TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.475 | Formula: C27H22N2O3
H donors: 1 H acceptors: 2 LogP: 4.61 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C1C2=C(OC(=C1C#N)N)CC(CC2=O)c1cccc2c1cccc2
InChi: 1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3
InChiKey: YBMGNDPBARCLFT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Starlite/ChEMBL	References
Rattus norvegicus	Excitatory amino acid transporter 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	excitatory amino acid transporter 3	Get druggable targets OG5_126739	All targets in OG5_126739
Schistosoma japonicum	ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Schistosoma japonicum	ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	excitatory amino acid transporter 2	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	excitatory amino acid transporter 2	Get druggable targets OG5_126739	All targets in OG5_126739
Brugia malayi	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Chlamydia trachomatis	glutamate symporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	neutral amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Schistosoma japonicum	Excitatory amino acid transporter 2, putative	Get druggable targets OG5_126739	All targets in OG5_126739
Theileria parva	glutamate transporter, putative	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	sodium:dicarboxylate symporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	sodium:dicarboxylate symporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	excitatory amino acid transporter 2	Get druggable targets OG5_126739	All targets in OG5_126739
Loa Loa (eye worm)	excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	Get druggable targets OG5_126739	All targets in OG5_126739
Onchocerca volvulus	Excitatory amino acid transporter homolog	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	neutral amino acid transporter A	Get druggable targets OG5_126739	All targets in OG5_126739
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	excitatory amino acid transporter 2	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus multilocularis	excitatory amino acid transporter 3	Get druggable targets OG5_126739	All targets in OG5_126739
Echinococcus granulosus	Excitatory amino acid transporter	Get druggable targets OG5_126739	All targets in OG5_126739

