Detailed information for compound 976014

Basic information

Technical information
  • TDR Targets ID: 976014
  • Name: 4-methyl-1H-benzo[g]quinoline-2,5,10-trione
  • MW: 239.226 | Formula: C14H9NO3
  • H donors: 1 H acceptors: 3 LogP: 1 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(=O)[nH]c2c1C(=O)c1ccccc1C2=O
  • InChi: 1S/C14H9NO3/c1-7-6-10(16)15-12-11(7)13(17)8-4-2-3-5-9(8)14(12)18/h2-6H,1H3,(H,15,16)
  • InChiKey: GYAHTYNHCVTZOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0013 0.0103 0.0119
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.0979 0.1732
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1414 0.2741
Leishmania major acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Echinococcus granulosus pyruvate kinase 0.0014 0.0132 0.0058
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0861 0.0989
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1414 0.2741
Echinococcus granulosus dna polymerase kappa 0.0037 0.1414 0.2593
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0013 0.0103 0.0548
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1883 1
Trypanosoma brucei unspecified product 0.0026 0.0778 0.1507
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.516 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Echinococcus multilocularis dna polymerase eta 0.0086 0.4121 0.7946
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.2233 0.2152
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Echinococcus multilocularis transcription factor btf3 0.0028 0.0933 0.1642
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0704 0.1364
Entamoeba histolytica transcription factor BTF3, putative 0.0028 0.0933 0.1642
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1883 0.3649
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0655 0.109
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.516 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0103 0.0546
Plasmodium vivax pyruvate kinase 2, putative 0.0014 0.0132 0.1062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.0979 0.1732
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0103 0.02
Brugia malayi Pre-SET motif family protein 0.0169 0.8709 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Giardia lamblia DINP protein human, muc B family 0.0037 0.1414 0.2741
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0013 0.0103 0.0119
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0013 0.0103 0.0546
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0013 0.0103 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.1414 0.1325
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0861 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0778 0.1507
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0013 0.0103 0.0546
Echinococcus multilocularis pyruvate kinase 0.0014 0.0132 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0861 0.0989
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0778 0.1507
Loa Loa (eye worm) hypothetical protein 0.0086 0.4121 0.4732
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.1246 0.6617
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0103 0.0546
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.1246 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0027 0.0861 0.4574
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Trypanosoma cruzi pyruvate kinase 2, putative 0.0027 0.0861 0.1669
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0103 0.02
Trypanosoma cruzi transcription factor btf3, putative 0.0028 0.0933 0.1809
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.1414 0.1624
Echinococcus multilocularis pyruvate kinase 0.0014 0.0132 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.1143 0.6071
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1883 0.3649
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.2707 0.5246
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.1883 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1883 0.2162
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.516 0.5109
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0103 0.0548
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.516 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0704 0.1364
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0013 0.0103 0.0828
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0013 0.0103 0.0546
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.1246 1
Brugia malayi ImpB/MucB/SamB family protein 0.0086 0.4121 0.4732
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.1246 0.6617
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0013 0.0103 0.0548
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0704 0.26
Plasmodium falciparum basic transcription factor 3b, putative 0.0028 0.0933 0.7491
Schistosoma mansoni acetyl-CoA synthetase 0.0013 0.0103 0.02
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0013 0.0103 0.0381
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.1143 0.6071
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0103 0.0381
