Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0262 | 0.9749 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.9524 | 0.977 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0262 | 0.9749 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7 | Agonist activity at RARbeta2 expressed in mouse NIH3T3 cells by R-SAT assay | ChEMBL. | 19239230 |
Efficacy (functional) | = 37 % | Agonist activity at RARbeta2 expressed in mouse NIH3T3 cells by R-SAT assay relative to Am-580 | ChEMBL. | 19239230 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.