TDR Targets

Basic information

Technical information

TDR Targets ID: 975429
Name: 2-[4-(2-piperidin-1-ylethyl)phenoxy]-1,3-benz othiazole
MW: 338.466 | Formula: C20H22N2OS
H donors: 0 H acceptors: 1 LogP: 5.38 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: C1CCN(CC1)CCc1ccc(cc1)Oc1nc2c(s1)cccc2
InChi: 1S/C20H22N2OS/c1-4-13-22(14-5-1)15-12-16-8-10-17(11-9-16)23-20-21-18-6-2-3-7-19(18)24-20/h2-3,6-11H,1,4-5,12-15H2
InChiKey: DHHMVJVCMLXZBO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[4-[2-(1-piperidyl)ethyl]phenoxy]-1,3-benzothiazole
2-[4-(2-piperidinoethyl)phenoxy]-1,3-benzothiazole

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	leukotriene A4 hydrolase	Starlite/ChEMBL	References
Mus musculus	leukotriene A4 hydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	leukotriene A4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	Get druggable targets OG5_129538	All targets in OG5_129538
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma japonicum	ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative	Get druggable targets OG5_129538	All targets in OG5_129538

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	leukotriene A4 hydrolase	611 aa	513 aa	24.0 %
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	leukotriene A4 hydrolase	611 aa	508 aa	22.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0015	0.0035	0.5
Brugia malayi	oxidoreductase	0.0015	0.0035	0.0077
Echinococcus multilocularis	carbonyl reductase 1	0.0015	0.0035	0.0035
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.003	0.0307	1
Trypanosoma cruzi	Aminopeptidase M1, putative	0.003	0.0307	1
Brugia malayi	Peptidase family M1 containing protein	0.003	0.0307	0.0687
Echinococcus granulosus	carbonyl reductase 1	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Possible oxidoreductase	0.0015	0.0035	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Trypanosoma cruzi	aminopeptidase, putative	0.003	0.0307	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Brugia malayi	Peptidase family M1 containing protein	0.003	0.0307	0.0687
Brugia malayi	dehydrogenases, short chain protein 2	0.0015	0.0035	0.0077
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0015	0.0035	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Mycobacterium ulcerans	aminopeptidase N PepN	0.003	0.0307	1
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable oxidoreductase	0.0015	0.0035	0.5
Schistosoma mansoni	carbonyl reductase	0.0015	0.0035	0.0035
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0015	0.0035	0.0077
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0015	0.0035	0.0035
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.003	0.0307	0.5532
Echinococcus multilocularis	steroid dehydrogenase	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0015	0.0035	0.5
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0558	1	1
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0015	0.0035	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Echinococcus multilocularis	aminopeptidase N	0.003	0.0307	0.0307
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Onchocerca volvulus		0.003	0.0307	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Toxoplasma gondii	aminopeptidase N, putative	0.003	0.0307	1
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0015	0.0035	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0015	0.0035	0.0035
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable oxidoreductase	0.0015	0.0035	0.5
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Echinococcus granulosus	WW domain containing oxidoreductase	0.0015	0.0035	0.0035
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0015	0.0035	0.5
Giardia lamblia	Reductase, putative	0.0015	0.0035	0.5
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Echinococcus granulosus	carbonyl reductase 1	0.0015	0.0035	0.0035
Schistosoma mansoni	retinal dehydrogenase	0.0015	0.0035	0.0035
Echinococcus granulosus	hypothetical protein	0.0015	0.0035	0.0035
Echinococcus granulosus	aminopeptidase N	0.003	0.0307	0.0307
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.003	0.0307	1
Toxoplasma gondii	aminopeptidase n, putative	0.003	0.0307	1
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0015	0.0035	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0015	0.0035	0.0077
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0527	1
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.003	0.0307	0.0307
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0015	0.0035	0.0035
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.003	0.0307	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Echinococcus granulosus	retinol dehydrogenase 11	0.0015	0.0035	0.0035
Onchocerca volvulus		0.003	0.0307	1
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	TATA binding protein associated factor	0.003	0.0307	0.0307
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0015	0.0035	0.0035
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0656	0.0656
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.003	0.0307	1
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable oxidoreductase	0.0015	0.0035	0.5
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Brugia malayi	dehydrogenases, short chain protein 9	0.0015	0.0035	0.0077
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0015	0.0035	0.0077
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.003	0.0307	1
Giardia lamblia	Short-chain dehydrogenase, putative	0.0015	0.0035	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0558	1	1
Loa Loa (eye worm)	dehydrogenase	0.0015	0.0035	0.0035
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.003	0.0307	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Mycobacterium leprae	Probable oxidoreductase	0.0015	0.0035	0.5
Brugia malayi	TATA binding protein associated factor	0.003	0.0307	0.0687
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Echinococcus multilocularis	carbonyl reductase 1	0.0015	0.0035	0.0035
Mycobacterium ulcerans	aminopeptidase N PepN	0.003	0.0307	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0527	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.003	0.0307	0.0307
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.003	0.0307	0.0307
