TDR Targets

Basic information

Technical information

TDR Targets ID: 976700
Name: N-(3-chloro-4-hydroxynaphthalen-1-yl)-2,4-dim ethylbenzenesulfonamide
MW: 361.843 | Formula: C18H16ClNO3S
H donors: 2 H acceptors: 3 LogP: 4.7 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)C)S(=O)(=O)Nc1cc(Cl)c(c2c1cccc2)O
InChi: 1S/C18H16ClNO3S/c1-11-7-8-17(12(2)9-11)24(22,23)20-16-10-15(19)18(21)14-6-4-3-5-13(14)16/h3-10,20-21H,1-2H3
InChiKey: HUKBNTCGEZRIAK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-chloro-4-hydroxy-1-naphthyl)-2,4-dimethyl-benzenesulfonamide
N-(3-chloro-4-hydroxy-1-naphthyl)-2,4-dimethylbenzenesulfonamide
N-(3-chloro-4-hydroxy-naphthalen-1-yl)-2,4-dimethyl-benzenesulfonamide
ZINC00972017
AG-690/15438123

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	hydroxysteroid 11-beta dehydrogenase 1	Starlite/ChEMBL	References
Homo sapiens	hydroxysteroid (11-beta) dehydrogenase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	short chain dehydrogenase	Get druggable targets OG5_132866	All targets in OG5_132866
Mycobacterium tuberculosis	Probable oxidoreductase	Get druggable targets OG5_132866	All targets in OG5_132866

