Detailed information for compound 977472

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 451.586 | Formula: C27H25N5S
  • H donors: 2 H acceptors: 2 LogP: 6.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnc2c(c1Nc1ccc3c(c1C)cc[nH]3)cc(s2)c1cc(ccc1C)CN(C)C
  • InChi: 1S/C27H25N5S/c1-16-5-6-18(15-32(3)4)11-21(16)25-12-22-26(19(13-28)14-30-27(22)33-25)31-23-7-8-24-20(17(23)2)9-10-29-24/h5-12,14,29H,15H2,1-4H3,(H,30,31)
  • InChiKey: JJFJVIQFBDEVSN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens protein kinase C, theta Starlite/ChEMBL References
Homo sapiens protein kinase C, delta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0164 0.0164
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0137 0.0512
Entamoeba histolytica hypothetical protein, conserved 0.0014 0.0078 0.0267
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0022 0.0277 0.1152
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0119
Echinococcus granulosus geminin 0.0165 0.3647 0.4327
Echinococcus multilocularis protein C ets 2 0.001 0.0005 0.0005
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0296 0.0296
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0026 0.0367 0.0435
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0202 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Echinococcus multilocularis protein kinase c iota type 0.0044 0.0797 0.0945
Leishmania major hypothetical protein, conserved 0.005 0.0928 0.4026
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0137 0.0463
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.2648 0.3141
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0437 0.1863
Brugia malayi RhoGAP domain containing protein 0.0023 0.0296 0.0296
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0852 0.101
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.2272 1
Toxoplasma gondii peptidase D, putative 0.0022 0.0277 0.1779
Echinococcus granulosus NDR protein kinase 0.0026 0.0367 0.0435
Brugia malayi glutathione reductase 0.0046 0.0852 0.0852
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0119 0.0141
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.1128 0.1339
Brugia malayi Protein kinase domain containing protein 0.0026 0.0367 0.0367
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2252 0.8865
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0137 0.0232
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0164 0.0195
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0146 0.0173
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0378 0.1585
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Trypanosoma cruzi aminopeptidase P, putative 0.0022 0.0277 0.1135
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0437 0.3284
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0368 0.843 1
Echinococcus granulosus glutamate receptor 2 0.0011 0.0018 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0164 0.0164
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0044 0.0044
Echinococcus granulosus tumor protein p63 0.0329 0.7513 0.8913
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0164 0.0164
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Trypanosoma cruzi Aminopeptidase M1, putative 0.0026 0.0378 0.1585
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1233 0.5385
Echinococcus multilocularis raf serine:threonine protein kinase 0.002 0.0218 0.0259
Echinococcus granulosus nAChR subunit 0.0012 0.0044 0.0053
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0005 0.0005
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) RecQ helicase 0.0021 0.0252 0.0252
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0437 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0044 0.0797 0.0945
Onchocerca volvulus 0.0012 0.0044 0.0027
Entamoeba histolytica protein kinase, putative 0.0026 0.0367 0.1549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0018 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0137 0.0512
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0044 0.0053
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0437 0.3284
Loa Loa (eye worm) hypothetical protein 0.0069 0.1381 0.1381
Echinococcus granulosus protein kinase c eta type 0.0018 0.0188 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0054 0.1039 0.1233
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0202 0.0239
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1233 0.5385
Schistosoma mansoni nAChR subunit 0.0012 0.0044 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0146 0.0173
Echinococcus granulosus raf serine:threonine protein kinase 0.002 0.0218 0.0259
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0018 0.0021
Schistosoma mansoni coup transcription factor 0.0017 0.0164 0.0195
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0852 0.3688
Echinococcus granulosus protein kinase c epsilon type 0.0044 0.0797 0.0945
Brugia malayi Cathepsin L-like precursor 0.0016 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0101 0.2141 0.2539
Brugia malayi C1-like domain containing protein 0.0019 0.0202 0.0202
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0019 0.0202 0.0239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0378 0.1601
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0044 0.0053
Plasmodium vivax amine transporter, putative 0.0015 0.0119 0.0325
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0137 0.0163
Schistosoma mansoni serine/threonine kinase 0.0026 0.0367 0.0435
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0252 0.1039
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0276 0.0327
Schistosoma mansoni hypothetical protein 0.0018 0.0188 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0005 0.0005
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0437 0.4133
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0005 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0164 0.0195
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1152 0.1366
Onchocerca volvulus 0.0016 0.0146 0.0128
Schistosoma mansoni ets-related 0.0219 0.4911 0.5826
Loa Loa (eye worm) peptidase family M1 containing protein 0.0026 0.0378 0.0378
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.2272 0.2695
Brugia malayi Protein kinase domain containing protein 0.0019 0.0202 0.0202
