Detailed information for compound 978800

Basic information

Technical information
  • TDR Targets ID: 978800
  • Name: 2-(2-aminoethylamino)-4-[(4-methylphenyl)amin o]pyrimidine-5-carboxamide
  • MW: 286.332 | Formula: C14H18N6O
  • H donors: 4 H acceptors: 3 LogP: 1.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCNc1ncc(c(n1)Nc1ccc(cc1)C)C(=O)N
  • InChi: 1S/C14H18N6O/c1-9-2-4-10(5-3-9)19-13-11(12(16)21)8-18-14(20-13)17-7-6-15/h2-5,8H,6-7,15H2,1H3,(H2,16,21)(H2,17,18,19,20)
  • InChiKey: PHHCDYHRFLEBMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-aminoethylamino)-4-[(4-methylphenyl)amino]-5-pyrimidinecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens spleen tyrosine kinase Starlite/ChEMBL References
Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tumor protein p63 0.0359 0.6718 0.6718
Trypanosoma brucei iron superoxide dismutase A, mitochondrial 0.0078 0.1252 1
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Brugia malayi Major Facilitator Superfamily protein 0.0019 0.0099 0.0116
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.0033 0.0033
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA 0.0078 0.1252 1
Toxoplasma gondii sugar transporter ST2 0.0019 0.0099 0.0213
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0118 0.0946
Schistosoma mansoni sugar transporter 0.0019 0.0099 0.0099
Brugia malayi Protein kinase domain containing protein 0.0016 0.0033 0.0038
Loa Loa (eye worm) SRC-1 0.0016 0.0033 0.0038
Trypanosoma brucei heat shock protein, putative 0.0034 0.0387 0.3093
Echinococcus multilocularis tyrosine protein kinase Srms 0.0016 0.0033 0.0033
Echinococcus granulosus tyrosine protein kinase Src64B 0.0016 0.0033 0.0033
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0019 0.0099 0.0142
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0387 0.0453
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0552 0.393
Trypanosoma brucei glucose transporter, putative 0.0019 0.0099 0.079
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0254 0.0259
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0019 0.0099 0.0099
Echinococcus granulosus geminin 0.0176 0.3153 0.3153
Onchocerca volvulus 0.0016 0.0033 0.0033
Echinococcus granulosus tyrosine kinase 0.0016 0.0033 0.0033
Trypanosoma brucei glucose transporter, putative 0.0019 0.0099 0.079
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0078 0.1252 0.128
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0016 0.0033 0.0033
Brugia malayi SH2 domain containing protein 0.0016 0.0033 0.0038
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0016 0.0033 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Plasmodium falciparum endoplasmin, putative 0.0021 0.0134 0.0288
Brugia malayi Protein kinase domain containing protein 0.0016 0.0033 0.0038
Trichomonas vaginalis glucose transporter, putative 0.0019 0.0099 0.0101
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0019 0.0099 0.0099
Loa Loa (eye worm) TK/ABL protein kinase 0.0016 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0054 0.0776 0.0907
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.175 0.175
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0134 0.0137
Loa Loa (eye worm) inositol-1 0.0042 0.0552 0.0645
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.1719 0.1719
Trypanosoma brucei glucose transporter, putative 0.0019 0.0099 0.079
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0082 0.0178
Brugia malayi SH2 domain containing protein 0.0016 0.0033 0.0038
Trypanosoma brucei heat shock protein, putative 0.0034 0.0387 0.3093
Leishmania major glucose transporter, lmgt2 0.0019 0.0099 0.079
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0016 0.0033 0.0033
Brugia malayi hypothetical protein 0.0021 0.0139 0.0162
Schistosoma mansoni hypothetical protein 0.0042 0.0554 0.0554
Echinococcus granulosus tyrosine protein kinase ABL1 0.0016 0.0033 0.0033
Trypanosoma brucei heat shock protein, putative 0.0034 0.0387 0.3093
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0033 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0082 0.0657
Wolbachia endosymbiont of Brugia malayi superoxide dismutase, SodA 0.0078 0.1252 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0019 0.0099 0.0142
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.2573 0.2573
Trichomonas vaginalis set domain proteins, putative 0.0517 0.9782 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0016 0.0033 0.0033
Trypanosoma brucei THT1 - hexose transporter, putative 0.0019 0.0099 0.079
