Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0205 | 0.1382 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0205 | 0.1382 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0205 | 0.1382 | 0.1382 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0125 | 0.0698 | 0.0698 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0205 | 0.1382 | 0.1382 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0205 | 0.1382 | 0.1382 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0205 | 0.1382 | 0.1382 |
Onchocerca volvulus | 0.0205 | 0.1382 | 0.5 | |
Trypanosoma brucei | trypanothione reductase | 0.0125 | 0.0698 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0205 | 0.1382 | 0.1382 |
Toxoplasma gondii | thioredoxin reductase | 0.0125 | 0.0698 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0205 | 0.1382 | 1 |
Echinococcus granulosus | neuroligin | 0.0205 | 0.1382 | 0.1382 |
Brugia malayi | Carboxylesterase family protein | 0.1216 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0205 | 0.1382 | 0.1382 |
Echinococcus granulosus | acetylcholinesterase | 0.1216 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0205 | 0.1382 | 0.1382 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0043 | 0 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1382 | 0.0736 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0205 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1382 | 0.0736 |
Echinococcus granulosus | carboxylesterase 5A | 0.1216 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0043 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0205 | 0.1382 | 0.1382 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0205 | 0.1382 | 0.1382 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0043 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0125 | 0.0698 | 1 |
Brugia malayi | glutathione reductase | 0.0125 | 0.0698 | 0.0698 |
Brugia malayi | Carboxylesterase family protein | 0.0205 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1382 | 0.0736 |
Onchocerca volvulus | 0.0205 | 0.1382 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1382 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.1216 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0125 | 0.0698 | 0.0698 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1216 | 1 | 1 |
Onchocerca volvulus | 0.0205 | 0.1382 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1382 | 0.0736 |
Brugia malayi | Thioredoxin reductase | 0.0125 | 0.0698 | 0.0698 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0205 | 0.1382 | 0.1382 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0205 | 0.1382 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0043 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0125 | 0.0698 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1216 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0205 | 0.1382 | 0.1382 |
Echinococcus multilocularis | acetylcholinesterase | 0.1216 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0205 | 0.1382 | 0.0736 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0205 | 0.1382 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1216 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0205 | 0.1382 | 0.1382 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0205 | 0.1382 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0205 | 0.1382 | 0.1382 |
Onchocerca volvulus | 0.0205 | 0.1382 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1382 | 0.0736 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0125 | 0.0698 | 0.5048 |
Loa Loa (eye worm) | carboxylesterase | 0.0205 | 0.1382 | 0.0736 |
Leishmania major | trypanothione reductase | 0.0125 | 0.0698 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0125 | 0.0698 | 1 |
Schistosoma mansoni | gliotactin | 0.0205 | 0.1382 | 0.1382 |
Brugia malayi | hypothetical protein | 0.0205 | 0.1382 | 0.1382 |
Onchocerca volvulus | 0.0205 | 0.1382 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1216 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1382 | 0.0736 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0205 | 0.1382 | 0.1382 |
Brugia malayi | Carboxylesterase family protein | 0.0205 | 0.1382 | 0.1382 |
Plasmodium vivax | glutathione reductase, putative | 0.0125 | 0.0698 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0125 | 0.0698 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1216 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1216 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1216 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 69 uM | Cytotoxicity against human MT4 cells by MTT assay | ChEMBL. | 19058881 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.