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0095	0.1079	0.2761
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0141	0.1664	0.2779
Onchocerca volvulus		0.0252	0.3097	0.8077
Brugia malayi	Excitatory amino acid transporter	0.0304	0.3771	0.6445
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.01	0.1145	0.2938
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0135	0.0083
Brugia malayi	Pre-SET motif family protein	0.0032	0.0265	0.0452
Loa Loa (eye worm)	excitatory amino acid transporter	0.0304	0.3771	0.6389
Chlamydia trachomatis	neutral amino acid transporter	0.0135	0.1592	0.4139
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.025	0.0341
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0135	0.1592	0.4139
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0304	0.3771	0.3739
Plasmodium falciparum	thioredoxin reductase	0.0044	0.0421	1
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0135	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0265	0.0302
Loa Loa (eye worm)	hypothetical protein	0.005	0.0504	0.0717
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0304	0.3771	0.3739
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1088	1
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0475	0.1137
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0045	0.0429	0.0379
Loa Loa (eye worm)	thioredoxin reductase	0.0044	0.0421	0.0574
Brugia malayi	jmjC domain containing protein	0.0068	0.0735	0.1255
Leishmania major	hypothetical protein, conserved	0.0018	0.009	0.1042
Echinococcus granulosus	neutral amino acid transporter A	0.0304	0.3771	0.6413
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0135	0.2247
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0385	0.0334
Brugia malayi	Thioredoxin reductase	0.0044	0.0421	0.072
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0475	0.0667
Schistosoma mansoni	hypothetical protein	0.004	0.0366	0.0843
Echinococcus granulosus	neutral amino acid transporter A	0.0304	0.3771	0.6413
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0385	0.0511
Echinococcus granulosus	thioredoxin glutathione reductase	0.0045	0.0429	0.065
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0135	0.2247
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0018	0.009	0.1042
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0135	0.0539
Trichomonas vaginalis	set domain proteins, putative	0.0252	0.3097	1
Schistosoma mansoni	protein phosphatase 2C	0.0018	0.009	0.0103
Loa Loa (eye worm)	jmjC domain-containing protein	0.0068	0.0735	0.1118
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0111	0.1289	0.3325
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0459	0.041
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0135	0.2247
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0044	0.0421	0.0992
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0135	0.1592	0.1548
Schistosoma mansoni	hypothetical protein	0.004	0.0366	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0385	0.0511
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0135	0.2247
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0265	0.0214
Brugia malayi	jmjC domain containing protein	0.0018	0.009	0.0155
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0385	0.0574
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0141	0.1664	0.2843
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0265	0.5761
Plasmodium vivax	JmjC domain containing protein	0.0018	0.009	0.1042
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.0304	0.3771	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.1664	0.4333
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.1107	0.2836
Onchocerca volvulus		0.0095	0.1079	0.2322
Echinococcus multilocularis	neutral amino acid transporter A	0.0304	0.3771	0.3739
Toxoplasma gondii	exonuclease III APE	0.0022	0.0135	0.2247
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0068	0.0735	0.1835
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0095	0.1079	0.1844
Leishmania major	trypanothione reductase	0.0044	0.0421	1
Echinococcus granulosus	tumor protein p63	0.0329	0.4083	0.6951
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0265	0.0572
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0111	0.1289	1
Echinococcus granulosus	sodium:dicarboxylate symporter	0.0304	0.3771	0.6413
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0135	1
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0304	0.3771	0.3739
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0018	0.009	0.1042
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0018	0.009	0.1042
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.01	0.1145	0.2938
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0141	0.1664	0.2779
Echinococcus granulosus	neutral amino acid transporter	0.0304	0.3771	0.6413
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0265	0.0367
Schistosoma mansoni	hypothetical protein	0.004	0.0366	0.0843
Mycobacterium tuberculosis	Probable dehydrogenase	0.01	0.1145	0.2938
Loa Loa (eye worm)	MH2 domain-containing protein	0.0097	0.1106	0.1764
Echinococcus multilocularis	phd:f box containing protein	0.0018	0.009	0.0039
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0111	0.1289	0.3325
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0385	0.0574
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0135	0.2247
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.01	0.1145	0.2938
Echinococcus granulosus	phd:f box containing protein	0.0018	0.009	0.0066
Echinococcus granulosus	lysine specific demethylase 5A	0.0068	0.0735	0.1177
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.0304	0.3771	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0141	0.1664	0.2731
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0018	0.009	0.0039
Plasmodium vivax	SET domain protein, putative	0.0032	0.0265	0.5761
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0018	0.009	0.1042
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0265	0.0572
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.0304	0.3771	1
Treponema pallidum	glutamate/aspartate transporter	0.0135	0.1592	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0135	0.0077
Brugia malayi	glutathione reductase	0.0044	0.0421	0.072
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0135	0.0223
Brugia malayi	jmjC domain containing protein	0.0068	0.0735	0.1255
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0135	0.1592	0.1548
Brugia malayi	CHE-14 protein	0.0041	0.0385	0.0657
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1088	0.1786
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1088	0.1731
Echinococcus multilocularis	survival motor neuron protein 1	0.0466	0.5852	0.583
Brugia malayi	Pre-SET motif family protein	0.0221	0.2704	0.4621
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.1616	0.2697
Schistosoma mansoni	phosphatidylserine receptor	0.0018	0.009	0.0103
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.01	0.1145	0.2938
Brugia malayi	jmjC domain containing protein	0.0018	0.009	0.0155
Echinococcus multilocularis	excitatory amino acid transporter 3	0.0304	0.3771	0.3739
Schistosoma mansoni	patched 1	0.0041	0.0385	0.0895
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.1616	0.1572
Echinococcus multilocularis	neutral amino acid transporter A	0.0304	0.3771	0.3739
Echinococcus granulosus	expressed conserved protein	0.009	0.1013	0.1657
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0068	0.0735	0.0686
Echinococcus multilocularis	jumonji domain containing 1A	0.0018	0.009	0.0039
Schistosoma mansoni	hypothetical protein	0.004	0.0366	0.0843
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0015	0.0052	0.0089
Echinococcus multilocularis	lysine specific demethylase 6a	0.0018	0.009	0.0039
Echinococcus multilocularis	lysine specific demethylase 5A	0.0068	0.0735	0.0686
Echinococcus multilocularis	Excitatory amino acid transporter	0.0304	0.3771	0.3739
Trypanosoma brucei	trypanothione reductase	0.0044	0.0421	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0135	0.0231
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0265	0.0572
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0265	0.0572
Mycobacterium tuberculosis	Probable reductase	0.01	0.1145	0.2938
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0135	0.1592	0.4139
Echinococcus granulosus	excitatory amino acid transporter 2	0.0304	0.3771	0.6413
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0385	0.1093
Echinococcus granulosus	excitatory amino acid transporter 3	0.0304	0.3771	0.6413
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.0421	1
Echinococcus multilocularis	JmjC domain containing protein 4	0.0018	0.009	0.0039
Schistosoma mansoni	phd/f-box containing protein	0.0018	0.009	0.0103
Echinococcus multilocularis	neutral amino acid transporter A	0.0304	0.3771	0.3739
Echinococcus granulosus	Excitatory amino acid transporter	0.0304	0.3771	0.6413
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0141	0.1664	0.162
Plasmodium falciparum	glutathione reductase	0.0044	0.0421	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.1664	0.4333
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0221	0.2704	0.4536
Echinococcus granulosus	lysine specific demethylase 6a	0.0018	0.009	0.0066
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0018	0.009	0.1042
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0068	0.0735	0.1177
Schistosoma mansoni	jumonji domain containing protein	0.0018	0.009	0.0103
Echinococcus multilocularis	Excitatory amino acid transporter	0.0304	0.3771	0.3739
Echinococcus multilocularis	expressed conserved protein	0.009	0.1013	0.0966
Echinococcus granulosus	excitatory amino acid transporter 2	0.0304	0.3771	0.6413
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.0304	0.3771	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0111	0.1289	0.3325
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0018	0.009	0.0066
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0135	0.2247
Echinococcus multilocularis	tumor protein p63	0.0329	0.4083	0.4052
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0135	0.0143
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0304	0.3771	0.3739
Brugia malayi	jmjC domain containing protein	0.0018	0.009	0.0155
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0135	0.0223
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0018	0.009	0.0103
Plasmodium vivax	thioredoxin reductase, putative	0.0044	0.0421	1
Toxoplasma gondii	thioredoxin reductase	0.0044	0.0421	1
Schistosoma mansoni	ap endonuclease	0.0022	0.0135	0.0223
Brugia malayi	jmjC domain containing protein	0.0018	0.009	0.0155
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1088	0.1859
Brugia malayi	hypothetical protein	0.0466	0.5852	1
Onchocerca volvulus		0.0048	0.0475	0.06
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0068	0.0735	0.1835
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1088	0.1041
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0141	0.1664	0.162
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0141	0.1664	0.4333
Schistosoma mansoni	ap endonuclease	0.0022	0.0135	0.0223
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0018	0.009	0.1042
Schistosoma mansoni	survival motor neuron protein	0.0095	0.1079	0.2761
Chlamydia trachomatis	glutamate symporter	0.0304	0.3771	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.5852	1
Brugia malayi	MH2 domain containing protein	0.0097	0.1106	0.1891
Echinococcus granulosus	jumonji domain containing 1A	0.0018	0.009	0.0066
Echinococcus granulosus	survival motor neuron protein 1	0.0466	0.5852	1
Plasmodium vivax	glutathione reductase, putative	0.0044	0.0421	1
Treponema pallidum	glutamate transporter	0.0135	0.1592	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0135	1
Schistosoma mansoni	jumonji domain containing protein	0.0068	0.0735	0.1835
Loa Loa (eye worm)	transcription factor SMAD2	0.0097	0.1106	0.1764
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0135	0.0272
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0265	0.0214
Echinococcus granulosus	Excitatory amino acid transporter	0.0304	0.3771	0.6413
Echinococcus multilocularis	protein patched	0.0041	0.0385	0.0334
Echinococcus granulosus	JmjC domain containing protein 4	0.0018	0.009	0.0066
Loa Loa (eye worm)	glutathione reductase	0.0044	0.0421	0.0574