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0656	0.0656
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0015	0.0035	0.5
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Echinococcus multilocularis	retinol dehydrogenase 13	0.0015	0.0035	0.0035
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.003	0.0307	1
Echinococcus multilocularis	oxidoreductase	0.0015	0.0035	0.0035
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.003	0.0307	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0015	0.0035	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0015	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.003	0.0307	0.0307
Brugia malayi	hypothetical protein	0.003	0.0307	0.0687
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0015	0.0035	0.5
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0015	0.0035	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0581	0.0581
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0015	0.0035	0.5
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.003	0.0307	0.5532
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0015	0.0035	0.0077
Echinococcus multilocularis	conserved hypothetical protein	0.0015	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.003	0.0307	0.0307
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0015	0.0035	0.0035
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.003	0.0307	1
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	dehydrogenase	0.0015	0.0035	0.0035
Trypanosoma cruzi	aminopeptidase, putative	0.003	0.0307	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0307	0.0307
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0015	0.0035	0.5
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0015	0.0035	0.5
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Brugia malayi	hypothetical protein	0.0256	0.447	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0581	0.1299
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Mycobacterium tuberculosis	Probable oxidoreductase	0.0015	0.0035	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Brugia malayi	hypothetical protein	0.0015	0.0035	0.0077
Trypanosoma brucei	Aminopeptidase M1, putative	0.003	0.0307	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.003	0.0307	0.0307
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Schistosoma mansoni	carbonyl reductase	0.0015	0.0035	0.0035
Brugia malayi	Retinol dehydrogenase 12	0.0015	0.0035	0.0077
Mycobacterium tuberculosis	Possible oxidoreductase	0.0015	0.0035	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0015	0.0035	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0015	0.0035	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0015	0.0035	0.0035
Schistosoma mansoni	carbonyl reductase	0.0015	0.0035	0.0035
Echinococcus multilocularis	retinol dehydrogenase 11	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.003	0.0307	1
Echinococcus granulosus	oxidoreductase	0.0015	0.0035	0.0035
Echinococcus multilocularis	carbonyl reductase 1	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.003	0.0307	1
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0015	0.0035	0.0035
Loa Loa (eye worm)	aminopeptidase N	0.003	0.0307	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Brugia malayi	Dehydrogenases, short chain protein 2	0.0015	0.0035	0.0077
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0015	0.0035	0.0035
Brugia malayi	Peptidase family M1 containing protein	0.003	0.0307	0.0687
Echinococcus granulosus	carbonyl reductase 1	0.0015	0.0035	0.0035
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Giardia lamblia	Hypothetical protein	0.0015	0.0035	0.5
Onchocerca volvulus		0.003	0.0307	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0581	0.0581
Schistosoma mansoni	aminopeptidase A (M01 family)	0.003	0.0307	0.0307
Echinococcus granulosus	steroid dehydrogenase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0558	1	1
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Trypanosoma brucei	aminopeptidase, putative	0.003	0.0307	1
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.003	0.0307	0.5532
Echinococcus granulosus	hypothetical protein	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable oxidoreductase	0.0015	0.0035	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0015	0.0035	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0035	0.0035
Brugia malayi	hypothetical protein	0.003	0.0307	0.0687
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0015	0.0035	0.5
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0473	0.0473
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.003	0.0307	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.003	0.0307	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0307	0.0307
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0581	0.0581
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.003	0.0307	1
Brugia malayi	hypothetical protein	0.0015	0.0035	0.0077
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.003	0.0307	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0015	0.0035	0.0035
Toxoplasma gondii	aminopeptidase N protein	0.003	0.0307	1
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0035	0.0077
Loa Loa (eye worm)	hypothetical protein	0.003	0.0307	0.0307
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0015	0.0035	0.5
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0015	0.0035	0.0035
Mycobacterium tuberculosis	Probable dehydrogenase	0.0015	0.0035	0.5
Entamoeba histolytica	aminopeptidase, putative	0.003	0.0307	1
Schistosoma mansoni	short chain dehydrogenase	0.0015	0.0035	0.0035

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 17 nM	Inhibition of human recombinant leukotriene A4 hydrolase by enzyme immunoassay	ChEMBL.	18588282
IC50 (binding)	= 280 nM	Inhibition of leukotriene A4 hydrolase activity in CD1 mouse whole blood assessed as A-23187-stimulated LTB4 production after 15 mins by enzyme immunoassay	ChEMBL.	18588282
IC50 (binding)	= 2 uM	Displacement of [3H]astemizole from human ERG potassium channel expressed in HEK293 cell membrane	ChEMBL.	18588282

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL470753

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 975429