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0387 0.3093
Loa Loa (eye worm) hypothetical protein 0.0078 0.1252 0.1463
Trypanosoma brucei glucose transporter 2A 0.0019 0.0099 0.079
Trypanosoma cruzi superoxide dismutase, putative 0.0044 0.0594 0.4742
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0082 0.0082
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0019 0.0099 0.0099
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0387 0.3093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Echinococcus multilocularis solute carrier family 22 0.0019 0.0099 0.0099
Echinococcus granulosus muscleblind protein 0.0155 0.2748 0.2748
Plasmodium falciparum superoxide dismutase [Fe] 0.0044 0.0594 0.1281
Trypanosoma brucei iron superoxide dismutase C, mitochondrial 0.0044 0.0594 0.4742
Trypanosoma cruzi Iron/manganese superoxide dismutases, C-terminal domain containing protein, putative 0.002 0.0111 0.0885
Onchocerca volvulus 0.0019 0.0099 0.0101
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1202 0.1202
Trypanosoma cruzi Iron/manganese superoxide dismutases, C-terminal domain containing protein, putative 0.002 0.0111 0.0885
Onchocerca volvulus 0.0019 0.0099 0.0101
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.1719 0.2008
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0584 0.0597
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.217 0.217
Schistosoma mansoni hypothetical protein 0.005 0.0705 0.0705
Treponema pallidum heat shock protein 90 0.0027 0.0254 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0552 0.3212
Schistosoma mansoni rab6-interacting 0.0021 0.0139 0.0139
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0082 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0101
Echinococcus multilocularis protein dispatched 1 0.005 0.0705 0.0705
Plasmodium vivax SET domain protein, putative 0.0065 0.0998 0.2151
Loa Loa (eye worm) sugar transporter 0.0019 0.0099 0.0116
Echinococcus granulosus intermediate filament protein 0.0028 0.0276 0.0276
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0552 0.393
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Onchocerca volvulus 0.0019 0.0099 0.0101
Leishmania major hypothetical protein, conserved 0.0019 0.0099 0.079
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0387 0.0836
Brugia malayi Muscleblind-like protein 0.0155 0.2748 0.3209
Schistosoma mansoni intermediate filament proteins 0.0028 0.0276 0.0276
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0019 0.0099 0.0099
Brugia malayi Major Facilitator Superfamily protein 0.0019 0.0099 0.0116
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.4507 0.4507
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0134 0.0137
Trypanosoma brucei glucose transporter, putative 0.0019 0.0099 0.079
Brugia malayi hypothetical protein 0.0016 0.0033 0.0038
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0082 0.0096
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0754 0.0754
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0552 0.441
Brugia malayi isocitrate dehydrogenase 0.0018 0.0082 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0272 0.0318
Plasmodium falciparum hexose transporter 0.0019 0.0099 0.0213
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0019 0.0099 0.0213
Onchocerca volvulus 0.0016 0.0033 0.0033
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0082 0.0096
Echinococcus multilocularis geminin 0.0176 0.3153 0.3153
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0387 0.3093
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0033 0.0033
Schistosoma mansoni tyrosine kinase 0.0016 0.0033 0.0033
Leishmania major superoxide dismutase, putative 0.0044 0.0594 0.4742
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0101
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0078 0.1252 0.128
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0016 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0019 0.0099 0.0099
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0033 0.0033
Trypanosoma brucei heat shock protein, putative 0.0034 0.0387 0.3093
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0101
Schistosoma mansoni loxhd1 0.0021 0.0139 0.0139
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0082 0.0178
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0387 0.3093
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0019 0.0099 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.1719 0.1719
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0082 0.0657
Onchocerca volvulus 0.0019 0.0099 0.0101