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0012 0.0044 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0164 0.0164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0378 0.1585
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0005 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2252 0.8461
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0378 0.1585
Onchocerca volvulus 0.0016 0.0146 0.0128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0119
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.0378 0.0378
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0119 0.0141
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0022 0.0277 0.1152
Chlamydia trachomatis neutral amino acid transporter 0.0054 0.1039 0.3741
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2252 0.8461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0137 0.0512
Schistosoma mansoni nAChR subunit 0.0012 0.0044 0.0053
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2252 0.8461
Schistosoma mansoni diacylglycerol kinase theta 0.0018 0.0188 0.0223
Loa Loa (eye worm) hypothetical protein 0.0435 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.2272 1
Onchocerca volvulus 0.0048 0.0893 0.0877
Entamoeba histolytica diacylglycerol kinase, putative 0.0018 0.0188 0.0758
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0164
Echinococcus multilocularis neutral amino acid transporter A 0.0123 0.2648 0.3141
Brugia malayi p70 ribosomal S6 kinase beta 0.0026 0.0367 0.0367
Echinococcus granulosus excitatory amino acid transporter 3 0.0123 0.2648 0.3141
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.2272 1
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0378 0.1585
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0437 0.1863
Trypanosoma brucei aminopeptidase, putative 0.0026 0.0378 0.1585
Echinococcus granulosus xaa Pro dipeptidase 0.0022 0.0277 0.0329
Brugia malayi steroid hormone receptor 0.0017 0.0164 0.0164
Entamoeba histolytica hypothetical protein 0.0035 0.0584 0.2513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0026 0.0367 0.0435
Echinococcus multilocularis Diacylglycerol kinase theta 0.0018 0.0188 0.0223
Loa Loa (eye worm) ctsf protein 0.0016 0.0146 0.0146
Entamoeba histolytica protein kinase, putative 0.0026 0.0367 0.1549
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.015 0.0178
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0367 0.0435
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0023 0.0296 0.0351
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0199 0.0551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0164 0.0164
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0119 0.0102
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0583 0.0692
Echinococcus granulosus Diacylglycerol kinase theta 0.0018 0.0188 0.0223
Schistosoma mansoni thyroid hormone receptor 0.014 0.3054 0.3622
Loa Loa (eye worm) raf kinase 0.0018 0.0188 0.0188
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0044 0.0044
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0018 0.0021
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0026 0.0367 0.0435
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0005 0.0005
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0797 0.0945
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0437 0.1863
Loa Loa (eye worm) AGC/NDR protein kinase 0.0026 0.0367 0.0367
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0119 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0137 0.0512
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0101 0.2141 0.2539
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0164
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.015 0.0178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0164 0.0195
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0146 0.0173
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0218 0.0259
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0018 0.0188 0.0223
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.3054 0.3622
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0292
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0378 0.1601
Toxoplasma gondii hypothetical protein 0.0015 0.0119 0.0292
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0044 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1233 0.5385
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0005 0.0005
Schistosoma mansoni protein kinase C mu 0.0018 0.0188 0.0223
Schistosoma mansoni protein kinase C 0.0018 0.0188 0.0223
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0164 0.0195
Loa Loa (eye worm) hypothetical protein 0.0037 0.0639 0.0639
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0164 0.0164
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0137 0.0224
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0044 0.0053
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1152 0.5023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0378 0.0378
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0164 0.0164
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.2272 0.2695
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0276 0.0327
Chlamydia trachomatis glutamate symporter 0.0123 0.2648 1
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.2272 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0378 0.1585
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0044 0.0044
Loa Loa (eye worm) excitatory amino acid transporter 0.0123 0.2648 0.2648
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0164 0.0195
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0022 0.0277 0.0329
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0019 0.0202 0.0239
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0164 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.015 0.0178
Onchocerca volvulus 0.0016 0.0146 0.0128
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0146 0.0146
Schistosoma mansoni protein kinase C mu 0.0019 0.0202 0.0239
Echinococcus multilocularis ets variant gene 4 0.001 0.0005 0.0005
Echinococcus granulosus neutral amino acid transporter A 0.0123 0.2648 0.3141
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1152 1
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0146 0.0128
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0378 0.1585
