Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neuroligin | 0.0049 | 0.0335 | 0.0181 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0154 | 0.1454 | 0.4772 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0049 | 0.0335 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.0335 | 0.0655 |
Onchocerca volvulus | 0.0049 | 0.0335 | 0.1484 | |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.2876 | 1 |
Onchocerca volvulus | 0.0049 | 0.0335 | 0.1484 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0335 | 0.1166 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0335 | 0.1166 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.0335 | 0.1166 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0072 | 0.0581 | 0.0431 |
Onchocerca volvulus | 0.0043 | 0.0271 | 0.0946 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0288 | 0.2876 | 0.2762 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0049 | 0.0335 | 1 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0157 | 0.0547 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0271 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0639 | 0.2221 |
Brugia malayi | hypothetical protein | 0.0145 | 0.1357 | 0.4718 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0049 | 0.0335 | 0.0655 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0049 | 0.0335 | 0.0655 |
Plasmodium vivax | choline kinase, putative | 0.008 | 0.0664 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0157 | 0.0547 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.0335 | 0.1166 |
Schistosoma mansoni | acetylcholinesterase | 0.0049 | 0.0335 | 0.0655 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.0581 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0288 | 0.2876 | 1 |
Echinococcus granulosus | neuroligin | 0.0049 | 0.0335 | 0.0655 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.0335 | 0.0655 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.0335 | 0.0655 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0049 | 0.0335 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1454 | 0.5057 |
Echinococcus granulosus | carboxylesterase 5A | 0.0288 | 0.2876 | 1 |
Onchocerca volvulus | 0.0043 | 0.0271 | 0.0946 | |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.008 | 0.0664 | 0.2308 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0272 | 0.2707 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0049 | 0.0335 | 0.0655 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0072 | 0.0581 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0049 | 0.0335 | 0.0265 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0157 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0335 | 0.1166 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0049 | 0.0335 | 0.0181 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.0335 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0335 | 0.1166 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0271 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1357 | 0.4718 |
Echinococcus multilocularis | acetylcholinesterase | 0.0288 | 0.2876 | 0.2762 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0335 | 0.1166 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0049 | 0.0335 | 0.0655 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0271 | 0.0941 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0271 | 0.5 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.008 | 0.0664 | 0.0515 |
Loa Loa (eye worm) | carboxylesterase | 0.0049 | 0.0335 | 0.1166 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.0335 | 0.1166 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0271 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0151 | 0.0525 |
Echinococcus granulosus | acetylcholinesterase | 0.0288 | 0.2876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0335 | 0.1166 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 0.0581 | 0.1559 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0335 | 0.1166 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0271 | 0.0941 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0271 | 0.0417 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0147 | 0.1375 | 0.4478 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.0581 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0555 | 0.1928 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0049 | 0.0335 | 0.0181 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0157 | 0.0547 |
Onchocerca volvulus | 0.0049 | 0.0335 | 0.1484 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0271 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0157 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0271 | 0.0941 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.0581 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0072 | 0.0581 | 0.1274 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0154 | 0.1454 | 0.1318 |
Loa Loa (eye worm) | carboxylesterase | 0.0288 | 0.2876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0271 | 0.0941 |
Echinococcus granulosus | acetylcholinesterase | 0.0288 | 0.2876 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0271 | 0.0115 |
Onchocerca volvulus | 0.0049 | 0.0335 | 0.1484 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0271 | 0.0941 |
Brugia malayi | Carboxylesterase family protein | 0.0288 | 0.2876 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0271 | 0.0417 |
Brugia malayi | Carboxylesterase family protein | 0.0288 | 0.2876 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0271 | 0.5 |
Onchocerca volvulus | 0.0049 | 0.0335 | 0.1484 | |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0271 | 0.0941 |
Onchocerca volvulus | Huntingtin homolog | 0.0145 | 0.1357 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0271 | 0.0941 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.008 | 0.0664 | 0.1863 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0271 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0049 | 0.0335 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1357 | 0.4718 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.2876 | 1 |
Onchocerca volvulus | 0.0043 | 0.0271 | 0.0946 | |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0072 | 0.0581 | 0.1559 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0049 | 0.0335 | 0.0265 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0049 | 0.0335 | 0.0655 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0288 | 0.2876 | 1 |
Plasmodium falciparum | choline kinase | 0.008 | 0.0664 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0271 | 0.0941 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0271 | 0.0417 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.008 | 0.0664 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0072 | 0.0581 | 0.7893 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.008 | 0.0664 | 0.2308 |
Onchocerca volvulus | Huntingtin homolog | 0.0145 | 0.1357 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.1454 | 0.4772 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 0.0581 | 0.1559 |
Echinococcus multilocularis | acetylcholinesterase | 0.0288 | 0.2876 | 0.2762 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0271 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0049 | 0.0335 | 0.208 |
Schistosoma mansoni | gliotactin | 0.0049 | 0.0335 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0335 | 0.1166 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0049 | 0.0335 | 0.0265 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0154 | 0.1454 | 0.4772 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0271 | 0.0941 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Cryptococcus neoformans at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antifungal activity against Saccharomyces cerevisiae at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antibacterial activity against Escherichia coli at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 | |
Activity (functional) | Antifungal activity against Candida albicans at 1 mM by almar blue dye reduction assay | ChEMBL. | 18585037 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.