Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0174 | 0.0562 | 0.039 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0174 | 0.0562 | 0.5 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0084 | 0.0179 | 0.0179 |
Treponema pallidum | adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.5 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | allatostatin A receptor | 0.0084 | 0.0179 | 0.0179 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0174 | 0.0562 | 0.0562 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0174 | 0.0562 | 0.1892 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0156 | 0.0487 | 0.0313 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0156 | 0.0487 | 0.0313 |
Echinococcus granulosus | g protein coupled receptor | 0.0084 | 0.0179 | 0.0179 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0156 | 0.0487 | 0.0313 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | neuropeptide receptor | 0.0084 | 0.0179 | 0.0179 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0084 | 0.0179 | 0.0179 |
Wolbachia endosymbiont of Brugia malayi | orotate phosphoribosyltransferase | 0.0559 | 0.2204 | 0.5 |
Echinococcus granulosus | serotonin receptor | 0.0084 | 0.0179 | 0.0179 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.0559 | 0.2204 | 0.2062 |
Schistosoma mansoni | cell adhesion molecule | 0.0156 | 0.0487 | 0.0313 |
Echinococcus granulosus | defective proboscis extension response | 0.0156 | 0.0487 | 0.0487 |
Plasmodium falciparum | orotate phosphoribosyltransferase | 0.0559 | 0.2204 | 0.174 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0084 | 0.0179 | 0.0179 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Echinococcus granulosus | adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.2204 |
Echinococcus granulosus | sex peptide receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | Immunoglobulin | 0.0156 | 0.0487 | 0.0487 |
Echinococcus granulosus | g protein coupled receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus multilocularis | Immunoglobulin | 0.0156 | 0.0487 | 0.0313 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2386 | 1 | 1 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.0559 | 0.2204 | 0.2062 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0084 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.0559 | 0.2204 | 0.2204 |
Trypanosoma brucei | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Toxoplasma gondii | orotate phosphoribosyltransferase | 0.0559 | 0.2204 | 0.174 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.1827 | 0.7617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Echinococcus granulosus | neuropeptide s receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.2264 | 0.9481 | 0.9481 |
Echinococcus granulosus | fmrfamide receptor | 0.0084 | 0.0179 | 0.0179 |
Leishmania major | adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.174 |
Treponema pallidum | hypothetical protein | 0.0559 | 0.2204 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0084 | 0.0179 | 0.0179 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.2062 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0084 | 0.0179 | 0.0179 |
Leishmania major | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative | 0.0559 | 0.2204 | 0.174 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.0559 | 0.2204 | 0.2062 |
Brugia malayi | hypothetical protein | 0.0156 | 0.0487 | 0.0313 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0084 | 0.0179 | 0.0179 |
Schistosoma mansoni | nephrin | 0.0156 | 0.0487 | 0.0313 |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0174 | 0.0562 | 0.039 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0174 | 0.0562 | 0.039 |
Echinococcus multilocularis | neuroglian | 0.0156 | 0.0487 | 0.0313 |
Echinococcus granulosus | roundabout 2 | 0.0156 | 0.0487 | 0.0487 |
Echinococcus granulosus | neuroglian | 0.0156 | 0.0487 | 0.0487 |
Trypanosoma cruzi | Adenine phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Trypanosoma cruzi | Adenine phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Echinococcus granulosus | aurora kinase A | 0.0174 | 0.0562 | 0.0562 |
Loa Loa (eye worm) | adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 1 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0084 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | AUR protein kinase | 0.0174 | 0.0562 | 0.1892 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0084 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | orotate phosphoribosyltransferase | 0.0559 | 0.2204 | 1 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2386 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor | 0.0084 | 0.0179 | 0.0179 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0181 | 0.0594 | 0.2046 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | hypothetical protein | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0084 | 0.0179 | 0.0179 |
Schistosoma mansoni | protein kinase | 0.0174 | 0.0562 | 0.039 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus multilocularis | Immunoglobulin | 0.0156 | 0.0487 | 0.0313 |
Loa Loa (eye worm) | AUR protein kinase | 0.0174 | 0.0562 | 0.1892 |
Echinococcus granulosus | orexin receptor type 2 | 0.0084 | 0.0179 | 0.0179 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.1827 | 0.7617 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.2062 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2386 | 1 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2386 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.0487 | 0.0313 |
Entamoeba histolytica | protein kinase, putative | 0.0174 | 0.0562 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0084 | 0.0179 | 0.0179 |
Leishmania major | xanthine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0156 | 0.0487 | 0.0313 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0174 | 0.0562 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0174 | 0.0562 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0156 | 0.0487 | 0.0313 |
Brugia malayi | Adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.2062 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0084 | 0.0179 | 0.0179 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.2386 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0174 | 0.0562 | 0.039 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0181 | 0.0594 | 0.0422 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0084 | 0.0179 | 0.0179 |
Giardia lamblia | Adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.174 |
Trichomonas vaginalis | ribose-phosphate pyrophosphokinase, putative | 0.0559 | 0.2204 | 0.174 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0084 | 0.0179 | 0.0179 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2386 | 1 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.0174 | 0.0562 | 0.039 |
Onchocerca volvulus | Adenine phosphoribosyltransferase homolog | 0.0559 | 0.2204 | 0.2062 |
Treponema pallidum | phosphoribosylpyrophosphate synthetase | 0.0559 | 0.2204 | 0.5 |
Echinococcus granulosus | twitchin | 0.0157 | 0.0493 | 0.0493 |
Entamoeba histolytica | protein kinase , putative | 0.0174 | 0.0562 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0174 | 0.0562 | 0.5 |
Trypanosoma cruzi | Adenine phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Trypanosoma cruzi | Adenine phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0084 | 0.0179 | 0.0179 |
Echinococcus multilocularis | adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.2062 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0156 | 0.0487 | 0.0487 |
Entamoeba histolytica | protein kinase, putative | 0.0174 | 0.0562 | 0.5 |
Echinococcus granulosus | somatostatin receptor | 0.0084 | 0.0179 | 0.0179 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.2386 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | amidophosphoribosyltransferase | 0.0559 | 0.2204 | 0.5 |
Trichomonas vaginalis | Ribose-phosphate pyrophosphokinase, putative | 0.0559 | 0.2204 | 0.174 |
Trypanosoma brucei | Adenine phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Schistosoma mansoni | uracil phosphoribosyltransferase | 0.0559 | 0.2204 | 0.2062 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0084 | 0.0179 | 0.0179 |
Trypanosoma brucei | Adenine phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0084 | 0.0179 | 0.0179 |
Schistosoma mansoni | vesicular amine transporter | 0.0156 | 0.0487 | 0.0313 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.2062 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.2386 | 1 | 1 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0559 | 0.2204 | 0.2062 |
Plasmodium vivax | orotate phosphoribosyltransferase, putative | 0.0559 | 0.2204 | 0.174 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0487 | 0.1519 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0084 | 0.0179 | 0.0179 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2386 | 1 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0174 | 0.0562 | 0.039 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0084 | 0.0179 | 0.0179 |
Onchocerca volvulus | 0.2386 | 1 | 1 | |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0084 | 0.0179 | 0.0179 |
Echinococcus granulosus | g-protein coupled receptor | 0.0084 | 0.0179 | 0.0179 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2386 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.