Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | 0.0143 | 0.5969 | 0.6483 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.9207 | 0.9207 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.2564 | 0.2637 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1702 | 0.1702 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.007 | 0.2378 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0027 | 0.0265 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.1702 | 0.1702 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0265 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3703 | 0.3703 |
Onchocerca volvulus | Huntingtin homolog | 0.0143 | 0.5969 | 0.6483 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0097 | 0.3703 | 0.4022 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.2564 | 0.2785 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.007 | 0.2378 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0928 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.9207 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.1702 | 0.175 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0027 | 0.0265 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0928 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.9207 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0265 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0928 | 0.1008 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.007 | 0.2378 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.2564 | 0.2564 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0928 | 0.0954 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.1702 | 0.175 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0928 | 0.1008 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.2564 | 0.2564 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.007 | 0.2378 | 0.2583 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0097 | 0.3703 | 0.4022 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0027 | 0.0265 | 0.5 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0097 | 0.3703 | 0.3808 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.007 | 0.2378 | 0.5 |
Brugia malayi | RNA binding protein | 0.0074 | 0.2564 | 0.2637 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0822 | 0.0892 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.2564 | 0.2564 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0822 | 0.0822 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0822 | 0.0845 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.2378 | 0.2446 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0928 | 0.1008 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.2564 | 0.2785 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0928 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2564 | 0.2785 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5969 | 0.5969 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1563 | 0.1563 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0928 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0027 | 0.0265 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.007 | 0.2378 | 0.2583 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.9207 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.9207 | 0.9468 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.9207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5969 | 0.5969 |
Brugia malayi | hypothetical protein | 0.0143 | 0.5969 | 0.6138 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0928 | 0.1008 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.007 | 0.2378 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2564 | 0.2785 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0027 | 0.0265 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.2564 | 0.2637 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2564 | 0.2785 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.022 | 0.9725 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.007 | 0.2378 | 0.2583 |
Brugia malayi | hypothetical protein | 0.0054 | 0.1563 | 0.1607 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2564 | 0.2785 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0.2378 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0027 | 0.0265 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2564 | 0.2785 |
Onchocerca volvulus | 0.0097 | 0.3703 | 0.4022 | |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0265 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0097 | 0.3703 | 0.4022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 88 nM | Inhibition of DPP4 in human plasma by fluorescence assay | ChEMBL. | 18243000 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.