TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 370.328 | Formula: C19H13F3N4O
H donors: 0 H acceptors: 3 LogP: 4.73 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)/C=C/c1nc2ccccc2n2c1nnc2C(F)(F)F
InChi: 1S/C19H13F3N4O/c1-27-13-9-6-12(7-10-13)8-11-15-17-24-25-18(19(20,21)22)26(17)16-5-3-2-4-14(16)23-15/h2-11H,1H3/b11-8+
InChiKey: JHBQEEJBMNHAQD-DHZHZOJOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Echinococcus granulosus	discoidin domain receptor	0.0031	0.0003	0.0003
Brugia malayi	celfurPC protein	0.2003	0.7973	0.7973
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0111	0.0324	1
Echinococcus granulosus	c4b binding protein beta chain	0.0035	0.0017	0.0017
Onchocerca volvulus		0.0035	0.0017	0.0417
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0035	0.0017	0.0013
Echinococcus granulosus	Coagulation factor 5 8 type C terminal	0.0031	0.0003	0.0003
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0324	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Leishmania major	hypothetical protein, conserved	0.0051	0.0082	0.2537
Brugia malayi	Kringle domain containing protein	0.0051	0.0082	0.0079
Schistosoma mansoni	hypothetical protein	0.0501	0.1903	0.1903
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Brugia malayi	hypothetical protein	0.0035	0.0017	0.0013
Loa Loa (eye worm)	endoprotease bli-4	0.2504	1	1
Plasmodium falciparum	plasmepsin V	0.0126	0.0385	1
Brugia malayi	hypothetical protein	0.0068	0.0151	0.0148
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1533	0.6072	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Echinococcus multilocularis	epidermal growth factor receptor	0.0251	0.0891	0.1118
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Trichomonas vaginalis	beta-hexosaminidase B, putative	0.0031	0.0003	0.0006
Brugia malayi	hypothetical protein	0.0035	0.0017	0.0013
Schistosoma mansoni	btb and poz domain-containing protein	0.0031	0.0003	0.0003
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Toxoplasma gondii	aspartyl protease ASP5	0.0115	0.034	1
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0324	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1533	0.6072	0.6072
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0151	0.0148
Schistosoma mansoni	growth factor receptor-bound protein	0.0127	0.0389	0.0389
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Onchocerca volvulus		0.0068	0.0151	0.4607
Toxoplasma gondii	subtilisin SUB11	0.0111	0.0324	0.9536
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0048	0.007	0.5
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0111	0.0324	0.0321
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.235	0.3871
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0082	0.0079
Entamoeba histolytica	hypothetical protein	0.0048	0.007	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.007	0.0066
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0111	0.0324	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0051	0.0082	0.0079
Brugia malayi	hypothetical protein	0.0035	0.0017	0.0013
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0035	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0111	0.0324	0.0321
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0111	0.0324	0.0324
Toxoplasma gondii	rhoptry neck protein RON9	0.0035	0.0017	0.0492
Plasmodium vivax	subtilisin-like protease 1	0.0111	0.0324	0.8416
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0251	0.0891	0.0888
Echinococcus granulosus	furin	0.2504	1	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0111	0.0324	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.235	0.3871
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1533	0.6072	0.7615
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0129	0.0399	1
Plasmodium falciparum	subtilisin-like protease 2	0.0111	0.0324	0.8416
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0111	0.0324	0.5
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0111	0.0324	0.5
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0111	0.0324	0.0406
Toxoplasma gondii	subtilisin SUB10	0.0111	0.0324	0.9536
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0031	0.0003	0.0098
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0129	0.0399	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0013
Schistosoma mansoni	hypothetical protein	0.0068	0.0151	0.0151
Echinococcus granulosus	discoidin domain containing receptor 2	0.0031	0.0003	0.0003
Onchocerca volvulus		0.0035	0.0017	0.0417
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Onchocerca volvulus		0.0035	0.0017	0.0417
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1533	0.6072	1
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0031	0.0003	0.0004
Echinococcus multilocularis	neuroendocrine convertase 2	0.1584	0.6279	0.7874
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0031	0.0003	0.0004
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0111	0.0324	0.0324
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Plasmodium vivax	apical sushi protein, putative	0.0035	0.0017	0.0434
