Detailed information for compound 976014

Basic information

Technical information
  • TDR Targets ID: 976014
  • Name: 4-methyl-1H-benzo[g]quinoline-2,5,10-trione
  • MW: 239.226 | Formula: C14H9NO3
  • H donors: 1 H acceptors: 3 LogP: 1 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(=O)[nH]c2c1C(=O)c1ccccc1C2=O
  • InChi: 1S/C14H9NO3/c1-7-6-10(16)15-12-11(7)13(17)8-4-2-3-5-9(8)14(12)18/h2-6H,1H3,(H,15,16)
  • InChiKey: GYAHTYNHCVTZOK-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Leishmania major acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0103 0.0548
Schistosoma mansoni transcription factor btf3 0.0028 0.0933 0.1809
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0103 0.0119
Schistosoma mansoni pyruvate kinase 0.0027 0.0861 0.1669
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.2233 0.2152
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.516 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Giardia lamblia Kinase, PLK 0.0105 0.516 1
Echinococcus multilocularis dna polymerase kappa 0.0037 0.1414 0.2593
Onchocerca volvulus 0.0046 0.1883 0.1798
Loa Loa (eye worm) pyruvate kinase-PB 0.0019 0.0408 0.0469
Echinococcus granulosus dna polymerase kappa 0.0037 0.1414 0.2593
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1414 0.2741
Toxoplasma gondii pyruvate kinase PyKII 0.0014 0.0132 0.0489
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0103 0.0546
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1883 0.3649
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.516 1
Echinococcus multilocularis pyruvate kinase 0.0027 0.0861 0.1499
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0013 0.0103 0.0548
Trypanosoma brucei transcription factor BTF3, putative 0.0028 0.0933 0.1809
Entamoeba histolytica hypothetical protein 0.0029 0.0979 0.1732
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.1883 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1883 0.3649
Brugia malayi Pre-SET motif family protein 0.0169 0.8709 1
Trypanosoma cruzi transcription factor btf3, putative 0.0028 0.0933 0.1809
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Echinococcus multilocularis pyruvate kinase 0.0014 0.0132 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.2707 0.5246
Entamoeba histolytica hypothetical protein 0.0029 0.0979 0.1732
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0103 0.0546
Plasmodium falciparum basic transcription factor 3b, putative 0.0028 0.0933 0.7491
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Onchocerca volvulus 0.0024 0.0704 0.0607
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0013 0.0103 0.0548
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0861 0.0989
Leishmania major DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Loa Loa (eye worm) oxidoreductase 0.0013 0.0103 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0704 0.1364
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.516 0.5925
Loa Loa (eye worm) hypothetical protein 0.0086 0.4121 0.4732
Brugia malayi Pyruvate kinase, muscle isozyme 0.0027 0.0861 0.0989
Plasmodium vivax basic transcription factor 3b, putative 0.0028 0.0933 0.7491
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.1414 0.1325
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0013 0.0103 0.0119
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0704 0.1188
Schistosoma mansoni pyruvate kinase 0.0027 0.0861 0.1669
Trichomonas vaginalis pyruvate kinase, putative 0.0027 0.0861 0.0766
Trypanosoma cruzi DNA polymerase eta, putative 0.0086 0.4121 0.7987
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0013 0.0103 0.0546
Entamoeba histolytica transcription factor BTF3, putative 0.0028 0.0933 0.1642
Echinococcus multilocularis pyruvate kinase 0.0021 0.0546 0.0875
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0027 0.0861 0.4574
Plasmodium vivax pyruvate kinase, putative 0.0027 0.0861 0.6913
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.1414 0.7511
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0103 0.0546
Brugia malayi beta-NAC-like protein 0.0028 0.0933 0.1072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.1143 0.6071
Trypanosoma brucei unspecified product 0.0026 0.0778 0.1507
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0861 0.0766
Leishmania major DNA polymerase eta, putative 0.0086 0.4121 0.7987
Loa Loa (eye worm) hypothetical protein 0.0046 0.1883 0.2162
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0013 0.0103 0.0381
Loa Loa (eye worm) hypothetical protein 0.0046 0.1883 0.2162
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.1883 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Plasmodium falciparum pyruvate kinase 2 0.0014 0.0132 0.1062
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.1414 0.7511
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.516 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.516 0.5109
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.1414 0.1624
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.0979 0.1897
