Detailed information for compound 977120

Basic information

Technical information
  • TDR Targets ID: 977120
  • Name: 2-fluoro-4-(4-heptylphenyl)benzoic acid
  • MW: 314.394 | Formula: C20H23FO2
  • H donors: 1 H acceptors: 2 LogP: 6.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCc1ccc(cc1)c1ccc(c(c1)F)C(=O)O
  • InChi: 1S/C20H23FO2/c1-2-3-4-5-6-7-15-8-10-16(11-9-15)17-12-13-18(20(22)23)19(21)14-17/h8-14H,2-7H2,1H3,(H,22,23)
  • InChiKey: DBNHLTPJKKCXJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens retinoic acid receptor, beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131607 All targets in OG5_131607
Brugia malayi nuclear hormone receptor Get druggable targets OG5_131607 All targets in OG5_131607
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) nuclear receptor nhr-7B Get druggable targets OG5_131607 All targets in OG5_131607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0058 0.0651
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.03 0.0588
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0386 0.0366
Onchocerca volvulus 0.0069 0.0359 0.0656
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Brugia malayi hypothetical protein 0.0045 0.0206 0.04
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0167
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0267 0.0267
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.006 0.03 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.1298 0.38
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.0206 0.3923
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0099 0.0099
Brugia malayi hypothetical protein 0.0032 0.012 0.0227
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0384 0.0364
Plasmodium falciparum thioredoxin reductase 0.0055 0.0267 0.52
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.1298 0.38
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Brugia malayi CXXC zinc finger family protein 0.0033 0.013 0.0247
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0016 0.002 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.006 0.03 0.03
Entamoeba histolytica hypothetical protein 0.0041 0.0179 0.124
Schistosoma mansoni kinase 0.011 0.062 0.0601
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0099 0.0099
Onchocerca volvulus Protein ultraspiracle homolog 0.006 0.03 0.0542
Brugia malayi AMP-binding enzyme family protein 0.0016 0.002 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.0131
Onchocerca volvulus Bile acid receptor homolog 0.006 0.03 0.0542
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0058 0.0102
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.0602
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0495 0.6049
Entamoeba histolytica hypothetical protein 0.0041 0.0179 0.124
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0244
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0099 0.0099
Schistosoma mansoni zinc finger protein 0.0028 0.0099 0.0079
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0217 0.1298 0.2604
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.006 0.03 0.03
Echinococcus multilocularis dna polymerase eta 0.0022 0.0058 0.0058
Giardia lamblia DINP protein human, muc B family 0.0022 0.0058 0.0149
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.013 0.0261
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.014 0.0806 0.0806
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.004
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0039 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Brugia malayi nuclear hormone receptor 0.0798 0.4987 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0265 0.3115
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0058 0.0483
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0386 0.0366
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0045 0.0206 0.0414
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0386 0.0366
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0041 0.0177 0.3026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.0355
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0359 0.034
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0602 0.1729
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.014 0.0806 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0714 0.8854
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0058 0.0258
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0055 0.0265 0.3115
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0296 0.3531
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0479 0.2964 0.5943
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0495 0.6049
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0386 0.076
Schistosoma mansoni hypothetical protein 0.0045 0.0206 0.0187
Brugia malayi hypothetical protein 0.0028 0.0099 0.0183
Echinococcus granulosus dna polymerase eta 0.0022 0.0058 0.0058
Brugia malayi nuclear receptor NHR-88 0.006 0.03 0.0588
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0265 0.0517
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0803 0.9965
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0099 0.0183
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.0806 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.006 0.03 0.0602
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Entamoeba histolytica hypothetical protein 0.0041 0.0179 0.124
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0016 0.002 0.0177
Loa Loa (eye worm) hypothetical protein 0.0055 0.0265 0.0531
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0099 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.006 0.03 0.03
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0099 0.0183
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0217 0.1298 0.1298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0163 0.1965
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0265 0.1914
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.006 0.03 0.03