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0005 0.0005
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0044 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Brugia malayi hypothetical protein 0.0228 0.5125 0.5125
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0119
Brugia malayi 6-phosphofructokinase 0.0107 0.2272 0.2272
Loa Loa (eye worm) hypothetical protein 0.004 0.0693 0.0693
Chlamydia trachomatis glutamine binding protein 0.0019 0.0199 0.047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0164 0.0164
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0437 0.1863
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2531 0.9544
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0019 0.0202 0.0202
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Leishmania major cathepsin L-like protease 0.0016 0.0146 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0146 0.0568
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0044 0.0044
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.1456 0.1727
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0137 0.0512
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0146 0.0549
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1152 0.4896
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0044 0.0053
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0928 0.7892
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0164 0.0164
Trypanosoma brucei Aminopeptidase M1, putative 0.0026 0.0378 0.1585
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0164 0.0164
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0026 0.0367 0.0435
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0018 0.0021
Echinococcus granulosus Excitatory amino acid transporter 0.0123 0.2648 0.3141
Echinococcus granulosus cathepsin l1 0.0011 0.0018 0.0021
Brugia malayi diacylglycerol kinase 0.0018 0.0188 0.0188
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0378 0.3429
Toxoplasma gondii cathepsin CPL 0.0016 0.0146 0.054
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0119 0.0325
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.1128 0.1339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0019 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0017 0.0152 0.0152
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0044 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0044 0.0053
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0378 0.1585
Echinococcus granulosus cathepsin l1 0.0016 0.0146 0.0173
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0101 0.2141 0.2539
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0018 0.0021
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0022 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Echinococcus granulosus protein kinase C gamma type 0.0026 0.0367 0.0435
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.037 0.0439
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Brugia malayi RhoGEF domain containing protein 0.0018 0.0188 0.0188
Treponema pallidum glutamate/aspartate transporter 0.0054 0.1039 0.4274
Entamoeba histolytica hypothetical protein 0.0018 0.0188 0.0758
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1152 0.418
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0232 0.0232
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0044 0.0053
Schistosoma mansoni zinc finger protein 0.0019 0.0208 0.0246
Mycobacterium tuberculosis Probable reductase 0.0106 0.2252 0.8461
Echinococcus granulosus protein C ets 2 0.001 0.0005 0.0005
Schistosoma mansoni bromodomain containing protein 0.0062 0.1211 0.1436
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0101 0.2141 0.2539
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2252 0.8461
Brugia malayi transcription factor E74 isoform 0.001 0.0005 0.0005
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.2272 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0137 0.0272
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0583 0.0692
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0852 0.3012
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0119 0.0141
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0199 0.047
Trypanosoma brucei ISWI complex protein 0.0015 0.0109 0.0389
Loa Loa (eye worm) hypothetical protein 0.0017 0.015 0.015
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0437 0.14
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0378 0.1585
Brugia malayi Protein kinase domain containing protein 0.0026 0.0367 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0164
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0044 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0367 0.0435
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0044 0.0044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0137 0.0512
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0022 0.002
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0368 0.843 0.843
Onchocerca volvulus 0.0015 0.0119 0.0102
Loa Loa (eye worm) serotonin transporter b 0.0015 0.0119 0.0119
Onchocerca volvulus Dipeptidase C homolog 0.0022 0.0277 0.026
Echinococcus multilocularis neutral amino acid transporter A 0.0123 0.2648 0.3141
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0026 0.0367 0.0367
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.1456 0.1456
Loa Loa (eye worm) hypothetical protein 0.0435 1 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0044 0.0044
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0893 0.106
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0054 0.1039 0.1233
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0188 0.0188
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0437 0.3937
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0119
Onchocerca volvulus 0.0012 0.0044 0.0027
Echinococcus multilocularis zinc finger protein 0.0019 0.0208 0.0246
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0054 0.1039 0.1233
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0022 0.0277 0.1152
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0283 0.0335
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0146 0.0173
Brugia malayi Cathepsin L-like precursor 0.0016 0.0146 0.0146
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0044 0.0044
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0137 0.0512