Toxoplasma gondii thioredoxin domain-containing protein 0.0252 0.4637 1
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0552 0.0565
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0082 0.0178
Brugia malayi Protein kinase domain containing protein 0.0016 0.0033 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trypanosoma cruzi iron superoxide dismutase, putative 0.0053 0.0769 0.6143
Onchocerca volvulus 0.0028 0.0276 0.0282
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0466 0.2127
Schistosoma mansoni rab6-interacting 0.0021 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.0162
Onchocerca volvulus 0.0019 0.0099 0.0101
Echinococcus multilocularis heat shock protein 90 0.0027 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0155 0.2748 0.3209
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0016 0.0033 0.0033
Echinococcus multilocularis solute carrier family 22 0.0019 0.0099 0.0099
Leishmania major glucose transporter, lmgt3 0.0019 0.0099 0.079
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0254 0.1465
Trypanosoma cruzi hexose transporter 0.0019 0.0099 0.079
Echinococcus granulosus heat shock protein 0.0034 0.0387 0.0387
Loa Loa (eye worm) TK protein kinase 0.0016 0.0033 0.0038
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Brugia malayi Inositol-1 0.0042 0.0552 0.0645
Chlamydia trachomatis superoxide dismutase 0.0078 0.1252 0.5
Schistosoma mansoni lamin 0.0028 0.0276 0.0276
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0082 0.0657
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0019 0.0099 0.0099
Trypanosoma brucei iron superoxide dismutase 0.0078 0.1252 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0101
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Echinococcus multilocularis tyrosine protein kinase Blk 0.0016 0.0033 0.0033
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0016 0.0033 0.0033
Echinococcus granulosus solute carrier family 22 0.0019 0.0099 0.0099
Toxoplasma gondii transporter, major facilitator family protein 0.0019 0.0099 0.0213
Onchocerca volvulus 0.0021 0.0139 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0552 0.1191
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0951 0.0951
Trypanosoma cruzi sugar transporter, putative 0.0019 0.0099 0.079
Schistosoma mansoni hypothetical protein 0.0042 0.0554 0.0554
Trypanosoma brucei heat shock protein, putative 0.0034 0.0387 0.3093
Trichomonas vaginalis myo-inositol transporter, putative 0.0019 0.0099 0.0101
Echinococcus granulosus Sugar transporter ERD6 protein 0.0019 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Onchocerca volvulus 0.0016 0.0033 0.0033
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0998 0.2151
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Echinococcus granulosus tumor protein p63 0.0359 0.6718 0.6718
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0466 0.3281
Schistosoma mansoni inositol monophosphatase 0.0042 0.0552 0.0552
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0078 0.1252 1
Echinococcus granulosus RUN 0.0021 0.0139 0.0139
Trypanosoma cruzi superoxide dismutase, putative 0.002 0.0111 0.0885
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0254 0.5367
Giardia lamblia Grp94/Hsp90 0.0027 0.0254 0.5367
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0998 0.0998
Echinococcus multilocularis manganese superoxide dismutase 0.0078 0.1252 0.1252
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative 0.0078 0.1252 0.1463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0322
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0019 0.0099 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Plasmodium falciparum superoxide dismutase [Fe] 0.0078 0.1252 0.2701
Toxoplasma gondii sugar transporter ST3 0.0019 0.0099 0.0213
Onchocerca volvulus 0.0019 0.0099 0.0101
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0033 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Trypanosoma cruzi superoxide dismutase, putative 0.0044 0.0594 0.4742
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0139 0.0299
Entamoeba histolytica iron-containing superoxide dismutase 0.0078 0.1252 0.7285
Trichomonas vaginalis sugar transport protein, putative 0.0019 0.0099 0.0101
Trypanosoma brucei THT1 - hexose transporter, putative 0.0019 0.0099 0.079
Brugia malayi intermediate filament protein 0.0028 0.0276 0.0322
Schistosoma mansoni tyrosine kinase 0.0516 0.9764 0.9764
Echinococcus multilocularis expressed conserved protein 0.0096 0.1599 0.1599
Echinococcus multilocularis heat shock protein 90 0.0034 0.0387 0.0387
