Detailed information for compound 974682

Basic information

Technical information
  • TDR Targets ID: 974682
  • Name: 3-[(E)-but-1-enyl]-5-hydroxyisochromen-1-one
  • MW: 216.233 | Formula: C13H12O3
  • H donors: 1 H acceptors: 2 LogP: 3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC/C=C/c1oc(=O)c2c(c1)c(O)ccc2
  • InChi: 1S/C13H12O3/c1-2-3-5-9-8-11-10(13(15)16-9)6-4-7-12(11)14/h3-8,14H,2H2,1H3/b5-3+
  • InChiKey: QBZHMYUXUVZDQT-HWKANZROSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(E)-but-1-enyl]-5-hydroxy-isochromen-1-one
  • 3-[(E)-but-1-enyl]-5-hydroxy-1-isochromenone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.1061 0.0987
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.003 0.0113 0.0158
Brugia malayi prostaglandin transporter 0.0055 0.0691 0.1328
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0133 0.0204
Echinococcus granulosus solute carrier family 22 0.0029 0.0081 0.0113
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0128 0.0227
Schistosoma mansoni hypothetical protein 0.0166 0.332 0.7945
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0039
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0282 0.0501
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0691 0.1271
Echinococcus multilocularis voltage gated potassium channel 0.0028 0.006 0.0063
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0056 0.0718 0.1021
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1915 0.6943
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0133 0.0238
Trichomonas vaginalis abcb9, putative 0.0031 0.0133 0.0204
Brugia malayi Carboxylesterase family protein 0.0133 0.2536 0.506
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0256 0.0534
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.2722 0.5549
Loa Loa (eye worm) acetylcholinesterase 1 0.0133 0.2536 0.3733
Plasmodium vivax PST-A protein 0.0141 0.2722 0.9701
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0282 0.0501
Loa Loa (eye worm) hypothetical protein 0.0097 0.1699 0.2483
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0133 0.0238
Toxoplasma gondii hypothetical protein 0.0144 0.2804 1
Schistosoma mansoni hypothetical protein 0.0031 0.0128 0.0307
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0806 0.1861
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0495 0.1567
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0028 0.006 0.0063
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0928 0.3111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0128 0.0227
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0081 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.003 0.0113 0.0189
Schistosoma mansoni glucose transport protein 0.0029 0.0081 0.0194
Trypanosoma cruzi membrane transporter protein, putative 0.0033 0.0191 0.0414
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1061 0.2119
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0806 0.1928
Loa Loa (eye worm) hypothetical protein 0.0055 0.0691 0.098
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0081 0.0113
Brugia malayi phosphofructokinase 0.0106 0.1915 0.3803
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0081 0.0097
Echinococcus multilocularis shaker cognate 0.0028 0.006 0.0063
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0752 0.1731
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0794 0.2699
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0256 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0092 0.0139
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0928 0.2156
Trichomonas vaginalis esterase, putative 0.007 0.1061 0.2119
Echinococcus multilocularis GPCR, family 2 0.0031 0.0128 0.0227
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0133 0.0204
Plasmodium falciparum esterase, putative 0.0144 0.2804 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0332 0.0253
Schistosoma mansoni hypothetical protein 0.0123 0.2312 0.5534
Plasmodium falciparum lysophospholipase, putative 0.0141 0.2722 0.9701
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0794 0.2699
Leishmania major trypanothione reductase 0.0046 0.0495 0.1567
Trichomonas vaginalis abcb9, putative 0.0031 0.0133 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Schistosoma mansoni sugar transporter 0.0029 0.0081 0.0194
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0282 0.0739
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0179 0.035
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0031 0.0133 0.0147
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0495 0.0417
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0029 0.0081 0.0113
Schistosoma mansoni follistatin 0.0037 0.0282 0.0675
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1915 0.4583
Leishmania major DNA polymerase kappa, putative 0.0039 0.0332 0.0949
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2129 0.5054
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0752 0.1731
Onchocerca volvulus 0.0029 0.0092 0.0022
Echinococcus multilocularis carboxylesterase 5A 0.0133 0.2536 0.6037
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0179 0.0293
Toxoplasma gondii sugar transporter ST3 0.0029 0.0081 0.0002
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0029 0.0088 0.008
Schistosoma mansoni lipoxygenase 0.0115 0.2129 0.5094
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.009 0.0035
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1915 0.4538
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0133 0.0204
Brugia malayi follicle stimulating hormone receptor 0.0236 0.4979 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0124 0.2322 0.8483
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.0691 0.098
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0233 0.0481
Loa Loa (eye worm) hypothetical protein 0.0072 0.1093 0.1579
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1896 0.6765
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1915 0.2806
