Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | colony stimulating factor 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | Get druggable targets OG5_132967 | All targets in OG5_132967 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.2752 | 0.41 | 0.41 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.3136 | 0.4677 | 0.5 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0501 | 0.0724 | 0.0724 |
Schistosoma mansoni | patched 1 | 0.2752 | 0.41 | 0.41 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.2752 | 0.41 | 0.41 |
Loa Loa (eye worm) | hypothetical protein | 0.2752 | 0.41 | 0.41 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.6684 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3136 | 0.4677 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.002 | 0.0002 | 0.0002 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.6684 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.2752 | 0.41 | 0.41 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.2752 | 0.41 | 0.41 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.6684 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.2752 | 0.41 | 0.41 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3136 | 0.4677 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.3136 | 0.4677 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.2752 | 0.41 | 0.41 |
Loa Loa (eye worm) | hypothetical protein | 0.6684 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.2752 | 0.41 | 0.4099 |
Echinococcus multilocularis | protein dispatched 1 | 0.2752 | 0.41 | 0.41 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.6684 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.6684 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.2752 | 0.41 | 0.41 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.6684 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.2752 | 0.41 | 0.41 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.6684 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.6684 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.8 uM | Antiproliferative activity against mouse 3T3 cells expressing human CSF1R after 72 hrs by Celltiter assay | ChEMBL. | 19112018 |
IC50 (binding) | = 0.052 uM | Inhibition of His-tagged CSF1R catalytic domain expressed in baculovirus by HTRF assay | ChEMBL. | 19112018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.