Detailed information for compound 974158

Basic information

Technical information
  • TDR Targets ID: 974158
  • Name: 2-amino-5-(2-methoxyphenoxy)-N-(4-methyl-1,3- thiazol-2-yl)benzamide
  • MW: 355.411 | Formula: C18H17N3O3S
  • H donors: 2 H acceptors: 2 LogP: 3.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1Oc1ccc(c(c1)C(=O)Nc1scc(n1)C)N
  • InChi: 1S/C18H17N3O3S/c1-11-10-25-18(20-11)21-17(22)13-9-12(7-8-14(13)19)24-16-6-4-3-5-15(16)23-2/h3-10H,19H2,1-2H3,(H,20,21,22)
  • InChiKey: SNFSLWVREUYDEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-5-(2-methoxyphenoxy)-N-(4-methylthiazol-2-yl)benzamide
  • 2-amino-5-(2-methoxyphenoxy)-N-(4-methyl-2-thiazolyl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucokinase (hexokinase 4) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Toxoplasma gondii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126743 All targets in OG5_126743
Treponema pallidum hexokinase (hxk) Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium parvum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium knowlesi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania braziliensis hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 2 Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi Hexokinase family protein Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Babesia bovis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium hominis hexokinase i Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium berghei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K00844 hexokinase [EC2.7.1.1], putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 1 Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania donovani hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase type II Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium falciparum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hexokinase family protein glucokinase (hexokinase 4) 465 aa 470 aa 30.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0738 0.4126
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0031 0.0418 0.0418
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0733 0.0733
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0988 0.4283
Echinococcus multilocularis hexokinase 0.0096 0.1618 0.1618
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0164 0.0632
Echinococcus granulosus hexokinase 0.0096 0.1618 0.1618
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.2088 1
Onchocerca volvulus 0.0048 0.0733 0.453
Plasmodium falciparum thioredoxin reductase 0.0048 0.0738 0.45
Echinococcus granulosus acetylcholinesterase 0.0555 1 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0083 0.0083
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.2088 1
Plasmodium falciparum glutathione reductase 0.0017 0.0164 0.0907
Schistosoma mansoni ap endonuclease 0.0019 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0031 0.0418 0.0418
Toxoplasma gondii hexokinase 0.0096 0.1618 1
Brugia malayi Hexokinase family protein 0.0096 0.1618 0.1618
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0164 0.0164
Loa Loa (eye worm) glutathione reductase 0.0048 0.0738 0.0738
Onchocerca volvulus 0.006 0.0962 0.5949
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0164 0.0632
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0738 0.0738
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.02 0.02
Plasmodium falciparum thioredoxin reductase 0.0017 0.0164 0.0907
Onchocerca volvulus Hexokinase homolog 0.006 0.0962 0.5949
Schistosoma mansoni acetylcholinesterase 0.0094 0.1573 0.1573
Mycobacterium ulcerans carboxylesterase, LipT 0.0094 0.1573 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0019 0.0019
Schistosoma mansoni neuroligin 3 (S09 family) 0.0094 0.1573 0.1573
Brugia malayi Hexokinase family protein 0.003 0.0403 0.0403
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0246 0.1195
Brugia malayi hexokinase type II 0.0031 0.0418 0.0418
Onchocerca volvulus 0.0096 0.1618 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0164 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0988 0.5851
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0164 0.0632
Loa Loa (eye worm) hypothetical protein 0.0094 0.1573 0.1573
Mycobacterium tuberculosis Carboxylesterase LipT 0.0094 0.1573 0.732
Treponema pallidum hexokinase (hxk) 0.0096 0.1618 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0164 0.0632
Plasmodium falciparum glutathione reductase 0.0048 0.0738 0.45
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.4143 0.4143
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0164 0.0907
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0164 0.0632
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0164 0.0164
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0164 0.0164
Leishmania major hexokinase, putative 0.0096 0.1618 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0167 0.0167
Onchocerca volvulus 0.0094 0.1573 0.9721
Toxoplasma gondii thioredoxin reductase 0.0048 0.0738 0.45
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0164 0.0632
