TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 485.571 | Formula: C30H31NO5
H donors: 0 H acceptors: 2 LogP: 4.52 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@]4(CCC1=O)OC(=O)/C=C/c1ccccc1)CC1CC1
InChi: 1S/C30H31NO5/c1-34-23-11-10-21-17-24-30(36-25(33)12-9-19-5-3-2-4-6-19)14-13-22(32)28-29(30,26(21)27(23)35-28)15-16-31(24)18-20-7-8-20/h2-6,9-12,20,24,28H,7-8,13-18H2,1H3/b12-9+/t24-,28+,29+,30-/m1/s1
InChiKey: WGDLNMCFJZEUHA-ATTGEPADSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	opioid receptor, mu 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, kappa 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Echinococcus granulosus	chromobox protein 1	0.0073	0.008	0.008
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	g-protein coupled receptor	0.0015	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1519	0.1976	0.1976
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0004	0.0004
Mycobacterium ulcerans	endonuclease IV	0.008	0.0089	0.0088
Mycobacterium leprae	PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING])	0.0086	0.0097	0.0085
Echinococcus granulosus	7tm_1 domain containing protein	0.0015	0.0004	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0012	0.0011
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0015	0.0004	0.0004
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0015	0.0004	0.0004
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0063	0.0067	0.0067
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0015	0.0004	0.0004
Echinococcus granulosus	dihydrofolate reductase	0.7639	1	1
Leishmania major	NAD synthase, putative	0.0086	0.0097	0.0131
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	7TM GPCR rhodopsin	0.0015	0.0004	0.0004
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0012	0.0000000000049767	0.0000000000067943
Echinococcus granulosus	Chromo domain	0.0012	0.0000000000049767	0.0000000000049767
Brugia malayi	Dopamine receptor protein 2	0.0015	0.0004	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0015	0.0004	0.0004
Schistosoma mansoni	opsin-like receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	neuropeptide s receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	growth hormone secretagogue receptor	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0248	0.0309	0.1564
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0000000000049767	0.0000000000067943
Schistosoma mansoni	amine GPCR	0.0015	0.0004	0.0004
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0077	0.0085	0.0085
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0014	0.0014
Schistosoma mansoni	opsin-like receptor	0.0015	0.0004	0.0004
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.5598	0.7325	1
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.0004	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0025	0.0025
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Echinococcus multilocularis	thymidylate synthase	0.1519	0.1976	0.1976
Echinococcus granulosus	GMP synthase glutamine hydrolyzing	0.0034	0.0029	0.0029
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Brugia malayi	G protein-coupled receptor F59B2.13	0.0015	0.0004	0.0004
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Onchocerca volvulus		0.0015	0.0004	0.0022
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.0004	0.0004
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.1519	0.1976	0.1967
Echinococcus granulosus	neuropeptide receptor A26	0.0015	0.0004	0.0004
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0004	0.0004
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0015	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0012	0.0012
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0001	0.0001
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Echinococcus multilocularis	neuropeptide s receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0000000000049767	0.0000000000049767
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	dihydrofolate reductase	0.7639	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0049	0.0048	0.0244
Brugia malayi	RE15519p	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Leishmania major	pteridine reductase 1	0.021	0.0259	0.0353
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.5598	0.7325	1
Echinococcus multilocularis	somatostatin receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0015	0.0004	0.0004
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0015	0.0004	0.0022
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	neuropeptide receptor A26	0.0015	0.0004	0.0004
Echinococcus granulosus	chromobox protein 1	0.0073	0.008	0.008
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0042	0.045
Brugia malayi	neuropeptide F receptor	0.0015	0.0004	0.0004
Brugia malayi	Death domain containing protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Brugia malayi	Pre-SET motif family protein	0.0217	0.027	0.027
Toxoplasma gondii	endonuclease IV APN	0.008	0.0089	0.0122
Toxoplasma gondii	glutamine-dependent NAD(+) synthetase protein, putative	0.0086	0.0097	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	adenoreceptor	0.0015	0.0004	0.0004
Entamoeba histolytica	NAD synthetase, putative	0.0086	0.0097	1
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0000000000049767	0.0000000000049767
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0025	0.0025
Onchocerca volvulus		0.0012	0.0000000028555	0.000000014447
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.008	0.008
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Brugia malayi	GnHR receptor homolog	0.0015	0.0004	0.0004
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0067	0.0067
Trypanosoma brucei	GMP synthase [glutamine-hydrolysing]	0.0034	0.0029	0.0038
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Brugia malayi	Hypothetical 29.7 kDa protein C05D11.5 in chromosome III	0.0021	0.0012	0.0012
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0038	0.0406
