Detailed information for compound 975729

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 979.374 | Formula: C58H94N2O10
  • H donors: 2 H acceptors: 4 LogP: 12.82 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCNC(=O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)[C@@H](OC(=O)C)C[C@H]1[C@H]2CC[C@H]2[C@]1(C)CC[C@]1(C2)OO[C@@]2(OO1)CC[C@]1([C@@H](C2)CC[C@@H]2[C@@H]1C[C@H](OC(=O)C)[C@]1([C@H]2CC[C@@H]1[C@@H](CCC(=O)NCCC)C)C)C)C
  • InChi: 1S/C58H94N2O10/c1-11-29-59-51(63)23-13-35(3)43-19-21-45-41-17-15-39-33-57(27-25-53(39,7)47(41)31-49(55(43,45)9)65-37(5)61)67-69-58(70-68-57)28-26-54(8)40(34-58)16-18-42-46-22-20-44(36(4)14-24-52(64)60-30-12-2)56(46,10)50(32-48(42)54)66-38(6)62/h35-36,39-50H,11-34H2,1-10H3,(H,59,63)(H,60,64)/t35-,36-,39-,40-,41+,42+,43-,44-,45+,46+,47+,48+,49+,50+,53+,54+,55-,56-,57-,58+/m1/s1
  • InChiKey: XNBJFFSFESTZGC-HUUKYUGDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0087 0.0086
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0087 0.0087
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0142 0.0141
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0111 0.0111
Echinococcus multilocularis sex peptide receptor 0.002 0.0087 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0087 0.0086
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0227 0.0247
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0185 0.0184
Brugia malayi MBOAT family protein 0.009 0.0861 0.1625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0312 0.056
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0312 0.0482
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.009 0.0861 0.0861
Brugia malayi MBOAT family protein 0.009 0.0861 0.1625
Brugia malayi larval opioid receptor 0.002 0.0087 0.0164
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.009 0.0861 0.0861
Brugia malayi Hhat protein 0.009 0.0861 0.1625
Brugia malayi MBOAT family protein 0.009 0.0861 0.1625
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0033 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0111
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0087 0.0164
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0087 0.0086
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.009 0.0861 0.2558
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.009 0.0861 0.086
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0087 0.0086
Schistosoma mansoni Smad4 0.0025 0.0142 0.0142
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0027 0.0166 0.0088
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0861 0.2514
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0087 0.0086
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.009 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0111 0.011
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0142 0.0142
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0028 0.0182 0.0182
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1299 0.1299
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0087 0.0164
Entamoeba histolytica hypothetical protein 0.0074 0.0682 0.1901
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0027 0.0166 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0087 0.0086
Echinococcus granulosus somatostatin receptor 0.002 0.0087 0.0086
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.009 0.0861 0.086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0197 0.0197
Trypanosoma brucei Valosin-containing protein 0.0027 0.0166 0.0023
Echinococcus multilocularis somatostatin receptor 0.002 0.0087 0.0086
Trypanosoma cruzi GUP1, putative 0.009 0.0861 0.2575
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0227 0.0227
Trypanosoma brucei polo-like protein kinase 0.0099 0.0954 0.2917
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0087 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0275 0.288 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0954 0.0953
Brugia malayi putative neuropeptide receptor 0.002 0.0087 0.0164
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0312 0.0409
Echinococcus multilocularis orexin receptor type 2 0.002 0.0087 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1299 0.1299
Entamoeba histolytica hypothetical protein, conserved 0.009 0.0861 0.2558
Schistosoma mansoni neuropeptide receptor 0.002 0.0087 0.0087
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0142 0.0141
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0087 0.0086
Brugia malayi sulfakinin receptor protein 0.002 0.0087 0.0164
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0111 0.0111
Echinococcus granulosus serotonin receptor 0.002 0.0087 0.0086
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0954 0.2917
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0111 0.0111
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.009 0.0861 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0087 0.0086
Brugia malayi Smad1 0.0025 0.0142 0.0268
Loa Loa (eye worm) hypothetical protein 0.0189 0.194 0.194
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.009 0.0861 0.0861
Entamoeba histolytica hypothetical protein 0.009 0.0861 0.2558
Echinococcus multilocularis serotonin receptor 0.002 0.0087 0.0086
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0087 0.0086
Brugia malayi Melatonin receptor type 1A 0.002 0.0087 0.0164
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0087 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0111 0.021
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0312 0.0409
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0087 0.0086
Brugia malayi hypothetical protein 0.0026 0.016 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.0363 0.3839 0.3839
Echinococcus granulosus membrane bound acyltransferase:hhat 0.009 0.0861 0.086
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0639 0.1207