Plasmodium falciparum glutathione reductase 0.0016 0.0137 0.0224
Echinococcus granulosus bloom syndrome protein 0.0021 0.0252 0.0299
Onchocerca volvulus 0.0016 0.0146 0.0128
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.2272 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1152 0.1366
Brugia malayi nuclear hormone receptor 0.0017 0.0164 0.0164
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0146 0.0173
Echinococcus multilocularis excitatory amino acid transporter 2 0.0123 0.2648 0.3141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0035 0.0584 0.2513
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0044 0.0044
Brugia malayi TATA binding protein associated factor 0.0026 0.0378 0.0378
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0146 0.0146
Brugia malayi Cation transporter family protein 0.0012 0.0044 0.0044
Echinococcus multilocularis Protein lozenge 0.0055 0.1043 0.1237
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0852 0.0852
Brugia malayi Ets-domain containing protein 0.0072 0.1456 0.1456
Onchocerca volvulus Putative nachr subunit 0.0012 0.0044 0.0027
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0026 0.0378 0.0449
Brugia malayi Excitatory amino acid transporter 0.0123 0.2648 0.2648
Brugia malayi Ets-domain containing protein 0.001 0.0005 0.0005
Loa Loa (eye worm) RasGEF domain-containing protein 0.0018 0.0188 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0367 0.0435
Loa Loa (eye worm) AGC/PKN protein kinase 0.0026 0.0367 0.0367
Brugia malayi Thioredoxin reductase 0.0046 0.0852 0.0852
Brugia malayi nuclear receptor NHR-88 0.0017 0.0164 0.0164
Echinococcus multilocularis serotonin transporter 0.0015 0.0119 0.0141
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0044 0.0053
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0044 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0146 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Schistosoma mansoni rac gtpase activating protein 0.0018 0.0188 0.0223
Schistosoma mansoni hypothetical protein 0.002 0.0232 0.0275
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0918 0.3982
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.005 0.0928 0.0928
Leishmania major cathepsin L-like protease 0.0063 0.1233 0.5385
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0928 0.4026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0164
Brugia malayi protein kinase C II. 0.0044 0.0797 0.0797
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0333 0.7614 0.7614
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0037 0.0037
Onchocerca volvulus 0.0026 0.0378 0.0362
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0164 0.0195
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0018 0.0188 0.0223
Schistosoma mansoni hypothetical protein 0.001 0.0005 0.0005
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0005 0.0005
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0022 0.0277 0.1152
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0044 0.0053
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0119 0.0141
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.2272 0.8536
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0164 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Echinococcus multilocularis xaa Pro dipeptidase 0.0022 0.0277 0.0329
Toxoplasma gondii hypothetical protein 0.0015 0.0119 0.0292
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0101 0.2141 0.2539
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.2272 0.2695
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.2272 1
Entamoeba histolytica protein kinase, putative 0.0026 0.0367 0.1549
Onchocerca volvulus 0.0018 0.0188 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.0378 0.0449
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0123 0.2648 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0164 0.0195
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0584 0.0693
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0378 0.0378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Brugia malayi phosphofructokinase 0.0107 0.2272 0.2272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0119 0.0141
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0437 0.1479
Leishmania major cathepsin L-like protease 0.0016 0.0146 0.0549
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0378 0.0378
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0022 0.0277 0.1152
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0044 0.0044
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0164 0.0164
Toxoplasma gondii aminopeptidase N protein 0.0026 0.0378 0.273
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2531 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0852 0.101
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0378 0.1585
Echinococcus granulosus Rac GTPase activating protein 1 0.0018 0.0188 0.0223
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0026 0.0367 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0164 0.0164
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0026 0.0378 0.0449
Schistosoma mansoni nAChR subunit 0.0012 0.0044 0.0053
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0137 0.0542
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.2272 0.2272
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0119 0.0141
Onchocerca volvulus 0.0333 0.7614 0.761
Schistosoma mansoni nAChR subunit 0.0012 0.0044 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Onchocerca volvulus 0.0015 0.0119 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Echinococcus granulosus neutral amino acid transporter 0.0123 0.2648 0.3141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Loa Loa (eye worm) solute carrier family 6 member 4 0.0015 0.0119 0.0119
Loa Loa (eye worm) fibroinase 0.0016 0.0146 0.0146
Loa Loa (eye worm) cysteine protease 0.0016 0.0146 0.0146
Brugia malayi Cation transporter family protein 0.0012 0.0044 0.0044
Onchocerca volvulus 0.0016 0.0146 0.0128
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0137 0.0137
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.0378 0.0449
Loa Loa (eye worm) fli-1 protein 0.0219 0.4911 0.4911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Plasmodium falciparum thioredoxin reductase 0.0046 0.0852 0.9061