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Activity of human EAAT1 expressed in HEK293 cells up to 100 uM	ChEMBL.	19161278
IC50 (binding)	> 3.5	Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells	ChEMBL.	19161278
IC50 (binding)	> 3.5	Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells	ChEMBL.	19161278
IC50 (binding)	= 6.02	Activity at rat EAAT1 expressed in TSA201 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay	ChEMBL.	19161278
IC50 (binding)	= 6.18	Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells	ChEMBL.	19161278
IC50 (binding)	= 6.18	Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay	ChEMBL.	20857912
IC50 (binding)	= 6.91	Activity at human EAAT1 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay	ChEMBL.	19161278
IC50 (binding)	= 120 nM	Activity at human EAAT1 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay	ChEMBL.	19161278
IC50 (binding)	= 970 nM	Activity at rat EAAT1 expressed in TSA201 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay	ChEMBL.	19161278
IC50 (binding)	= 0.66 uM	Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells	ChEMBL.	19161278
IC50 (binding)	= 0.66 uM	Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay	ChEMBL.	20857912
IC50 (binding)	= 0.66 uM	Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method	ChEMBL.	22594609
IC50 (binding)	> 300 uM	Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells	ChEMBL.	19161278
IC50 (binding)	> 300 uM	Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells	ChEMBL.	19161278
Inhibition (binding)		Inhibition of human EAAT3 expressed in HEK293 cells at 300 uM by [3H]D-Asp uptake assay	ChEMBL.	20857912
Inhibition (binding)		Inhibition of human EAAT2 expressed in HEK293 cells at 300 uM by [3H]D-Asp uptake assay	ChEMBL.	20857912

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL474133

Bibliographic References

3 literature references were collected for this gene.

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Detailed information for compound 976566