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0163 0.1965
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0039 0.0403
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0386 0.0386
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0058 0.0294
Schistosoma mansoni RAR-like nuclear receptor 0.006 0.03 0.0281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Brugia malayi hypothetical protein 0.0045 0.0206 0.04
Onchocerca volvulus 0.0025 0.0077 0.0109
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0016 0.002 0.0177
Plasmodium vivax SET domain protein, putative 0.0069 0.0359 0.7137
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0271 0.1641 0.1641
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0296 0.3633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.006 0.03 0.0602
Brugia malayi hypothetical protein 0.0028 0.0099 0.0183
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0267 0.1684
Schistosoma mansoni thyroid hormone receptor 0.006 0.03 0.0281
Toxoplasma gondii aldehyde dehydrogenase 0.014 0.0806 1
Brugia malayi hypothetical protein 0.0032 0.012 0.0227
Echinococcus multilocularis FTZ F1 alpha 0.006 0.03 0.03
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0179 0.0159
Brugia malayi AMP-binding enzyme family protein 0.0016 0.002 0.0026
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0803 0.9965
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0039 0.0403
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.002 0.002
Trichomonas vaginalis set domain proteins, putative 0.0545 0.3384 1
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.1487 1
Leishmania major DNA polymerase eta, putative 0.0022 0.0058 0.0258
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0265 0.1668
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.0602
Echinococcus multilocularis microtubule associated protein 2 0.1586 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0206 0.0414
Onchocerca volvulus 0.0028 0.0099 0.0152
Plasmodium vivax multidomain scavenger receptor, putative 0.0045 0.0206 0.3923
Echinococcus granulosus dna polymerase kappa 0.0022 0.0058 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0099 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.1487 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0206 0.0206
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0099 0.0152
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0274 0.0536
Mycobacterium ulcerans hypothetical protein 0.0028 0.0099 0.1006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0069 0.0359 0.4317
Schistosoma mansoni thyroid hormone receptor 0.006 0.03 0.0281
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.012 0.0227
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.002 0.0177
Schistosoma mansoni steroid hormone receptor ad4bp 0.006 0.03 0.0281
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0039
Onchocerca volvulus 0.0045 0.0206 0.0361
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.012 0.0241
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0265 0.3237
Echinococcus multilocularis Polycystic kidney disease protein 0.0045 0.0206 0.0206
Schistosoma mansoni nuclear receptor 0.0028 0.0099 0.0079
Onchocerca volvulus 0.0033 0.013 0.0213
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0336 0.4019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.006 0.03 0.0602
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.004
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0039 0.0057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.006 0.03 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.1298 0.38
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.012 0.012
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0058 0.0102
Loa Loa (eye worm) oxidoreductase 0.0016 0.002 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0058 0.0258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.0131
Loa Loa (eye worm) glutathione reductase 0.0055 0.0267 0.0536
Trypanosoma brucei hypothetical protein, conserved 0.0247 0.1487 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.006 0.03 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0602 0.1729
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0099 0.0198
Loa Loa (eye worm) hypothetical protein 0.0032 0.012 0.0241
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0495 0.607
Leishmania major DNA polymerase kappa, putative 0.0022 0.0058 0.0258
Loa Loa (eye worm) steroid hormone receptor 0.006 0.03 0.0602
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0041 0.0177 0.2142
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0039 0.0244
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0019
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0039 0.0403
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0117 0.124
Brugia malayi Nuclear hormone receptor family member nhr-41 0.006 0.03 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-49 0.006 0.03 0.0588
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.03 0.0588
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.002 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.1298 0.38
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0099 0.1006
Plasmodium vivax acyl-CoA synthetase, putative 0.0041 0.0177 0.3307
Plasmodium vivax glutathione reductase, putative 0.0055 0.0267 0.52
Brugia malayi Nuclear hormone receptor family member nhr-40 0.006 0.03 0.0588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.0131
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0217 0.1298 0.1298
Schistosoma mansoni DNA polymerase eta 0.0022 0.0058 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.0355
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0296 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0016 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0116
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0016 0.002 0.0177
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0039 0.0403
