Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.3169 | 0.3169 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Loa Loa (eye worm) | cysteine protease | 0.0182 | 0.047 | 0.047 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0182 | 0.047 | 0.047 |
Echinococcus granulosus | proteasome prosome macropain | 0.1126 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Brugia malayi | hypothetical protein | 0.0279 | 0.1441 | 0.1019 |
Echinococcus multilocularis | insulin growth factor binding | 0.0595 | 0.4639 | 0.4375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trypanosoma cruzi | metacaspase, putative | 0.0369 | 0.2351 | 0.2351 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0192 | 0.0566 | 0.0102 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0408 | 0.275 | 0.2393 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Leishmania major | cathepsin L-like protease | 0.0182 | 0.047 | 0.047 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0347 | 0.2131 | 0.2131 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0369 | 0.2351 | 0.1974 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.1126 | 1 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Brugia malayi | Cell death protein 3 precursor | 0.0777 | 0.6473 | 0.6299 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.045 | 0.3169 | 0.2832 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.045 | 0.3169 | 0.2832 |
Toxoplasma gondii | cathepsin CPL | 0.0182 | 0.047 | 0.047 |
Plasmodium vivax | hypothetical protein, conserved | 0.0369 | 0.2351 | 0.1974 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Loa Loa (eye worm) | ctsf protein | 0.0182 | 0.047 | 0.047 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.1126 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0347 | 0.2131 | 0.2131 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Leishmania major | cathepsin L-like protease | 0.0182 | 0.047 | 0.047 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0347 | 0.2131 | 0.2131 |
Echinococcus multilocularis | caspase 3 | 0.0357 | 0.2235 | 0.1852 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0369 | 0.2351 | 0.2351 |
Echinococcus granulosus | ankyrin repeat protein | 0.0192 | 0.0566 | 0.0102 |
Echinococcus granulosus | cathepsin b | 0.0347 | 0.2131 | 0.1744 |
Echinococcus multilocularis | cathepsin b | 0.0347 | 0.2131 | 0.1744 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.1441 | 0.1441 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0369 | 0.2351 | 0.2351 |
Trypanosoma brucei | metacaspase MCA3 | 0.0369 | 0.2351 | 0.2351 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0347 | 0.2131 | 0.1744 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1126 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0369 | 0.2351 | 0.2351 |
Loa Loa (eye worm) | thyroglobulin type-1 repeat family protein | 0.045 | 0.3169 | 0.3169 |
Loa Loa (eye worm) | fibroinase | 0.0182 | 0.047 | 0.047 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0279 | 0.1441 | 0.1019 |
Echinococcus granulosus | caspase | 0.0726 | 0.5958 | 0.5758 |
Leishmania major | cathepsin L-like protease | 0.0182 | 0.047 | 0.047 |
Trypanosoma cruzi | metacaspase, putative | 0.0369 | 0.2351 | 0.2351 |
Trypanosoma cruzi | metacaspase, putative | 0.0369 | 0.2351 | 0.2351 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.3169 | 0.3169 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0347 | 0.2131 | 0.2131 |
Loa Loa (eye worm) | thyroglobulin type-1 repeat family protein | 0.045 | 0.3169 | 0.3169 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.2131 | 0.2131 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0726 | 0.5958 | 0.5958 |
Echinococcus granulosus | cathepsin b | 0.0347 | 0.2131 | 0.1744 |
Leishmania major | cathepsin L-like protease | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0369 | 0.2351 | 0.2351 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.045 | 0.3169 | 0.2832 |
Brugia malayi | hypothetical protein | 0.0408 | 0.275 | 0.2393 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Leishmania major | cathepsin L-like protease | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Plasmodium falciparum | metacaspase 1 | 0.0369 | 0.2351 | 0.1974 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Leishmania major | cysteine peptidase A (CPA) | 0.0182 | 0.047 | 0.047 |
Trypanosoma brucei | metacaspase | 0.0369 | 0.2351 | 0.2351 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.1126 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Echinococcus granulosus | insulin growth factor binding | 0.0595 | 0.4639 | 0.4375 |
Onchocerca volvulus | 0.045 | 0.3169 | 0.4496 | |