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxysteroid 11-beta dehydrogenase 1	292 aa	246 aa	25.2 %
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxysteroid (11-beta) dehydrogenase 1	292 aa	250 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0084	0.084	0.0734
Toxoplasma gondii	proliferation-associated protein 2G4, putative	0.0084	0.084	0.0734
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0084	0.084	0.0734
Echinococcus granulosus	Proliferation associated protein 2G4	0.0084	0.084	0.0811
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0019	0.0031	0.0031
Leishmania major	hypothetical protein, conserved	0.0084	0.084	0.0734
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0575	0.0546
Plasmodium falciparum	FACT complex subunit SPT16, putative	0.0084	0.084	0.0734
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0815	1	1
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Leishmania major	hypothetical protein, conserved	0.0153	0.1709	0.1613
Chlamydia trachomatis	methionine aminopeptidase	0.0662	0.8083	1
Toxoplasma gondii	peptidase D, putative	0.0084	0.084	0.0734
Trypanosoma cruzi	hypothetical protein, conserved	0.0153	0.1709	0.1613
Schistosoma mansoni	hypothetical protein	0.0037	0.0252	0.0274
Brugia malayi	Cation transporter family protein	0.0019	0.0031	0.0031
Echinococcus granulosus	xaa Pro dipeptidase	0.0084	0.084	0.0811
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0084	0.084	0.0734
Trypanosoma cruzi	aminopeptidase P1, putative	0.0084	0.084	0.0734
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0662	0.8083	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0019	0.0031	0.0031
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0084	0.084	0.084
Plasmodium falciparum	methionine aminopeptidase 2	0.0084	0.084	0.0734
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0027	0.0125	0.0011
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0575	0.0546
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0031	0.0031
Brugia malayi	metallopeptidase family M24 containing protein	0.0084	0.084	0.084
Plasmodium vivax	proliferation-associated protein 2g4, putative	0.0084	0.084	0.0734
Toxoplasma gondii	transcriptional elongation factor FACT140	0.0084	0.084	0.0734
Giardia lamblia	Methionine aminopeptidase	0.0084	0.084	1
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0084	0.084	0.0811
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0084	0.084	0.0811
Echinococcus multilocularis	FACT complex subunit SPT16	0.0084	0.084	0.0811
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0662	0.8083	0.8077
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0031	0.0031
Trypanosoma cruzi	aminopeptidase P, putative	0.0084	0.084	0.0734
Brugia malayi	Cation transporter family protein	0.0019	0.0031	0.0031
Plasmodium falciparum	proliferation-associated protein 2g4, putative	0.0084	0.084	0.0734
Plasmodium vivax	hypothetical protein, conserved	0.0153	0.1709	0.1613
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0115	0.0085
Echinococcus granulosus	methionine aminopeptidase type I	0.0084	0.084	0.0811
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0019	0.0031	0.0031
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0662	0.8083	1
Brugia malayi	Cation transporter family protein	0.0019	0.0031	0.0031
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0027	0.0125	0.0011
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0019	0.0031	0.0031
Echinococcus multilocularis	flap endonuclease 1	0.0027	0.0125	0.0094
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0084	0.084	0.0734
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0084	0.084	0.1004
Echinococcus multilocularis	xaa pro aminopeptidase	0.0084	0.084	0.0811
Trypanosoma brucei	methionine aminopeptidase, putative	0.0815	1	1
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0084	0.084	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0114	0.0083
Onchocerca volvulus		0.0084	0.084	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0252	0.1774
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0031	0.0031
Brugia malayi	Flap endonuclease-1	0.0027	0.0125	0.0125
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Toxoplasma gondii	hypothetical protein	0.0153	0.1709	0.1613
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0662	0.8083	1
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0815	1	1
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0084	0.084	0.0811
Plasmodium falciparum	HP12 protein homolog, putative	0.0153	0.1709	0.1613
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0815	1	1
Leishmania major	aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0252	0.0221
Giardia lamblia	Xaa-Pro dipeptidase	0.0084	0.084	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.084	0.0811
Giardia lamblia	Xaa-Pro dipeptidase	0.0084	0.084	1
Plasmodium falciparum	aminopeptidase P	0.0084	0.084	0.0734
Leishmania major	methionine aminopeptidase 2, putative	0.0084	0.084	0.0734
Entamoeba histolytica	methionine aminopeptidase, putative	0.0084	0.084	1
Plasmodium vivax	methionine aminopeptidase 1c, putative	0.0084	0.084	0.0734
Brugia malayi	initiation factor 2-associated protein.	0.0084	0.084	0.084
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0575	0.0675
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0662	0.8083	0.9769
Plasmodium falciparum	methionine aminopeptidase 1c, putative	0.0084	0.084	0.0734
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Brugia malayi	metallopeptidase family M24 containing protein	0.0084	0.084	0.084
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0027	0.0125	0.0011
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0031	0.0031
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0575	0.0546
Plasmodium vivax	flap endonuclease 1, putative	0.0027	0.0125	0.0011
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0031	0.0031
Trypanosoma brucei	hypothetical protein, conserved	0.0153	0.1709	0.1613
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0662	0.8083	0.9769
Treponema pallidum	methionine aminopeptidase (map)	0.0662	0.8083	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0252	0.0221
Mycobacterium ulcerans	methionine aminopeptidase	0.0662	0.8083	0.9769
Toxoplasma gondii	methionine aminopeptidase	0.0815	1	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0252	0.1774
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0084	0.084	0.0811
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0019	0.0031	0.0031
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0019	0.0031	0.0031
