Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | flavodoxin family protein | 0.0086 | 0.2911 | 0.2405 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0086 | 0.2911 | 0.2405 |
Leishmania major | p450 reductase, putative | 0.0086 | 0.2911 | 0.086 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0086 | 0.2911 | 0.1289 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0086 | 0.2911 | 0.1289 |
Chlamydia trachomatis | sulfite reductase | 0.0053 | 0.0667 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0086 | 0.2911 | 0.1289 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0086 | 0.2911 | 0.1289 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0086 | 0.2911 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0076 | 0.2244 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0086 | 0.2911 | 0.1289 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0086 | 0.2911 | 0.086 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0086 | 0.2911 | 0.2405 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0086 | 0.2911 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0086 | 0.2911 | 0.1289 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0086 | 0.2911 | 0.1289 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0086 | 0.2911 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0086 | 0.2911 | 0.2405 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0086 | 0.2911 | 0.2405 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0086 | 0.2911 | 0.2911 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2911 | 0.2405 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0076 | 0.2244 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0053 | 0.0667 | 0.0667 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0086 | 0.2911 | 0.2405 |
Brugia malayi | FAD binding domain containing protein | 0.0086 | 0.2911 | 0.2405 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0086 | 0.2911 | 0.1289 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0086 | 0.2911 | 0.5 |
Leishmania major | 0.0189 | 1 | 1 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.3 uM | Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry | ChEMBL. | 19348494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.