Plasmodium falciparum thioredoxin reductase 0.0046 0.0495 0.1521
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0028 0.006 0.0063
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0495 0.1112
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0179 0.0429
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1896 0.1829
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0176 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0794 0.2699
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0081 0.0113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1699 0.2483
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0092 0.0041
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0202 0.4178 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0045 0.0469 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0282 0.0739
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0179 0.0429
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0133 0.0204
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0256 0.0661
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0133 0.0204
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0081 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0794 0.1833
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0034 0.0082
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0179 0.0371
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0928 0.3206
Brugia malayi beta-lactamase 0.007 0.1061 0.2076
Loa Loa (eye worm) hypothetical protein 0.0051 0.0606 0.0853
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1915 0.6736
Brugia malayi Cytochrome P450 family protein 0.0033 0.0176 0.0287
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0128 0.019
Mycobacterium ulcerans beta-lactamase 0.007 0.1061 0.3708
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.1061 0.2476
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1915 0.3882
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0135
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1915 0.3882
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0191 0.0414
Schistosoma mansoni lipoxygenase 0.0081 0.1308 0.313
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1915 0.3882
Brugia malayi hypothetical protein 0.0035 0.0233 0.0403
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0691 0.1328
Echinococcus granulosus dna polymerase kappa 0.0059 0.0794 0.1833
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.4214 0.6236
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0133 0.0238
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0202 0.4178 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0133 0.0204
Echinococcus granulosus voltage dependent calcium channel 0.0094 0.1613 0.3809
Schistosoma mansoni organic anion transporter 0.0055 0.0691 0.1654
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2129 0.5054
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0081 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0105 0.1884 0.3741
Leishmania major hypothetical protein, conserved 0.0033 0.0191 0.0414
Echinococcus granulosus potassium voltage gated channel protein 0.0105 0.1884 0.4463
Echinococcus multilocularis follistatin 0.0037 0.0282 0.0598
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.0661
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0176 0.0212
Plasmodium falciparum hexose transporter 0.0029 0.0081 0.0002
Loa Loa (eye worm) inositol-1 0.0036 0.0256 0.033
Echinococcus granulosus solute carrier family 22 0.0029 0.0081 0.0113
Schistosoma mansoni hypothetical protein 0.0166 0.332 0.7945
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.1061 0.3708
Loa Loa (eye worm) hypothetical protein 0.0036 0.0258 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Loa Loa (eye worm) carboxylesterase 0.0133 0.2536 0.3733
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.0661
Loa Loa (eye worm) hypothetical protein 0.007 0.1061 0.1531
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0028 0.006 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.009 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1061 0.3708
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1061 0.2119
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Leishmania major monoglyceride lipase, putative 0.0141 0.2722 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.2312 0.5497
Echinococcus granulosus solute carrier family 22 0.0029 0.0081 0.0113
Onchocerca volvulus 0.0031 0.0133 0.0108
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0179 0.0371
Brugia malayi Thioredoxin reductase 0.0046 0.0495 0.0932
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0081 0.0113
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.0133 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0179 0.035
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0028 0.006 0.0053
Echinococcus multilocularis conserved hypothetical protein 0.0045 0.0469 0.1049
Brugia malayi Carboxylesterase family protein 0.0133 0.2536 0.506
Echinococcus multilocularis sodium channel protein 0.0121 0.2253 0.5355
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0051 0.0608 0.1384
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0128 0.014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0752 0.1731
Giardia lamblia Hexose transporter 0.0029 0.0081 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2804 0.5717
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0034 0.0082
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1915 0.3882
Plasmodium vivax hypothetical protein, conserved 0.007 0.1061 0.3598
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0806 0.2743
Toxoplasma gondii thioredoxin reductase 0.0046 0.0495 0.1521
Echinococcus granulosus dna polymerase eta 0.0033 0.0179 0.035
Leishmania major DNA polymerase eta, putative 0.0033 0.0179 0.0371
Echinococcus multilocularis voltage gated potassium channel 0.003 0.0113 0.0189
