Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | kinase | 0.0053 | 0.2309 | 0.4476 |
Onchocerca volvulus | 0.0024 | 0.0704 | 0.0607 | |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0979 | 0.1732 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0034 | 0.1246 | 1 |
Toxoplasma gondii | propionate-CoA ligase | 0.0013 | 0.0103 | 0.0381 |
Brugia malayi | Pre-SET motif family protein | 0.0024 | 0.0704 | 0.0808 |
Schistosoma mansoni | DNA polymerase eta | 0.0086 | 0.4121 | 0.7987 |
Plasmodium vivax | SET domain protein, putative | 0.0024 | 0.0704 | 0.5649 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0013 | 0.0103 | 0.02 |
Giardia lamblia | DINP protein human, muc B family | 0.0037 | 0.1414 | 0.2741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0013 | 0.0103 | 0.0828 |
Echinococcus granulosus | dna polymerase kappa | 0.0037 | 0.1414 | 0.2593 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0046 | 0.1883 | 0.3519 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0037 | 0.1414 | 0.2741 |
Echinococcus multilocularis | transcription factor btf3 | 0.0028 | 0.0933 | 0.1642 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0013 | 0.0103 | 0.0548 |
Leishmania major | basic transcription factor 3a, putative | 0.0028 | 0.0933 | 0.1809 |
Loa Loa (eye worm) | ICD-1 protein | 0.0028 | 0.0933 | 0.1072 |
Echinococcus granulosus | pyruvate kinase | 0.0014 | 0.0132 | 0.0058 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0979 | 0.1732 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0778 | 0.1507 |
Loa Loa (eye worm) | pyruvate kinase | 0.0027 | 0.0861 | 0.0989 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0032 | 0.1143 | 0.6071 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0013 | 0.0103 | 0.0381 |
Brugia malayi | AMP-binding enzyme family protein | 0.0013 | 0.0103 | 0.0119 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0013 | 0.0103 | 0.0546 |
Echinococcus multilocularis | pyruvate kinase | 0.0014 | 0.0132 | 0.0058 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.516 | 0.5109 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0013 | 0.0103 | 0.0548 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0029 | 0.0979 | 0.1732 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0032 | 0.1143 | 0.6071 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0028 | 0.0933 | 0.7491 |
Leishmania major | DNA polymerase eta, putative | 0.0061 | 0.2707 | 0.5246 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0027 | 0.0861 | 0.1669 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0024 | 0.0704 | 0.1364 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0046 | 0.1883 | 1 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0013 | 0.0103 | 0.0381 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0105 | 0.516 | 0.5109 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.1883 | 0.2162 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Brugia malayi | AMP-binding enzyme family protein | 0.0013 | 0.0103 | 0.0119 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0013 | 0.0103 | 0.0548 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0979 | 0.1124 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0013 | 0.0103 | 0.02 |
Trichomonas vaginalis | set domain proteins, putative | 0.0193 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0933 | 0.0839 |
Mycobacterium ulcerans | pyruvate kinase | 0.0027 | 0.0861 | 0.4575 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0979 | 0.1732 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0013 | 0.0103 | 0.0119 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0046 | 0.1883 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1246 | 0.1431 |
Brugia malayi | AMP-binding enzyme family protein | 0.0013 | 0.0103 | 0.0119 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0023 | 0.0655 | 0.109 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0029 | 0.0979 | 0.1732 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0028 | 0.0933 | 0.1809 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0037 | 0.1414 | 0.2741 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.516 | 0.5109 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0037 | 0.1414 | 0.2741 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0013 | 0.0103 | 0.0548 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0027 | 0.0861 | 0.0766 |
Echinococcus multilocularis | pyruvate kinase | 0.0014 | 0.0132 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1883 | 0.2162 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0013 | 0.0103 | 0.0546 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0014 | 0.0132 | 0.0489 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.1883 | 0.3649 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0105 | 0.516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0861 | 0.0989 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0408 | 0.0469 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0034 | 0.1246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0103 | 0.0119 |
Schistosoma mansoni | pyruvate kinase | 0.0027 | 0.0861 | 0.1669 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0014 | 0.0132 | 0.1062 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0086 | 0.4121 | 0.4732 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0105 | 0.516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4121 | 0.4732 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0027 | 0.0861 | 0.0989 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Leishmania major | DNA polymerase eta, putative | 0.0086 | 0.4121 | 0.7987 |
Echinococcus granulosus | pyruvate kinase | 0.0014 | 0.0132 | 0.0058 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0061 | 0.2707 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0027 | 0.0861 | 0.0989 |
