Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0031 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0031 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0031 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0031 | 1 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldehyde reductase | 0.0022 | 0.4474 | 0.4474 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0031 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0027 | 0.7772 | 0.7772 |
Trypanosoma cruzi | aldo-keto reductase | 0.0031 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Onchocerca volvulus | 0.0027 | 0.7772 | 0.7772 | |
Giardia lamblia | Aldose reductase | 0.0031 | 1 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0027 | 0.7772 | 0.7772 |
Schistosoma mansoni | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 1 | 0.5 |
Echinococcus granulosus | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase | 0.0031 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0031 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0027 | 0.7772 | 0.7772 |
Onchocerca volvulus | 0.0027 | 0.7772 | 0.7772 | |
Schistosoma mansoni | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Onchocerca volvulus | 0.0027 | 0.7772 | 0.7772 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0027 | 0.7772 | 0.7772 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Mycobacterium ulcerans | oxidoreductase | 0.0031 | 1 | 0.5 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0031 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0031 | 1 | 0.5 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0027 | 0.7772 | 0.7772 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | LGC-31 protein | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0027 | 0.7772 | 0.7772 |
Trypanosoma brucei | prostaglandin f synthase | 0.0031 | 1 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.7772 | 0.7772 | |
Leishmania major | prostaglandin f synthase, putative | 0.0031 | 1 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0031 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0031 | 1 | 1 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | oxidoreductase | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | Cation transporter family protein | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Schistosoma mansoni | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase | 0.0031 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0027 | 0.7772 | 0.7772 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 1 | 0.5 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0027 | 0.7772 | 0.7772 |
Schistosoma mansoni | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0027 | 0.7772 | 0.7772 |
Onchocerca volvulus | 0.0027 | 0.7772 | 0.7772 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0031 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | hypothetical protein | 0.0031 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0027 | 0.7772 | 0.7772 |
Onchocerca volvulus | 0.0031 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0031 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0022 | 0.4474 | 0.4474 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0027 | 0.7772 | 0.7772 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0027 | 0.7772 | 0.7772 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase | 0.0031 | 1 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0027 | 0.7772 | 0.7772 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0027 | 0.7772 | 0.7772 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0027 | 0.7772 | 0.7772 |
Echinococcus granulosus | aldo keto reductase | 0.0031 | 1 | 1 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0027 | 0.7772 | 0.7772 |
Onchocerca volvulus | 0.0027 | 0.7772 | 0.7772 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0031 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 13 ug ml-1 | Antifungal activity against Candida albicans MTCC 227 by serial dilution method | ChEMBL. | 18597896 |
MIC (functional) | = 17 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 739 by serial dilution method | ChEMBL. | 18597896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.