TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.579 | Formula: C23H32F3N3O3S
H donors: 0 H acceptors: 4 LogP: 4.08 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(C1CN(CCN1c1ccc(cn1)C(F)(F)F)S(=O)(=O)C[C@]12CC[C@@H](C2(C)C)CC1=O)C
InChi: 1S/C23H32F3N3O3S/c1-15(2)18-13-28(9-10-29(18)20-6-5-17(12-27-20)23(24,25)26)33(31,32)14-22-8-7-16(11-19(22)30)21(22,3)4/h5-6,12,15-16,18H,7-11,13-14H2,1-4H3/t16-,18?,22-/m1/s1
InChiKey: MWSYRMOEKUQMHZ-GOWJYDFKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tar DNA binding protein	0.0461	0.3259	0.3249
Onchocerca volvulus		0.0037	0.0145	0.0303
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.005	0.0237	0.5323
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0132	0.0613
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0132	0.0613
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Brugia malayi	PHD-finger family protein	0.0033	0.0111	0.0223
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.006	0.0313	0.0299
Brugia malayi	RE15519p	0.0037	0.0145	0.0328
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0132	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.0145	0.0328
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0145	0.013
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0437	0.3083	0.9455
Echinococcus granulosus	tar DNA binding protein	0.0461	0.3259	0.3249
Brugia malayi	beta-lactamase family protein	0.0036	0.0132	0.0287
Brugia malayi	Serotonin receptor	0.0037	0.0145	0.0328
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0128	0.0808	0.0794
Brugia malayi	latrophilin 2 splice variant baaae	0.0139	0.0895	0.2657
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0037	0.0145	0.013
Brugia malayi	G-protein coupled receptor	0.0037	0.0145	0.0328
Echinococcus granulosus	hypothetical protein	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0132	0.0287
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0037	0.0145	0.013
Echinococcus multilocularis	GPCR, family 2	0.0065	0.0344	0.033
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0145	0.013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Onchocerca volvulus		0.0037	0.0145	0.0303
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0065	0.0344	0.0946
Loa Loa (eye worm)	RNA binding protein	0.0461	0.3259	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0132	0.0613
Brugia malayi	Bromodomain containing protein	0.0091	0.0539	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0046	0.0019
Brugia malayi	follicle stimulating hormone receptor	0.0037	0.0145	0.0328
Echinococcus multilocularis	survival motor neuron protein 1	0.0235	0.16	0.1587
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0145	0.0145
Echinococcus granulosus	neuropeptide FF receptor 2	0.0037	0.0145	0.013
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0145	0.013
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0037	0.0145	0.0145
Echinococcus granulosus	allatostatin A receptor	0.0037	0.0145	0.013
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0164	0.1072	0.1059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0138	0.0883	0.087
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0037	0.0145	0.013
Schistosoma mansoni	amine GPCR	0.0037	0.0145	0.0145
Brugia malayi	beta-lactamase family protein	0.0036	0.0132	0.0287
Brugia malayi	ORL1-like opioid receptor	0.0037	0.0145	0.0328
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0145	0.013
Schistosoma mansoni	hypothetical protein	0.0139	0.0895	0.0895
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.0145	0.013
Echinococcus granulosus	7tm_1 domain containing protein	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0132	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1369	0.4131
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0145	0.0145
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.005	0.0237	0.5323
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0145	0.0145
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0132	0.0613
Loa Loa (eye worm)	acetyltransferase	0.0164	0.1072	0.3209
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0083	0.0476	0.0476
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0145	0.0145
Brugia malayi	Pre-SET motif family protein	0.0063	0.033	0.0904
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.0145	0.013
Echinococcus granulosus	tumor protein p63	0.0722	0.5174	0.5167
Schistosoma mansoni	hypothetical protein	0.0037	0.0145	0.0145
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0132	0.0613
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.0145	0.013
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0063	0.033	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0039	0.2983
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0062	0.0047
Brugia malayi	GnHR receptor homolog	0.0037	0.0145	0.0328
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.005	0.0237	0.5323
Entamoeba histolytica	hypothetical protein	0.0185	0.1232	1
Schistosoma mansoni	zinc finger protein	0.0027	0.0065	0.0065
Echinococcus multilocularis	dro:myosuppressin receptor	0.0037	0.0145	0.013
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0185	0.1232	0.1219
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0132	0.0117
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.0145	0.0328
Schistosoma mansoni	amine GPCR	0.0037	0.0145	0.0145
Onchocerca volvulus		0.0037	0.0145	0.0303
Schistosoma mansoni	hypothetical protein	0.0024	0.0046	0.0046
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.0145	0.013
Onchocerca volvulus		0.0063	0.033	0.0835
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0222	0.0568
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0065	0.0344	0.033
Onchocerca volvulus		0.0037	0.0145	0.0303
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Echinococcus granulosus	histone lysine methyltransferase setb	0.0083	0.0476	0.0462