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.1061 0.2076
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0202 0.4178 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0691 0.098
Loa Loa (eye worm) beta-lactamase 0.007 0.1061 0.1531
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1915 0.6736
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0105 0.1884 0.4463
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.1061 0.0987
Brugia malayi glutathione reductase 0.0046 0.0495 0.0932
Schistosoma mansoni glucose transporter 0.0029 0.0081 0.0194
Toxoplasma gondii transporter, cation channel family protein 0.0094 0.1613 0.5626
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.1061 0.2476
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0972 0.1896
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.1061 0.0987
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0133 0.0238
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0028 0.006 0.0063
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0081 0.0095
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0133 0.0238
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1896 0.1829
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0056 0.0718 0.1651
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.2722 0.5549
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0133 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0691 0.098
Onchocerca volvulus 0.0055 0.0691 0.1271
Toxoplasma gondii hypothetical protein 0.0072 0.1093 0.3716
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0797 0.1907
Schistosoma mansoni smdr2 0.0031 0.0133 0.0318
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.006 0.0145
Trichomonas vaginalis set domain proteins, putative 0.0232 0.4878 1
Echinococcus granulosus potassium voltage gated channel protein 0.0028 0.006 0.0063
Entamoeba histolytica hypothetical protein 0.0035 0.0233 0.0561
Plasmodium falciparum lysophospholipase, putative 0.0141 0.2722 0.9701
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0806 0.1928
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1915 0.2806
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.4979 0.7377
Toxoplasma gondii ABC1 family protein 0.007 0.1061 0.3598
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Echinococcus multilocularis dna polymerase eta 0.0033 0.0179 0.035
Brugia malayi Sugar transporter family protein 0.0029 0.0081 0.0095
Loa Loa (eye worm) hypothetical protein 0.0133 0.2536 0.3733
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.0133 0.0196
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1699 0.3366
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.2722 0.5549
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0081 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0191 0.0414
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.1061 0.0987
Echinococcus multilocularis solute carrier family 22 0.0029 0.0081 0.0113
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.0661
Schistosoma mansoni hypothetical protein 0.0035 0.0233 0.0559
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2174 0.211
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0081 0.0113
Loa Loa (eye worm) hypothetical protein 0.0066 0.0972 0.1399
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0034 0.0082
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.1061 0.3708
Brugia malayi 6-phosphofructokinase 0.0107 0.1923 0.3819
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0191 0.0414
Schistosoma mansoni voltage-gated potassium channel 0.0105 0.1884 0.4509
Brugia malayi 6-phosphofructokinase 0.0106 0.1915 0.3803
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1915 0.6736
Loa Loa (eye worm) hypothetical protein 0.0055 0.0691 0.098
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0133 0.0204
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0133 0.0204
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0282 0.0501
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0176 0.0361
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0028 0.006 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0806 0.2743
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0081 0.0113
Brugia malayi hypothetical protein 0.0055 0.0691 0.1328
Loa Loa (eye worm) voltage-dependent calcium channel 0.0094 0.1613 0.2355
Echinococcus multilocularis potassium voltage gated channel protein 0.0105 0.1884 0.4463
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0033 0.0191 0.0377
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0282 0.0739
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0495 0.1112
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0034 0.0082
Mycobacterium tuberculosis Probable reductase 0.0106 0.1896 0.1829
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Brugia malayi jmjC domain containing protein 0.0057 0.0752 0.1451
Loa Loa (eye worm) glutathione reductase 0.0046 0.0495 0.0687
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0794 0.1569
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.132 0.3158
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0133 0.0192
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0133 0.0204
Schistosoma mansoni multidrug resistance protein 0.0033 0.0191 0.0456
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1699 0.3366
Echinococcus granulosus voltage gated potassium channel 0.003 0.0113 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0691 0.1328
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0495 0.0687
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0081 0.0097
Giardia lamblia Sugar-proton symporter 0.0029 0.0081 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0099 0.1749 0.2559
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.0691 0.2241
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0056 0.0718 0.1384
