Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0788 | 0.2427 | 0.2427 |
Brugia malayi | Carboxylesterase family protein | 0.0702316 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0359 | 0 | 0.5 |
Onchocerca volvulus | 0.0359 | 0 | 0.5 | |
Onchocerca volvulus | 0.0359 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0702316 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0359 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0702316 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0702316 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0702316 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0359 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0702316 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0702316 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2126 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0702316 | 0 | 0.5 |
Onchocerca volvulus | 0.0359 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0359 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0702316 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0702316 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0359 | 0 | 0.5 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0787429 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0702316 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2126 | 1 | 1 |
Onchocerca volvulus | 0.0359 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2126 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2126 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0359 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2126 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2126 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0702316 | 0 | 0.5 |
Onchocerca volvulus | 0.0359 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2126 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2126 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2126 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2126 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2126 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2126 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 23 nM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes expressing beta-galactosidase in mouse 3T3 fibroblast after 7 days by alamar blue assay | ChEMBL. | 19239254 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 19239254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.