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.009 0.0861 0.086
Entamoeba histolytica hypothetical protein 0.0074 0.0682 0.1901
Mycobacterium ulcerans lipoprotein LpqF 0.0067 0.0601 0.0873
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0227 0.2116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0111 0.021
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0087 0.0164
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0087 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0407 0.0833
Echinococcus granulosus hypothetical protein 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0087 0.0086
Plasmodium falciparum diacylglycerol O-acyltransferase 0.009 0.0861 1
Brugia malayi RNA binding protein 0.0131 0.1299 0.2453
Plasmodium vivax SET domain protein, putative 0.003 0.0197 0.0527
Onchocerca volvulus 0.003 0.0197 0.0212
Echinococcus multilocularis g protein coupled receptor 0.002 0.0087 0.0086
Brugia malayi Pre-SET motif family protein 0.003 0.0197 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0111 0.0111
Brugia malayi Serotonin receptor 0.002 0.0087 0.0164
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0312 0.0482
Trichomonas vaginalis transmembrane protein nessy, putative 0.009 0.0861 0.2514
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0312 0.056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Brugia malayi vesicle-fusing ATPase 0.0017 0.0054 0.0102
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0954 0.2901
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Brugia malayi Serotonin receptor 0.002 0.0087 0.0164
Echinococcus multilocularis tar DNA binding protein 0.0131 0.1299 0.1298
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.009 0.0861 0.086
Schistosoma mansoni biogenic amine receptor 0.002 0.0087 0.0087
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0087 0.0087
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0682 0.0682
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus granulosus o acyltransferase membrane bound domain 0.009 0.0861 0.086
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0087 0.0164
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0227 0.0226
Loa Loa (eye worm) hypothetical protein 0.0836 0.9011 0.9011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0111 0.0111
Treponema pallidum alginate O-acetylation protein (algI) 0.009 0.0861 0.5
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0227 0.0247
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0995 0.0995
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0067 0.0601 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0926 1 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0312 0.2174
Echinococcus granulosus neuropeptide s receptor 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Brugia malayi diacylglycerol acyltransferase 0.009 0.0861 0.1625
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0111 0.021
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0275 0.288 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0111 0.0111
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0087 0.0086
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0087 0.0164
Brugia malayi G-protein coupled receptor 0.002 0.0087 0.0164
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.009 0.0861 0.0861
Brugia malayi nuclear receptor NHR-88 0.0022 0.0111 0.021
Schistosoma mansoni smad1 5 8 and 0.0025 0.0142 0.0142
Brugia malayi neuropeptide F receptor 0.002 0.0087 0.0164
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Trypanosoma brucei glycerol uptake protein, putative 0.009 0.0861 0.2575
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.009 0.0861 0.2558
Schistosoma mansoni neuropeptide receptor 0.002 0.0087 0.0087
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0312 0.0482
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Mycobacterium ulcerans lipase LipD 0.004 0.0312 0.0409
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0087 0.0086
Trypanosoma cruzi glycerol uptake protein, putative 0.009 0.0861 0.2575
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.009 0.0861 0.086
Entamoeba histolytica vacuolar protein sorting 26 0.009 0.0861 0.2558
Echinococcus granulosus lysophospholipid acyltransferase 7 0.009 0.0861 0.086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0227 0.0247
Brugia malayi MH1 domain containing protein 0.0025 0.0142 0.0268
Mycobacterium ulcerans hypothetical protein 0.004 0.0312 0.0409
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0312
Brugia malayi Dopamine receptor 0.002 0.0087 0.0164
Leishmania major glycerol uptake protein, putative 0.009 0.0861 0.2575
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.009 0.0861 0.086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0111 0.0111
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0087 0.0087
Echinococcus multilocularis Smad4 0.0025 0.0142 0.0141
Mycobacterium tuberculosis Probable oxidoreductase 0.0587 0.6286 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0227 0.0226
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0087 0.0087
Schistosoma mansoni histamine h1 receptor 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0312 0.3277 0.3277
Loa Loa (eye worm) MBOAT family protein 0.009 0.0861 0.0861
Schistosoma mansoni smad 0.0025 0.0142 0.0142
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.009 0.0861 0.086
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0087 0.0086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0227 0.0428
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0312
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0111 0.011
Schistosoma mansoni hypothetical protein 0.0033 0.0227 0.0227
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0227 0.0247