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0133 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Loa Loa (eye worm) sugar transporter 0.0029 0.0081 0.007
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1915 0.6943
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.0691 0.1585
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0141 0.2722 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0128 0.014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1061 0.2538
Schistosoma mansoni hypothetical protein 0.0031 0.0128 0.0307
Loa Loa (eye worm) hypothetical protein 0.0055 0.0691 0.098
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0081 0.0113
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0179 0.0362
Mycobacterium ulcerans lysophospholipase 0.0141 0.2722 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0081 0.0113
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0099 0.1745 0.4128
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.0642 0.2122
Brugia malayi multidrug resistance protein 3 0.0031 0.0133 0.02
Brugia malayi polk-prov protein 0.0036 0.0258 0.0452
Brugia malayi Cytochrome P450 family protein 0.0033 0.0176 0.0287
Schistosoma mansoni sugar transporter 0.0029 0.0081 0.0194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0128 0.0227
Toxoplasma gondii sugar transporter ST2 0.0029 0.0081 0.0002
Schistosoma mansoni glucose transport protein 0.0029 0.0081 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0081 0.0097
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0133 0.0204
Schistosoma mansoni thyroid hormone receptor 0.014 0.2721 0.6513
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0176 0.0361
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0202 0.4178 1
Echinococcus multilocularis acetylcholinesterase 0.0133 0.2536 0.6037
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.1061 0.0987
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0176 0.0361
Plasmodium vivax unspecified product 0.0144 0.2804 1
Mycobacterium ulcerans hypothetical protein 0.0141 0.2722 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Brugia malayi jmjC domain containing protein 0.0057 0.0752 0.1451
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2174 0.211
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0133 0.0204
Entamoeba histolytica hypothetical protein 0.0035 0.0233 0.0561
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0198 0.0339
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0117
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0133 0.0204
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Brugia malayi SPARC precursor 0.0037 0.0282 0.0501
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1915 0.6841
Toxoplasma gondii facilitative glucose transporter GT1 0.0029 0.0081 0.0002
Mycobacterium leprae Probable lipase LipE 0.007 0.1061 0.3499
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1061 0.2119
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0928 0.3206
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Brugia malayi Pre-SET motif family protein 0.0204 0.4214 0.8453
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0081 0.007
Trichomonas vaginalis abcb9, putative 0.0031 0.0133 0.0204
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0081 0.0096
Mycobacterium tuberculosis Probable hydrolase 0.007 0.1061 0.0987
Schistosoma mansoni organic anion transporter 0.0055 0.0691 0.1654
Schistosoma mansoni hypothetical protein 0.0066 0.0972 0.2326
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0202 0.4178 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0133 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0081 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0113 0.027
Toxoplasma gondii sugar transporter ST1 0.0029 0.0081 0.0002
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0081 0.007
Loa Loa (eye worm) calcium channel 0.0202 0.4178 0.6183
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0191 0.0414
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0028 0.006 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.009 0.0035
Loa Loa (eye worm) voltage-gated potassium channel 0.0028 0.006 0.0039
Mycobacterium tuberculosis Conserved protein 0.007 0.1061 0.0987
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0133 0.0204
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1915 0.6943
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0133 0.0204
Plasmodium falciparum esterase, putative 0.0141 0.2722 0.9701
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0285 0.0605
Schistosoma mansoni thyroid hormone receptor 0.014 0.2721 0.6513
Schistosoma mansoni inositol monophosphatase 0.0036 0.0256 0.0612
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus granulosus agrin 0.0037 0.0282 0.0598
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.006 0.0145
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0121 0.2253 0.5355
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.1061 0.2119
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.0691 0.1585
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0034 0.0082
Leishmania major p-glycoprotein 0.0031 0.0133 0.0196
Echinococcus granulosus geminin 0.0166 0.332 0.7928
Brugia malayi hypothetical protein 0.0029 0.0081 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.006 0.0145
Onchocerca volvulus 0.0055 0.0691 0.1271
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Plasmodium falciparum lysophospholipase, putative 0.0144 0.2804 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0282 0.0501
Loa Loa (eye worm) hypothetical protein 0.0072 0.1093 0.1579
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0133 0.0192
Onchocerca volvulus 0.0232 0.4878 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2174 0.211
Schistosoma mansoni voltage-gated cation channel 0.0202 0.4178 1
Schistosoma mansoni sugar transporter 0.0029 0.0081 0.0194
Echinococcus multilocularis voltage dependent calcium channel 0.0202 0.4178 1