Loa Loa (eye worm) hypothetical protein 0.0555 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0164 0.0289
Onchocerca volvulus 0.0094 0.1573 0.9721
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.02 0.089
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0164 0.0164
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0988 0.0988
Brugia malayi Carboxylesterase family protein 0.0094 0.1573 0.1573
Trypanosoma cruzi hexokinase, putative 0.0096 0.1618 1
Onchocerca volvulus 0.0094 0.1573 0.9721
Loa Loa (eye worm) hexokinase 0.006 0.0962 0.0962
Schistosoma mansoni DNA helicase recq5 0.0009 0.0019 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.2088 1
Entamoeba histolytica hexokinase 1 0.0096 0.1618 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0555 1 1
Brugia malayi hexokinase 0.0096 0.1618 0.1618
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0164 0.0632
Leishmania major trypanothione reductase 0.0048 0.0738 0.4334
Echinococcus granulosus hexokinase type 2 0.0096 0.1618 0.1618
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0555 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.02 0.02
Trypanosoma brucei trypanothione reductase 0.0048 0.0738 0.4334
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0738 0.0738
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0738 0.0738
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.02 0.0187
Plasmodium falciparum hexokinase 0.0096 0.1618 1
Echinococcus granulosus para nitrobenzyl esterase 0.0094 0.1573 0.1573
Loa Loa (eye worm) carboxylesterase 0.0094 0.1573 0.1573
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0094 0.1573 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0738 0.4126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0094 0.1573 0.1573
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0164 0.0632
Loa Loa (eye worm) hypothetical protein 0.0066 0.1059 0.1059
Brugia malayi Hexokinase family protein 0.006 0.0962 0.0962
Brugia malayi hypothetical protein 0.0094 0.1573 0.1573
Loa Loa (eye worm) hexokinase 0.0096 0.1618 0.1618
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0164 0.0907
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.02 0.0865
Schistosoma mansoni ap endonuclease 0.0019 0.02 0.02
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0164 0.801
Loa Loa (eye worm) hexokinase type II 0.0096 0.1618 0.1618
Echinococcus multilocularis carboxylesterase 5A 0.0555 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0988 0.0988
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.02 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0164 0.0632
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0094 0.1573 0.1573
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.1865 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0164 0.0632
Toxoplasma gondii exonuclease III APE 0.0019 0.02 0.1133
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.1865 0.8837
Plasmodium vivax hexokinase, putative 0.0096 0.1618 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0083 0.0083
Schistosoma mansoni hexokinase 0.0096 0.1618 0.1618
Loa Loa (eye worm) carboxylesterase 0.0555 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.1573 0.1573
Echinococcus multilocularis para nitrobenzyl esterase 0.0094 0.1573 0.1573
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0246 0.0246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0164 0.0632
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0164 0.0632
Loa Loa (eye worm) hypothetical protein 0.0234 0.4143 0.4143
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.02 0.0256
Entamoeba histolytica hexokinase 2 0.0096 0.1618 1
Brugia malayi Carboxylesterase family protein 0.0094 0.1573 0.1573
Onchocerca volvulus 0.0094 0.1573 0.9721
Echinococcus granulosus bloom syndrome protein 0.0021 0.0246 0.0246
Echinococcus granulosus hexokinase 0.0096 0.1618 0.1618
Brugia malayi Thioredoxin reductase 0.0048 0.0738 0.0738
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0094 0.1573 0.1573
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0164 0.0907
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0164 0.0907
Echinococcus multilocularis hexokinase type 2 0.0096 0.1618 0.1618
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0988 0.5943
Loa Loa (eye worm) hypothetical protein 0.0094 0.1573 0.1573
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0094 0.1573 0.1573
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0988 0.6062
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0246 0.1195
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.02 0.1133
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0019 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0988 0.5851
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0048 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.0094 0.1573 0.1573
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0164 0.0632
Echinococcus granulosus neuroligin 0.0094 0.1573 0.1573
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.02 0.0865
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0738 0.2985
