Detailed information for compound 978111

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 319.278 | Formula: C17H12F3NO2
  • H donors: 1 H acceptors: 1 LogP: 3.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)NC(=O)/C/2=C/c1cccc(c1)C(F)(F)F
  • InChi: 1S/C17H12F3NO2/c1-23-12-5-6-13-14(16(22)21-15(13)9-12)8-10-3-2-4-11(7-10)17(18,19)20/h2-9H,1H3,(H,21,22)/b14-8+
  • InChiKey: IMMSTTLCNQGIBC-RIYZIHGNSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0043 0.0076
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0018 0.0045
Brugia malayi intermediate filament protein 0.0027 0.0105 0.0218
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0116 0.0715 0.1567
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0116 0.0715 0.141
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0116 0.0715 0.141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0436 0.2919 0.2905
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0029 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0019 0.0049
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0105 0.0218
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0019 0.0038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0036 0.0045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0194 0.057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0109
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0075 0.0056
Brugia malayi cytochrome P450 0.0015 0.0019 0.0003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0043 0.0086
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0175 0.0513
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0165 0.0328
Treponema pallidum NADH oxidase 0.0436 0.2919 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0043 0.0086
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0194 0.0175
Echinococcus multilocularis glutamate synthase 0.0116 0.0715 0.141
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0029 0.0029
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0436 0.2919 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.002
Schistosoma mansoni cpg binding protein 0.0033 0.0145 0.0259
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.0715 0.0697
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0436 0.2919 0.7304
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0116 0.0715 0.1571
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1464 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0436 0.2919 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0116 0.0715 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.0454
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0116 0.0715 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.0432
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0116 0.0715 0.1754
Onchocerca volvulus 0.0027 0.0105 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0097 0.0275
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0029 0.0058
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0339 0.2252 0.5032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0043 0.0064
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0116 0.0715 0.2161
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0116 0.0715 0.1911
Mycobacterium ulcerans glutamate synthase subunit beta 0.0116 0.0715 0.2398
Brugia malayi follicle stimulating hormone receptor 0.024 0.1574 0.3917
Schistosoma mansoni glutamate synthase 0.0116 0.0715 0.1291
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.025 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.025 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0116 0.0334
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0029 0.001
Brugia malayi glutaminase DH11.1 0.0296 0.1958 0.4886
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0182 0.0163
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.025 0.0231
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1237 0.8442 0.8439
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.025 0.0231
Mycobacterium ulcerans monoxygenase 0.0116 0.0715 0.2398
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0116 0.0715 0.1567
Echinococcus multilocularis GPCR, family 2 0.0017 0.0036 0.0071
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0022 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0036 0.0045
Loa Loa (eye worm) programmed cell death 8 0.0116 0.0715 0.1791
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0036 0.0071
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0194 0.0175
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0019 0.0049
Schistosoma mansoni inositol monophosphatase 0.004 0.0194 0.0348
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0043 0.0064
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0022 0.0043
Plasmodium falciparum thioredoxin reductase 0.0591 0.3989 1
Echinococcus multilocularis tumor protein p63 0.0362 0.2414 0.4762
Onchocerca volvulus 0.0053 0.0283 0.0741
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0043 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.025 0.0742
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0109
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0116 0.0715 0.0697
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0029 0.005
Echinococcus granulosus intermediate filament protein 0.0027 0.0105 0.0207
Schistosoma mansoni inositol monophosphatase 0.004 0.0194 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0346 0.0623
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.032 0.2122 0.5299
Plasmodium falciparum thioredoxin reductase 0.0436 0.2919 0.7244
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0436 0.2919 0.5759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0165 0.0482
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0043 0.0086
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0116 0.0715 0.2398
Echinococcus granulosus geminin 0.0337 0.2242 0.4423
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0715 0.0697
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0043 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0201 0.0593
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0043 0.0086
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0116 0.0715 0.0697
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0182 0.0163
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1574 0.3944
Echinococcus multilocularis 0.0015 0.0019 0.0038
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0116 0.0715 0.141
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0116 0.0715 0.141