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Echinococcus granulosus tyrosine protein kinase Srms 0.0016 0.0033 0.0033
Schistosoma mansoni lipoxygenase 0.0125 0.217 0.217
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0387 0.3093
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0387 0.2253
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0082 0.0657
Trypanosoma brucei heat shock protein, putative 0.0034 0.0387 0.3093
Echinococcus multilocularis RUN 0.0021 0.0139 0.0139
Echinococcus multilocularis solute carrier family 22 0.0019 0.0099 0.0099
Plasmodium vivax sugar transporter, putative 0.0019 0.0099 0.0213
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0276 0.0322
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0033 0.0033
Toxoplasma gondii superoxide dismutase SOD3 0.0078 0.1252 0.2701
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0552 0.0565
Loa Loa (eye worm) hypothetical protein 0.0053 0.0754 0.088
Schistosoma mansoni glucose transport protein 0.0019 0.0099 0.0099
Echinococcus multilocularis muscleblind protein 1 0.0155 0.2748 0.2748
Plasmodium falciparum heat shock protein 90 0.0034 0.0387 0.0836
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0044 0.0584 0.0682
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Onchocerca volvulus 0.005 0.0705 0.0721
Trypanosoma cruzi iron superoxide dismutase, putative 0.0078 0.1252 1
Echinococcus granulosus endoplasmin 0.0027 0.0254 0.0254
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0139 0.0139
Echinococcus granulosus tyrosine protein kinase Lyn 0.0016 0.0033 0.0033
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0019 0.0099 0.0099
Schistosoma mansoni endoplasmin 0.0034 0.0387 0.0387
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0552 0.0565
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Schistosoma mansoni inositol monophosphatase 0.0042 0.0552 0.0552
Loa Loa (eye worm) major facilitator superfamily transporter 0.0019 0.0099 0.0116
Toxoplasma gondii sugar transporter ST1 0.0019 0.0099 0.0213
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0254 0.1342
Brugia malayi Sugar transporter family protein 0.0019 0.0099 0.0116
Onchocerca volvulus 0.0019 0.0099 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0998 0.0998
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0254 0.1342
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Schistosoma mansoni heat shock protein 0.0034 0.0387 0.0387
Echinococcus multilocularis tyrosine kinase 0.0016 0.0033 0.0033
Schistosoma mansoni superoxide dismutase [mn] 0.0078 0.1252 0.1252
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0019 0.0099 0.079
Echinococcus multilocularis musashi 0.0028 0.0276 0.0276
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1202 0.1202
Echinococcus multilocularis synaptic vesicle 2 protein 0.0019 0.0099 0.0099
Brugia malayi hypothetical protein 0.0021 0.0139 0.0162
Trypanosoma cruzi iron superoxide dismutase, putative 0.0078 0.1252 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0584 0.0584
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0387 0.3093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0082 0.0082
Echinococcus multilocularis lamin 0.0028 0.0276 0.0276
Echinococcus multilocularis muscleblind protein 0.0155 0.2748 0.2748
Loa Loa (eye worm) major facilitator superfamily transporter 0.0019 0.0099 0.0116
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0099 0.079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0998 0.0998
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trypanosoma brucei Mitochondrial SSU ribosomal protein, putative 0.002 0.0111 0.0885
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0276 0.0322
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0082 0.0082
Plasmodium falciparum thioredoxin 3 0.0252 0.4637 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0998 0.0998
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0552 0.441
Echinococcus multilocularis tyrosine protein kinase Abl 0.0016 0.0033 0.0033
Trypanosoma brucei glucose transporter, putative 0.0019 0.0099 0.079
Toxoplasma gondii superoxide dismutase SOD2 0.0078 0.1252 0.2701
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0552 0.441
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Brugia malayi heat shock protein 90 0.0034 0.0387 0.0453
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0454 0.8562 1
Trichomonas vaginalis glucose transporter, putative 0.0019 0.0099 0.0101
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.0162
