Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome P450 reductase, putative | 0.0118 | 0.8159 | 0.8159 |
Giardia lamblia | Hypothetical protein | 0.0118 | 0.8159 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0082 | 0.3805 | 0.3805 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0133 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0118 | 0.8159 | 0.8159 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0133 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0133 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0133 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0133 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0066 | 0.1841 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0133 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0133 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0082 | 0.3805 | 0.2407 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0133 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0133 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0133 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0067 | 0.1964 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0082 | 0.3805 | 0.3805 |
Treponema pallidum | flavodoxin | 0.0051 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0133 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0133 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0051 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0066 | 0.1841 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0133 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0118 | 0.8159 | 0.8159 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0133 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0118 | 0.8159 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0082 | 0.3805 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0133 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0133 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0051 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0133 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0051 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0133 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0133 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0133 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.