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0116 0.0715 0.0697
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0218 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0029 0.0068
Echinococcus multilocularis neuropeptide s receptor 0.0508 0.3415 0.6739
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0436 0.2919 0.7244
Echinococcus granulosus GPCR family 2 0.0017 0.0036 0.0071
Schistosoma mansoni cytochrome P450 0.0015 0.0019 0.0032
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0062
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0194 0.0439
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0043 0.0076
Brugia malayi steroid hormone receptor 0.0018 0.0043 0.0064
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0116 0.0715 0.141
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0436 0.2919 1
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0032
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0116 0.0715 0.2398
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0116 0.0715 0.1567
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0043 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1464 1 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0002 0.0003
Trichomonas vaginalis glutamate synthase, putative 0.0116 0.0715 0.2161
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0019 0.0049
Brugia malayi Cytochrome P450 family protein 0.0015 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0054 0.029 0.0727
Schistosoma mansoni hypothetical protein 0.0337 0.2242 0.4055
Echinococcus granulosus cpg binding protein 0.0033 0.0145 0.0285
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0116 0.0715 0.2161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0328
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0036 0.009
Trypanosoma brucei trypanothione reductase 0.0591 0.3989 0.3978
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0346 0.0683
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0346 0.0683
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0116 0.0715 0.2161
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.025 0.0231
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0029 0.001
Leishmania major NADH dehydrogenase, putative 0.0116 0.0715 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0116 0.0334
Leishmania major hypothetical protein, conserved 0.0116 0.0715 0.0697
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0043 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1086 0.74 0.7395
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0116 0.0715 0.2161
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0043 0.0086
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0116 0.0715 0.2398
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0172 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0043 0.0064
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0132 0.0332
Giardia lamblia Glutamate synthase 0.0116 0.0715 0.1741
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0043 0.0076
Schistosoma mansoni intermediate filament proteins 0.0027 0.0105 0.0187
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.034 0.0807
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0043 0.0109
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0062
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0436 0.2919 0.7244
Loa Loa (eye worm) glutaminase 2 0.0296 0.1958 0.4909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0097 0.0275
Echinococcus granulosus neuropeptide receptor A26 0.0508 0.3415 0.6739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0141 0.0408
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0036 0.0071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0055
Echinococcus multilocularis lamin dm0 0.0027 0.0105 0.0207
Toxoplasma gondii NADPH-glutathione reductase 0.0436 0.2919 0.7303
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.029 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0043 0.0064
Schistosoma mansoni hypothetical protein 0.0116 0.0715 0.1291
Brugia malayi hypothetical protein 0.0017 0.0038 0.0051
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0105 0.0262
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0116 0.0715 0.2398
Loa Loa (eye worm) thioredoxin reductase 0.0591 0.3989 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.025 0.0231
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0715 0.0697
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1086 0.74 0.7395
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0043 0.0064
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0116 0.0715 0.2398
Onchocerca volvulus 0.0488 0.3281 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0339 0.2252 0.5032
Mycobacterium ulcerans hypothetical protein 0.0116 0.0715 0.2398
Brugia malayi nuclear hormone receptor 0.0018 0.0043 0.0064
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0436 0.2919 0.2905
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0116 0.0715 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0116 0.0715 0.141
Echinococcus granulosus dnaJ subfamily B 0.0443 0.2971 0.5861
Trypanosoma cruzi trypanothione reductase, putative 0.0436 0.2919 0.2905
Trichomonas vaginalis mercuric reductase, putative 0.0436 0.2919 0.8893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0182 0.0534
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0116 0.0715 0.0697
Trichomonas vaginalis set domain proteins, putative 0.0488 0.3281 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0715 0.1791
Entamoeba histolytica disulphide oxidoreductase, putative 0.0116 0.0715 1
Plasmodium vivax SET domain protein, putative 0.0062 0.0346 0.0622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0043 0.0109
Schistosoma mansoni glutamate synthase 0.0116 0.0715 0.1291
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0116 0.0715 0.1567
Entamoeba histolytica thioredoxin reductase, putative 0.0116 0.0715 1
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0043 0.0064
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0339 0.2252 0.5032
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0104 0.0214
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0104 0.0085
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0326 0.0643
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0218 0.0429
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0116 0.0715 0.2398
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0436 0.2919 0.528