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0146 0.0146
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0022 0.0277 0.1152
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0005 0.0005
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0146 0.0173
Plasmodium falciparum thioredoxin reductase 0.0016 0.0137 0.0224
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.2272 0.2272
Echinococcus multilocularis excitatory amino acid transporter 2 0.0123 0.2648 0.3141
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0137 0.0512
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0044 0.0053
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0018 0.0021
Entamoeba histolytica aminopeptidase, putative 0.0026 0.0378 0.1601
Loa Loa (eye worm) hypothetical protein 0.0022 0.0277 0.0277
Echinococcus multilocularis Rac GTPase activating protein 1 0.0018 0.0188 0.0223
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0119 0.0141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0101 0.2141 0.2141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0026 0.0378 0.0378
Leishmania major cathepsin L-like protease 0.0063 0.1233 0.5385
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0164 0.0195
Echinococcus multilocularis aminopeptidase N 0.0026 0.0378 0.0449
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0119
Onchocerca volvulus 0.0018 0.0188 0.0171
Leishmania major cathepsin L-like protease 0.0016 0.0146 0.0549
Loa Loa (eye worm) hypothetical protein 0.0101 0.2141 0.2141
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0333 0.7614 0.7614
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.015 0.0178
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0584 0.0693
Echinococcus granulosus xaa Pro dipeptidase 0.0022 0.0277 0.0329
Schistosoma mansoni nAChR subunit 0.0012 0.0044 0.0053
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0437 0.4133
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0146 0.0173
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.0013 0.0016
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0022 0.0277 0.1152
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0378 0.3429
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0123 0.2648 0.3141
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Leishmania major cathepsin L-like protease 0.0016 0.0146 0.0549
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.2272 1
Schistosoma mansoni hypothetical protein 0.0165 0.3647 0.4327
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0164 0.0164
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0164 0.0164
Brugia malayi hypothetical protein 0.0032 0.0513 0.0513
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.5169 0.5169
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0015 0.0109 0.013
Onchocerca volvulus 0.0012 0.0044 0.0027
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0018 0.0021
Brugia malayi hypothetical protein 0.0035 0.0584 0.0584
Schistosoma mansoni diacylglycerol kinase theta 0.0018 0.0188 0.0223
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0018 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0437 0.1863
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0164 0.0164
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0137 0.0512
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.2272 1
Entamoeba histolytica protein kinase, putative 0.0026 0.0367 0.1549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1105 0.4816
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Echinococcus granulosus serine:threonine protein kinase N2 0.0026 0.0367 0.0435
Trypanosoma cruzi ISWI complex protein 0.0015 0.0109 0.0389
Echinococcus multilocularis unc 13 (munc13) 0.0018 0.0188 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0146 0.0568
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Onchocerca volvulus 0.0026 0.0378 0.0362
Loa Loa (eye worm) hypothetical protein 0.0359 0.8222 0.8222
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) runx1 0.0055 0.1043 0.1043
Echinococcus multilocularis protein kinase c eta type 0.0018 0.0188 0.0223
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Brugia malayi Protein kinase domain containing protein 0.0026 0.0367 0.0367
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0164 0.0195
Echinococcus multilocularis xaa Pro dipeptidase 0.0022 0.0277 0.0329
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0119 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0164 0.0164
Echinococcus multilocularis nAChR subunit 0.0012 0.0044 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0137 0.0512
Echinococcus multilocularis tumor protein p63 0.0329 0.7513 0.8913
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0019 0.0202 0.0202
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1152 0.1366
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0044 0.0797 0.0797
Brugia malayi ecdysteroid receptor 0.0017 0.0164 0.0164
Brugia malayi Ets-domain containing protein 0.0072 0.1456 0.1456
Loa Loa (eye worm) hypothetical protein 0.0048 0.0893 0.0893
Loa Loa (eye worm) aminopeptidase N 0.0026 0.0378 0.0378
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0119 0.0141
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.015 0.0178
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0164 0.0195
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0026 0.0378 0.0449
Toxoplasma gondii thioredoxin reductase 0.0046 0.0852 0.7178
Plasmodium vivax vivapain-2 0.0016 0.0146 0.0641
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0137 0.0531
Echinococcus multilocularis N chimaerin 0.0023 0.0296 0.0351
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0252 0.0252
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0119 0.0141
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0023 0.0296 0.0351
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0137 0.0163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0164 0.0195
Treponema pallidum NADH oxidase 0.0016 0.0137 0.0084
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.2272 1
Loa Loa (eye worm) phosphofructokinase 0.0107 0.2272 0.2272
Onchocerca volvulus 0.0012 0.0044 0.0027
Loa Loa (eye worm) hypothetical protein 0.0333 0.7614 0.7614
Echinococcus multilocularis geminin 0.0165 0.3647 0.4327
Echinococcus multilocularis cysteine protease 0.0016 0.0146 0.0173