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0954 0.2917
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0111 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0407 0.0833
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0312 0.0409
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0087 0.0087
Trypanosoma brucei beta lactamase 0.0067 0.0601 0.1621
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Brugia malayi N-terminal motif family protein 0.0189 0.194 0.3663
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0227 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0111 0.021
Brugia malayi Dopamine receptor protein 1 0.002 0.0087 0.0164
Echinococcus granulosus allatostatin A receptor 0.002 0.0087 0.0086
Brugia malayi ecdysteroid receptor 0.0022 0.0111 0.021
Giardia lamblia Rrm3p helicase 0.0275 0.288 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0111 0.011
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0954 0.1664
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1299 0.1299
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0111 0.0111
Loa Loa (eye worm) RNA binding protein 0.0131 0.1299 0.1299
Giardia lamblia Kinase, PLK 0.0099 0.0954 0.3175
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.009 0.0861 0.086
Schistosoma mansoni neuropeptide receptor 0.002 0.0087 0.0087
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0227 0.0247
Echinococcus granulosus smad 0.0025 0.0142 0.0141
Mycobacterium tuberculosis Conserved protein 0.004 0.0312 0.0409
Echinococcus granulosus sex peptide receptor 0.002 0.0087 0.0086
Schistosoma mansoni amine GPCR 0.002 0.0087 0.0087
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0275 0.288 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0087 0.0086
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0197 0.1738
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0028 0.0182 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0111 0.0111
Leishmania major hypothetical protein, conserved 0.009 0.0861 0.2575
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0087 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0087 0.0086
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0087 0.0086
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0087 0.0087
Brugia malayi MH2 domain containing protein 0.0025 0.0142 0.0268
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0312 0.0312
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0227 0.096
Toxoplasma gondii hypothetical protein 0.009 0.0861 1
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0087 0.0086
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0275 0.288 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0087 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0111 0.0111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.002 0.0087 0.0087
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0312 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0111 0.021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0227 0.0226
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0087 0.0086
Echinococcus multilocularis g protein coupled receptor 0.002 0.0087 0.0086
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0111 0.021
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0087 0.0086
Brugia malayi MH2 domain containing protein 0.0025 0.0142 0.0268
Echinococcus multilocularis neuropeptide receptor 0.002 0.0087 0.0086
Brugia malayi steroid hormone receptor 0.0022 0.0111 0.021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Brugia malayi nuclear hormone receptor 0.0022 0.0111 0.021
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0227 0.0428
Loa Loa (eye worm) hypothetical protein 0.003 0.0197 0.0197
Brugia malayi beta-lactamase family protein 0.004 0.0312 0.059
Echinococcus granulosus neuropeptide receptor 0.002 0.0087 0.0086
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0067 0.0601 0.0873
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0087 0.0087
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0227 0.043
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.009 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0103 0.0995 0.0995
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2456 0.8428
Schistosoma mansoni zinc finger protein 0.009 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.009 0.0861 1
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Loa Loa (eye worm) hypothetical protein 0.0926 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0954 0.2859
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0028 0.0182 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0111 0.0111
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0682 0.0681
Trypanosoma cruzi glycerol uptake protein, putative 0.009 0.0861 0.2575
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0111 0.0111
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.009 0.0861 0.2558
Loa Loa (eye worm) MBOAT family protein 0.009 0.0861 0.0861
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0197 0.0196
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0087 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0954 0.2859
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0087 0.0087
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0087 0.0086
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0028 0.0182 0.0182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Leishmania major glycerol uptake protein, putative 0.009 0.0861 0.2575
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1299 0.1299
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0995 0.1879
Loa Loa (eye worm) Smad1 0.0025 0.0142 0.0142
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0111 0.011
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.1299 0.2453
