Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Schistosoma japonicum | Protein tyrosine kinase 2 beta, putative | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Loa Loa (eye worm) | TK/FAK protein kinase | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Schistosoma japonicum | expressed protein | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Schistosoma japonicum | expressed protein | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Echinococcus granulosus | protein tyrosine kinase | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Echinococcus multilocularis | protein tyrosine kinase | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | choline O acetyltransferase | 0.0178 | 0.0302 | 0.0302 |
Brugia malayi | Protein kinase domain containing protein | 0.0309 | 0.2027 | 0.2027 |
Onchocerca volvulus | 0.0155 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0155 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0155 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0915 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0155 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0915 | 1 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0178 | 0.0302 | 0.0302 |
Onchocerca volvulus | 0.0155 | 0 | 0.5 | |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0309 | 0.2027 | 0.2027 |
Brugia malayi | Choline O-acetyltransferase | 0.0178 | 0.0302 | 0.0302 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0915 | 1 | 1 |
Onchocerca volvulus | 0.0155 | 0 | 0.5 | |
Onchocerca volvulus | 0.0155 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0155 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0305 | 0.1979 | 0.1979 |
Loa Loa (eye worm) | hypothetical protein | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0302 | 0.0302 |
Onchocerca volvulus | 0.0155 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0915 | 1 | 1 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0305 | 0.1979 | 0.1979 |
Schistosoma mansoni | choline o-acyltransferase | 0.0178 | 0.0302 | 0.0302 |
Echinococcus multilocularis | acetylcholinesterase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0155 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0915 | 1 | 1 |
Echinococcus granulosus | protein tyrosine kinase | 0.0305 | 0.1979 | 0.1979 |
Brugia malayi | Choline O-acetyltransferase | 0.0178 | 0.0302 | 0.0302 |
Echinococcus granulosus | acetylcholinesterase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0155 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0178 | 0.0302 | 0.0302 |
Echinococcus granulosus | carboxylesterase 5A | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0915 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.33 uM | Antiproliferative activity against Homo sapiens (human) HepG2 cells assessed as growth inhibition after 48 hr by MTT assay | ChEMBL. | No reference |
IC50 (binding) | = 17.4 uM | Inhibition of full-length Homo sapiens (human) recombinant FAK assessed as remaining ATP content after 4 hr by Kinase-Glo luminescence analysis | ChEMBL. | No reference |
IZ (functional) | Antimicrobial activity against Candida albicans ATCC 60193 at 10 mg/mL after 18 hrs by agar-well diffusion method | ChEMBL. | 18676062 | |
IZ (functional) | = 30 mm | Antimicrobial activity against Escherichia coli ATCC 25922 at 10 mg/mL after 18 hrs by agar-well diffusion method | ChEMBL. | 18676062 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.