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0025	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0038	0.0406
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0348	0.0441	0.0441
Brugia malayi	putative neuropeptide receptor NPR1	0.0015	0.0004	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	serotonin receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0015	0.0004	0.0004
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0063	0.0067	0.0089
Onchocerca volvulus		0.0015	0.0005	0.0023
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0004	0.0004
Trypanosoma brucei	NAD+ synthase, putative	0.0086	0.0097	0.0131
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Brugia malayi	G protein-coupled receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0015	0.0004	0.0004
Trypanosoma brucei	oxidoreductase-like protein	0.0015	0.0005	0.0005
Echinococcus multilocularis	orexin receptor type 2	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0038	0.0038
Brugia malayi	Melatonin receptor type 1A	0.0015	0.0004	0.0004
Echinococcus granulosus	netrin receptor unc 5	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0723	0.0932	0.1271
Onchocerca volvulus	Netrin receptor homolog	0.0015	0.0004	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.008	0.0089	0.0122
Schistosoma mansoni	glutamine-dependent NAD(+) synthetase	0.0086	0.0097	0.0097
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0038	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0015	0.0004	0.0022
Onchocerca volvulus		0.0015	0.0004	0.0022
Onchocerca volvulus		0.1519	0.1976	1
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0238	0.0297	0.0297
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0025	0.0025
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.001	0.0014
Treponema pallidum	NAD synthetase	0.0086	0.0097	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0001	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.5598	0.7325	1
Echinococcus granulosus	survival motor neuron protein 1	0.0238	0.0297	0.0297
Echinococcus granulosus	thymidylate synthase	0.1519	0.1976	0.1976
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.7639	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Trypanosoma cruzi	NAD+ synthase, putative	0.0086	0.0097	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0001	0.0001
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0014	0.0014
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0015	0.0004	0.0004
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0014	0.0014
Echinococcus multilocularis	Chromo domain	0.0012	0.0000000000049767	0.0000000000049767
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0008	0.0008
Toxoplasma gondii	bifunctional GMP synthase/glutamine amidotransferase protein	0.0034	0.0029	0.004
Schistosoma mansoni	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Brugia malayi	Serotonin receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0000000000049767	0.0000000000049767
Brugia malayi	AKH receptor	0.0015	0.0004	0.0004
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Onchocerca volvulus		0.0043	0.0041	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Leishmania major	oxidoreductase-like protein	0.0015	0.0005	0.0005
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0067	0.0067
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0077	0.0085	0.0085
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0004	0.0004
Brugia malayi	Uncoordinated protein 44	0.0015	0.0004	0.0004
Brugia malayi	larval opioid receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Trichomonas vaginalis	set domain proteins, putative	0.0248	0.0309	0.3315
Brugia malayi	Pre-SET motif family protein	0.0031	0.0025	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0015	0.0004	0.0004
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0004	0.0004
Echinococcus granulosus	fmrfamide receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0029	0.0029
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0004	0.0004
Trichomonas vaginalis	nh(3)-dependent NAD(+) synthetase, putative	0.0086	0.0097	0.104
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0026	0.0026
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049767	0.00000000051351
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0015	0.0004	0.0004
Echinococcus multilocularis	survival motor neuron protein 1	0.0238	0.0297	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0004	0.0004
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0005	0.0003
Loa Loa (eye worm)	CHromoDomain protein family member	0.0012	0.0000000000049767	0.0000000000049767
Echinococcus granulosus	sex peptide receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	glutamine-dependent NAD(+) synthetase	0.0052	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Echinococcus granulosus	Ankyrin	0.0015	0.0004	0.0004
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.5598	0.7325	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0000000000049767	0.0000000000049767
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0043	0.0041	0.0041
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0015	0.0004	0.0004
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0014	0.0014
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0007	0.0007
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Plasmodium falciparum	glutamine-dependent NAD(+) synthetase, putative	0.0086	0.0097	0.0132
Schistosoma mansoni	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Brugia malayi	sulfakinin receptor protein	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Brugia malayi	Dihydrofolate reductase	0.7639	1	1
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0001	0.0001
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1519	0.1976	0.1973
Echinococcus granulosus	neuropeptide FF receptor 2	0.0015	0.0004	0.0004
Echinococcus multilocularis	allatostatin A receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0000000028555	0.0000000028555