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0133 0.0192
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.0133 0.0052
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0282 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0258 0.0669
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0066 0.0078
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0092 0.0139
Schistosoma mansoni multidrug resistance protein 0.0031 0.0133 0.0318
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0133 0.0204
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.2722 0.5549
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.0133 0.0192
Brugia malayi beta-lactamase family protein 0.007 0.1061 0.2076
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0179 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus granulosus potassium voltage gated channel protein 0.0103 0.184 0.4356
Echinococcus multilocularis voltage dependent calcium channel 0.0202 0.4178 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0133 0.0204
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1896 0.1829
Onchocerca volvulus 0.007 0.1061 0.2042
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.006 0.0145
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0752 0.1799
Loa Loa (eye worm) hypothetical protein 0.0031 0.0133 0.0147
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0202 0.4178 1
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0133 0.0204
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0091 0.1544 0.554
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.0125 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0332 0.0949
Echinococcus granulosus solute carrier family 22 0.0029 0.0081 0.0113
Brugia malayi Inositol-1 0.0036 0.0256 0.0448
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0081 0.0095
Brugia malayi secreted modular calcium-binding protein 1 0.0037 0.0282 0.0501
Leishmania major cytochrome p450-like protein 0.0033 0.0176 0.0361
Echinococcus granulosus shaker cognate 0.0028 0.006 0.0063
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0256 0.0643
Echinococcus multilocularis solute carrier family 22 0.0029 0.0081 0.0113
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0113 0.027
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0081 0.0113
Echinococcus granulosus carboxylesterase 5A 0.0133 0.2536 0.6037
Echinococcus multilocularis transfer RNA-Gly 0.0028 0.006 0.0063
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.0133 0.0192
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0045 0.0469 0.1049
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.0691 0.1585
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Mycobacterium tuberculosis Conserved protein 0.007 0.1061 0.0987
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Schistosoma mansoni glucose transport protein 0.0029 0.0081 0.0194
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.0133 0.0192
Schistosoma mansoni hypothetical protein 0.0031 0.0128 0.0307
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0133 0.0204
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0928 0.2221
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0202 0.4178 0.8381
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0081 0.0097
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0928 0.1807
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0176 0.0212
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0691 0.1271
Echinococcus multilocularis agrin 0.0037 0.0282 0.0598
Plasmodium vivax lysophospholipase, putative 0.0144 0.2804 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Echinococcus granulosus acetylcholinesterase 0.0133 0.2536 0.6037
Echinococcus granulosus voltage dependent calcium channel 0.0202 0.4178 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0806 0.073
Loa Loa (eye worm) hypothetical protein 0.0094 0.1613 0.2355
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0056 0.0718 0.1651
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0133 0.0204
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0928 0.3206
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0081 0.0096
Echinococcus multilocularis acetylcholinesterase 0.0133 0.2536 0.6037
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1915 0.6943
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.0133 0.0192
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Echinococcus granulosus voltage gated potassium channel 0.0028 0.006 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0258 0.0669
Echinococcus granulosus follistatin 0.0037 0.0282 0.0598
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0166 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0092 0.022
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1915 0.1849
Loa Loa (eye worm) hypothetical protein 0.0045 0.0469 0.0649
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0133 0.0238
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0202 0.4178 1
Brugia malayi Sugar transporter family protein 0.0029 0.0081 0.0095
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0928 0.2156
Schistosoma mansoni inositol monophosphatase 0.0036 0.0256 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0081 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0806 0.2743
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0179 0.0216
Trypanosoma brucei unspecified product 0.0052 0.0642 0.2122
Schistosoma mansoni multidrug resistance protein 0.0031 0.0133 0.0318
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0081 0.0097
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1896 0.1829
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.006 0.0145
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trypanosoma brucei monoglyceride lipase, putative 0.0141 0.2722 1
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0133 0.2536 0.3733
