Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4B, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.035 | 0.3758 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.3758 | 0.3758 |
Schistosoma mansoni | nuclear hormone receptor | 0.035 | 0.3758 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.035 | 0.3758 | 0.649 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.035 | 0.3758 | 0.3758 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.035 | 0.3758 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0624 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.035 | 0.3758 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.035 | 0.3758 | 0.649 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.035 | 0.3758 | 0.3758 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.035 | 0.3758 | 0.649 |
Echinococcus multilocularis | FTZ F1 alpha | 0.035 | 0.3758 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.035 | 0.3758 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.035 | 0.3758 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.035 | 0.3758 | 0.3758 |
Brugia malayi | nuclear hormone receptor | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.035 | 0.3758 | 0.3758 |
Schistosoma mansoni | coup transcription factor | 0.035 | 0.3758 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0355 | 0.3873 | 0.3873 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.3758 | 0.3758 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.035 | 0.3758 | 0.649 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.035 | 0.3758 | 0.3758 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.035 | 0.3758 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.3758 | 0.3758 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.035 | 0.3758 | 0.3758 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.035 | 0.3758 | 0.3758 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.035 | 0.3758 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.035 | 0.3758 | 0.3758 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.035 | 0.3758 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.035 | 0.3758 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.035 | 0.3758 | 0.649 |
Brugia malayi | ecdysteroid receptor | 0.035 | 0.3758 | 0.3758 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.035 | 0.3758 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0115 | 0.0115 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.035 | 0.3758 | 0.3758 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.035 | 0.3758 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.035 | 0.3758 | 0.649 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.035 | 0.3758 | 0.3758 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.035 | 0.3758 | 0.3758 |
Schistosoma mansoni | thyroid hormone receptor | 0.035 | 0.3758 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.035 | 0.3758 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.3758 | 0.3758 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.035 | 0.3758 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.035 | 0.3758 | 0.3758 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.035 | 0.3758 | 0.3758 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0439 | 0.5791 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.035 | 0.3758 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.3758 | 0.3758 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.035 | 0.3758 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.035 | 0.3758 | 0.649 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.3758 | 0.3758 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.035 | 0.3758 | 0.649 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.035 | 0.3758 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.035 | 0.3758 | 0.3758 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.035 | 0.3758 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.035 | 0.3758 | 0.3758 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.054 | 0.8082 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.035 | 0.3758 | 0.649 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.035 | 0.3758 | 0.3758 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.035 | 0.3758 | 0.3758 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.035 | 0.3758 | 0.3758 |
Brugia malayi | nuclear hormone receptor | 0.0355 | 0.3873 | 0.3873 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.035 | 0.3758 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.1 | Inhibition of human recombinant PDE4B by scintillation proximity assay | ChEMBL. | 19195882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.