Echinococcus multilocularis	neuropeptide receptor A26	0.0037	0.0145	0.013
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0132	1
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0037	0.0145	0.013
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.0145	0.0145
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0037	0.0145	0.0328
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.005	0.0237	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0262	0.0693
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0037	0.0145	0.0145
Echinococcus multilocularis	g-protein coupled receptor	0.0037	0.0145	0.013
Schistosoma mansoni	hypothetical protein	0.0065	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0235	0.16	0.4846
Schistosoma mansoni	tar DNA-binding protein	0.0461	0.3259	0.3259
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.0145	0.013
Brugia malayi	MH2 domain containing protein	0.0241	0.1645	0.4986
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.0145	0.013
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0132	0.0287
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0344	0.0946
Trichomonas vaginalis	set domain proteins, putative	0.0498	0.3527	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	G protein coupled receptor 139	0.0037	0.0145	0.013
Schistosoma mansoni	thyroid hormone receptor	0.0138	0.0883	0.0883
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Echinococcus granulosus	serotonin receptor	0.0037	0.0145	0.013
Schistosoma mansoni	tar DNA-binding protein	0.0461	0.3259	0.3259
Onchocerca volvulus		0.0037	0.0145	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0132	0.0287
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.0145	0.013
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0037	0.0145	0.0328
Onchocerca volvulus		0.0037	0.0145	0.0303
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0037	0.0145	0.013
Onchocerca volvulus		0.0037	0.0145	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0132	0.0287
Onchocerca volvulus		0.0037	0.0145	0.0303
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0073	0.0408	0.0394
Onchocerca volvulus		0.0037	0.0145	0.0303
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.0145	0.013
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0132	0.0287
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	tumor protein p63	0.0722	0.5174	0.5167
Onchocerca volvulus		0.0037	0.0145	0.0303
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0132	0.0132
Trichomonas vaginalis	bromodomain-containing protein, putative	0.005	0.0237	0.0312
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0065	0.0344	0.033
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Brugia malayi	putative neuropeptide receptor	0.0037	0.0145	0.0328
Echinococcus granulosus	neuropeptide s receptor	0.0037	0.0145	0.013
Schistosoma mansoni	hypothetical protein	0.0185	0.1232	0.1232
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0204	0.1369	0.4131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.0176	0.0161
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0145	0.013
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0037	0.0145	0.0145
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0062	0.0062
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.1545	1
Brugia malayi	neuropeptide F receptor	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Brugia malayi	neuropeptide F receptor	0.0037	0.0145	0.0328
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0083	0.0476	0.0476
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0037	0.0145	0.0328
Schistosoma mansoni	hypothetical protein	0.0065	0.0344	0.0344
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0065	0.0344	0.033
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0037	0.0145	0.013
Brugia malayi	larval opioid receptor	0.0037	0.0145	0.0328
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.0176	0.0161
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Brugia malayi	G protein-coupled receptor	0.0037	0.0145	0.0328
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0132	0.0613
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0083	0.0476	0.0462
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0132	0.0613
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0065	0.0344	0.033
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Onchocerca volvulus		0.0037	0.0145	0.0303
Onchocerca volvulus		0.0037	0.0145	0.0303
Brugia malayi	hypothetical protein	0.0235	0.16	0.4846
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0145	0.0145
Onchocerca volvulus		0.0036	0.0132	0.0265
Echinococcus granulosus	orexin receptor type 2	0.0037	0.0145	0.013
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.0145	0.013
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.0145	0.0145
Entamoeba histolytica	hypothetical protein	0.0185	0.1232	1
Onchocerca volvulus		0.0037	0.0145	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.0145	0.0328
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	opsin-like receptor	0.0037	0.0145	0.0145
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.0188	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0037	0.0145	0.013
Onchocerca volvulus		0.0037	0.0145	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Brugia malayi	putative neuropeptide receptor NPR1	0.0037	0.0145	0.0328
Schistosoma mansoni	tar DNA-binding protein	0.0461	0.3259	0.3259
Schistosoma mansoni	growth hormone secretagogue receptor	0.0037	0.0145	0.0145
Echinococcus granulosus	fmrfamide receptor	0.0037	0.0145	0.013
Echinococcus granulosus	G protein coupled receptor 139	0.0037	0.0145	0.013
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	myosin xvIII	0.0037	0.0145	0.0145
Schistosoma mansoni	microtubule-associated protein tau	0.1378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Mycobacterium ulcerans	lipase LipD	0.0036	0.0132	1