Echinococcus granulosus tar DNA binding protein 0.0074 0.0386 0.0386
Brugia malayi ecdysteroid receptor 0.006 0.03 0.0588
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0495 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.03 0.0588
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.006 0.03 0.03
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0829 0.5189 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Schistosoma mansoni hypothetical protein 0.0056 0.0274 0.0255
Brugia malayi steroid hormone receptor 0.006 0.03 0.0588
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.012 0.012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.03 0.03
Brugia malayi Nuclear hormone receptor family member nhr-14 0.006 0.03 0.0588
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0058 0.0294
Schistosoma mansoni cpg binding protein 0.0035 0.0142 0.0122
Echinococcus granulosus FTZ F1 alpha 0.006 0.03 0.03
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0386 0.0773
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0495 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0714 0.8854
Entamoeba histolytica hypothetical protein 0.0041 0.0179 0.124
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0117 0.2042
Trypanosoma cruzi polo-like protein kinase, putative 0.0217 0.1298 0.8712
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0099 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.03 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.006 0.03 0.0602
Trypanosoma cruzi polo-like protein kinase, putative 0.0217 0.1298 0.8712
Schistosoma mansoni Tr4/Tr2 (homologue) 0.006 0.03 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.1298 0.38
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Brugia malayi Doublecortin family protein 0.0045 0.0206 0.04
Mycobacterium ulcerans hypothetical protein 0.0055 0.0265 0.3115
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.0338 0.0338
Brugia malayi tailless protein 0.0028 0.0099 0.0183
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0495 0.0495
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0099 0.0183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0163 0.1965
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.03 0.0588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.0131
Schistosoma mansoni coup transcription factor 0.006 0.03 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.006 0.03 0.0602
Brugia malayi TAR-binding protein 0.0074 0.0386 0.076
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.0131
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0016 0.002 0.0177
Loa Loa (eye worm) hypothetical protein 0.0032 0.012 0.0241
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0039 0.0057
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0028 0.0099 0.0099
Brugia malayi hypothetical protein 0.0274 0.1662 0.3324
Trypanosoma brucei unspecified product 0.0022 0.0058 0.0294
Mycobacterium ulcerans hypothetical protein 0.0028 0.0099 0.1006
Schistosoma mansoni survival motor neuron protein 0.0056 0.0274 0.0255
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.0602
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0055 0.0265 0.3237
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0267 0.3267
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0769 0.4807 0.9639
Leishmania major trypanothione reductase 0.0055 0.0267 0.1684
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.0806 0.0787
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.03 0.0588
Trypanosoma brucei polo-like protein kinase 0.0217 0.1298 0.8717
Loa Loa (eye worm) hypothetical protein 0.0055 0.0265 0.0531
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0016 0.002 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0265 0.3115
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0495 0.6049
Onchocerca volvulus 0.006 0.03 0.0542
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0039 0.0131
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.1662 0.1662
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0217 0.1298 0.8712
Brugia malayi AMP-binding enzyme family protein 0.0016 0.002 0.0026
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0803 0.9965
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0039 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-1 0.006 0.03 0.0588
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0714 0.8866
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.0602
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.0131
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0039 0.0244
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0032 0.012 0.0241
Schistosoma mansoni nuclear hormone receptor 0.006 0.03 0.0281
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0039 0.0167
Schistosoma mansoni loxhd1 0.0045 0.0206 0.0187
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0039 0.0131
Echinococcus granulosus cpg binding protein 0.0035 0.0142 0.0142
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0099 0.0099
Loa Loa (eye worm) RNA binding protein 0.0074 0.0386 0.0773
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.006 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0069 0.0359 0.072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0058 0.0258
Onchocerca volvulus 0.0055 0.0265 0.0473
Echinococcus granulosus ecdysone induced protein 78C 0.006 0.03 0.03
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0359 0.034
Brugia malayi glutathione reductase 0.0055 0.0267 0.0522
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0099 0.0198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0039 0.0131
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0039 0.0244
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0296 0.3633
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.012 0.0227
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0267 0.0267