Echinococcus multilocularis pyruvate kinase 0.0027 0.0861 0.1499
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0013 0.0103 0.0546
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.1414 0.2593
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.1883 0.3519
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0704 0.1188
Loa Loa (eye worm) hypothetical protein 0.0024 0.0704 0.0808
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0103 0.0546
Entamoeba histolytica hypothetical protein 0.0028 0.0933 0.1642
Mycobacterium ulcerans hypothetical protein 0.0046 0.1883 1
Entamoeba histolytica pyruvate kinase, putative 0.0019 0.0408 0.0603
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.1883 1
Toxoplasma gondii propionate-CoA ligase 0.0013 0.0103 0.0381
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0013 0.0103 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.1143 0.6071
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0013 0.0103 0.0546
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.1414 0.7511
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0861 0.0766
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.1414 0.7511
Trypanosoma brucei unspecified product 0.0026 0.0778 0.1507
Schistosoma mansoni pyruvate kinase 0.0027 0.0861 0.1669
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0861 0.0766
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0704 0.1364
Leishmania major acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.1414 0.2741
Onchocerca volvulus 0.0046 0.1883 0.1798
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.1414 0.2741
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0061 0.2707 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.516 0.5925
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0013 0.0103 0.0548
Brugia malayi Pyruvate kinase, M2 isozyme 0.0027 0.0861 0.0989
Loa Loa (eye worm) hypothetical protein 0.0046 0.1883 0.2162
Plasmodium vivax basic transcription factor 3b, putative 0.0028 0.0933 0.7491
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0103 0.02
Plasmodium vivax acetyl-CoA synthetase, putative 0.0013 0.0103 0.0828
Trichomonas vaginalis set domain proteins, putative 0.0193 1 1
Plasmodium vivax pyruvate kinase, putative 0.0027 0.0861 0.6913
Entamoeba histolytica hypothetical protein 0.0029 0.0979 0.1732
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Leishmania major DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1883 1
Echinococcus granulosus transcription factor btf3 0.0028 0.0933 0.1642
Leishmania major pyruvate kinase 0.0027 0.0861 0.1669
Echinococcus multilocularis pyruvate kinase 0.0014 0.0132 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0103 0.0546
Schistosoma mansoni pyruvate kinase 0.0027 0.0861 0.1669
Toxoplasma gondii pyruvate kinase PyKII 0.0014 0.0132 0.0489
Echinococcus multilocularis pyruvate kinase 0.0021 0.0546 0.0875
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.1883 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.1883 1
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.1883 0.3519
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0704 0.1188
Trypanosoma brucei transcription factor BTF3, putative 0.0028 0.0933 0.1809
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1883 0.3649
Mycobacterium ulcerans acetyl-CoA synthetase 0.0013 0.0103 0.0548
Leishmania major DNA polymerase eta, putative 0.0061 0.2707 0.5246
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Leishmania major pyruvate kinase 0.0027 0.0861 0.1669
Plasmodium falciparum pyruvate kinase 0.0027 0.0861 0.6913
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0013 0.0103 0.0548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0704 0.1364
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1414 0.2741
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0103 0.0119
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.1414 0.1325
Leishmania major basic transcription factor 3a, putative 0.0028 0.0933 0.1809
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Brugia malayi beta-NAC-like protein 0.0028 0.0933 0.1072
Toxoplasma gondii pyruvate kinase PyK1 0.0027 0.0861 0.3182
Loa Loa (eye worm) hypothetical protein 0.0046 0.1883 0.2162
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.516 1
Onchocerca volvulus 0.0024 0.0704 0.0607
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.1414 0.2593
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.1414 0.7511
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.2233 0.2152
Trypanosoma brucei unspecified product 0.0037 0.1414 0.2741
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.1883 1
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.0979 0.1897
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.1414 0.2741
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0704 0.1188
Loa Loa (eye worm) pyruvate kinase-PB 0.0019 0.0408 0.0469
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.1246 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.1883 1