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0202 0.4178 1
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0691 0.1271
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0081 0.0096
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0202 0.4178 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.1061 0.2538
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0081 0.0097
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0033 0.0191 0.0377
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.2536 0.607
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0141 0.2722 0.5549
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1896 0.1829
Plasmodium vivax hexose transporter 0.0029 0.0081 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.022
Brugia malayi Sugar transporter family protein 0.0029 0.0081 0.0095
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0081 0.0096
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0806 0.2662
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0198 0.0339
Schistosoma mansoni agrin 0.0037 0.0282 0.0675
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0128 0.0227
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0133 0.0204
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0928 0.3206
Onchocerca volvulus 0.0055 0.0691 0.1271
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0081 0.0097
Brugia malayi hypothetical protein 0.0119 0.2216 0.4413
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0133 0.0204
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0332 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0081 0.0097
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.2721 0.6484
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.1061 0.1531
Toxoplasma gondii protease inhibitor PI2 0.0037 0.0282 0.0739
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0806 0.1861
Entamoeba histolytica P-glycoprotein-5 0.0031 0.0133 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.022
Schistosoma mansoni hypothetical protein 0.0031 0.0128 0.0307
Loa Loa (eye worm) hypothetical protein 0.0033 0.0179 0.0216
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.0691 0.1585
Brugia malayi major facilitator superfamily protein 0.0029 0.0081 0.0095
Loa Loa (eye worm) hypothetical protein 0.031 0.6737 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0029 0.0081 0.0113
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0133 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0191 0.0414
Onchocerca volvulus 0.0055 0.0691 0.1271
Loa Loa (eye worm) hypothetical protein 0.007 0.1061 0.1531
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.0133 0.0147
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0133 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.2722 0.5549
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Trypanosoma cruzi MFS transporter, putative 0.0055 0.0691 0.2309
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0191 0.0414
Loa Loa (eye worm) hypothetical protein 0.007 0.1061 0.1531
Onchocerca volvulus 0.0037 0.0282 0.0419
Brugia malayi major facilitator superfamily protein 0.0029 0.0081 0.0095
Loa Loa (eye worm) sugar transporter 0.0029 0.0081 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0806 0.2743
Brugia malayi ABC transporter family protein 0.0031 0.0133 0.02
Schistosoma mansoni multidrug resistance protein 0.0031 0.0133 0.0318
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0051 0.0608 0.1384
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0752 0.107
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0081 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0081 0.0096
Echinococcus multilocularis solute carrier family 22 0.0029 0.0081 0.0113
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1915 0.2806
Schistosoma mansoni hypothetical protein 0.0029 0.0081 0.0194
Loa Loa (eye worm) hypothetical protein 0.0055 0.0691 0.098
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0282 0.0739
Trypanosoma brucei trypanothione reductase 0.0046 0.0495 0.1567
Brugia malayi hypothetical protein 0.0099 0.1749 0.3469
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0133 0.0238
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Trichomonas vaginalis taga, putative 0.0031 0.0133 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0691 0.098
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0081 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0133 0.0204
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0133 0.0238
Mycobacterium ulcerans lipase LipD 0.007 0.1061 0.3708
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0081 0.0113
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0256 0.0457
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0285 0.0605
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0133 0.0204
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0141 0.2722 0.9701
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0133 0.0238
Echinococcus granulosus acetylcholinesterase 0.0133 0.2536 0.6037
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.0125 0.0219
Trypanosoma brucei membrane transporter protein, putative 0.0033 0.0191 0.0414
Brugia malayi hypothetical protein 0.0029 0.0081 0.0095
Plasmodium vivax SET domain protein, putative 0.0029 0.0092 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0081 0.0096
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0256 0.0661
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.037
Entamoeba histolytica P-glycoprotein-1 0.0031 0.0133 0.0192
Onchocerca volvulus 0.0055 0.0691 0.1271
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0029 0.0081 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0233 0.0481
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0794 0.1569
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.1061 0.0987
Trypanosoma cruzi monoglyceride lipase, putative 0.0141 0.2722 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0133 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1061 0.3708
