Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.9551 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0067 | 0 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.9551 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0088 | 0.2386 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.9551 | 0.941 |
Entamoeba histolytica | cyclin family protein | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.2386 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0088 | 0.2386 | 0.5 |
Giardia lamblia | Cyclin A | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0088 | 0.2386 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.9551 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0156 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.9551 | 0.941 |
Trichomonas vaginalis | cyclins, putative | 0.0088 | 0.2386 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.9551 | 0.941 |
Onchocerca volvulus | 0.0088 | 0.2386 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.9551 | 0.941 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0088 | 0.2386 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.9551 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.9551 | 0.941 |
Plasmodium falciparum | cyclin | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclin D, putative | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclin D, putative | 0.0088 | 0.2386 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0156 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0156 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0088 | 0.2386 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0156 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0088 | 0.2386 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.9551 | 0.941 |
Echinococcus multilocularis | acetylcholinesterase | 0.0156 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.9551 | 0.941 |
Trichomonas vaginalis | cyclins, putative | 0.0088 | 0.2386 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0088 | 0.2386 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0156 | 1 | 1 |
Trichomonas vaginalis | cyclin B3, putative | 0.0088 | 0.2386 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0156 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0156 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0156 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0088 | 0.2386 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0088 | 0.2386 | 0.5 |
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.9551 | 0.941 |
Echinococcus granulosus | carboxylesterase 5A | 0.0156 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 230 nM | Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human GST-tagged p38alpha by fluorescence polarisation assay | ChEMBL. | 18614366 |
Ki (binding) | = 370 nM | Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human GST-tagged p38alpha by fluorescence polarisation assay | ChEMBL. | 18614366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.