Trypanosoma brucei polo-like protein kinase 0.0105 0.516 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.516 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.1414 0.2593
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.1414 0.7511
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.1246 0.6617
Trichomonas vaginalis set domain proteins, putative 0.0193 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0933 0.0839
Giardia lamblia DINP protein human, muc B family 0.0037 0.1414 0.2741
Trypanosoma cruzi pyruvate kinase 2, putative 0.0027 0.0861 0.1669
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Loa Loa (eye worm) hypothetical protein 0.0027 0.0861 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0778 0.1507
Leishmania major DNA polymerase eta, putative 0.0061 0.2707 0.5246
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.1143 0.6071
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.1883 1
Echinococcus multilocularis pyruvate kinase 0.0027 0.0861 0.1499
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0169 0.8709 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.1414 0.2741
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1883 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.1414 0.2741
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0861 0.0989
Echinococcus granulosus dna polymerase eta 0.0086 0.4121 0.7946
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.1143 0.6071
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0103 0.02
Trypanosoma brucei unspecified product 0.0037 0.1414 0.2741
Brugia malayi Pyruvate kinase, M2 isozyme 0.0027 0.0861 0.0989
Plasmodium vivax SET domain protein, putative 0.0024 0.0704 0.5649
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.1414 0.2741
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0103 0.0546
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.0979 0.1732
Loa Loa (eye worm) hypothetical protein 0.0019 0.0408 0.0469
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.0979 0.1732
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1414 0.2741
Brugia malayi hypothetical protein 0.0029 0.0979 0.1124
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0013 0.0103 0.0548
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.2233 0.2152
Echinococcus multilocularis dna polymerase eta 0.0086 0.4121 0.7946
Trypanosoma brucei unspecified product 0.0026 0.0778 0.1507
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0933 0.0839
Mycobacterium ulcerans pyruvate kinase 0.0027 0.0861 0.4575
Leishmania major pyruvate kinase 0.0027 0.0861 0.1669
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0013 0.0103 0.0548
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.1414 0.2593
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.1883 0.3519
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0704 0.1364
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0861 0.0766
Entamoeba histolytica pyruvate kinase, putative 0.0019 0.0408 0.0603
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.1143 0.6071
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Mycobacterium leprae Probable pyruvate kinase PykA 0.0027 0.0861 0.426
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0013 0.0103 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0778 0.1507
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0013 0.0103 0.0546
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1883 0.2162
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.1246 0.6617
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0013 0.0103 0.0546
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0704 0.1364
Echinococcus granulosus pyruvate kinase 0.0014 0.0132 0.0058
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Mycobacterium ulcerans hypothetical protein 0.0046 0.1883 1
Schistosoma mansoni pyruvate kinase 0.0014 0.0132 0.0256
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.1414 0.7511
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0103 0.0381
Toxoplasma gondii pyruvate kinase PyK1 0.0027 0.0861 0.3182
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Trichomonas vaginalis pyruvate kinase, putative 0.0027 0.0861 0.0766
Loa Loa (eye worm) pyruvate kinase 0.0027 0.0861 0.0989
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0704 0.1188
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0013 0.0103 0.0546
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0103 0.02
Trypanosoma brucei pyruvate kinase 1, putative 0.0027 0.0861 0.1669
Schistosoma mansoni acetyl-CoA synthetase 0.0013 0.0103 0.02
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0655 0.109
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.1883 1
Echinococcus granulosus pyruvate kinase 0.0014 0.0132 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0704 0.0808
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.1883 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0027 0.0861 0.1669
Leishmania major acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0013 0.0103 0.0546