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0387 0.0836
Schistosoma mansoni hypothetical protein 0.0042 0.0554 0.0554
Entamoeba histolytica hypothetical protein 0.0076 0.1202 0.6988
Loa Loa (eye worm) hypothetical protein 0.0065 0.0998 0.1165
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0033 0.0033
Onchocerca volvulus 0.0019 0.0099 0.0101
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Onchocerca volvulus 0.0028 0.0276 0.0282
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Trichomonas vaginalis iron superoxide dismutase A, putative 0.0078 0.1252 0.128
Echinococcus granulosus tyrosine kinase 0.0016 0.0033 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Leishmania major glucose transporter, lmgt1 0.0019 0.0099 0.079
Echinococcus granulosus manganese superoxide dismutase 0.0078 0.1252 0.1252
Schistosoma mansoni tyrosine kinase 0.0016 0.0033 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0139 0.0139
Brugia malayi major facilitator superfamily protein 0.0019 0.0099 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Schistosoma mansoni glucose transporter 0.0019 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Plasmodium vivax superoxide dismutase [Fe], putative 0.0044 0.0594 0.1281
Loa Loa (eye worm) hypothetical protein 0.0028 0.0266 0.031
Echinococcus granulosus heat shock protein 90 0.0027 0.0254 0.0254
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0998 0.0998
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus granulosus solute carrier family 22 0.0019 0.0099 0.0099
Brugia malayi Pre-SET motif family protein 0.0065 0.0998 0.1165
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0139 0.0139
Schistosoma mansoni lipoxygenase 0.0088 0.1436 0.1436
Trypanosoma brucei glucose transporter, putative 0.0019 0.0099 0.079
Trichomonas vaginalis superoxide dismutase, putative 0.0078 0.1252 0.128
Schistosoma mansoni polycystin 1-related 0.0021 0.0139 0.0139
Brugia malayi hypothetical protein 0.0076 0.1202 0.1403
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0033 0.0033
Echinococcus granulosus heat shock protein 90 0.0034 0.0387 0.0387
Echinococcus granulosus tyrosine protein kinase Blk 0.0016 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0016 0.0033 0.0033
Trypanosoma brucei heat shock protein, putative 0.0034 0.0387 0.3093
Onchocerca volvulus 0.0517 0.9782 1
Brugia malayi Sugar transporter family protein 0.0019 0.0099 0.0116
Onchocerca volvulus 0.0065 0.0998 0.102
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0016 0.0033 0.0033
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0099 0.079
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0584 0.0584
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0078 0.1252 0.128
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0139 0.0139
Entamoeba histolytica hypothetical protein 0.0076 0.1202 0.6988
Schistosoma mansoni hypothetical protein 0.0076 0.1202 0.1202
Echinococcus granulosus lamin dm0 0.0028 0.0276 0.0276
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus granulosus solute carrier family 22 0.0019 0.0099 0.0099
Schistosoma mansoni heat shock protein 0.0034 0.0387 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0998 0.0998
Leishmania major iron superoxide dismutase, putative 0.0078 0.1252 1
Brugia malayi Pre-SET motif family protein 0.0454 0.8562 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0387 1
Plasmodium vivax superoxide dismutase [Fe], putative 0.0078 0.1252 0.2701
Plasmodium vivax thioredoxin 3, putative 0.0252 0.4637 1
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0387 0.0836
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Trypanosoma cruzi iron superoxide dismutase, putative 0.0078 0.1252 1
Onchocerca volvulus 0.0346 0.6451 0.6595
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0176 0.3153 0.3153
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Schistosoma mansoni tyrosine kinase 0.0016 0.0033 0.0033
Brugia malayi protein-tyrosine kinase 0.0016 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0254 0.2026
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0254 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0387 0.0396
Echinococcus multilocularis tyrosine protein kinase shark 0.0528 1 1
Echinococcus multilocularis protein patched 0.0044 0.0584 0.0584
Brugia malayi hypothetical protein 0.0019 0.0099 0.0116
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0552 0.0552
Onchocerca volvulus 0.0019 0.0099 0.0101
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0139 0.0299
