Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0802 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.1166 | 0.0468 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0802 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.23 | 0.23 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0802 | 1 | 1 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0279 | 0.23 | 0.1692 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0802 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0802 | 1 | 1 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0279 | 0.23 | 0.1692 |
Brugia malayi | Dihydrofolate reductase | 0.0802 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0222 | 0.1464 | 0.079 |
Brugia malayi | thymidylate synthase | 0.0222 | 0.1464 | 0.079 |
Brugia malayi | Protein kinase domain containing protein | 0.0202 | 0.1166 | 0.0468 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0585 | 0.6804 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0585 | 0.6804 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0222 | 0.1464 | 0.079 |
Loa Loa (eye worm) | thymidylate synthase | 0.0222 | 0.1464 | 0.1464 |
Echinococcus granulosus | dihydrofolate reductase | 0.0802 | 1 | 1 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0173 | 0.0732 | 0.0732 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0802 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0585 | 0.6804 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0802 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0585 | 0.6804 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0202 | 0.1166 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1569 | 0.1569 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0279 | 0.23 | 0.1692 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0585 | 0.6804 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0585 | 0.6804 | 1 |
Onchocerca volvulus | 0.0222 | 0.1464 | 0.5 | |
Echinococcus multilocularis | thymidylate synthase | 0.0222 | 0.1464 | 0.079 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.89 uM | Inhibition of CHK1 | ChEMBL. | 19111462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.