Leishmania major basic transcription factor 3a, putative 0.0028 0.0933 0.1809
Giardia lamblia Pyruvate kinase 0.0027 0.0861 0.1669
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0704 0.1188
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.516 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.1414 0.1624
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.1883 0.3649
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.1414 0.2593
Leishmania major pyruvate kinase 0.0027 0.0861 0.1669
Schistosoma mansoni kinase 0.0053 0.2309 0.4476
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.516 1
Echinococcus granulosus pyruvate kinase 0.0027 0.0861 0.1499
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.1883 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0013 0.0103 0.0548
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1883 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.1883 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0061 0.2707 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.1883 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0013 0.0103 0.0828
Brugia malayi Pre-SET motif family protein 0.0024 0.0704 0.0808
Giardia lamblia Pyruvate kinase 0.0014 0.0132 0.0256
Trypanosoma cruzi transcription factor btf3, putative 0.0028 0.0933 0.1809
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0013 0.0103 0.02
Toxoplasma gondii NAC domain-containing protein 0.0028 0.0933 0.3448
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0103 0.0548
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0103 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Entamoeba histolytica hypothetical protein 0.0029 0.0979 0.1732
Echinococcus granulosus pyruvate kinase 0.0014 0.0132 0.0058
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.1246 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.1883 0.3519
Plasmodium falciparum pyruvate kinase 0.0027 0.0861 0.6913
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.516 1
Trypanosoma brucei pyruvate kinase 1 0.0027 0.0861 0.1669
Echinococcus multilocularis pyruvate kinase 0.0014 0.0132 0.0058
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.1883 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0013 0.0103 0.0548
Schistosoma mansoni hypothetical protein 0.0029 0.0979 0.1897
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.516 0.5925
Onchocerca volvulus Pyruvate kinase homolog 0.0027 0.0861 0.0766
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0933 0.0839
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0704 0.1364
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0778 0.1507
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.1246 1
Entamoeba histolytica hypothetical protein 0.0029 0.0979 0.1732
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.1883 0.3519
Loa Loa (eye worm) ICD-1 protein 0.0028 0.0933 0.1072
Brugia malayi ImpB/MucB/SamB family protein 0.0086 0.4121 0.4732
Loa Loa (eye worm) hypothetical protein 0.0046 0.1883 0.2162
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0013 0.0103 0.0546
Echinococcus granulosus pyruvate kinase 0.0027 0.0861 0.1499
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0704 0.26
Echinococcus multilocularis transcription factor btf3 0.0028 0.0933 0.1642
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0103 0.02
Plasmodium vivax pyruvate kinase 2, putative 0.0014 0.0132 0.1062
Schistosoma mansoni DNA polymerase eta 0.0086 0.4121 0.7987
Plasmodium vivax acetyl-CoA synthetase, putative 0.0013 0.0103 0.0828
Trypanosoma brucei DNA polymerase eta, putative 0.0086 0.4121 0.7987
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0013 0.0103 0.0548
Toxoplasma gondii propionate-CoA ligase 0.0013 0.0103 0.0381
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1414 0.2741
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1883 0.2162
Echinococcus granulosus transcription factor btf3 0.0028 0.0933 0.1642
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0013 0.0103 0.0548
Echinococcus multilocularis pyruvate kinase 0.0014 0.0132 0.0058
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.1414 0.1325
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0103 0.0119
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1414 0.2741
Brugia malayi AMP-binding enzyme family protein 0.0046 0.1883 0.2162
Entamoeba histolytica hypothetical protein 0.0028 0.0933 0.1642
Loa Loa (eye worm) hypothetical protein 0.0034 0.1246 0.1431
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.516 0.5109
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.1246 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.42 uM Cytotoxicity against human A549 cells after 48 hrs by SRB assay ChEMBL. 10543899
ED50 (functional) = 0.42 uM Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay ChEMBL. 10543899
ED50 (functional) = 0.42 uM Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay ChEMBL. 10543899
ED50 (functional) = 0.84 uM Cytotoxicity against human U251 cells after 48 hrs by SRB assay ChEMBL. 10543899

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.