Loa Loa (eye worm) sugar transporter 0.0019 0.0099 0.0116
Plasmodium vivax endoplasmin, putative 0.0034 0.0387 0.0836
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trypanosoma brucei sugar transporter, putative 0.0019 0.0099 0.079
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0254 0.2026
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0101
Brugia malayi CHE-14 protein 0.0044 0.0584 0.0682
Schistosoma mansoni survival motor neuron protein 0.005 0.0705 0.0705
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.2573 0.2573
Onchocerca volvulus 0.0016 0.0033 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trypanosoma brucei glucose transporter, putative 0.0019 0.0099 0.079
Trypanosoma brucei THT1 - hexose transporter, putative 0.0019 0.0099 0.079
Mycobacterium ulcerans superoxide dismutase [Fe] SodA 0.0078 0.1252 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0552 0.441
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0705 0.0824
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.217 0.217
Brugia malayi Tyrosine-protein kinase abl-1 0.0016 0.0033 0.0038
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0023 0.0027
Leishmania major superoxide dismutase, putative 0.0044 0.0594 0.4742
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Onchocerca volvulus 0.0016 0.0033 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0155 0.2748 0.3209
Trypanosoma brucei glucose transporter, putative 0.0019 0.0099 0.079
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0139 0.0139
Schistosoma mansoni lamin 0.0028 0.0276 0.0276
Brugia malayi Doublecortin family protein 0.0021 0.0139 0.0162
Onchocerca volvulus 0.0019 0.0099 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0101
Trypanosoma brucei iron superoxide dismutase 0.0078 0.1252 1
Brugia malayi Endoplasmin precursor 0.0034 0.0387 0.0453
Schistosoma mansoni hypothetical protein 0.0176 0.3153 0.3153
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0584 0.0584
Brugia malayi SRC-1 0.0016 0.0033 0.0038
Onchocerca volvulus Putative transporter 0.0019 0.0099 0.0101
Trypanosoma cruzi glucose transporter, putative 0.0019 0.0099 0.079
Echinococcus multilocularis lamin dm0 0.0028 0.0276 0.0276
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0033 0.0033
Brugia malayi Sugar transporter family protein 0.0019 0.0099 0.0116
Schistosoma mansoni glucose transport protein 0.0019 0.0099 0.0099
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0099 0.079
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0016 0.0033 0.0033
Brugia malayi Major Facilitator Superfamily protein 0.0019 0.0099 0.0116
Leishmania major iron superoxide dismutase, putative 0.0078 0.1252 1
Brugia malayi hypothetical protein 0.0246 0.4507 0.5264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0019 0.0099 0.0099
Mycobacterium leprae Probable superoxide dismutase SodA 0.0078 0.1252 1
Trypanosoma brucei glucose transporter 1E 0.0019 0.0099 0.079
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0078 0.1252 0.128
Trypanosoma brucei heat shock protein, putative 0.0034 0.0387 0.3093
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0998 0.0998
Brugia malayi Protein kinase domain containing protein 0.0016 0.0033 0.0038
Schistosoma mansoni tyrosine kinase 0.0528 1 1
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0082 0.0082
Echinococcus granulosus solute carrier family 22 0.0019 0.0099 0.0099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0033 0.0033
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0016 0.0033 0.0033
Brugia malayi hypothetical protein 0.0019 0.0099 0.0116
Toxoplasma gondii superoxide dismutase 0.0078 0.1252 0.2701
Loa Loa (eye worm) endoplasmin 0.0034 0.0387 0.0453
Brugia malayi Protein kinase domain containing protein 0.0016 0.0033 0.0038
Trypanosoma cruzi superoxide dismutase, putative 0.0044 0.0594 0.4742
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus granulosus tyrosine protein kinase Src42A 0.0016 0.0033 0.0033
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0078 0.1252 0.128
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0099 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0019 0.0099 0.0099
Entamoeba histolytica hypothetical protein 0.0076 0.1202 0.6988
Trypanosoma brucei superoxide dismutase, putative 0.0044 0.0594 0.4742
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0276 0.0322
Trypanosoma cruzi superoxide dismutase, putative 0.0044 0.0594 0.4742
Brugia malayi Cytochrome P450 family protein 0.0028 0.0272 0.0318
Onchocerca volvulus 0.0053 0.0754 0.077