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0022 0.0043
Brugia malayi ecdysteroid receptor 0.0018 0.0043 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0043 0.0109
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0194 0.057
Schistosoma mansoni sulfide quinone reductase 0.0116 0.0715 0.1291
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0043 0.0086
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0043 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0165 0.0482
Plasmodium falciparum glutathione reductase 0.0436 0.2919 0.7244
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.025 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0043 0.0109
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0194 0.0175
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0116 0.0715 0.2398
Onchocerca volvulus 0.0031 0.0132 0.0275
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0008 0.0016
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0116 0.0715 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1086 0.74 0.7395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0097 0.0275
Plasmodium vivax glutathione reductase, putative 0.0591 0.3989 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0659 0.4456 1
Giardia lamblia Thioredoxin reductase 0.0116 0.0715 0.1741
Mycobacterium ulcerans ferredoxin reductase 0.0116 0.0715 0.2398
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0043 0.0076
Schistosoma mansoni disulfide oxidoreductase 0.0116 0.0715 0.1291
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0116 0.0715 0.1751
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0104 0.0085
Echinococcus multilocularis dnaJ subfamily B 0.0443 0.2971 0.5861
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0043 0.0086
Echinococcus multilocularis thioredoxin glutathione reductase 0.0591 0.3989 0.7871
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0165 0.0328
Echinococcus multilocularis musashi 0.0027 0.0105 0.0207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0109
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0194 0.057
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0043 0.0076
Toxoplasma gondii thioredoxin reductase 0.0591 0.3989 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0043 0.0064
Brugia malayi glutamate synthase 0.0116 0.0715 0.1754
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0109
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0043 0.0076
Schistosoma mansoni glutamate synthase 0.0116 0.0715 0.1291
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0036 0.0071
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.025 0.108
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0029 0.001
Echinococcus multilocularis geminin 0.0337 0.2242 0.4423
Trichomonas vaginalis glutaminase, putative 0.0296 0.1958 0.5959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0029 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0043 0.0064
Trichomonas vaginalis apoptosis inducing factor, putative 0.0116 0.0715 0.2161
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0043 0.0086
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0436 0.2919 0.2905
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0043 0.0086
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0116 0.0715 0.1911
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0182 0.0163
Loa Loa (eye worm) hypothetical protein 0.0062 0.0346 0.0867
Brugia malayi Pre-SET motif family protein 0.0429 0.2874 0.7191
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0116 0.0715 0.1571
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0262
Plasmodium vivax thioredoxin reductase, putative 0.0591 0.3989 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0019 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0043 0.0086
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0116 0.0715 0.0697
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0436 0.2919 0.7303
Echinococcus granulosus microtubule associated protein 2 0.0748 0.5068 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0029 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0182 0.0534
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0116 0.0715 0.141
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.025 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0097 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0097 0.0275
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1237 0.8442 0.8439
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0043 0.0064
Echinococcus granulosus lamin 0.0027 0.0105 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0097 0.0275
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0436 0.2919 0.5759
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0116 0.0715 0.1571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0134 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0029 0.0068
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0104 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0346 0.0623
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0043 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1464 1 1
Schistosoma mansoni lamin 0.0027 0.0105 0.0187
Trypanosoma cruzi trypanothione reductase, putative 0.0591 0.3989 0.3978
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0043 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0328
Trichomonas vaginalis glutamate synthase, putative 0.0116 0.0715 0.2161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0116 0.0334
Schistosoma mansoni cpg binding protein 0.0031 0.0132 0.0237
Schistosoma mansoni microtubule-associated protein tau 0.0748 0.5068 0.9171
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0062
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0116 0.0715 0.1751
Trypanosoma brucei NADH dehydrogenase 0.0116 0.0715 0.0697
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0036 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1086 0.74 0.7395
Echinococcus multilocularis cpg binding protein 0.0033 0.0145 0.0285
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0029 0.001
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0116 0.0715 0.2161
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0116 0.0715 0.0697
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0116 0.0715 0.1567
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.2874 0.7203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0043 0.0086
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0659 0.4456 1