Plasmodium vivax | pyruvate kinase, putative | 0.0027 | 0.0861 | 0.6913 |
Echinococcus multilocularis | pyruvate kinase | 0.0014 | 0.0132 | 0.0058 |
Schistosoma mansoni | pyruvate kinase | 0.0014 | 0.0132 | 0.0256 |
Leishmania major | pyruvate kinase | 0.0027 | 0.0861 | 0.1669 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0037 | 0.1414 | 0.2593 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.0013 | 0.0103 | 0.0548 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0037 | 0.1414 | 0.7511 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0032 | 0.1143 | 0.6071 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0086 | 0.4121 | 0.7987 |
Echinococcus granulosus | transcription factor btf3 | 0.0028 | 0.0933 | 0.1642 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0028 | 0.0933 | 0.7491 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0028 | 0.0933 | 0.1809 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0027 | 0.0861 | 0.4574 |
Brugia malayi | beta-NAC-like protein | 0.0028 | 0.0933 | 0.1072 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1883 | 0.2162 |
Trypanosoma brucei | unspecified product | 0.0037 | 0.1414 | 0.2741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0013 | 0.0103 | 0.0546 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0105 | 0.516 | 0.5925 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0105 | 0.516 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0.2233 | 0.2152 |
Echinococcus granulosus | pyruvate kinase | 0.0014 | 0.0132 | 0.0058 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0105 | 0.516 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0046 | 0.1883 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0027 | 0.0861 | 0.3182 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0933 | 0.1642 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0061 | 0.2707 | 0.5246 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0013 | 0.0103 | 0.02 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0032 | 0.1143 | 0.6071 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0013 | 0.0103 | 0.0828 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0013 | 0.0103 | 0.02 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0024 | 0.0704 | 0.1188 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0027 | 0.0861 | 0.0989 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Trypanosoma brucei | unspecified product | 0.0026 | 0.0778 | 0.1507 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0013 | 0.0103 | 0.0548 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0037 | 0.1414 | 0.2593 |
Trypanosoma brucei | unspecified product | 0.0026 | 0.0778 | 0.1507 |
Brugia malayi | Pre-SET motif family protein | 0.0169 | 0.8709 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0933 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1246 | 0.1431 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0037 | 0.1414 | 0.7511 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1883 | 0.2162 |
Leishmania major | pyruvate kinase | 0.0027 | 0.0861 | 0.1669 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0024 | 0.0704 | 0.1188 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.516 | 0.5109 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0778 | 0.1507 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0024 | 0.0704 | 0.26 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0019 | 0.0408 | 0.0469 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0046 | 0.1883 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0013 | 0.0103 | 0.02 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.516 | 0.5109 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.516 | 0.5109 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.1883 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0013 | 0.0103 | 0.0119 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0037 | 0.1414 | 0.1624 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Brugia malayi | AMP-binding enzyme family protein | 0.0013 | 0.0103 | 0.0119 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.1883 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0103 | 0.0119 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1246 | 0.1431 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0037 | 0.1414 | 0.7511 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0046 | 0.1883 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0037 | 0.1414 | 0.2593 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0013 | 0.0103 | 0.0548 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0027 | 0.0861 | 0.1669 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0019 | 0.0408 | 0.0603 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0024 | 0.0704 | 0.1364 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0013 | 0.0103 | 0.0546 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.1883 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0037 | 0.1414 | 0.7511 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.516 | 0.5109 |
Schistosoma mansoni | pyruvate kinase | 0.0027 | 0.0861 | 0.1669 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0028 | 0.0933 | 0.1642 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0027 | 0.0861 | 0.0766 |