Schistosoma mansoni pyruvate kinase 0.0014 0.0132 0.0256
Trichomonas vaginalis pyruvate kinase, putative 0.0027 0.0861 0.0766
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0861 0.0766
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0013 0.0103 0.0548
Echinococcus granulosus pyruvate kinase 0.0014 0.0132 0.0058
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Trypanosoma brucei DNA polymerase eta, putative 0.0086 0.4121 0.7987
Trypanosoma brucei pyruvate kinase 1 0.0027 0.0861 0.1669
Schistosoma mansoni DNA polymerase eta 0.0086 0.4121 0.7987
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Plasmodium falciparum pyruvate kinase 2 0.0014 0.0132 0.1062
Giardia lamblia Pyruvate kinase 0.0014 0.0132 0.0256
Leishmania major DNA polymerase eta, putative 0.0086 0.4121 0.7987
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Giardia lamblia Pyruvate kinase 0.0027 0.0861 0.1669
Brugia malayi Pyruvate kinase, muscle isozyme 0.0027 0.0861 0.0989
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Echinococcus granulosus pyruvate kinase 0.0014 0.0132 0.0058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0408 0.0469
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.1883 1
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.1414 0.7511
Loa Loa (eye worm) ICD-1 protein 0.0028 0.0933 0.1072
Trypanosoma cruzi DNA polymerase eta, putative 0.0086 0.4121 0.7987
Loa Loa (eye worm) hypothetical protein 0.0027 0.0861 0.0989
Echinococcus multilocularis pyruvate kinase 0.0027 0.0861 0.1499
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Echinococcus granulosus pyruvate kinase 0.0027 0.0861 0.1499
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0013 0.0103 0.0546
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.516 1
Echinococcus granulosus pyruvate kinase 0.0027 0.0861 0.1499
Brugia malayi Pre-SET motif family protein 0.0024 0.0704 0.0808
Echinococcus multilocularis dna polymerase kappa 0.0037 0.1414 0.2593
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1883 0.2162
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0933 0.0839
Trypanosoma cruzi pyruvate kinase 2, putative 0.0027 0.0861 0.1669
Loa Loa (eye worm) hypothetical protein 0.0046 0.1883 0.2162
Giardia lamblia Kinase, PLK 0.0105 0.516 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.1883 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.516 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0027 0.0861 0.1669
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.516 0.5925
Mycobacterium leprae Probable pyruvate kinase PykA 0.0027 0.0861 0.426
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0778 0.1507
Schistosoma mansoni kinase 0.0053 0.2309 0.4476
Plasmodium vivax SET domain protein, putative 0.0024 0.0704 0.5649
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0933 0.0839
Brugia malayi hypothetical protein 0.0029 0.0979 0.1124
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.1414 0.1624
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.1143 0.6071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0169 0.8709 1
Entamoeba histolytica hypothetical protein 0.0029 0.0979 0.1732
Toxoplasma gondii NAC domain-containing protein 0.0028 0.0933 0.3448
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0103 0.02
Trichomonas vaginalis pyruvate kinase, putative 0.0027 0.0861 0.0766
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0013 0.0103 0.0548
Trypanosoma brucei polo-like protein kinase 0.0105 0.516 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1883 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Schistosoma mansoni transcription factor btf3 0.0028 0.0933 0.1809
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.1414 0.2593
Schistosoma mansoni hypothetical protein 0.0029 0.0979 0.1897
Trypanosoma cruzi transcription factor btf3, putative 0.0028 0.0933 0.1809
Mycobacterium ulcerans pyruvate kinase 0.0027 0.0861 0.4575
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.1883 0.3519
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Echinococcus granulosus dna polymerase eta 0.0086 0.4121 0.7946
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Entamoeba histolytica hypothetical protein 0.0029 0.0979 0.1732
Entamoeba histolytica hypothetical protein 0.0029 0.0979 0.1732
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.516 1
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1883 0.2162
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0933 0.0839

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.42 uM Cytotoxicity against human A549 cells after 48 hrs by SRB assay ChEMBL. 10543899
ED50 (functional) = 0.42 uM Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay ChEMBL. 10543899
ED50 (functional) = 0.42 uM Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay ChEMBL. 10543899
ED50 (functional) = 0.84 uM Cytotoxicity against human U251 cells after 48 hrs by SRB assay ChEMBL. 10543899

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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