Mycobacterium ulcerans	short chain dehydrogenase	0.0676	0.8255	1
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0575	0.0546
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0084	0.084	0.1004
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0084	0.084	0.1004
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0815	1	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Echinococcus multilocularis	xaa Pro dipeptidase	0.0084	0.084	0.0811
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0031	0.0031
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0575	0.0675
Loa Loa (eye worm)	DNA-binding protein	0.0084	0.084	0.0811
Echinococcus granulosus	methionyl aminopeptidase 2	0.0084	0.084	0.0811
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0575	0.0546
Leishmania major	transcription factor-like protein	0.0084	0.084	0.0734
Trypanosoma cruzi	hypothetical protein, conserved	0.0153	0.1709	0.1613
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.0084	0.084	0.0734
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Brugia malayi	RNA binding protein	0.0063	0.0575	0.0575
Plasmodium vivax	peptidase, putative	0.0084	0.084	0.0734
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0115	0.0115
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0084	0.084	0.1004
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Schistosoma mansoni	flap endonuclease-1	0.0024	0.0093	0.0077
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0084	0.084	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Brugia malayi	metallopeptidase family M24 containing protein	0.0084	0.084	0.084
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0575	0.0675
Loa Loa (eye worm)	flap endonuclease-1	0.0027	0.0125	0.0094
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Brugia malayi	hypothetical protein	0.0026	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0084	0.084	0.0811
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0252	0.0274
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Entamoeba histolytica	hypothetical protein	0.0037	0.0252	0.1774
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0662	0.8083	0.9769
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0815	1	1
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0084	0.084	0.1004
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0019	0.0031	0.0031
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0575	0.0675
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0031	0.0031
Entamoeba histolytica	hypothetical protein, conserved	0.0084	0.084	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.084	0.0811
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0084	0.084	0.0811
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Echinococcus granulosus	FACT complex subunit SPT16	0.0084	0.084	0.0811
Onchocerca volvulus	FACT complex subunit SPT16 homolog	0.0084	0.084	1
Onchocerca volvulus	Dipeptidase C homolog	0.0084	0.084	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0815	1	1
Entamoeba histolytica	aminopeptidase, putative	0.0084	0.084	1
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0815	1	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0084	0.084	0.0734
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0662	0.8083	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0084	0.084	0.0734
Entamoeba histolytica	hypothetical protein	0.0037	0.0252	0.1774
Mycobacterium tuberculosis	Probable oxidoreductase	0.0676	0.8255	1
Toxoplasma gondii	creatinase domain-containing protein	0.0084	0.084	0.0734
Echinococcus multilocularis	xaa Pro dipeptidase	0.0084	0.084	0.0811
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0084	0.084	0.1004
Entamoeba histolytica	peptidase, putative	0.0084	0.084	1
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0084	0.084	0.0811
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0815	1	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0019	0.0031	0.0031
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0027	0.0125	0.0011
Toxoplasma gondii	methionine aminopeptidase	0.0662	0.8083	0.8061
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0662	0.8083	0.8061
Brugia malayi	hypothetical protein	0.0037	0.0252	0.0252
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0084	0.084	0.0734
Entamoeba histolytica	Xaa-Pro dipeptidase, putative	0.0084	0.084	1
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0084	0.084	0.0734
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0031	0.0031
Brugia malayi	TAR-binding protein	0.0063	0.0575	0.0575
Echinococcus granulosus	xaa Pro dipeptidase	0.0084	0.084	0.0811
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0575	0.0675
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0084	0.084	0.0811
Plasmodium vivax	FACT complex subunit SPT16, putative	0.0084	0.084	0.0734
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0084	0.084	0.0734
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0031	0.0031
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0662	0.8083	0.8061
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0662	0.8083	1
Echinococcus granulosus	flap endonuclease 1	0.0027	0.0125	0.0094
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0084	0.084	0.0734
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0084	0.084	0.1004
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0662	0.8083	0.8061
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0815	1	1
Echinococcus granulosus	xaa pro aminopeptidase	0.0084	0.084	0.0811
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0815	1	1
Plasmodium falciparum	flap endonuclease 1	0.0027	0.0125	0.0011
Schistosoma mansoni	peptidase	0.0084	0.084	0.1004
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0084	0.084	1
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0575	0.0575

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in presence of NADPH	ChEMBL.	18653260
IC50 (binding)	= 4 uM	Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in presence of NADPH	ChEMBL.	18653260
IC50 (binding)	> 10 uM	Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in presence of NADPH	ChEMBL.	18653260
Inhibition (binding)		Inhibition of mouse 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol at 100 uM by scintillation proximity assay in presence of NADPH	ChEMBL.	18653260
Inhibition (binding)		Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol at 100 uM by scintillation proximity assay in presence of NADPH	ChEMBL.	18653260

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL474575

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 976700