Schistosoma mansoni	furin-1 (S08 family)	0.1083	0.4252	0.4252
Onchocerca volvulus		0.0077	0.0188	0.5772
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0031	0.0003	0.0098
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Brugia malayi	Furin-like cysteine rich region family protein	0.0251	0.0891	0.0888
Onchocerca volvulus		0.0035	0.0017	0.0417
Toxoplasma gondii	kringle domain-containing protein	0.0051	0.0082	0.242
Plasmodium vivax	subtilisin-like serine protease, putative	0.0111	0.0324	0.8416
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0111	0.0324	0.0324
Brugia malayi	Angiotensin-converting enzyme family protein	0.0625	0.2404	0.2402
Onchocerca volvulus		0.0035	0.0017	0.0417
Echinococcus multilocularis	c4b binding protein beta chain	0.0035	0.0017	0.0021
Brugia malayi	Sex muscle abnormal protein 5	0.0127	0.0389	0.0386
Schistosoma mansoni	growth factor receptor-bound protein	0.0127	0.0389	0.0389
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0082	0.0079
Brugia malayi	GCC2 and GCC3 family protein	0.0043	0.0052	0.0048
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Plasmodium vivax	plasmepsin V, putative	0.0126	0.0385	1
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0111	0.0324	1
Echinococcus multilocularis	tissue type plasminogen activator	0.0051	0.0082	0.0103
Toxoplasma gondii	PA14 domain-containing protein	0.0031	0.0003	0.0098
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0035	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0013
Toxoplasma gondii	subtilisin SUB1	0.0111	0.0324	0.9536
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0111	0.0324	0.0324
Plasmodium vivax	subtilisin-like protease 2, putative	0.0111	0.0324	0.8416
Brugia malayi	Subtilase family protein	0.0111	0.0324	0.0321
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0972	0.3804	0.3802
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0082	0.0378
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Toxoplasma gondii	subtilisin SUB2	0.0111	0.0324	0.9536
Plasmodium vivax	LCCL domain-containing protein	0.0031	0.0003	0.0087
Plasmodium falciparum	apical sushi protein	0.0035	0.0017	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0013
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Brugia malayi	hypothetical protein	0.0035	0.0017	0.0013
Brugia malayi	hypothetical protein	0.0048	0.007	0.0066
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0031	0.0003	0.0006
Echinococcus multilocularis	Furin 1	0.0612	0.235	0.2948
Schistosoma mansoni	hypothetical protein	0.0068	0.0151	0.0151
Schistosoma mansoni	septate junction protein	0.004	0.0038	0.0038
Echinococcus granulosus	membrane bound transcription factor site 1	0.0111	0.0324	0.0324
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.007	0.0161	0.0161
Echinococcus multilocularis	nuclear receptor 2C2 associated protein	0.0031	0.0003	0.0004
Onchocerca volvulus		0.0035	0.0017	0.0417
Schistosoma mansoni	dock	0.0031	0.0003	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Plasmodium falciparum	LCCL domain-containing protein	0.0031	0.0003	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Onchocerca volvulus		0.0111	0.0324	1
Echinococcus granulosus	tissue type plasminogen activator	0.0051	0.0082	0.0082
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.235	0.3871
Schistosoma mansoni	hypothetical protein	0.0031	0.0003	0.0003
Mycobacterium leprae	Possible secreted protease	0.0111	0.0324	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Plasmodium vivax	LCCL domain-containing protein	0.0031	0.0003	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0324	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0151	0.0148
Loa Loa (eye worm)	proprotein convertase 2	0.0612	0.235	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0052	0.0048
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Loa Loa (eye worm)	subtilase	0.0111	0.0324	0.0321
Onchocerca volvulus		0.0068	0.0151	0.4607
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0129	0.0399	1
Brugia malayi	proprotein convertase 2	0.1584	0.6279	0.6277
Giardia lamblia	High cysteine membrane protein Group 2	0.0921	0.3598	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0127	0.0389	0.0386
Schistosoma mansoni	c4b-binding protein beta chain	0.0035	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534
Brugia malayi	pregnancy-associated plasma protein-A	0.0035	0.0017	0.0013
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0501	0.1903	0.3134
Loa Loa (eye worm)	TK/ALK protein kinase	0.0068	0.0151	0.0148
Brugia malayi	Sushi domain	0.0035	0.0017	0.0013
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0051	0.0082	0.2135
Plasmodium falciparum	subtilisin-like protease 1	0.0111	0.0324	0.8416
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0612	0.235	0.235
Echinococcus multilocularis	MAM	0.0068	0.0151	0.0189
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0501	0.1903	0.3134
Toxoplasma gondii	subtilisin SUB6	0.0111	0.0324	0.9536
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0324	0.0534
Echinococcus multilocularis	Coagulation factor 5 8 type, C terminal	0.0031	0.0003	0.0004