Echinococcus multilocularis hexokinase 0.0096 0.1618 0.1618
Loa Loa (eye worm) hypothetical protein 0.0009 0.0019 0.0019
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.02 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.02 0.0248
Schistosoma mansoni survival motor neuron protein 0.0048 0.0733 0.0733
Onchocerca volvulus 0.0096 0.1618 1
Brugia malayi Carboxylesterase family protein 0.0094 0.1573 0.1573
Echinococcus granulosus acetylcholinesterase 0.0555 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0199 0.1126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0164 0.0632
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0164 0.0632
Echinococcus granulosus hexokinase 0.0096 0.1618 0.1618
Schistosoma mansoni BC026374 protein (S09 family) 0.0094 0.1573 0.1573
Brugia malayi Carboxylesterase family protein 0.0094 0.1573 0.1573
Onchocerca volvulus 0.0094 0.1573 0.9721
Trypanosoma cruzi hexokinase, putative 0.0096 0.1618 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0988 0.0988
Echinococcus multilocularis neuroligin 0.0094 0.1573 0.1573
Loa Loa (eye worm) carboxylesterase 0.0094 0.1573 0.1573
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0094 0.1573 0.1573
Echinococcus granulosus carboxylesterase 5A 0.0555 1 1
Onchocerca volvulus 0.0096 0.1618 1
Echinococcus multilocularis acetylcholinesterase 0.0555 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.02 0.02
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0117 0.0617
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.4143 0.4143
Loa Loa (eye worm) hexokinase 0.003 0.0403 0.0403
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0988 0.0988
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.1865 0.8837
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0738 0.4334
Trichomonas vaginalis spcc417.12 protein, putative 0.0094 0.1573 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0094 0.1573 0.1573
Brugia malayi Carboxylesterase family protein 0.0555 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0164 0.0632
Loa Loa (eye worm) hypothetical protein 0.0094 0.1573 0.1573
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0019 0.0019
Trypanosoma brucei hexokinase, putative 0.0096 0.1618 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0094 0.1573 0.1573
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.1865 0.8837
Mycobacterium tuberculosis Probable reductase 0.011 0.1865 0.8837
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0164 0.0632
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0019 0.0019
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0019 0.0019
Trypanosoma brucei hexokinase 0.0096 0.1618 1
Brugia malayi glutathione reductase 0.0048 0.0738 0.0738
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.02 0.089
Leishmania major hexokinase, putative 0.0096 0.1618 1
Loa Loa (eye worm) RecQ helicase 0.0021 0.0246 0.0246
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0164 0.0651
Brugia malayi hypothetical protein 0.0234 0.4143 0.4143
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0988 0.5851
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0164 0.0651
Schistosoma mansoni DNA helicase recq1 0.0009 0.0019 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.02 0.0865
Echinococcus multilocularis hexokinase 0.0096 0.1618 0.1618
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.02 0.0865
Schistosoma mansoni gliotactin 0.0094 0.1573 0.1573
Loa Loa (eye worm) hypothetical protein 0.0094 0.1573 0.1573
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0094 0.1573 0.732
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0164 0.0289
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.2088 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0019 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.1865 0.8837
Loa Loa (eye worm) hypothetical protein 0.0555 1 1
Loa Loa (eye worm) hexokinase 0.0096 0.1618 0.1618
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.02 0.053
Trypanosoma brucei hexokinase 0.0096 0.1618 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0094 0.1573 0.732
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0019 0.00000000045449
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.02 0.0865
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0019 0.0019
Echinococcus granulosus BC026374 protein S09 family 0.0094 0.1573 0.1573
Echinococcus multilocularis acetylcholinesterase 0.0555 1 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.12 uM Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose ChEMBL. 19188063
EC50 (binding) = 0.41 uM Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose ChEMBL. 19188063
FC (binding) = 1.6 Activation of human glucokinase assessed as maximal response by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose relative to control ChEMBL. 19188063
FC (binding) = 8 Activation of human glucokinase assessed as maximal response by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose relative to control ChEMBL. 19188063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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