0022 0.0042
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0022 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0002 0.0002
Onchocerca volvulus 0.0167 0.0106 0.1378
Brugia malayi Cathepsin L-like precursor 0.0018 0.0002 0.0018
Brugia malayi GRF zinc finger family protein 0.0167 0.0106 0.1074
Leishmania major mitochondrial DNA topoisomerase II 0.2056 0.1432 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0016 0.0014
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0108 0.0065 0.0058
Trypanosoma cruzi heat shock protein 85, putative 0.0134 0.0083 0.0569
Chlamydia trachomatis DNA gyrase subunit B 0.1503 0.1044 0.7013
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0085
Loa Loa (eye worm) intermediate filament protein 0.0029 0.001 0.0096
Brugia malayi Cation transporter family protein 0.0018 0.0002 0.0018
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0007 0.0037
Plasmodium falciparum DNA topoisomerase 3, putative 0.0167 0.0106 0.0703
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) fibroinase 0.0018 0.0002 0.0018
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0037 0.025
Schistosoma mansoni pyruvate dehydrogenase 0.0108 0.0065 0.0642
Trypanosoma brucei Heat shock protein 83, putative 0.0134 0.0083 0.0472
Brugia malayi Cation transporter family protein 0.0018 0.0002 0.0018
Echinococcus multilocularis Protein lozenge 0.0056 0.0029 0.0272
Echinococcus granulosus endoplasmin 0.0026 0.0007 0.0054
Echinococcus multilocularis heat shock protein 90 0.0026 0.0007 0.0054
Mycobacterium ulcerans two component regulator - sensor kinase 0.0108 0.0065 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0037 0.0149
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0592 0.0405 0.4081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Trypanosoma cruzi heat shock protein 85, putative 0.0134 0.0083 0.0569
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0004 0.0012
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.0022 0.002
Brugia malayi Cathepsin L-like precursor 0.0018 0.0002 0.0018
Brugia malayi Cathepsin L-like precursor 0.0018 0.0002 0.0018
Schistosoma mansoni lamin 0.0029 0.001 0.0079
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0108 0.0065 0.0622
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.2135 0.1487 0.1485
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0008 0.0047
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0626 0.0428 0.0425
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0053 0.0518
Onchocerca volvulus 0.0039 0.0016 0.0193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0002 0.0018
Trypanosoma cruzi heat shock protein 90, putative 0.0134 0.0083 0.0569
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0017 0.0152
Brugia malayi beta-lactamase family protein 0.0039 0.0016 0.0166
Brugia malayi Pre-SET motif family protein 0.0648 0.0444 0.4488
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0016 0.0014
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0108 0.0065 0.0062
Giardia lamblia Heat shock protein HSP 90-alpha 0.0134 0.0083 0.084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0002 0.0018
Trichomonas vaginalis esterase, putative 0.0039 0.0016 0.0148
Trypanosoma cruzi Heat shock protein 83, putative 0.0134 0.0083 0.0569
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0016 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.147 0.1021 1
Echinococcus granulosus GPCR family 2 0.0018 0.0002 0.0002
Plasmodium falciparum DNA gyrase subunit A 0.0626 0.0428 0.287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0002 0.0018
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0017 0.0014
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.1258 0.0872 0.6042
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0016 0.0099
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0108 0.0065 0.0642
Trypanosoma brucei heat shock protein, putative 0.0134 0.0083 0.0472
Onchocerca volvulus DNA topoisomerase 2 homolog 0.1098 0.0759 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0002 0.0000089926
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0008 0.0005
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0108 0.0065 0.0062
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0017 0.0101
Loa Loa (eye worm) cysteine protease 0.0018 0.0002 0.0018
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0167 0.0106 0.1058
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0008 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0002 0.0019
Plasmodium vivax heat shock protein 86, putative 0.0134 0.0083 0.0548
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Echinococcus multilocularis heat shock protein 0.0134 0.0083 0.0825
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0108 0.0065 0.0642
Brugia malayi beta-lactamase family protein 0.0039 0.0016 0.0166
Leishmania major heat shock protein 83-1 0.0134 0.0083 0.0569
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0002 0.0000089926
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0672 0.046 0.4657
Leishmania major cathepsin L-like protease 0.0069 0.0037 0.025
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0016 0.0148
Entamoeba histolytica DNA topoisomerase II, putative 0.1425 0.0989 1
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Mycobacterium tuberculosis Conserved protein 0.0039 0.0016 0.0014
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 1.4267 1 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.8 Displacement of [125I]CXCL10 from human CXCR3 expressed in HEK293T cells ChEMBL. 19299127

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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