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0387 0.2253
Trichomonas vaginalis glucose transporter, putative 0.0019 0.0099 0.0101
Onchocerca volvulus 0.0019 0.0099 0.0101
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0082 0.0178
Loa Loa (eye worm) hypothetical protein 0.0346 0.6451 0.7534
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0099 0.079
Leishmania major glucose transporter/membrane transporter D2, putative 0.0019 0.0099 0.079
Trichomonas vaginalis superoxide dismutase [mn], putative 0.0078 0.1252 0.128
Schistosoma mansoni sugar transporter 0.0019 0.0099 0.0099
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Echinococcus multilocularis endoplasmin 0.0027 0.0254 0.0254
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0078 0.1252 1
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0053 0.0769 0.0787
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Loa Loa (eye worm) hypothetical protein 0.0246 0.4507 0.5264
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0387 0.3093
Brugia malayi hypothetical protein 0.0019 0.0099 0.0116
Echinococcus granulosus expressed conserved protein 0.0096 0.1599 0.1599
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0552 0.0552
Onchocerca volvulus 0.0019 0.0099 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0099 0.0101
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0016 0.0033 0.0033
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.4507 0.4507
Brugia malayi hypothetical protein 0.0346 0.6451 0.7534
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0387 0.3093
Plasmodium vivax hexose transporter 0.0019 0.0099 0.0213
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0016 0.0033 0.0191
Onchocerca volvulus 0.0021 0.0139 0.0142
Schistosoma mansoni hypothetical protein 0.0021 0.0139 0.0139
Brugia malayi major facilitator superfamily protein 0.0019 0.0099 0.0116
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0139 0.0162
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1202 0.1202
Schistosoma mansoni glucose transport protein 0.0019 0.0099 0.0099
Onchocerca volvulus 0.0019 0.0099 0.0101
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0254 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Schistosoma mansoni tyrosine kinase 0.0016 0.0033 0.0033
Echinococcus granulosus synaptic vesicle 2 protein 0.0019 0.0099 0.0099
Toxoplasma gondii facilitative glucose transporter GT1 0.0019 0.0099 0.0213
Loa Loa (eye worm) hypothetical protein 0.0102 0.1719 0.2008
Echinococcus multilocularis solute carrier family 22 0.0019 0.0099 0.0099
Onchocerca volvulus 0.0019 0.0099 0.0101
Leishmania major myo-inositol/proton symporter (MIT) 0.0019 0.0099 0.079
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0584 0.0682
Schistosoma mansoni tyrosine kinase 0.0016 0.0033 0.0033
Onchocerca volvulus 0.0016 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0116
Echinococcus granulosus lamin 0.0028 0.0276 0.0276
Schistosoma mansoni endoplasmin 0.0034 0.0387 0.0387
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.1719 1
Leishmania major heat shock protein 83-1 0.0034 0.0387 0.3093
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0023 0.0027
Trichomonas vaginalis superoxide dismutase, putative 0.0078 0.1252 0.128
Schistosoma mansoni sugar transporter 0.0019 0.0099 0.0099
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0254 0.2026
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0082 0.0082
Echinococcus multilocularis heat shock protein 0.0034 0.0387 0.0387
Schistosoma mansoni patched 1 0.0044 0.0584 0.0584
Schistosoma mansoni hypothetical protein 0.0042 0.0554 0.0554
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0033 0.0033
Onchocerca volvulus 0.0019 0.0099 0.0101
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0082 0.0657
Schistosoma mansoni sugar transporter 0.0019 0.0099 0.0099
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0033 0.0033
Onchocerca volvulus 0.0019 0.0099 0.0101
Leishmania major iron superoxide dismutase 0.0078 0.1252 1
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.0033 0.0038
Entamoeba histolytica hypothetical protein 0.0076 0.1202 0.6988

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 150 nM Inhibition of recombinant Syk ChEMBL. 19254842
IC50 (binding) = 0.15 uM Inhibition of spleen tyrosine kinase (unknown origin) ChEMBL. 23917087
IC50 (binding) = 6.5 uM Inhibition of human GST-fused ZAP-70 expressed in Sf9 cells ChEMBL. 19674816

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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