Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ABL proto-oncogene 1, non-receptor tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | SRC proto-oncogene, non-receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.024 | 0.9143 | 0.9143 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0041 | 0.0505 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0041 | 0.0505 | 0.0524 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0505 | 0.0505 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0114 | 0.3677 | 0.3677 |
Echinococcus granulosus | acetylcholinesterase | 0.024 | 0.9143 | 0.9143 |
Echinococcus granulosus | acetylcholinesterase | 0.024 | 0.9143 | 0.9143 |
Schistosoma mansoni | tyrosine kinase | 0.0054 | 0.1076 | 0.1115 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0.0505 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0251 | 0.9645 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.9143 | 0.9143 |
Loa Loa (eye worm) | TK protein kinase | 0.0038 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0505 | 0.0505 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0054 | 0.1076 | 0.1076 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0038 | 0.0375 | 0.0375 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0054 | 0.1076 | 0.1076 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.0505 | 0.0553 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0054 | 0.1076 | 0.1076 |
Onchocerca volvulus | 0.0041 | 0.0505 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.024 | 0.9143 | 0.9143 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.0505 | 0.0553 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0054 | 0.1076 | 0.1076 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0046 | 0.073 | 0.073 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0046 | 0.073 | 0.073 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0054 | 0.1076 | 0.1076 |
Echinococcus granulosus | tyrosine kinase | 0.0046 | 0.073 | 0.073 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0054 | 0.1076 | 0.1076 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0505 | 0.0505 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.026 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.0505 | 0.0524 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0041 | 0.0505 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0046 | 0.073 | 0.073 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0054 | 0.1076 | 0.1076 |
Onchocerca volvulus | 0.0041 | 0.0505 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.024 | 0.9143 | 0.9143 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0054 | 0.1076 | 0.1076 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0054 | 0.1076 | 0.1076 |
Brugia malayi | protein-tyrosine kinase | 0.0046 | 0.073 | 0.0798 |
Echinococcus granulosus | choline O acetyltransferase | 0.0193 | 0.7125 | 0.7125 |
Schistosoma mansoni | tyrosine kinase | 0.0054 | 0.1076 | 0.1115 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0041 | 0.0505 | 0.0524 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0046 | 0.073 | 0.073 |
Schistosoma mansoni | choline o-acyltransferase | 0.0193 | 0.7125 | 0.7387 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0043 | 0.063 | 0.063 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0054 | 0.1076 | 0.1076 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0043 | 0.063 | 0.063 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0029 | 0 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0114 | 0.3677 | 0.4022 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0041 | 0.0505 | 0.0505 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0041 | 0.0505 | 0.0505 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.0505 | 0.0553 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0054 | 0.1076 | 0.1076 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0041 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.9143 | 0.9143 |
Onchocerca volvulus | 0.0041 | 0.0505 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2977 | 0.2977 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0054 | 0.1076 | 0.1076 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0.0505 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0505 | 0.0505 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0041 | 0.0505 | 0.0505 |
Loa Loa (eye worm) | SRC-1 | 0.0054 | 0.1076 | 0.1076 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0041 | 0.0505 | 0.0524 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0041 | 0.0505 | 0.0505 |
Schistosoma mansoni | acetylcholinesterase | 0.0041 | 0.0505 | 0.0524 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0505 | 0.0553 |
Echinococcus granulosus | neuroligin | 0.0041 | 0.0505 | 0.0505 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.0375 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0046 | 0.073 | 0.073 |
Loa Loa (eye worm) | carboxylesterase | 0.0041 | 0.0505 | 0.0505 |
Brugia malayi | Carboxylesterase family protein | 0.024 | 0.9143 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0054 | 0.1076 | 0.1076 |
Onchocerca volvulus | 0.0041 | 0.0505 | 1 | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0041 | 0.0505 | 0.0505 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0029 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0193 | 0.7125 | 0.7792 |
Brugia malayi | SRC-1 | 0.0054 | 0.1076 | 0.1176 |
Brugia malayi | Carboxylesterase family protein | 0.024 | 0.9143 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.024 | 0.9143 | 0.9143 |
Echinococcus multilocularis | acetylcholinesterase | 0.024 | 0.9143 | 0.9143 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.024 | 0.9143 | 0.9479 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.024 | 0.9143 | 0.9143 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0046 | 0.073 | 0.073 |
Echinococcus multilocularis | neuroligin | 0.0041 | 0.0505 | 0.0505 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0029 | 0 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0154 | 0.5418 | 0.5925 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0054 | 0.1076 | 0.1076 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.0505 | 0.0524 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0038 | 0.0375 | 0.0375 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.0505 | 0.0524 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0041 | 0.0505 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0041 | 0.0505 | 0.0505 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0029 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0193 | 0.7125 | 0.7792 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.7125 | 0.7125 |
Onchocerca volvulus | 0.0041 | 0.0505 | 1 | |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0193 | 0.7125 | 0.7125 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0505 | 0.0505 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0041 | 0.0505 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0505 | 0.0505 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.0505 | 0.0553 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0054 | 0.1076 | 0.1076 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0054 | 0.1076 | 0.1076 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0193 | 0.7125 | 0.7125 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0054 | 0.1076 | 0.1076 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0029 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.