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0132	0.0613
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0132	0.0287
Echinococcus granulosus	zinc finger protein	0.0027	0.0065	0.0051
Brugia malayi	Dopamine receptor protein 1	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Brugia malayi	Pre-SET motif family protein	0.0437	0.3083	0.9455
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.0188	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0204	0.1369	0.4131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Brugia malayi	G-protein coupled receptor	0.0037	0.0145	0.0328
Echinococcus granulosus	neuropeptide receptor	0.0037	0.0145	0.013
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0037	0.0145	0.0145
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.0145	0.013
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0132	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0156	0.1019	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0473	0.1347
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0132	0.0613
Onchocerca volvulus		0.0037	0.0145	0.0303
Loa Loa (eye worm)	TYRA-2 protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.0145	0.013
Brugia malayi	Latrophilin receptor protein 2	0.0065	0.0344	0.0946
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0037	0.0145	0.0145
Brugia malayi	RNA recognition motif domain containing protein	0.0461	0.3259	1
Echinococcus granulosus	sex peptide receptor	0.0037	0.0145	0.013
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0145	0.013
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.0145	0.013
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0132	0.0117
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.033	0.033
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Onchocerca volvulus		0.0106	0.0646	0.1739
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Echinococcus multilocularis	microtubule associated protein 2	0.1378	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.0145	0.013
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0461	0.3259	1
Loa Loa (eye worm)	bromodomain containing protein	0.0024	0.0049	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	MH2 domain-containing protein	0.0241	0.1645	0.4986
Brugia malayi	AKH receptor	0.0037	0.0145	0.0328
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0037	0.0145	0.0328
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.0188	0.1249
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0037	0.0145	0.0328
Echinococcus multilocularis	zinc finger protein	0.0027	0.0065	0.0051
Brugia malayi	Dopamine receptor protein 2	0.0037	0.0145	0.0328
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0185	0.1232	0.1219
Schistosoma mansoni	hypothetical protein	0.0065	0.0344	0.0344
Echinococcus granulosus	neuropeptide receptor	0.0037	0.0145	0.013
Schistosoma mansoni	opsin-like receptor	0.0037	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	transcription factor SMAD2	0.0241	0.1645	0.4986
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0132	1
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.0145	0.013
Leishmania major	hypothetical protein, conserved	0.0036	0.0132	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0145	0.013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0037	0.0145	0.0145
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0132	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0037	0.0145	0.0328
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.0145	0.013
Echinococcus granulosus	neuropeptide receptor A26	0.0037	0.0145	0.013
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0132	0.0287
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0037	0.0145	0.0328
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0246	0.0642
Echinococcus granulosus	7TM GPCR rhodopsin	0.0037	0.0145	0.013
Loa Loa (eye worm)	TAR-binding protein	0.0461	0.3259	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Echinococcus multilocularis	sex peptide receptor	0.0037	0.0145	0.013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0037	0.0145	0.0328
Onchocerca volvulus		0.0037	0.0145	0.0303
Echinococcus granulosus	dro:myosuppressin receptor	0.0037	0.0145	0.013
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.0145	0.013
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0039	0.2983
Brugia malayi	Melatonin receptor type 1A	0.0037	0.0145	0.0328
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.0145	0.0145
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0145	0.013
Onchocerca volvulus		0.0036	0.0132	0.0265
Echinococcus granulosus	histone acetyltransferase KAT2B	0.005	0.0237	0.0223
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0065	0.0344	0.0946
Schistosoma mansoni	bromodomain containing protein	0.0077	0.0439	0.0439
Echinococcus multilocularis	serotonin receptor	0.0037	0.0145	0.013
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0164	0.1072	0.1072
Schistosoma mansoni	opsin-like receptor	0.0037	0.0145	0.0145
Schistosoma mansoni	histamine h1 receptor	0.0037	0.0145	0.0145
Schistosoma mansoni	tar DNA-binding protein	0.0461	0.3259	0.3259
Brugia malayi	acetyltransferase, GNAT family protein	0.0164	0.1072	0.3209
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0132	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	hypothetical protein	0.0065	0.0344	0.0344
Brugia malayi	sulfakinin receptor protein	0.0037	0.0145	0.0328
Schistosoma mansoni	thyroid hormone receptor	0.0138	0.0883	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0646	0.1884
Onchocerca volvulus		0.0037	0.0145	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.0145	0.013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Brugia malayi	Bromodomain containing protein	0.0048	0.0225	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	allatostatin A receptor	0.0037	0.0145	0.013