Echinococcus granulosus glutamate synthase 0.0116 0.0715 0.141
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0043 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0165 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0182 0.0534
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0116 0.0715 0.2161
Brugia malayi Cytochrome P450 family protein 0.0015 0.0019 0.0003
Mycobacterium ulcerans dehydrogenase 0.0116 0.0715 0.2398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0097 0.0275
Onchocerca volvulus 0.0116 0.0715 0.2073
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0043 0.0076
Schistosoma mansoni glutaminase 0.0296 0.1958 0.3542
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.009
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0116 0.0715 0.1571
Loa Loa (eye worm) inositol-1 0.004 0.0194 0.0486
Plasmodium falciparum glutathione reductase 0.0591 0.3989 1
Plasmodium vivax ferrodoxin reductase, putative 0.0116 0.0715 0.1571
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0388 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.025 0.0742
Schistosoma mansoni coup transcription factor 0.0018 0.0043 0.0076
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0002 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0043 0.0109
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0105 0.0262
Schistosoma mansoni hypothetical protein 0.0443 0.2971 0.5374
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0116 0.0715 0.0697
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0022 0.0037
Schistosoma mansoni lamin 0.0027 0.0105 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0346 0.0623
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0591 0.3989 0.8949
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0022 0.0037
Loa Loa (eye worm) hypothetical protein 0.0053 0.0283 0.071
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0116 0.0715 0.1567
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0116 0.0715 0.2161
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1237 0.8442 0.8439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0165 0.0482
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0116 0.0715 0.1567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0165 0.0482
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0436 0.2919 0.6536
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.025 0.0627
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0243 0.0437
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0436 0.2919 1
Schistosoma mansoni cpg binding protein 0.0033 0.0145 0.0259
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0019 0.0049
Leishmania major trypanothione reductase 0.0591 0.3989 0.3978
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0182 0.0534
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0116 0.0715 0.1751
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0116 0.0715 1
Brugia malayi nuclear receptor NHR-88 0.0018 0.0043 0.0064
Echinococcus granulosus thioredoxin glutathione reductase 0.0591 0.3989 0.7871
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0116 0.0715 0.0697
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0116 0.0715 0.1751
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0116 0.0715 0.141
Brugia malayi Pre-SET motif family protein 0.0062 0.0346 0.0826
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0116 0.0715 0.141
Brugia malayi Thioredoxin reductase 0.0591 0.3989 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.025 0.108
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0043 0.0109
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.025 0.0493
Schistosoma mansoni hypothetical protein 0.0037 0.0172 0.0309
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0339 0.2252 0.5032
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0436 0.2919 0.2905
Giardia lamblia NADH oxidase lateral transfer candidate 0.0436 0.2919 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0659 0.4456 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0043 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0043 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0043 0.0109
Leishmania major hypothetical protein, conserved 0.0116 0.0715 0.0697
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.025 0.0231
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0029 0.001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0029 0.001
Trypanosoma cruzi NADH dehydrogenase, putative 0.0116 0.0715 0.0697
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.025 0.045
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0436 0.2919 0.7244
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0218 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0165 0.0482
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0116 0.0715 0.141
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0436 0.2919 1
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0194 0.0382
Loa Loa (eye worm) cytochrome P450 0.0015 0.0019 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0182 0.0534
Echinococcus multilocularis microtubule associated protein 2 0.0748 0.5068 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0043 0.0086
Loa Loa (eye worm) glutathione reductase 0.0591 0.3989 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0043 0.0109
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0116 0.0715 0.0697
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.032 0.2122 0.5299
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0116 0.0715 0.1567
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0116 0.0715 0.0697
Brugia malayi glutathione reductase 0.0591 0.3989 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0175 0.0513
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0436 0.2919 0.7244
Mycobacterium ulcerans NADH dehydrogenase 0.0116 0.0715 0.2398
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0116 0.0715 0.1567
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0116 0.0715 0.0697
Onchocerca volvulus 0.0027 0.0105 0.019
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0022 0.001
Echinococcus granulosus neuropeptide s receptor 0.0508 0.3415 0.6739
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0346 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0029 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0109
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0243 0.0437
Mycobacterium tuberculosis Probable oxidoreductase 0.0659 0.4456 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0194 0.0175
