Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0063 | 0.3826 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3826 | 0.8104 |
Plasmodium falciparum | phd finger protein, putative | 0.0034 | 0.0077 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3193 | 0.6763 |
Echinococcus multilocularis | peregrin | 0.0034 | 0.0077 | 0.0077 |
Echinococcus granulosus | FTZ F1 alpha | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | jmjC domain containing protein | 0.0041 | 0.0994 | 0.0994 |
Brugia malayi | nuclear receptor NHR-88 | 0.0063 | 0.3826 | 0.3826 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3826 | 0.8104 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3173 | 0.6721 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0077 | 0.0162 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0063 | 0.3826 | 0.3826 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 1 | 1 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0077 | 0.0077 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0041 | 0.0994 | 0.0994 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0063 | 0.3826 | 0.3826 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0063 | 0.3826 | 0.8104 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0077 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0994 | 0.1408 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.3173 | 0.6721 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0063 | 0.3826 | 0.5416 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0063 | 0.3826 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0063 | 0.3826 | 0.5416 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0041 | 0.0994 | 0.2106 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0077 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3826 | 0.8104 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | ecdysteroid receptor | 0.0063 | 0.3826 | 0.3826 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0063 | 0.3826 | 0.3826 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0063 | 0.3826 | 0.5416 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.4721 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0813 | 0.0813 |
Echinococcus granulosus | peregrin | 0.0034 | 0.0077 | 0.0077 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0063 | 0.3826 | 0.3826 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0063 | 0.3826 | 0.3826 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3826 | 0.8104 |
Schistosoma mansoni | nuclear hormone receptor | 0.0063 | 0.3826 | 0.5416 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0063 | 0.3826 | 0.3826 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0063 | 0.3826 | 0.8104 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0063 | 0.3826 | 0.8104 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0063 | 0.3826 | 0.3826 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3826 | 0.8104 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0063 | 0.3826 | 0.3826 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0063 | 0.3826 | 0.3826 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0063 | 0.3826 | 0.8104 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0063 | 0.3826 | 0.3826 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0063 | 0.3826 | 0.5416 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.1785 | 0.1785 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.1785 | 0.1785 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0063 | 0.3826 | 0.3826 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0063 | 0.3826 | 0.5416 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0063 | 0.3826 | 0.3826 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0063 | 0.3826 | 0.8104 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0077 | 0.0077 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0063 | 0.3826 | 0.3826 |
Schistosoma mansoni | coup transcription factor | 0.0063 | 0.3826 | 0.5416 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0063 | 0.3826 | 0.8104 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0063 | 0.3826 | 0.3826 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0077 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0063 | 0.3826 | 0.5416 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0077 | 0.0109 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0063 | 0.3826 | 0.3826 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0063 | 0.3826 | 0.5416 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0063 | 0.3826 | 0.3826 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.7064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3826 | 0.8104 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0063 | 0.3826 | 0.8104 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0063 | 0.3826 | 0.3826 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0063 | 0.3826 | 0.3826 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0063 | 0.3826 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0034 | 0.0077 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0063 | 0.3826 | 0.5416 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3826 | 0.8104 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0063 | 0.3826 | 0.3826 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3826 | 0.8104 |
Schistosoma mansoni | thyroid hormone receptor | 0.0063 | 0.3826 | 0.5416 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0063 | 0.3826 | 0.3826 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0994 | 0.1408 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0063 | 0.3826 | 0.8104 |
Brugia malayi | steroid hormone receptor | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0063 | 0.3826 | 0.3826 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0813 | 0.1151 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0063 | 0.3826 | 0.3826 |
Brugia malayi | nuclear hormone receptor | 0.0063 | 0.3826 | 0.3826 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.0077 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0077 | 0.0109 |
Schistosoma mansoni | thyroid hormone receptor | 0.0063 | 0.3826 | 0.5416 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0063 | 0.3826 | 0.5416 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.0077 | 0.0077 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0063 | 0.3826 | 0.3826 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0813 | 0.1723 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.3173 | 0.3173 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0063 | 0.3826 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (ADMET) | > 10 ug ml-1 | Cytotoxicity against HUVEC after 24 hrs by MTT assay | ChEMBL. | 12662090 |
ID50 (functional) | > 10 ug ml-1 | Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay | ChEMBL. | 12662090 |
ID50 (functional) | > 10 ug ml-1 | Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay | ChEMBL. | 12662090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.