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0044 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0164 0.0195
Brugia malayi hypothetical protein 0.0026 0.0378 0.0378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Leishmania major hypothetical protein, conserved 0.0015 0.0109 0.0389
Schistosoma mansoni hypothetical protein 0.0123 0.2648 0.3141
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0025 0.0353 0.149
Treponema pallidum glutamate transporter 0.0054 0.1039 0.4274
Echinococcus granulosus leukotriene A 4 hydrolase 0.0368 0.843 1
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0018 0.0188 0.0188
Toxoplasma gondii AGC kinase 0.0026 0.0367 0.2618
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0164
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0292
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0164 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Echinococcus multilocularis Excitatory amino acid transporter 0.0123 0.2648 0.3141
Onchocerca volvulus 0.0018 0.0188 0.0171
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0044 0.0044
Echinococcus granulosus myotubularin protein 13 0.0018 0.0188 0.0223
Toxoplasma gondii aminopeptidase N, putative 0.0026 0.0378 0.273
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0164 0.0195
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0119 0.0141
Schistosoma mansoni vav2 0.0023 0.0296 0.0351
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0252 0.0299
Brugia malayi Fli-1 protein 0.0219 0.4911 0.4911
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0137 0.0512
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0119 0.0141
Entamoeba histolytica cysteine protease, putative 0.0016 0.0146 0.0568
Onchocerca volvulus 0.0012 0.0044 0.0027
Brugia malayi hypothetical protein 0.0015 0.0119 0.0119
Plasmodium falciparum glutathione reductase 0.0046 0.0852 0.9061
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0164 0.0164
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.1456 0.1727
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0352 0.8044 0.8044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0044 0.0053
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0164 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0164 0.0195
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0044 0.0053
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0044 0.0044
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0137 0.0272
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.2272 0.8944
Brugia malayi hypothetical protein 0.005 0.0928 0.0928
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0164 0.0164
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0026 0.0367 0.0367
Onchocerca volvulus 0.0015 0.0119 0.0102
Echinococcus granulosus serotonin transporter 0.0015 0.0119 0.0141
Schistosoma mansoni hypothetical protein 0.0165 0.3647 0.4327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0164 0.0195
Echinococcus multilocularis excitatory amino acid transporter 3 0.0123 0.2648 0.3141
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2531 0.9544
Echinococcus multilocularis serine threonine protein kinase 0.0026 0.0367 0.0435
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0022 0.0277 0.1135
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0146 0.0327
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0023 0.0296 0.0351
Schistosoma mansoni zinc finger protein 0.0015 0.0109 0.013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0119
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0164 0.0195
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0164 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0146 0.0568
Brugia malayi cathepsin L-like precursor 0.0011 0.0018 0.0018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0378 0.1601
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0137 0.0512
Echinococcus granulosus Excitatory amino acid transporter 0.0123 0.2648 0.3141
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0123 0.2648 0.3141
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0164 0.0195
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0022 0.0277 0.1152
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0022 0.0277 0.0329
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2252 0.8461
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0146 0.0549
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0137 0.0531
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0368 0.843 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0044 0.0053
Toxoplasma gondii diacylglycerol kinase, putative 0.0018 0.0188 0.0944
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0146 0.0568
Brugia malayi Bromodomain containing protein 0.0037 0.0637 0.0637
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0378 0.1371
Entamoeba histolytica hypothetical protein 0.0035 0.0584 0.2513
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0044 0.0044
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.1233 0.5385
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0164 0.0164
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0044 0.0053
Entamoeba histolytica hypothetical protein 0.0035 0.0584 0.2513
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0584 0.0693
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0928 1
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0005 0.0005
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0437 0.3937
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0022 0.0277 0.1135
Onchocerca volvulus 0.0016 0.0146 0.0128
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0119 0.0141
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0119
Schistosoma mansoni nAChR subunit 0.0012 0.0044 0.0053
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0119 0.0141
Loa Loa (eye worm) glutathione reductase 0.0046 0.0852 0.0852
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Loa Loa (eye worm) hypothetical protein 0.0062 0.1209 0.1209
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0137 0.0512
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0928 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0252 0.1039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0164 0.0164