Loa Loa (eye worm) hhat protein 0.009 0.0861 0.0861
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0227 0.0227
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0111 0.011
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0217 0.0217
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2142 0.2142
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0275 0.288 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0111 0.0111
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0142 0.0142
Loa Loa (eye worm) vesicle-fusing ATPase 0.0017 0.0054 0.0054
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.009 0.0861 0.0861
Brugia malayi G-protein coupled receptor 0.002 0.0087 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0087 0.0086
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0217 0.041
Loa Loa (eye worm) TAR-binding protein 0.0131 0.1299 0.1299
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0087 0.0086
Loa Loa (eye worm) diacylglycerol acyltransferase 0.009 0.0861 0.0861
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0312 0.0312
Leishmania major hypothetical protein, conserved 0.004 0.0312 0.056
Echinococcus multilocularis g protein coupled receptor 0.002 0.0087 0.0086
Brugia malayi hypothetical protein 0.0074 0.0682 0.1288
Loa Loa (eye worm) hypothetical protein 0.009 0.0861 0.0861
Echinococcus granulosus g protein coupled receptor 0.002 0.0087 0.0086
Brugia malayi Pre-SET motif family protein 0.0208 0.2142 0.4045
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0954 0.2859
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0227 0.2116
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0312 0.0409
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0033 0.0227 0.0227
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.009 0.0861 1
Trichomonas vaginalis esterase, putative 0.004 0.0312 0.0482
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0087 0.0087
Brugia malayi Dopamine receptor protein 2 0.002 0.0087 0.0164
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0111
Brugia malayi MBOAT family protein 0.009 0.0861 0.1625
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Mycobacterium tuberculosis Conserved protein 0.004 0.0312 0.0409
Schistosoma mansoni hypothetical protein 0.0033 0.0227 0.0227
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Mycobacterium ulcerans beta-lactamase 0.004 0.0312 0.0409
Echinococcus granulosus g-protein coupled receptor 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0954 0.0954
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0087 0.0087
Leishmania major glycerol uptake protein, putative 0.009 0.0861 0.2575
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.0074 0.0682 0.0682
Echinococcus multilocularis fmrfamide receptor 0.002 0.0087 0.0086
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0275 0.288 1
Schistosoma mansoni opsin-like receptor 0.002 0.0087 0.0087
Brugia malayi MH1 domain containing protein 0.0025 0.0142 0.0268
Echinococcus granulosus o acyltransferase membrane bound domain 0.009 0.0861 0.086
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.009 0.0861 0.0861
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0111 0.021
Schistosoma mansoni hypothetical protein 0.002 0.0087 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0111 0.0047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.007 0.0639 0.0639
Schistosoma mansoni biogenic amine receptor 0.002 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0111 0.021
Leishmania major glycerol uptake protein, putative 0.009 0.0861 0.2575
Schistosoma mansoni coup transcription factor 0.0022 0.0111 0.0111
Schistosoma mansoni amine GPCR 0.002 0.0087 0.0087
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0312
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0087 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0111 0.011
Schistosoma mansoni sterol O-acyltransferase 1 0.0926 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0087 0.0086
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0087 0.0086
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0027 0.0166 0.0166
Echinococcus multilocularis neuropeptide receptor 0.002 0.0087 0.0086
Brugia malayi neuropeptide F receptor 0.002 0.0087 0.0164
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0312 0.0409
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0227 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1299 0.1299
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0142 0.0141
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0111 0.0111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0682 0.0681
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0087 0.0086
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0087 0.0086
Brugia malayi GnHR receptor homolog 0.002 0.0087 0.0164
Toxoplasma gondii cell division protein CDC48CY 0.0028 0.0182 0.1555
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0087 0.0086
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0087 0.0087
Onchocerca volvulus 0.009 0.0861 0.1486
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.016 0.1279
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0111 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0111 0.011
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.009 0.0861 0.086
Schistosoma mansoni hypothetical protein 0.002 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0227 0.096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0087 0.0086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0227 0.0227
Echinococcus granulosus Smad4 0.0025 0.0142 0.0141
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Brugia malayi MH1 domain containing protein 0.0014 0.0021 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0111 0.011
Schistosoma mansoni neuropeptide receptor 0.002 0.0087 0.0087