Echinococcus granulosus | dna polymerase eta | 0.0086 | 0.4121 | 0.7946 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0037 | 0.1414 | 0.1624 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0037 | 0.1414 | 0.2741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0778 | 0.1507 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0027 | 0.0861 | 0.0766 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0979 | 0.1732 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0013 | 0.0103 | 0.02 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0861 | 0.1499 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0027 | 0.0861 | 0.0766 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0013 | 0.0103 | 0.0546 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0034 | 0.1246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0704 | 0.0808 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0028 | 0.0933 | 0.1809 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0013 | 0.0103 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1246 | 0.1431 |
Giardia lamblia | Pyruvate kinase | 0.0014 | 0.0132 | 0.0256 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.1883 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.1883 | 0.3649 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0024 | 0.0704 | 0.1364 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0027 | 0.0861 | 0.426 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0034 | 0.1246 | 0.6617 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0037 | 0.1414 | 0.1325 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0052 | 0.2233 | 0.2152 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0013 | 0.0103 | 0.02 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.1883 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0027 | 0.0861 | 0.0766 |
Schistosoma mansoni | transcription factor btf3 | 0.0028 | 0.0933 | 0.1809 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0013 | 0.0103 | 0.02 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.1883 | 0.2162 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0027 | 0.0861 | 0.1669 |
Echinococcus granulosus | pyruvate kinase | 0.0027 | 0.0861 | 0.1499 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.1883 | 0.3519 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0169 | 0.8709 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0013 | 0.0103 | 0.0546 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.516 | 0.5109 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0105 | 0.516 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.1883 | 0.3649 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Echinococcus multilocularis | dna polymerase kappa | 0.0037 | 0.1414 | 0.2593 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0013 | 0.0103 | 0.0119 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0105 | 0.516 | 0.5925 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0013 | 0.0103 | 0.0546 |
Plasmodium falciparum | pyruvate kinase | 0.0027 | 0.0861 | 0.6913 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0034 | 0.1246 | 0.6617 |
Trypanosoma brucei | polo-like protein kinase | 0.0105 | 0.516 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0024 | 0.0704 | 0.1188 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0933 | 0.0839 |
Onchocerca volvulus | 0.0046 | 0.1883 | 0.1798 | |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0037 | 0.1414 | 0.2741 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0861 | 0.1499 |
Echinococcus multilocularis | pyruvate kinase | 0.0021 | 0.0546 | 0.0875 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0103 | 0.0119 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0013 | 0.0103 | 0.02 |
Loa Loa (eye worm) | pyruvate kinase | 0.0027 | 0.0861 | 0.0989 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0013 | 0.0103 | 0.0546 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0029 | 0.0979 | 0.1897 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.1883 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0013 | 0.0103 | 0.02 |
Giardia lamblia | Pyruvate kinase | 0.0027 | 0.0861 | 0.1669 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0013 | 0.0103 | 0.0546 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0046 | 0.1883 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0086 | 0.4121 | 0.7987 |
Loa Loa (eye worm) | oxidoreductase | 0.0013 | 0.0103 | 0.0119 |
Echinococcus multilocularis | dna polymerase eta | 0.0086 | 0.4121 | 0.7946 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0027 | 0.0861 | 0.1669 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0024 | 0.0704 | 0.1364 |
Leishmania major | DNA polymerase kappa, putative | 0.0037 | 0.1414 | 0.2741 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0105 | 0.516 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.1883 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.1883 | 0.3519 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0037 | 0.1414 | 0.1325 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0013 | 0.0103 | 0.0546 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0014 | 0.0132 | 0.1062 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0105 | 0.516 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.0028 | 0.0933 | 0.3448 |
Echinococcus granulosus | pyruvate kinase | 0.0027 | 0.0861 | 0.1499 |
Giardia lamblia | Kinase, PLK | 0.0105 | 0.516 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0979 | 0.1897 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0037 | 0.1414 | 0.2741 |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.0013 | 0.0103 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1246 | 0.1431 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.42 uM | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | ChEMBL. | 10543899 |
ED50 (functional) | = 0.42 uM | Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay | ChEMBL. | 10543899 |
ED50 (functional) | = 0.42 uM | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay | ChEMBL. | 10543899 |
ED50 (functional) | = 0.84 uM | Cytotoxicity against human U251 cells after 48 hrs by SRB assay | ChEMBL. | 10543899 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.