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0165 0.0367
Echinococcus multilocularis neuropeptide receptor A26 0.0508 0.3415 0.6739
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0116 0.0715 0.1751
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0116 0.0715 0.1567
Trichomonas vaginalis glutathione reductase, putative 0.0436 0.2919 0.8893
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0116 0.0715 0.1754
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0346 0.0623
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0436 0.2919 1
Echinococcus multilocularis lamin 0.0027 0.0105 0.0207
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0116 0.0715 0.1754
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.029 0.0685
Mycobacterium ulcerans glutaminase 0.0296 0.1958 0.6687
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0029 0.0074
Schistosoma mansoni hypothetical protein 0.0337 0.2242 0.4055
Toxoplasma gondii selenide, water dikinase 0.0116 0.0715 0.1751
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0346 0.0683
Brugia malayi Inositol-1 0.004 0.0194 0.0442
Schistosoma mansoni sulfide quinone reductase 0.0116 0.0715 0.1291
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0056 0.0037
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0116 0.0715 0.141
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0062
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0339 0.2252 0.5032
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0116 0.0715 0.2161
Leishmania major hypothetical protein, conserved 0.0116 0.0715 0.0697
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.029 0.0685
Plasmodium falciparum ferrodoxin reductase-like protein 0.0116 0.0715 0.1571
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0043 0.0064
Onchocerca volvulus 0.0062 0.0346 0.0935
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0116 0.0715 0.1911
Mycobacterium tuberculosis Probable reductase 0.0339 0.2252 0.5032
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0022 0.0043
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0116 0.0715 0.1791
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0043 0.0086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0101 0.0254
Leishmania major hypothetical protein, conserved 0.0027 0.0104 0.0085
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0339 0.2252 0.5032
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0116 0.0715 0.141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0165 0.0482
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1237 0.8442 0.8439
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0283 0.051
Schistosoma mansoni hypothetical protein 0.0055 0.03 0.054
Trypanosoma cruzi NADH dehydrogenase, putative 0.0116 0.0715 0.0697
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0218 0.0429
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0043 0.0086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0104 0.0261
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Brugia malayi CXXC zinc finger family protein 0.0031 0.0132 0.0288
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0194 0.0382
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0116 0.0715 0.1741
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0116 0.0715 0.2161
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0194 0.0602
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0008 0.0016
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0043 0.0086
Brugia malayi hypothetical protein 0.0027 0.0104 0.0217
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0116 0.0715 0.2161
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0043 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0043 0.0064
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0043 0.0076
Brugia malayi Cytochrome P450 family protein 0.0015 0.0019 0.0003
Echinococcus granulosus tumor protein p63 0.0362 0.2414 0.4762
Echinococcus granulosus lamin dm0 0.0027 0.0105 0.0207
Loa Loa (eye worm) glutaminase 0.0296 0.1958 0.4909

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 4.39 % Cell cycle arrest in human HCT116 cells released from G1 block assessed as accumulation at sub G1 phase at 5 uM after 24 hrs by flow cytometry ChEMBL. 19200740
Activity (functional) = 17.5 % Cell cycle arrest in human HCT116 cells released from G1 block assessed as accumulation at G1 phase at 5 uM after 24 hrs by flow cytometry ChEMBL. 19200740
Activity (functional) = 17.96 % Cell cycle arrest in human HCT116 cells released from G2 block assessed as accumulation at S phase at 5 uM after 24 hrs by flow cytometry ChEMBL. 19200740
Activity (functional) = 19.12 % Cell cycle arrest in human HCT116 cells released from G1 block assessed as accumulation at S phase at 5 uM after 24 hrs by flow cytometry ChEMBL. 19200740
Activity (functional) = 20.69 % Cell cycle arrest in human HCT116 cells released from G2 block assessed as accumulation at sub G1 phase at 5 uM after 24 hrs by flow cytometry ChEMBL. 19200740
Activity (functional) = 30.55 % Cell cycle arrest in human HCT116 cells released from G2 block assessed as accumulation at G1 phase at 5 uM after 24 hrs by flow cytometry ChEMBL. 19200740
Activity (functional) = 31.58 % Cell cycle arrest in human HCT116 cells released from G2 block assessed as accumulation at G2/M phase at 5 uM after 24 hrs by flow cytometry ChEMBL. 19200740
Activity (functional) = 59.16 % Cell cycle arrest in human HCT116 cells released from G1 block assessed as accumulation at G2/M phase at 5 uM after 24 hrs by flow cytometry ChEMBL. 19200740
IC50 (functional) = 1.9 uM Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay ChEMBL. 19200740
IC50 (functional) = 3.8 uM Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay ChEMBL. 19200740
Ratio (binding) = 0.085 Induction of NQO1 activity in mouse Hepa-1c1c7 cells assessed as drug level required to double basal enzyme activity after 48 hrs by MTT assay ChEMBL. 19200740
Ratio (ADMET) = 1.36 Induction of CYP1A1 activity in mouse Hepa-1c1c7 cells assessed as induction ratio at 0.5 uM after 48 hrs by EROD assay relative to control ChEMBL. 19200740
Ratio (binding) = 4.22 Induction of NQO1 activity in mouse Hepa-1c1c7 cells assessed as induction ratio at 0.5 uM after 48 hrs by MTT assay relative to control ChEMBL. 19200740

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19200740

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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