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.194 0.3558
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0087 0.0087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0087 0.0086
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0142 0.0141
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0312 0.0312
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0087 0.0086
Schistosoma mansoni hypothetical protein 0.0033 0.0227 0.0227
Onchocerca volvulus 0.0022 0.0111 0.0047
Echinococcus granulosus GPCR family 2 0.0033 0.0227 0.0226
Brugia malayi ORL1-like opioid receptor 0.002 0.0087 0.0164
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0139 0.1392 0.2143
Brugia malayi beta-lactamase family protein 0.004 0.0312 0.059
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0312 0.0409
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0312 0.0482
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0111 0.021
Trypanosoma cruzi GUP1, putative 0.009 0.0861 0.2575
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0312 0.0409
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0087 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0087 0.0086
Echinococcus granulosus g protein coupled receptor 0.002 0.0087 0.0086
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0087 0.0086
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0954 0.1801
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0111 0.021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0197 0.0196
Brugia malayi RE15519p 0.002 0.0087 0.0164
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0111 0.011
Echinococcus granulosus neuropeptide receptor 0.002 0.0087 0.0086
Brugia malayi valosin containing protein 0.0017 0.0054 0.0102
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0111 0.0111
Echinococcus multilocularis GPCR, family 2 0.0033 0.0227 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0861 0.2514
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0197 0.0197
Toxoplasma gondii ABC1 family protein 0.004 0.0312 0.3174
Schistosoma mansoni biogenic amine receptor 0.002 0.0087 0.0087
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0954 0.0953
Schistosoma mansoni adenoreceptor 0.002 0.0087 0.0087
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0087 0.0086
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0275 0.288 0.288
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0312 0.056
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0312
Trypanosoma cruzi Valosin-containing protein, putative 0.0027 0.0166 0.0023
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0275 0.288 0.288
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0111 0.021
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0954 0.2859
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0275 0.288 0.288
Loa Loa (eye worm) transcription factor SMAD2 0.0363 0.3839 0.3839
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0087 0.0086
Onchocerca volvulus 0.004 0.0312 0.0433
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0111 0.021
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus multilocularis smad 0.0025 0.0142 0.0141
Echinococcus multilocularis fmrfamide receptor 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Trichomonas vaginalis porcupine, putative 0.009 0.0861 0.2514
Brugia malayi MBOAT family protein 0.009 0.0861 0.1625
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0087 0.0086
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0087 0.0086
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0087 0.0086
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0087 0.0087
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.009 0.0861 0.0861
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0026 0.016 0.016
Entamoeba histolytica hypothetical protein, conserved 0.0275 0.288 1
Brugia malayi MH1 domain containing protein 0.0014 0.0021 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0312
Brugia malayi hypothetical protein 0.0017 0.0058 0.0109
Echinococcus multilocularis allatostatin A receptor 0.002 0.0087 0.0086
Brugia malayi TAR-binding protein 0.0131 0.1299 0.2453
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0954 0.2859
Schistosoma mansoni myosin xvIII 0.002 0.0087 0.0087
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.009 0.0861 0.086
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0087 0.0087
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0087 0.0087
Loa Loa (eye worm) nuclear factor I 0.0014 0.0021 0.0021
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0087 0.0087
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0995 0.1879
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0954 0.2917
Brugia malayi MH2 domain containing protein 0.0363 0.3839 0.725
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0087 0.0086
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0312 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0954 0.0954
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0227 0.0227
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0087 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0111 0.011
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0227 0.0273
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0087 0.0086
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0111
Schistosoma mansoni amine GPCR 0.002 0.0087 0.0087
Onchocerca volvulus 0.004 0.0312 0.0433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0087 0.0087
Schistosoma mansoni smad1 5 8 and 0.0025 0.0142 0.0142
Loa Loa (eye worm) hhat protein 0.009 0.0861 0.0861
Mycobacterium tuberculosis Conserved protein 0.004 0.0312 0.0409
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0087 0.0086
Trypanosoma brucei glycerol uptake protein, putative 0.009 0.0861 0.2575
