Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GC50 (binding) | = 18 uM | Inhibition of phospholipase C gamma2 in human A431 cells assessed as reduction of calcium release after 45 mins by FLIPR assay | ChEMBL. | 19303309 |
Inhibition (binding) | = 27 % | Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infected Sf9 cells at 50 uM using [3H]PIP2 by flashplate biochemical assay | ChEMBL. | 19303309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.