Brugia malayi PHD-finger family protein 0.0024 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0044 0.0053
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.0378 0.3208
Echinococcus multilocularis cysteine protease 0.0016 0.0146 0.0173
Schistosoma mansoni thyroid hormone receptor 0.014 0.3054 0.3622
Schistosoma mansoni hypothetical protein 0.0022 0.0283 0.0335
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1152 0.4896
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0146 0.0568
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0022 0.0277 0.1135
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0018 0.0018
Leishmania major cathepsin L-like protease 0.0063 0.1233 0.5385
Echinococcus granulosus sodium:dicarboxylate symporter 0.0123 0.2648 0.3141
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0022 0.0277 0.0329
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0005 0.0005
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0022 0.0277 0.1152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Trypanosoma brucei rac serine-threonine kinase, putative 0.0026 0.0367 0.1532
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0928 0.4026
Echinococcus granulosus zinc finger protein 0.0019 0.0208 0.0246
Brugia malayi Cathepsin L-like precursor 0.0016 0.0146 0.0146
Schistosoma mansoni atypical protein kinase C 0.0044 0.0797 0.0945
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0437 0.1863
Loa Loa (eye worm) hypothetical protein 0.0022 0.0277 0.0277
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0005 0.0005
Echinococcus granulosus protein kinase c iota type 0.0044 0.0797 0.0945
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0137 0.0542
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0164 0.0195
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0378 0.1585
Giardia lamblia Xaa-Pro dipeptidase 0.0022 0.0277 0.4665
Trypanosoma cruzi ISWI complex protein 0.0015 0.0109 0.0389
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0044 0.0053
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0054 0.1039 0.1233
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0044 0.0053
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0852 0.9092
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0199 0.0369
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0119 0.0141
Echinococcus granulosus aminopeptidase N 0.0026 0.0378 0.0449
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0797 0.0945
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0137 0.0272
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0018 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.2272 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0018 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0164 0.0195
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.2272 0.2695
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0928 0.4026
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.2648 0.3141
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.037 0.0439
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2531 0.9544
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0119 0.0141
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0164 0.0195
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0119
Echinococcus granulosus excitatory amino acid transporter 2 0.0123 0.2648 0.3141
Entamoeba histolytica diacylglycerol kinase, putative 0.0018 0.0188 0.0758
Schistosoma mansoni hypothetical protein 0.0035 0.0584 0.0693
Onchocerca volvulus 0.0012 0.0044 0.0027
Echinococcus granulosus Protein kinase C brain isozyme 0.0044 0.0797 0.0945
Brugia malayi Bromodomain containing protein 0.0073 0.148 0.148
Schistosoma mansoni unc-13 (munc13) 0.0018 0.0188 0.0223
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0005 0.0005
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0148 0.0175
Schistosoma mansoni unc-13 (munc13) 0.0018 0.0188 0.0223
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0378 0.1371
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0146 0.0173
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0146 0.0327
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0044 0.0053
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0015 0.0119 0.0161
Schistosoma mansoni lozenge 0.0055 0.1043 0.1237
Brugia malayi Ras association domain family 1 isoform A 0.0018 0.0188 0.0188
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.037 0.0439
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0026 0.0367 0.0367
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0137 0.0463
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0137 0.0224
Brugia malayi 6-phosphofructokinase 0.0107 0.2272 0.2272
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0123 0.2648 0.3141
Onchocerca volvulus 0.0026 0.0378 0.0362
Toxoplasma gondii aminopeptidase n, putative 0.0026 0.0378 0.273
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Brugia malayi Cation transporter family protein 0.0012 0.0044 0.0044
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0119 0.0141
Echinococcus multilocularis serine:threonine protein kinase 38 0.0026 0.0367 0.0435
Brugia malayi follicle stimulating hormone receptor 0.023 0.5169 0.5169
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0044 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0367 0.0435
Echinococcus multilocularis neutral amino acid transporter A 0.0123 0.2648 0.3141
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0026 0.0367 0.0435
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0164
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0044 0.0044
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1152 0.1366
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0013 0.0057 0.0157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0164 0.0164
Brugia malayi hypothetical protein 0.0026 0.0378 0.0378
Echinococcus granulosus neutral amino acid transporter A 0.0123 0.2648 0.3141
Brugia malayi protein kinase C3,putative 0.0019 0.0202 0.0202
Echinococcus multilocularis Excitatory amino acid transporter 0.0123 0.2648 0.3141
Echinococcus granulosus N chimaerin 0.0023 0.0296 0.0351
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0276 0.0327
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0023 0.0296 0.0296
Trypanosoma brucei Aminopeptidase M1, putative 0.0026 0.0378 0.1585