Entamoeba histolytica hypothetical protein 0.0074 0.0682 0.1901
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0312 0.059
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Onchocerca volvulus 0.0496 0.5296 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0312 0.0409
Onchocerca volvulus 0.004 0.0312 0.0433
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0197 0.0196
Echinococcus granulosus tar DNA binding protein 0.0131 0.1299 0.1298
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.269 0.4226
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0087 0.0087
Brugia malayi isocitrate dehydrogenase 0.0033 0.0227 0.043
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0087 0.0086
Schistosoma mansoni hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) MBOAT family protein 0.009 0.0861 0.0861
Echinococcus multilocularis serotonin receptor 0.002 0.0087 0.0086
Echinococcus granulosus fmrfamide receptor 0.002 0.0087 0.0086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0111 0.021
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.1299 0.1299
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0087 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0954 0.2859
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0111 0.021
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0111 0.011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0111 0.021
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0861 0.2514
Schistosoma mansoni hypothetical protein 0.007 0.0639 0.0639
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0027 0.0166 0.0088
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0087 0.0087
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0275 0.288 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0087 0.0087
Loa Loa (eye worm) pax transcription factor protein 2 0.0496 0.5296 0.5296
Echinococcus granulosus g protein coupled receptor 0.002 0.0087 0.0086
Schistosoma mansoni amine GPCR 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0087 0.0087
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0275 0.288 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0312 0.0482
Echinococcus granulosus o acyltransferase membrane bound domain 0.009 0.0861 0.086
Schistosoma mansoni opsin-like receptor 0.002 0.0087 0.0087
Brugia malayi hypothetical protein 0.002 0.0087 0.0164
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0111 0.0111
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0111 0.011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0111 0.011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0087 0.0087
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0087 0.0086
Brugia malayi follicle stimulating hormone receptor 0.002 0.0087 0.0164
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0087 0.0086
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0139 0.1392 0.2143
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0142 0.0142
Toxoplasma gondii cell division protein CDC48AP 0.0017 0.0058 0.0000015233
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0087
Entamoeba histolytica hypothetical protein 0.0074 0.0682 0.1901
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0111 0.011
Onchocerca volvulus 0.0236 0.2456 0.4549
Mycobacterium ulcerans short chain dehydrogenase 0.0587 0.6286 1
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0087 0.0164
Loa Loa (eye worm) hypothetical protein 0.009 0.0861 0.0861
Entamoeba histolytica DNA repair and recombination protein, putative 0.0275 0.288 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0087 0.0087
Onchocerca volvulus 0.0312 0.3277 0.6125
Brugia malayi G protein-coupled receptor 0.002 0.0087 0.0164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0111 0.021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0111 0.011
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0087 0.0086
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0087 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0954 0.2859
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0087 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0111 0.011
Schistosoma mansoni opsin-like receptor 0.002 0.0087 0.0087
Loa Loa (eye worm) beta-lactamase 0.004 0.0312 0.0312
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0087 0.0087
Schistosoma mansoni smad1 5 8 and 0.0025 0.0142 0.0142
Echinococcus granulosus orexin receptor type 2 0.002 0.0087 0.0086
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0087 0.0087
Brugia malayi beta-lactamase 0.004 0.0312 0.059
Leishmania major glycerol uptake protein, putative 0.009 0.0861 0.2575
Brugia malayi hypothetical protein 0.0312 0.3277 0.6188
Brugia malayi AKH receptor 0.002 0.0087 0.0164
Schistosoma mansoni amine GPCR 0.002 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0087 0.0086
Schistosoma mansoni kinase 0.005 0.0421 0.0421
Trypanosoma cruzi glycerol uptake protein, putative 0.009 0.0861 0.2575
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0197 0.0197
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0087 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0087 0.0086
Brugia malayi Pax transcription factor protein 2 0.0496 0.5296 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0111 0.0111
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.009 0.0861 0.086
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0087 0.0164
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0111 0.011
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0087 0.0086
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0087 0.0086

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.48 Cytotoxicity against human HeLa cells ChEMBL. 20705369

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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