Schistosoma mansoni cpg binding protein 0.0033 0.013 0.011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.006 0.03 0.0281
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0099 0.0183
Onchocerca volvulus 0.0545 0.3384 0.6508
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0386 0.0773
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Brugia malayi nuclear hormone receptor 0.006 0.03 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-3 0.006 0.03 0.0588
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0265 0.1668
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0039 0.0131
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.002 0.002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0099 0.0099
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0179 0.0179
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0058 0.0294
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0163 0.1965
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.0806 0.0787
Brugia malayi Pre-SET motif family protein 0.0479 0.2964 0.5937
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0495 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0069 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0028 0.0099 0.0235
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.014 0.0806 0.0806
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0495 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0265 0.3115
Schistosoma mansoni rab6-interacting 0.0045 0.0206 0.0187
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0058 0.0258
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0265 0.3127
Onchocerca volvulus Serine\/threonine kinase homolog 0.0217 0.1298 0.2473
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.002 0.0177
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0099 0.0099
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0495 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.012 0.01
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0058 0.0294
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0117 0.2042
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.0602
Loa Loa (eye worm) hypothetical protein 0.0032 0.012 0.0241
Brugia malayi serine/threonine-protein kinase plk-2 0.0217 0.1298 0.2593
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.002 0.0026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0359 0.034
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.0602
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0058 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0265 0.1668
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.1662 0.1662
Trypanosoma brucei trypanothione reductase 0.0055 0.0267 0.1714
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0028 0.0099 0.1165
Brugia malayi photoreceptor-specific nuclear receptor 0.006 0.03 0.0588
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0058 0.0651
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.0355
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0177 0.2
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0058 0.0038
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0267 0.52
Onchocerca volvulus 0.0028 0.0099 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0058 0.0258
Schistosoma mansoni nuclear receptor 0.0028 0.0099 0.0079
Echinococcus multilocularis RUN 0.0045 0.0206 0.0206
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0099 0.0183
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0058 0.0258
Entamoeba histolytica serine/threonine protein kinase, putative 0.0217 0.1298 1
Schistosoma mansoni polycystin 1-related 0.0045 0.0206 0.0187
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0271 0.1641 0.1641
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0099 0.0099
Toxoplasma gondii hypothetical protein 0.0031 0.0117 0.1235
Loa Loa (eye worm) hypothetical protein 0.0091 0.0495 0.0993
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0099 0.0538
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0058 0.0113
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0495 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0058 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.0806 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.03 0.0281
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0055 0.0265 0.3115
Onchocerca volvulus 0.0056 0.0274 0.0491
Schistosoma mansoni microtubule-associated protein tau 0.1586 1 1
Toxoplasma gondii thioredoxin reductase 0.0055 0.0267 0.3145
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0714 0.8854
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0016 0.002 0.0177
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0386 0.0366
Loa Loa (eye worm) hypothetical protein 0.0055 0.0265 0.0531
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.002 0.004
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0016 0.002 0.0177
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0099 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0099 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0039 0.0167
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0039 0.0131
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.0602
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0028 0.0099 0.1006
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0099 0.0538
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Schistosoma mansoni rab6-interacting 0.0045 0.0206 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.1298 0.38
Onchocerca volvulus 0.0045 0.0206 0.0361
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.014 0.0806 0.5353
Echinococcus granulosus retinoic acid receptor rxr beta a 0.006 0.03 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0099 0.0183
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0058 0.0116
Brugia malayi Steroid receptor seven-up type 2 0.006 0.03 0.0588
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0099 0.1006
Brugia malayi hypothetical protein 0.0041 0.0179 0.0344