Echinococcus multilocularis	discoidin domain containing receptor 2	0.0031	0.0003	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0151	0.0148
Trichomonas vaginalis	hypothetical protein	0.0501	0.1903	0.3134
Onchocerca volvulus		0.0035	0.0017	0.0417
Toxoplasma gondii	rhoptry neck protein RON1	0.0035	0.0017	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0013
Plasmodium falciparum	LCCL domain-containing protein	0.0031	0.0003	0.0087
Toxoplasma gondii	subtilisin SUB7	0.0111	0.0324	0.9536
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0324	0.0321
Onchocerca volvulus		0.0035	0.0017	0.0417
Echinococcus granulosus	discoidin domain containing receptor 2	0.0031	0.0003	0.0003
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.2504	1	1
Trichomonas vaginalis	hypothetical protein	0.0031	0.0003	0.0006
Schistosoma mansoni	tyrosine kinase	0.0251	0.0891	0.0891
Echinococcus multilocularis		0.2003	0.7973	1
Schistosoma mansoni	discoidin domain receptor	0.0031	0.0003	0.0003
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0111	0.0324	0.0406
Toxoplasma gondii	subtilisin SUB8	0.0111	0.0324	0.9536
Brugia malayi	hypothetical protein	0.0035	0.0017	0.0013
Toxoplasma gondii	subtilisin SUB12	0.0111	0.0324	0.9536
Echinococcus granulosus	neuroendocrine convertase 2	0.1584	0.6279	0.6279
Onchocerca volvulus		0.0035	0.0017	0.0417
Toxoplasma gondii	subtilisin SUB4	0.0111	0.0324	0.9536
Toxoplasma gondii	subtilisin SUB9	0.0111	0.0324	0.9536
Echinococcus granulosus	epidermal growth factor receptor	0.0251	0.0891	0.0891
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0031	0.0003	0.0006
Plasmodium falciparum	cysteine repeat modular protein 1	0.0051	0.0082	0.2135
Loa Loa (eye worm)	hypothetical protein	0.2504	1	1
Onchocerca volvulus		0.0051	0.0082	0.246
Echinococcus granulosus	C type lectin domian containing protein	0.0035	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Echinococcus granulosus	growth factor receptor bound protein 2	0.0127	0.0389	0.0389
Echinococcus granulosus	MAM	0.0068	0.0151	0.0151
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0111	0.0324	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0219	0.0216
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0111	0.0324	1
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0111	0.0324	0.7715
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.235	0.3871
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0501	0.1903	0.3134
Leishmania major	subtilisin-like serine peptidase	0.0111	0.0324	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0003	0.0006
Brugia malayi	hypothetical protein	0.0035	0.0017	0.0013
Onchocerca volvulus		0.0035	0.0017	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0151	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0013
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.235	0.3871
Trypanosoma brucei	subtilisin peptidase	0.0111	0.0324	0.7715
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0111	0.0324	0.5
Plasmodium falciparum	subtilisin-like protease 3	0.0111	0.0324	0.8416
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0013
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0111	0.0324	0.0324
Echinococcus granulosus	Furin 1	0.0612	0.235	0.235
Toxoplasma gondii	F5/8 type C domain-containing protein	0.0031	0.0003	0.0098
Brugia malayi	hypothetical protein	0.0035	0.0017	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0324	0.0534
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0625	0.2404	0.2402
Schistosoma mansoni	discoidin domain receptor	0.0031	0.0003	0.0003
Echinococcus multilocularis	discoidin domain receptor	0.0031	0.0003	0.0004
Toxoplasma gondii	subtilisin SUB5	0.0111	0.0324	0.9536
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0127	0.0389	0.0488
Trypanosoma cruzi	subtilisin peptidase	0.0111	0.0324	0.7715
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0612	0.235	0.3871
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Schistosoma mansoni	hypothetical protein	0.0051	0.0082	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.1903	0.3134
Brugia malayi	neuroendocrine convertase 1 precursor	0.1584	0.6279	0.6277
Echinococcus multilocularis	C type lectin domian containing protein	0.0035	0.0017	0.0021
Echinococcus granulosus	discoidin domain containing receptor 2	0.0031	0.0003	0.0003
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0111	0.0324	0.0534

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 100 %	Anticonvulsant activity in Swiss albino mouse assessed as protection against pentylenetetrazole-induced seizures at 10 mg/kg administered 1 hr before PTZ challenge relative to control	ChEMBL.	18672315
Activity (functional)	= 0 s	Anticonvulsant activity in Swiss albino mouse assessed as duration of pentylenetetrazole-induced seizures at 10 mg/kg administered 1 hr before PTZ challenge	ChEMBL.	18672315

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL474240

Bibliographic References

No literature references available for this target.

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Detailed information for compound 976859