Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuropeptides capa receptor | Histamine H3 receptor | 445 aa | 441 aa | 20.4 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 412 aa | 23.8 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 386 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.0549 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Echinococcus granulosus | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Onchocerca volvulus | 1.0162 | 0.9632 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.0162 | 0.9632 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.0549 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1011 | 0.0929 | 0.0965 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.0549 | 1 | 1 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0101 | 0.0064 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1011 | 0.0929 | 0.0904 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.0549 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Brugia malayi | thymidylate synthase | 1.0162 | 0.9632 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.0162 | 0.9632 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4834 | 0.4565 | 1 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0101 | 0.0064 | 0.0067 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0101 | 0.0064 | 0.0067 |
Echinococcus granulosus | dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1011 | 0.0929 | 0.0965 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.0549 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.4834 | 0.4565 | 0.453 |
Mycobacterium tuberculosis | Hypothetical protein | 0.4834 | 0.4565 | 0.474 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1011 | 0.0929 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0101 | 0.0064 | 0.0067 |
Brugia malayi | hypothetical protein | 0.4834 | 0.4565 | 0.4704 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0154 | 0.0114 | 0.0118 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1011 | 0.0929 | 0.0965 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.0162 | 0.9632 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0101 | 0.0064 | 0.0067 |
Schistosoma mansoni | dihydrofolate reductase | 0.1011 | 0.0929 | 0.0904 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0154 | 0.0114 | 0.0118 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0154 | 0.0114 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | > 4 | Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as histamine-induced contractions | ChEMBL. | 18990469 |
Kd (functional) | = 7.78 | Antagonist activity at histamine H3 receptor in guinea pig jejunum assessed as electrically evoked contractions | ChEMBL. | 18990469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.