Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholecystokinin A receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | sulfakinin receptor protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | rhodopsin orphan GPCR | cholecystokinin A receptor | 428 aa | 373 aa | 19.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0905 | 0.0905 |
Brugia malayi | hypothetical protein | 0.0258 | 0.0905 | 0.0905 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1058 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0179 | 0 | 0.5 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1058 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1058 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1058 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0179 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1058 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0179 | 0 | 0.5 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1058 | 1 | 1 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0179 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1058 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1058 | 1 | 1 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0179 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0179 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1058 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1058 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1058 | 1 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0258 | 0.0905 | 0.0905 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | <= 20 % | Agonist activity against human CCK2 receptor assessed as receptor activation at 10000 nM | ChEMBL. | 18614364 |
Activity (functional) | = 89 % | Agonist activity against human CCK1 receptor assessed as receptor activation at 10000 nM | ChEMBL. | 18614364 |
EC50 (functional) | = 74 nM | Agonist activity against human CCK1 receptor | ChEMBL. | 18614364 |
IC50 (binding) | = 14 nM | Inhibition of human CCK1 receptor | ChEMBL. | 18614364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.