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.015 0.0178
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0283 0.0335
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0137 0.0163
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.2272 1
Brugia malayi RhoGAP domain containing protein 0.0018 0.0188 0.0188
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0164 0.0195
Brugia malayi diacylglycerol kinase 0.0018 0.0188 0.0188
Onchocerca volvulus 0.0016 0.0146 0.0128
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0132 0.0157
Loa Loa (eye worm) hypothetical protein 0.0042 0.0737 0.0737
Trypanosoma brucei trypanothione reductase 0.0046 0.0852 0.3688
Brugia malayi Hr1 repeat family protein 0.0026 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Schistosoma mansoni gabp alpha 0.0072 0.1456 0.1727
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0164 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0146 0.0568
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0146 0.0327
Leishmania major trypanothione reductase 0.0046 0.0852 0.3688
Schistosoma mansoni nAChR subunit 0.0012 0.0044 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0437 0.1863
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0797 0.0945
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0044 0.0044
Echinococcus granulosus excitatory amino acid transporter 2 0.0123 0.2648 0.3141
Brugia malayi Pleckstrin Homology Domain 0.0018 0.0188 0.0188
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0044 0.0044
Schistosoma mansoni elf1 0.001 0.0005 0.0005
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0437 0.3284
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0192 0.09
Plasmodium vivax glutathione reductase, putative 0.0046 0.0852 0.9092
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0137 0.0232
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0013 0.0057 0.0068
Brugia malayi metallopeptidase family M24 containing protein 0.0022 0.0277 0.0277
Schistosoma mansoni ets 0.001 0.0005 0.0005
Echinococcus granulosus unc 13 munc13 0.0018 0.0188 0.0223
Loa Loa (eye worm) AGC/AKT protein kinase 0.0026 0.0367 0.0367
Schistosoma mansoni hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0012 0.0044 0.0053
Brugia malayi Cathepsin L-like precursor 0.0011 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0164 0.0164
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0164 0.0164
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0123 0.2648 0.2635
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0044 0.0053
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0164 0.0147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0044 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0367 0.0435
Leishmania major cathepsin L-like protease 0.0016 0.0146 0.0549
Brugia malayi Cathepsin L-like precursor 0.0011 0.0018 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0137 0.0512
Plasmodium vivax vivapain-2 0.0016 0.0146 0.0641
Brugia malayi Cathepsin L-like precursor 0.0016 0.0146 0.0146
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0119 0.0141
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0437 0.14
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0044 0.0053
Onchocerca volvulus 0.0017 0.0164 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0164 0.0164
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0378 0.0378
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0044 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0367 0.1549
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0023 0.0296 0.0351
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0378 0.0378
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1152 0.4896
Schistosoma mansoni ets-related 0.001 0.0005 0.0005
Brugia malayi Cathepsin L-like precursor 0.0016 0.0146 0.0146
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0164 0.0195
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0137 0.0512
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.015 0.0178
Loa Loa (eye worm) norepinephrine transporter 0.0015 0.0119 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0137 0.0512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1233 0.5385
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0026 0.0378 0.0449
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0044 0.0053
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0026 0.0367 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.015 0.0178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0119 0.0119
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0164 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Brugia malayi Protein kinase c protein 2 0.0019 0.0202 0.0202
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0123 0.2648 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0437 0.1863
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0199 0.0369
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0367 0.0435
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0005 0.0005
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0928 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0378 0.1585
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0146 0.0128
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.0378 0.3208
Brugia malayi Cathepsin L-like precursor 0.0016 0.0146 0.0146
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0137 0.0512
Onchocerca volvulus 0.0435 1 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0037 0.0037
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0378 0.1585
Loa Loa (eye worm) hypothetical protein 0.0018 0.0188 0.0188
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0199 0.047
Brugia malayi Aminopeptidase P, N-terminal domain containing protein 0.0018 0.0178 0.0178
Echinococcus multilocularis protein kinase c epsilon type 0.0044 0.0797 0.0945
Echinococcus multilocularis myotubularin protein 13 0.0018 0.0188 0.0223

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 100 nM Inhibition of human full length PKCtheta ChEMBL. 19111463
IC50 (binding) = 230 nM Inhibition of Lyn ChEMBL. 19111463
IC50 (binding) = 410 nM Inhibition of human full length PKCdelta ChEMBL. 19111463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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