Giardia lamblia	NH3-dependent NAD+ synthetase	0.0086	0.0097	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.7639	1	1
Echinococcus multilocularis	chromobox protein 1	0.0073	0.008	0.008
Echinococcus granulosus	G protein coupled receptor 139	0.0015	0.0004	0.0004
Trypanosoma cruzi	NAD+ synthase, putative	0.0086	0.0097	0.0131
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0015	0.0004	0.0004
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0015	0.0004	0.0004
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0004	0.0004
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0067	0.0065
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0015	0.0005	0.0003
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0032	0.0026	0.0133
Trypanosoma brucei	pteridine reductase 1	0.0203	0.0251	0.0341
Brugia malayi	G-protein coupled receptor	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0000000000049767	0.0000000000049767
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0004	0.0004
Plasmodium vivax	glutamine-dependent NAD(+) synthetase, putative	0.0086	0.0097	0.0132
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0004	0.0004
Brugia malayi	Dopamine receptor protein 1	0.0015	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0005	0.0003
Brugia malayi	hypothetical protein	0.0723	0.0932	0.0932
Brugia malayi	G-protein coupled receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	netrin receptor unc5	0.0015	0.0004	0.0004
Mycobacterium ulcerans	NAD synthetase	0.0086	0.0097	0.0096
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0012	0.0000000000049767	0.0000000000049767
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	tm gpcr rhodopsin	0.064	0.0824	0.0824
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0025	0.0035
Chlamydia trachomatis	dihydrofolate reductase	0.7639	1	1
Onchocerca volvulus		0.0015	0.0004	0.0022
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0004	0.0004
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0063	0.0067	0.0062
Echinococcus granulosus	orexin receptor type 2	0.0015	0.0004	0.0004
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0015	0.0004	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0004	0.0004
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0042	0.0212
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.008	0.0089	0.0089
Echinococcus granulosus	dro:myosuppressin receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.027	0.027
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0063	0.0067	0.0067
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0004	0.0004
Brugia malayi	chromobox protein homolog 3	0.0041	0.0038	0.0038
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0067	0.0065
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0048	0.0048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0004	0.0004
Brugia malayi	follicle stimulating hormone receptor	0.0256	0.032	0.032
Onchocerca volvulus		0.0015	0.0004	0.0022
Onchocerca volvulus	Putative hydroxypyruvate isomerase	0.0021	0.0012	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0238	0.0297	0.0297
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.008	0.0089	0.0122
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0000000000049767	0.0000000000049767
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0000000000049767	0.0000000000049767
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0015	0.0004	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0012	0.0000000000049767	0.0000000000049767
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Mycobacterium ulcerans	epimerase	0.0021	0.0012	0.0011
Echinococcus granulosus	serotonin receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	chromobox protein	0.0073	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	melatonin receptor type 1A	0.0015	0.0004	0.0004
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Onchocerca volvulus		0.0015	0.0004	0.0022
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049767	0.00000000051351
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0001	0.0001
Schistosoma mansoni	amine GPCR	0.0015	0.0004	0.0004
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0048	0.0048
Echinococcus multilocularis	GMP synthase (glutamine hydrolyzing)	0.0034	0.0029	0.0029
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0042	0.045
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0012	0.0007
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.7639	1	1
Brugia malayi	Heterochromatin protein 1	0.0073	0.008	0.008
Echinococcus multilocularis	sex peptide receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	G protein coupled receptor 139	0.0015	0.0004	0.0004
Mycobacterium tuberculosis	Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing])	0.0086	0.0097	0.0092
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0004	0.0004
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.5598	0.7325	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	chromobox protein	0.0073	0.008	0.008
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0015	0.0004	0.0004
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.5598	0.7325	1
Mycobacterium tuberculosis	Hypothetical protein	0.0723	0.0932	0.0928
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0004	0.0004
Brugia malayi	thymidylate synthase	0.1519	0.1976	0.1976
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus granulosus	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Brugia malayi	Dopamine receptor	0.0015	0.0004	0.0004
Onchocerca volvulus		0.0015	0.0004	0.0022
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.008	0.0089	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0022	0.0239
Loa Loa (eye worm)	dihydrofolate reductase	0.7639	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Brugia malayi	putative neuropeptide receptor	0.0015	0.0004	0.0004
