Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Raf-1 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma japonicum | ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Brugia malayi | Raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus granulosus | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0149 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0008 | 0.0008 |
Echinococcus granulosus | acetylcholinesterase | 0.0881 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0881 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0149 | 0.0008 | 0.5 |
Onchocerca volvulus | 0.0149 | 0.0008 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0149 | 0.0008 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0149 | 0.0008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0881 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0881 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0881 | 1 | 1 |
Onchocerca volvulus | 0.0149 | 0.0008 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0149 | 0.0008 | 0.5 |
Onchocerca volvulus | 0.0149 | 0.0008 | 0.5 | |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0008 | 0.0008 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 0.1545 | 0.1538 |
Loa Loa (eye worm) | hypothetical protein | 0.0881 | 1 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0262 | 0.1545 | 0.1538 |
Loa Loa (eye worm) | carboxylesterase | 0.0149 | 0.0008 | 0.0008 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0881 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0881 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0881 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0008 | 0.0008 |
Onchocerca volvulus | 0.0149 | 0.0008 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0149 | 0.0008 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0881 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0149 | 0.0008 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0881 | 1 | 1 |
Onchocerca volvulus | 0.0149 | 0.0008 | 0.5 | |
Brugia malayi | Raf kinase | 0.0253 | 0.1421 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0008 | 0.0008 |
Echinococcus granulosus | carboxylesterase 5A | 0.0881 | 1 | 1 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0262 | 0.1545 | 0.1538 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.015 uM | Inhibition of C-Raf by ELISA | ChEMBL. | 18942827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.