Onchocerca volvulus		0.0048	0.0222	0.0525
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0132	1
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Plasmodium vivax	SET domain protein, putative	0.0063	0.033	1
Echinococcus granulosus	g-protein coupled receptor	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	neuropeptide f receptor 76f	0.0037	0.0145	0.0145
Echinococcus multilocularis	serotonin receptor	0.0037	0.0145	0.013
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0145	0.0145
Schistosoma mansoni	hypothetical protein	0.0037	0.0145	0.0145
Echinococcus granulosus	somatostatin receptor	0.0037	0.0145	0.013
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0037	0.0145	0.0145
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0204	0.1369	0.4131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.0145	0.0145
Echinococcus multilocularis	neuropeptide s receptor	0.0037	0.0145	0.013
Schistosoma mansoni	amine GPCR	0.0037	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0197	0.049
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.0145	0.013
Schistosoma mansoni	amine GPCR	0.0037	0.0145	0.0145
Echinococcus granulosus	survival motor neuron protein 1	0.0235	0.16	0.1587
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0037	0.0145	0.0328
Schistosoma mansoni	amine GPCR	0.0037	0.0145	0.0145
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0063	0.033	0.033
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0132	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0145	0.013
Schistosoma mansoni	hypothetical protein	0.0128	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0145	0.0145
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0037	0.0145	0.0328
Brugia malayi	TAR-binding protein	0.0461	0.3259	1
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0132	0.0287
Brugia malayi	hypothetical protein	0.0185	0.1232	0.3705
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.0145	0.013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Brugia malayi	Dopamine receptor	0.0037	0.0145	0.0328
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0073	0.0408	0.0394
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0222	0.0222
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0039	0.2983
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0145	0.0145
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0128	0.0808	0.0794
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	adenoreceptor	0.0037	0.0145	0.0145
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0132	0.0613
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0037	0.0145	0.013
Schistosoma mansoni	tar DNA-binding protein	0.0461	0.3259	0.3259
Onchocerca volvulus		0.0498	0.3527	1
Brugia malayi	RNA binding protein	0.0461	0.3259	1
Entamoeba histolytica	hypothetical protein	0.0185	0.1232	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Schistosoma mansoni	cellular tumor antigen P53	0.0106	0.0646	0.0646
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.0145	0.0145
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0037	0.0145	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	melatonin receptor type 1A	0.0037	0.0145	0.0328
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0037	0.0145	0.013
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.0145	0.0145
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0132	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0476	0.1356
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0037	0.0145	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Onchocerca volvulus		0.0036	0.0132	0.0265
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0145	0.0145
Schistosoma mansoni	hypothetical protein	0.0048	0.0222	0.0222
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0037	0.0145	0.0145
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0145	0.013
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0145	0.013
Echinococcus granulosus	GPCR family 2	0.0065	0.0344	0.033
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0063	0.033	0.0316
Brugia malayi	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0037	0.0145	0.013
Schistosoma mansoni	hypothetical protein	0.0037	0.0145	0.0145
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0062	0.0047
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Brugia malayi	beta-lactamase	0.0036	0.0132	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0895	0.2657
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0037	0.0145	0.013
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0145	0.0328
Echinococcus multilocularis	somatostatin receptor	0.0037	0.0145	0.013
Schistosoma mansoni	hypothetical protein	0.0037	0.0145	0.0145
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0037	0.0145	0.0145
Entamoeba histolytica	hypothetical protein	0.0185	0.1232	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0037	0.0145	0.0328
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0145	0.013
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.0145	0.013
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0037	0.0145	0.013
Echinococcus multilocularis	orexin receptor type 2	0.0037	0.0145	0.013
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0037	0.0145	0.0303
Schistosoma mansoni	transcription factor LCR-F1	0.0185	0.1232	0.1232
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0145	0.013
Brugia malayi	Serotonin receptor	0.0037	0.0145	0.0328

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 4.5	Antagonist activity at human recombinant CXCR3 receptor expressed in CHO-K1 cells assessed as human IP10-induced calcium flux by FLIPR assay	ChEMBL.	19014886

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL479813

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 977619