Leishmania major | cathepsin L-like protease | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Onchocerca volvulus | 0.0408 | 0.275 | 0.3799 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0182 | 0.047 | 0.047 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0777 | 0.6473 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0196 | 0.0606 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0777 | 0.6473 | 0.6473 |
Echinococcus multilocularis | cathepsin b | 0.0347 | 0.2131 | 0.1744 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0196 | 0.0606 | 0.0143 |
Trypanosoma brucei | metacaspase MCA2 | 0.0369 | 0.2351 | 0.2351 |
Leishmania major | proteasome beta 5 subunit, putative | 0.1126 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.1126 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.1126 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.1126 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Plasmodium falciparum | metacaspase-like protein | 0.0369 | 0.2351 | 0.1974 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0369 | 0.2351 | 0.2351 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.1126 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0369 | 0.2351 | 0.2351 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0182 | 0.047 | 0.047 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0347 | 0.2131 | 0.2131 |
Trypanosoma brucei | Metacaspase-4 | 0.0369 | 0.2351 | 0.2351 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0369 | 0.2351 | 0.2351 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0192 | 0.0566 | 0.0566 |
Echinococcus multilocularis | caspase 2 | 0.0777 | 0.6473 | 0.6299 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Onchocerca volvulus | 0.045 | 0.3169 | 0.4496 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Echinococcus granulosus | caspase 2 | 0.0777 | 0.6473 | 0.6299 |
Schistosoma mansoni | insulin-like growth factor binding protein-related | 0.0595 | 0.4639 | 0.4639 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0726 | 0.5958 | 0.5758 |
Leishmania major | cathepsin L-like protease | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.2351 | 0.2351 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0279 | 0.1441 | 0.1019 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0369 | 0.2351 | 0.2351 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0408 | 0.275 | 0.2393 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.3169 | 0.3169 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1126 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Echinococcus multilocularis | caspase 8 | 0.0369 | 0.2351 | 0.1974 |
Onchocerca volvulus | 0.045 | 0.3169 | 0.4496 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0369 | 0.2351 | 0.2351 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.1126 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.1126 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.1126 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0182 | 0.047 | 0.047 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0369 | 0.2351 | 0.2351 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.045 | 0.3169 | 0.2832 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1126 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.1126 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0182 | 0.047 | 0.047 |
Trypanosoma brucei | metacaspase 5, putative | 0.0369 | 0.2351 | 0.2351 |
Echinococcus multilocularis | caspase | 0.0726 | 0.5958 | 0.5758 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0369 | 0.2351 | 0.2351 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.275 | 0.275 |
Plasmodium vivax | metacaspase 1, putative | 0.0369 | 0.2351 | 0.1974 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0369 | 0.2351 | 0.2351 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0726 | 0.5958 | 0.5758 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0369 | 0.2351 | 0.2351 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0182 | 0.047 | 0.047 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0777 | 0.6473 | 0.6473 |
Echinococcus granulosus | caspase 8 | 0.0369 | 0.2351 | 0.1974 |
Onchocerca volvulus | 0.045 | 0.3169 | 0.4496 | |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0726 | 0.5958 | 0.5958 |
Leishmania major | metacaspase, putative | 0.0369 | 0.2351 | 0.2351 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.1126 | 1 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0369 | 0.2351 | 0.2351 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0182 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.3169 | 0.3169 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Echinococcus granulosus | caspase 3 | 0.0357 | 0.2235 | 0.1852 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0182 | 0.047 | 0.047 |
Schistosoma mansoni | hypothetical protein | 0.0408 | 0.275 | 0.275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Cytotoxicity against human ACHN cells after 72 hrs by MTT assay | ChEMBL. | 23489626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.