Mycobacterium ulcerans hypothetical protein 0.007 0.1061 0.3708
Plasmodium falciparum glutathione reductase 0.0046 0.0495 0.1521
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1915 0.4538
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0133 0.0238
Loa Loa (eye worm) hypothetical protein 0.007 0.1061 0.1531
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Plasmodium vivax glutathione reductase, putative 0.0046 0.0495 0.1521
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Echinococcus granulosus sodium channel protein 0.0091 0.1544 0.3644
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.0133 0.0147
Loa Loa (eye worm) agrin synaptic family protein 0.0037 0.0282 0.037
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0691 0.1328
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.003 0.0121 0.021
Schistosoma mansoni voltage-gated potassium channel 0.0103 0.184 0.4403
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.0133 0.0192
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0495 0.1521
Plasmodium falciparum lysophospholipase, putative 0.0141 0.2722 0.9701
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0141 0.2722 0.5549
Leishmania major hypothetical protein, conserved 0.0033 0.0191 0.0414
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0256 0.0457
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.2312 0.5497
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.2722 0.5549
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.037
Schistosoma mansoni vesicular amine transporter 0.0028 0.006 0.0145
Loa Loa (eye worm) hypothetical protein 0.0202 0.4178 0.6183
Echinococcus granulosus potassium voltage gated channel protein 0.0045 0.0469 0.1049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0752 0.1799
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0144 0.2804 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0092 0.0139
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0141 0.2722 0.9701
Mycobacterium tuberculosis Conserved protein 0.007 0.1061 0.0987
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0133 0.0238
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1915 0.4583
Leishmania major hypothetical protein, conserved 0.007 0.1061 0.3708
Echinococcus granulosus GPCR family 2 0.0031 0.0128 0.0227
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.1061 0.2119
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2174 0.7854
Plasmodium falciparum esterase, putative 0.0144 0.2804 1
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0794 0.2699
Mycobacterium tuberculosis Possible lysophospholipase 0.0141 0.2722 0.2663
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0133 0.0238
Brugia malayi Pre-SET motif family protein 0.0029 0.0092 0.0116
Trypanosoma brucei MATE efflux family protein, putative 0.0033 0.0191 0.0414
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0752 0.1731
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0191 0.0414
Giardia lamblia DINP protein human, muc B family 0.0039 0.0332 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0028 0.006 0.0063
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0081 0.132 0.26
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0794 0.2699
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Mycobacterium leprae conserved hypothetical protein 0.007 0.1061 0.3499
Entamoeba histolytica hypothetical protein 0.0035 0.0233 0.0561
Brugia malayi beta-lactamase family protein 0.007 0.1061 0.2076
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.003 0.0113 0.0189
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0797 0.1907
Onchocerca volvulus 0.007 0.1061 0.2042
Schistosoma mansoni sugar transporter 0.0029 0.0081 0.0194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.007
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0124 0.2322 0.8483
Trypanosoma brucei hypothetical protein, conserved 0.007 0.1061 0.3708
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0179 0.0293
Loa Loa (eye worm) hypothetical protein 0.007 0.1061 0.1531
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0034 0.0082
Loa Loa (eye worm) hypothetical protein 0.0045 0.0469 0.0649
Loa Loa (eye worm) hypothetical protein 0.0105 0.1884 0.276
Onchocerca volvulus 0.007 0.1061 0.2042
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0176 0.0361
Echinococcus multilocularis expressed protein 0.0037 0.0282 0.0598
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0128 0.019
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0928 0.1333
Brugia malayi hypothetical protein 0.0029 0.0081 0.0095
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0256 0.0643
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.007 0.0168
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1915 1
Entamoeba histolytica hypothetical protein 0.0035 0.0233 0.0561
Trypanosoma brucei monoglyceride lipase, putative 0.0141 0.2722 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0086
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0233 0.0559
Schistosoma mansoni DNA polymerase eta 0.0033 0.0179 0.0429
Loa Loa (eye worm) hypothetical protein 0.007 0.1061 0.1531
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0752 0.1799
Brugia malayi hypothetical protein 0.0055 0.0691 0.1328
Plasmodium vivax sugar transporter, putative 0.0029 0.0081 0.0002
Echinococcus multilocularis geminin 0.0166 0.332 0.7928
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0256 0.0534
Schistosoma mansoni voltage-gated potassium channel 0.0105 0.1884 0.4509
Echinococcus multilocularis potassium voltage gated channel protein 0.0103 0.184 0.4356
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0081 0.0097
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0256 0.0457

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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