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0004	0.0004
Entamoeba histolytica	hypothetical protein	0.0012	0.0000000000049767	0.00000000051351
Schistosoma mansoni	hypothetical protein	0.0049	0.0048	0.0048
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0012	0.0000000000049767	0.0000000000067943
Schistosoma mansoni	neuropeptide f receptor 76f	0.0015	0.0004	0.0004
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.064	0.0824	0.0824
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0004	0.0004
Brugia malayi	ORL1-like opioid receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0025	0.0025
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0024	0.0024
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0025	0.0025
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.0069	0.0069
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0004	0.0004
Echinococcus multilocularis	chromobox protein 1	0.0073	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.008	0.0089	0.0089
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0015	0.0004	0.0004
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.008	0.0857
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	netrin receptor unc 5	0.0015	0.0004	0.0004
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0025	0.0025
Echinococcus multilocularis	geminin	0.0348	0.0441	0.0441
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0256	0.032	0.032
Echinococcus granulosus	g-protein coupled receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	Ankyrin	0.0015	0.0004	0.0004
Plasmodium falciparum	GMP synthase [glutamine-hydrolyzing]	0.0034	0.0029	0.004
Onchocerca volvulus		0.0015	0.0004	0.0022
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.008	0.0089	0.0077
Brugia malayi	Serotonin receptor	0.0015	0.0004	0.0004
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0015	0.0004	0.0006
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.008	0.0857
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0015	0.0004	0.0004
Trichomonas vaginalis	DNA helicase recq1, putative	0.0022	0.0014	0.0146
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Leishmania major	GMP synthase, putative,glutamine amidotransferase, putative	0.0034	0.0029	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0000000028555	0.0000000028555
Schistosoma mansoni	hypothetical protein	0.0348	0.0441	0.0441
Brugia malayi	GMP synthase	0.0034	0.0029	0.0029
Onchocerca volvulus		0.0015	0.0004	0.0022
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Trichomonas vaginalis	conserved hypothetical protein	0.0723	0.0932	1
Echinococcus granulosus	somatostatin receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	opsin-like receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0004	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Mycobacterium ulcerans	thymidylate synthase	0.1519	0.1976	0.1975
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Echinococcus multilocularis	dihydrofolate reductase	0.7639	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0015	0.0004	0.0004
Plasmodium vivax	GMP synthetase, putative	0.0034	0.0029	0.004
Brugia malayi	neuropeptide F receptor	0.0015	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0004	0.0004
Echinococcus granulosus	allatostatin A receptor	0.0015	0.0004	0.0004
Mycobacterium ulcerans	sugar phosphate isomerases/epimerases	0.0021	0.0012	0.0011
Echinococcus multilocularis	serotonin receptor	0.0015	0.0004	0.0004
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0015	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0015	0.0004	0.0004
Mycobacterium ulcerans	GMP synthase	0.0034	0.0029	0.0028
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0014	0.0146
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049767	0.00000000051351
Schistosoma mansoni	myosin xvIII	0.0015	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0015	0.0004	0.0004
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0015	0.0004	0.0004
Echinococcus multilocularis	dro:myosuppressin receptor	0.0015	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0015	0.0004	0.0004
Echinococcus granulosus	death domain containing protein	0.0015	0.0004	0.0004
Schistosoma mansoni	histamine h1 receptor	0.0015	0.0004	0.0004
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049767	0.000000000053394
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0000000000049767	0.0000000000049767
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	thymidylate synthase	0.1519	0.1976	0.1976
Schistosoma mansoni	GMP synthetase	0.0034	0.0029	0.0029
Plasmodium vivax	SET domain protein, putative	0.0031	0.0025	0.0035
Brugia malayi	SET domain containing protein	0.0013	0.0002	0.0002
Brugia malayi	CHD4 protein	0.0012	0.0000000000049767	0.0000000000049767
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0022	0.0239
Echinococcus granulosus	geminin	0.0348	0.0441	0.0441

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 35 %	Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding relative to DAMGO	ChEMBL.	19253983
Activity (functional)	= 64 %	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding relative to DPDPE	ChEMBL.	19253983
Activity (functional)	= 76 %	Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding relative to U69593	ChEMBL.	19253983
EC50 (functional)	= 26 nM	Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL.	19253983
EC50 (functional)	= 34.4 nM	Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL.	19253983
EC50 (functional)	= 430 nM	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL.	19253983
Ki (binding)	= 2.5 nM	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells	ChEMBL.	19253983
Ki (binding)	= 4.3 nM	Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells	ChEMBL.	19253983
Ki (binding)	= 180 nM	Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cells	ChEMBL.	19253983

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL474755

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 974488