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.002 0.0026
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0099 0.0152
Brugia malayi Thioredoxin reductase 0.0055 0.0267 0.0522
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.1298 0.38
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0296 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.03 0.0588
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0058 0.0483
Echinococcus granulosus Polycystic kidney disease protein 0.0045 0.0206 0.0206
Plasmodium falciparum glutathione reductase 0.0019 0.0039 0.0403
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.006 0.03 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.006 0.03 0.0602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.002 0.0177
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0265 0.0517
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0714 0.8854
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0099 0.0099
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0206 0.0206
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0058 0.0113
Brugia malayi nuclear receptor RXR 0.0028 0.0099 0.0183
Entamoeba histolytica acyl-coA synthetase, putative 0.0055 0.0265 0.1914
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.006 0.03 0.0281
Loa Loa (eye worm) hypothetical protein 0.006 0.03 0.0602
Loa Loa (eye worm) hypothetical protein 0.0032 0.012 0.0241
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.002 0.0177
Brugia malayi nuclear receptor NHR-88 0.0028 0.0099 0.0183
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0099 0.0079
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0099 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0386 0.0366
Loa Loa (eye worm) DR-78 0.0028 0.0099 0.0198
Brugia malayi Probable ClpP-like protease 0.0091 0.0495 0.098
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0206 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0359 0.034
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.012 0.01
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0099 0.0099
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0039 0.0244
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0714 0.8854
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0359 0.0359
Brugia malayi nuclear receptor RXR 0.0032 0.012 0.0227
Echinococcus granulosus RUN 0.0045 0.0206 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-31 0.006 0.03 0.0588
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0495 0.6049
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0058 0.0294
Schistosoma mansoni lipoxygenase 0.019 0.1123 0.1105
Schistosoma mansoni cpg binding protein 0.0035 0.0142 0.0122
Echinococcus multilocularis ecdysone induced protein 78C 0.006 0.03 0.03
Echinococcus multilocularis cpg binding protein 0.0035 0.0142 0.0142
Schistosoma mansoni lipoxygenase 0.0271 0.1641 0.1625
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.0355
Mycobacterium tuberculosis Probable reductase 0.0125 0.0714 0.8854
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0039 0.0064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.006 0.03 0.0602
Schistosoma mansoni retinoic acid receptor RXR 0.006 0.03 0.0281
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0265 0.3115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.03 0.0588
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.0806 1
Loa Loa (eye worm) hypothetical protein 0.0274 0.1662 0.3334
Leishmania major hypothetical protein, conserved 0.0247 0.1487 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0798 0.4987 1
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0267 0.0536
Mycobacterium tuberculosis Conserved protein 0.0028 0.0099 0.1165
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0117 0.1708
Plasmodium falciparum thioredoxin reductase 0.0019 0.0039 0.0403
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0055 0.0265 0.3115
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0058 0.0058
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0265 0.3127
Brugia malayi conserved hypotetical protein 0.0028 0.0099 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0265 0.0517
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.1298 0.1281
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0099 0.0079
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0179 0.0179
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.002 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.03 0.03
Plasmodium falciparum acyl-CoA synthetase 0.0041 0.0177 0.3307
Schistosoma mansoni hypothetical protein 0.0041 0.0179 0.0159
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0099 0.0538
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.006 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Brugia malayi RNA binding protein 0.0074 0.0386 0.076
Brugia malayi ecdysone receptor 0.0028 0.0099 0.0183
Loa Loa (eye worm) doublecortin family protein 0.0045 0.0206 0.0414
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0058 0.0297
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0803 1
Plasmodium falciparum glutathione reductase 0.0055 0.0267 0.52
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0039 0.0131
Giardia lamblia Kinase, PLK 0.0217 0.1298 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0265 0.1914
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0198
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0206 0.0206
Brugia malayi Pre-SET motif family protein 0.0069 0.0359 0.0707
Brugia malayi nuclear receptor NHR-67 0.0028 0.0099 0.0183

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 6.9 Agonist activity at RARbeta2 expressed in mouse NIH3T3 cells by R-SAT assay ChEMBL. 19239230
Efficacy (functional) = 50 % Agonist activity at RARbeta2 expressed in mouse NIH3T3 cells by R-SAT assay relative to Am-580 ChEMBL. 19239230

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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