Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.029 | 0.0211 | 0.0284 |
Echinococcus granulosus | protein kinase c iota type | 0.0433 | 0.1207 | 0.3514 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | raf kinase | 0.0277 | 0.0123 | 0.0123 |
Brugia malayi | Protein kinase domain containing protein | 0.0286 | 0.0182 | 0.0061 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0684 | 0.2956 | 0.9184 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0684 | 0.2956 | 0.2936 |
Loa Loa (eye worm) | hypothetical protein | 0.1112 | 0.5939 | 0.5939 |
Echinococcus granulosus | unc 13 munc13 | 0.029 | 0.0211 | 0.0284 |
Echinococcus granulosus | protein kinase C gamma type | 0.0407 | 0.1025 | 0.2924 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.1663 | 0.9775 | 0.9775 |
Echinococcus granulosus | protein kinase c epsilon type | 0.072 | 0.3208 | 1 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0318 | 0.0407 | 0.0921 |
Loa Loa (eye worm) | hypothetical protein | 0.1377 | 0.7784 | 0.7784 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.1663 | 0.9775 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0123 | 0.0123 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0283 | 0.0164 | 0.0133 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0277 | 0.0123 | 0.0123 |
Echinococcus granulosus | myotubularin protein 13 | 0.0318 | 0.0407 | 0.0921 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | hypothetical protein | 0.0991 | 0.5092 | 0.5092 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.029 | 0.0211 | 0.0284 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.072 | 0.3208 | 0.3208 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0286 | 0.0182 | 0.0191 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0286 | 0.0182 | 0.0061 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0286 | 0.0182 | 0.0061 |
Onchocerca volvulus | 0.1654 | 0.9716 | 0.971 | |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0123 | 0.0123 |
Brugia malayi | C1-like domain containing protein | 0.1663 | 0.9775 | 1 |
Onchocerca volvulus | 0.0835 | 0.4008 | 0.3879 | |
Loa Loa (eye worm) | hypothetical protein | 0.1377 | 0.7784 | 0.7784 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.1785 | 0.1785 |
Loa Loa (eye worm) | hypothetical protein | 0.1654 | 0.9716 | 0.9716 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.072 | 0.3208 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0286 | 0.0182 | 0.0191 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0684 | 0.2956 | 0.2936 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0684 | 0.2956 | 0.9184 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.043 | 0.1189 | 0.3455 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 0.4008 | 0.4008 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0123 | 0.0123 |
Schistosoma mansoni | unc-13 (munc13) | 0.029 | 0.0211 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0123 | 0.0123 |
Brugia malayi | protein kinase C II. | 0.072 | 0.3208 | 0.3196 |
Schistosoma mansoni | vav2 | 0.0318 | 0.0407 | 0.0294 |
Schistosoma mansoni | atypical protein kinase C | 0.0433 | 0.1207 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.0407 | 0.0407 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0277 | 0.0123 | 0.5 |
Brugia malayi | protein kinase C3,putative | 0.0286 | 0.0182 | 0.0061 |
Schistosoma mansoni | serine/threonine protein kinase | 0.072 | 0.3208 | 0.3196 |
Onchocerca volvulus | 0.1695 | 1 | 1 | |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0324 | 0.0448 | 1 |
Echinococcus multilocularis | unc 13 (munc13) | 0.029 | 0.0211 | 0.0284 |
Brugia malayi | Pleckstrin Homology Domain | 0.0318 | 0.0407 | 0.0294 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0407 | 0.1025 | 0.2924 |
Schistosoma mansoni | protein kinase C mu | 0.1663 | 0.9775 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.0211 | 0.0211 |
Onchocerca volvulus | 0.1377 | 0.7784 | 0.7737 | |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0277 | 0.0123 | 0.0123 |
Brugia malayi | Protein kinase c protein 2 | 0.0537 | 0.1931 | 0.1874 |
Schistosoma mansoni | unc-13 (munc13) | 0.029 | 0.0211 | 0.0091 |
Schistosoma mansoni | protein kinase C | 0.029 | 0.0211 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0277 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0277 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0286 | 0.0182 | 0.0182 |
Echinococcus multilocularis | protein kinase c iota type | 0.0433 | 0.1207 | 0.3514 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.1385 | 0.7843 | 0.7843 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 56.2 uM | Anticancer activity against human KB cells after 3 days by SRB assay | ChEMBL. | 20735140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.